EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Histone H3.3C (Embryonic)H3f3c Gm14384P0230115
Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3)Kpna3 Qip2O3534415
Integral membrane protein 2C (Transmembrane protein BRI3) [Cleaved into: CT-BRI3]Itm2cQ91VK415
Integrin alpha-3 (CD49 antigen-like family member C) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]Itga3Q6247015
Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain]Itga2bQ9QUM015
Intercellular adhesion molecule 1 (ICAM-1) (MALA-2) (MyD10) (CD antigen CD54)Icam1 Icam-1P1359715
Interleukin enhancer-binding factor 3Ilf3Q9Z1X415
Keratin, type II cytoskeletal 8 (Cytokeratin endo A) (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)Krt8 Krt2-8P1167915
Leucine-rich repeat-containing protein 59Lrrc59Q922Q815
Matrix metalloproteinase-14 (MMP-14) (EC (MMP-X1) (MT-MMP) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)Mmp14 MtmmpP5369015
Mitogen-activated protein kinase kinase kinase kinase 4 (EC (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)Map4k4 NikP9782015
MLV-related proviral Env polyprotein [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]0P1040415
Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3)Slc16a3 Mct4P5778715
Multidrug resistance protein 1B (EC (ATP-binding cassette sub-family B member 1B) (P-glycoprotein 1) (CD antigen CD243)Abcb1b Abcb1 Mdr1 Mdr1b Pgy1 Pgy1-1P0679515
Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B)Mvb12b Fam125bQ6KAU415
Nck-associated protein 1 (NAP 1) (Brain protein H19) (MH19) (Membrane-associated protein HEM-2) (p125Nap1)Nckap1 Hem2 Kiaa0587 Nap1P2866015
Niemann-Pick C1 proteinNpc1O3560415
Nucleobindin-1 (CALNUC)Nucb1 Nuc NucbQ0281915
Poliovirus receptor (Putative uncharacterized protein) (Tage4 receptor)Pvr D7Ertd458e Tage4 mCG_4885Q8K09415
Protein FAM234A (Protein ITFG3)Fam234a Itfg3Q8C0Z115
Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22)Ppp1r7 Sds22Q3UM4515
Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11)S100a10 Cal1lP0820715
Putative helicase MOV-10 (EC (Moloney leukemia virus 10 protein)Mov10 Gb110P2324915
Ras-related GTP-binding protein C (Rag C) (RagC) (GTPase-interacting protein 2) (TIB929)RragcQ99K7015
Ribonucleoside-diphosphate reductase large subunit (EC (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)Rrm1P0774215
Ribosomal proteinRpl10a mCG_123122 mCG_18533Q5XJF615
Serine/threonine-protein kinase MRCK beta (EC (CDC42-binding protein kinase beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)Cdc42bpb Kiaa1124Q7TT5015
Serine/threonine-protein phosphatase 2A activator (EC (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')Ptpa Ppp2r4P5838915
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC (Protein phosphatase 1C catalytic subunit)Ppp1ccP6308715
SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes)Sh3kbp1 Ruk SetaQ8R55015
Small nuclear ribonucleoprotein-associated protein B (snRNP-B) (snRPB) (Sm protein B) (Sm-B) (SmB)SnrpbP2704815
SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)SparcP0721415
Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61)Sf3a3 Sap61Q9D55415
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (U2 snRNP auxiliary factor large subunit)U2af2 U2af65P2636915
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC (Flavoprotein subunit of complex II) (Fp)SdhaQ8K2B315
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (mSnf2h)Smarca5 Snf2hQ91ZW315
Titin (EC (Connectin)TtnA2ASS615
Tripeptidyl-peptidase 1 (TPP-1) (EC (Lysosomal pepstatin-insensitive protease) (LPIC) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I)Tpp1 Cln2O8902315
Tyrosine-protein phosphatase non-receptor type 23 (EC Kiaa1471Q6PB4415
Vacuolar protein-sorting-associated protein 36 (ESCRT-II complex subunit VPS36)Vps36Q91XD615
Voltage-dependent anion-selective channel protein 3 (VDAC-3) (mVDAC3) (Outer mitochondrial membrane protein porin 3)Vdac3Q6093115
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC; Xanthine oxidase (XO) (EC (Xanthine oxidoreductase) (XOR)]XdhQ0051915
Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)Slc39a10 Kiaa1265 Zip10Q6P5F615
60S ribosomal protein L23aRpl23aP6275114
60S ribosomal protein L37aRpl37aP6151414
Acetyl-CoA acetyltransferase, mitochondrial (EC (Acetoacetyl-CoA thiolase)Acat1Q8QZT114
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma-adaptin 3b) (Sigma2-adaptin)Ap2s1 Ap17 Claps2P6274314
BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)Bag2Q91YN914
Calpain-1 catalytic subunit (EC (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Micromolar-calpain) (muCANP)Capn1 Canp1 Capa1O3535014
Calponin-3 (Calponin, acidic isoform)Cnn3Q9DAW914
Casein kinase II subunit beta (CK II beta) (Phosvitin)Csnk2b Ck2nP6787114
CD166 antigen (Activated leukocyte cell adhesion molecule) (BEN) (Protein DM-GRASP) (CD antigen CD166)AlcamQ6149014
Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Vacuolar protein sorting-associated protein 24)Chmp3 Vps24Q9CQ1014
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin]Col18a1P3906114
Collagen alpha-2(IV) chain [Cleaved into: Canstatin]Col4a2P0812214
Complement factor H (Protein beta-1-H)Cfh Hf1P0690914
Copine-2 (Copine II)Cpne2P5910814
Cyclin-Y (Cyclin fold protein 1)Ccny Cfp1Q8BGU514
Cysteine-rich protein 2 (CRP-2) (Heart LIM protein)Crip2 Crp2 HlpQ9DCT814
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)Dync1i2 Dnci2 Dncic2O8848714
Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic)Dync1li2 Dncli2 Dnclic2Q6PDL014
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (MCG2872, isoform CRA_a) (Probable ATP-dependent RNA helicase DDX5) (Putative uncharacterized protein)Ddx5 mCG_2872Q8BTS014
Desmoplakin (DP)DspE9Q55714
Dihydrofolate reductase (EC
Dihydrolipoyl dehydrogenase, mitochondrial (EC (Dihydrolipoamide dehydrogenase)DldO0874914
Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Unc-33-like phosphoprotein 3) (ULIP-3)Crmp1 Dpysl1 Ulip3P9742714
Dipeptidyl peptidase 3 (EC (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B)Dpp3Q99KK714
Disheveled-associated activator of morphogenesis 1Daam1Q8BPM014
DnaJ homolog subfamily B member 4Dnajb4Q9D83214
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit)DdostO5473414
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2)Rpn2Q9DBG614
Drebrin-like protein (Actin-binding protein 1) (SH3 domain-containing protein 7)Dbnl Abp1 Sh3p7Q6241814
E3 ubiquitin-protein ligase HUWE1 (EC (E3Histone) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)Huwe1 Kiaa0312 Ureb1Q7TMY814
Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1)Eef1a2 Eef1al StnP6263114
Epidermal growth factor receptor (EC
Epididymal secretory protein E1 (mE1) (Niemann Pick type C2 protein homolog)Npc2Q9Z0J014
Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)Erbin Erbb2ip Kiaa1225 Lap2Q80TH214
Eukaryotic translation elongation factor 1 epsilon-1 (Elongation factor p18) (Multisynthase complex auxiliary component p18)Eef1e1Q9D1M414
Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta)Eif2s2Q99L4514
Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)Eif3g Eif3p42 Eif3s4Q9Z1D114
Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1)Eif4g1Q6NZJ614
FAT atypical cadherin 1Fat1F2Z4A314
FerritinFtl1 Ftl1-ps1 mCG_17237Q9CPX414
Fibulin-1 (FIBL-1) (Basement-membrane protein 90) (BM-90)Fbln1Q0887914
GDP-L-fucose synthase (EC (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) (Protein FX) (Red cell NADP(H)-binding protein) (Transplantation antigen P35B) (Tum-P35B antigen)Tsta3 P35b Tstap35bP2359114
GDP-mannose 4,6 dehydratase (EC (GDP-D-mannose dehydratase) (GMD)GmdsQ8K0C914
Glia-derived nexin (GDN) (Peptidase inhibitor 7) (PI-7) (Protease nexin 1) (PN-1) (Protease nexin I) (Serine protease-inhibitor 4) (Serpin E2)Serpine2 Pi7 Pn1 Spi4Q0723514
Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH)PrkcshO0879514
Glycerol-3-phosphate dehydrogenase 1-like protein (EC Kiaa0089Q3ULJ014
GTP-binding protein Rheb (Ras homolog enriched in brain)RhebQ921J214
GTPase HRas (H-Ras-1) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]Hras Hras1Q6141114
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)Gnb4P2938714
H-2 class I histocompatibility antigen, Q10 alpha chainH2-Q10P0189814
Histone H2B type 1-H (h2B-221)Hist1h2bhQ6447814
Immunoglobulin superfamily member 3 (IgSF3)Igsf3 Kiaa0466Q6ZQA614
Laminin subunit beta-2 (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta)Lamb2 LamsQ6129214
LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1)Lims1 Pinch1Q99JW414
Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC (Low molecular weight cytosolic acid phosphatase) (EC
Low-density lipoprotein receptor (LDL receptor)LdlrP3595114
MCG5400 (Myosin, light chain 12A, regulatory, non-sarcomeric) (Putative uncharacterized protein)Myl12a 2900073G15Rik mCG_5400Q6ZWQ914
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