EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL mopA PA4385P3071815
DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC (RNA polymerase subunit beta) (Transcriptase subunit beta)rpoB PA4270Q5156115
Outer membrane porin FoprF PA1777P1379415
LPS-assembly protein LptDlptD imp ostA PA0595Q9I5U214
Outer membrane protein OprGoprG PA4067Q9HWW114
Anaerobically-induced outer membrane porin OprEoprE PA0291G3XDA513
ATP synthase subunit alpha (EC (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha)atpA PA5556Q9HT1813
ATP synthase subunit beta (EC (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)atpD PA5554Q9HT2013
B-type flagellinfliC PA1092P7215113
DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC (RNA polymerase subunit alpha) (Transcriptase subunit alpha)rpoA PA4238O5276013
DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC (RNA polymerase subunit beta') (Transcriptase subunit beta')rpoC PA4269Q9HWC913
Fimbrial protein (Pilin)pilA fimA PA4525P0473913
LPS-assembly lipoprotein LptElptE PA3988Q9HX3213
Outer membrane protein assembly factor BamBbamB PA3800Q9HXJ713
Peptidoglycan-associated lipoproteinpal oprL PA0973Q9I4Z413
PhoP/Q and low Mg2+ inducible outer membrane protein H1oprH PA1178G3XD1113
Porin D (EC 3.4.21.-) (Imipenem/basic amino acid-specific outer membrane pore) (Outer membrane protein D2)oprD PA0958P3272213
Probable outer membrane proteinPA1288Q9I45613
Probable outer membrane proteinPA2760Q9I08313
Succinate dehydrogenase flavoprotein subunit (EC PA1583Q9I3D513
Ubiquinol-cytochrome c reductase iron-sulfur subunit (EC
Uncharacterized proteinPA0833Q9I5A713
30S ribosomal protein S1rpsA PA3162Q9HZ7112
Arginine deiminase (ADI) (EC (Arginine dihydrolase) (AD)arcA PA5171P1398112
Cysteine desulfurase IscS (EC EcE24377A_2815A7ZPX412
Esterase EstA (EC (Autotransporter esterase EstA)estA papA PA5112O3340712
Fructose-1,6-bisphosphatase class 1 (FBPase class 1) (EC (D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1)fbp AM266_13880A0A0D0NE3212
Glutamine synthetase (GS) (EC (Glutamate--ammonia ligase) (Glutamine synthetase I beta) (GSI beta)glnA PA5119Q9HU6512
Head protein (Minor capsid protein E)BE932_30125 SY51_06460A0A061KGU912
Lipid A deacylase PagL (EC (LPS 3-O-deacylase PagL) (Outer membrane enzyme PagL) (PhoP/PhoQ-activated gene product L)pagL PA4661Q9HVD112
Major outer membrane lipoprotein (Outer membrane lipoprotein I)oprI PA2853P1122112
Ornithine carbamoyltransferase, catabolic (OTCase) (EC PA5172P0830812
Outer membrane protein OprMoprM oprK PA0427Q5148712
Porin B (Glucose porin) (Outer membrane protein D1)oprB PA3186Q5148512
Probable outer membrane proteinPA4974Q9HUJ112
Protein HflChflC PA4941Q9HUM312
Pyruvate dehydrogenase E1 component (PDH E1 component) (EC aceA PA5015Q5963712
S-adenosylmethionine synthase (AdoMet synthase) (EC (MAT) (Methionine adenosyltransferase)metK EcE24377A_3284A7ZR6412
Succinate--CoA ligase [ADP-forming] subunit beta (EC (Succinyl-CoA synthetase subunit beta) (SCS-beta)sucC PA1588P5359312
Uncharacterized proteinPA4423Q9HVZ212
2-methylcitrate dehydratase (EC mmgE BE932_25345 SY51_01840A0A061YGI311
2-oxoglutarate dehydrogenase (E1 subunit)sucA PA1585Q9I3D311
50S ribosomal protein L19rplS PA3742Q9HXQ211
50S ribosomal protein L21rplU PA4568Q9HVL611
Acyl carrier protein (ACP) (Cytosolic-activating factor) (CAF) (Fatty acid synthase acyl carrier protein)acpP SF1098 S1178P0A6B311
Adenosylhomocysteinase (EC (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase)ahcY sahH PA0432Q9I68511
Amidophosphoribosyltransferase (ATase) (EC (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPATase)purF BE932_09165 SY51_13205A0A061YKW811
B-type flagellar hook-associated protein 2 (HAP2) (Filament cap protein) (Flagellar cap protein)fliD PA1094Q9K3C511
