EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
UPF0325 protein YaeHyaeH BY96_04885A0A027U2406
Uridylate kinase (UK) (EC (Uridine monophosphate kinase) (UMP kinase) (UMPK)pyrH EcE24377A_0175A7ZHR16
Vacuolating cytotoxin autotransporter [Cleaved into: Vacuolating cytotoxin; Vacuolating cytotoxin translocator]vacA HP_0887P559816
1,4-alpha-glucan branching enzyme GlgB (EC (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Glycogen branching enzyme) (BE)glgB Ecok1_34110 APECO1_3025A1AGW55
1,4-beta-N-acetylmuramidase (EC spr1431Q8DP075
2-hydroxy-3-oxopropionate reductase (EC (Tartronate semialdehyde reductase) (TSAR)garR APU18_16730 BE932_14530 SY51_18060A0A061YP035
2-hydroxyacid dehydrogenase (D-lactate dehydrogenase) (Fermentative D-lactate dehydrogenase) (Fermentative D-lactate dehydrogenase, NAD-dependent) (Lactate dehydrogenase) (EC (NAD-dependent fermentative D-lactate dehydrogenase)ldhA A5958_24820 AA102_23370 AC067_16095 AC789_1c15090 ACN002_1665 ACN77_11940 ACN81_14125 ACN87_19380 AKG99_21825 AM270_05105 AMK83_00390 AML07_18010 AML35_28190 APT94_18025 APU18_11185 APZ14_18455 ARC77_03125 AU473_17505 AUS26_06695 BE932_02645 BE949_03385 BE957_16755 BE963_21995 BHF46_12255 BIQ85_08290 BK251_04385 BK292_03800 BK373_11340 BK375_17465 BK400_18020 BMT53_03315 BMT61_07835 BMT91_24470 BMT94_19190 BN17_12011 BV389_13835 BWP17_15895 BXT93_25670 ECs2002 EL75_2366 EL79_2369 EL80_2377 ERS085366_01003 ERS085379_01714 ERS085383_03619 ERS085386_04098 ERS085404_03558 ERS085406_00659 ERS139235_02077 FORC28_3350 GJ12_09260 HMPREF3040_04157 JD73_26645 MJ49_24845 PU06_28605 RG28_15385 SM09_04153 SY51_08270 UC41_22425 UN86_23870 UN91_06400 WQ89_18615 WR15_00340C3TB725
2-methylisocitrate lyase (2-MIC) (MICL) (EC ((2R,3S)-2-methylisocitrate lyase)prpB BE932_25335 SY51_01830 WM48_02050A0A061YA815
2-oxoisovalerate dehydrogenase subunit beta (EC (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDH E1-beta)bkdA2 PA2248Q9I1M15
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC (EC (KDO 8-P phosphatase)BX06_10085A0A028AJV65
3-methyl-2-oxobutanoate hydroxymethyltransferase 2 (EC (Ketopantoate hydroxymethyltransferase 2) (KPHMT 2)panB2 PA4729Q9HV705
30S Ribosomal protein S1rpsA spr0764Q8CWR95
30S ribosomal protein S11rpsK PA4240Q9HWF85
30S ribosomal protein S15rpsO EcE24377A_3649A7ZS625
30S ribosomal protein S19rpsS PA4259Q9HWD95
30S ribosomal protein S2rpsB spr2020Q8CWM85
30S ribosomal protein S3rpsC spr0195P0A4C45
5'-deoxynucleotidase YfbR (EC (5'-deoxyribonucleotidase) (Nucleoside 5'-monophosphate phosphohydrolase)yfbR UMNK88_2841A0A0E0U0U45
50S ribosomal protein L1rplA NGO1854Q5F5R25
50S ribosomal protein L10rplJ EcE24377A_4525A7ZUJ85
50S ribosomal protein L18rplR CKO_04717A8AQJ95
50S ribosomal protein L19rplS spr1171Q8CWQ95
50S ribosomal protein L23rplW PA4261Q9HWD75
50S ribosomal protein L24rplX ESA_00016A7MPH55
50S ribosomal protein L27rpmA EcE24377A