Chaperone protein HtpG (Heat shock protein HtpG) (High temperature protein G)htpG PA1596Q9I3C511
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (E2)aceF aceB PA5016Q5963811
Elongation factor G 1 (EF-G 1)fusA fusA1 PA4266Q9HWD211
Elongation factor Tu (EF-Tu)tufA PA4265; tufB PA4277P0959111
Fimbrial assembly protein PilQpilQ PA5040P3475011
Flagellar hook protein FlgEflgE PA1080Q9I4P911
Glucans biosynthesis protein GopgG PA5078Q9HUA511
Glycine betaine transmethylasegbt PA3082Q9HZC611
Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC PA3770Q9HXM511
Insulin-cleaving metalloproteinase outer membrane proteinicmP PA4370Q9HW3211
Isocitrate dehydrogenaseidh PA2624Q9I0L411
Multidrug resistance protein MexAmexA PA0425P5247711
Probable bacteriophage proteinPA0623Q9I5S911
Probable bacteriophage proteinPA0622G3XD3911
Probable cytochrome c1PA4429Q9HVY611
Probable TonB-dependent receptorPA4675Q9HVC011
Putative copper transport outer membrane porin OprCoprC PA3790G3XD8911
Trigger factor (TF) (EC (PPIase)tig PA1800Q9I2U211
Uncharacterized proteinPA4632Q9HVF911
Uncharacterized proteinPA3309Q9HYT511
Uncharacterized proteinPA1053Q9I4S111
Uncharacterized proteinPA2462Q9I12011
Uncharacterized proteinPA0070Q9I76211
Uncharacterized proteinPA4639Q9HVF211
Uncharacterized proteinPA3674Q9HXW611
Uncharacterized proteinECO9455_29784K4VWN011
30S ribosomal protein S18rpsR CKO_03630A8AMJ610
30S ribosomal protein S6 (Small ribosomal subunit protein bS6) [Cleaved into: 30S ribosomal protein S6, fully modified isoform; 30S ribosomal protein S6, non-modified isoform]rpsF b4200 JW4158P0235810
30S ribosomal protein S9rpsI PA4432Q9HVY310
50S ribosomal protein L14rplN PA4253Q9HWE510
50S ribosomal protein L18rplR PA4247Q9HWF110
50S ribosomal protein L25 (General stress protein CTC)rplY ctc PA4671Q9HVC410
50S ribosomal protein L6rplF PA4248Q9HWF010
Aconitate hydratase B (ACN) (Aconitase) (EC ((2R,3S)-2-methylisocitrate dehydratase) ((2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase) (2-methyl-cis-aconitate hydratase) (EC (Iron-responsive protein-like) (IRP-like) (RNA-binding protein)acnB PA1787Q9I2V510
Adenylosuccinate synthetase (AMPSase) (AdSS) (EC (IMP--aspartate ligase)purA BE932_21360 SY51_24070A0A061Y7T910
ATP synthase gamma chain (ATP synthase F1 sector gamma subunit) (F-ATPase gamma subunit)atpG PA5555Q9HT1910
ATP-dependent 6-phosphofructokinase isozyme 1 (ATP-PFK 1) (Phosphofructokinase 1) (EC (6-phosphofructokinase isozyme I) (Phosphohexokinase 1)pfkA EcE24377A_4449A7ZUC910
Beta-lactamase HcpA (EC (Cysteine-rich 28 kDa protein)hcpA HP_0211O2500110
Biotin carboxylase (EC (Acetyl-CoA carboxylase subunit A) (ACC) (EC fabG PA4848P3779810
Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70)dnaK PA4761Q9HV4310
Cytochrome c oxidase, cbb3-type, CcoO subunitccoO1 PA1553Q9I3G410
Delta-aminolevulinic acid dehydratase (ALAD) (ALADH) (EC (Porphobilinogen synthase)hemB PA5243Q5964310
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex)sucB PA1586Q9I3D210
Fe(3+)-pyochelin receptor (Fe(III)-pyochelin receptor)fptA PA4221P4251210
Gamma-glutamyltransferase (Gamma-glutamyltranspeptidase) (EC BE932_16185 SY51_19675A0A066SWG210
Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.-)PA3001Q9HZK410
Isocitrate dehydrogenase [NADP] (EC PA2623Q9I0L510
Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein (LIVAT-BP) (Leu/Ile/Val/Thr/Ala-binding protein)braC PA1074P2117510
NAD-specific glutamate dehydrogenase (NAD-GDH) (EC (NAD(+)-dependent glutamate dehydrogenase)gdhB PA3068Q9HZE010
Outer membrane protein assembly factor BamAopr86 bamA PA3648Q9HXY410
Peptidyl-prolyl cis-trans isomerase (EC
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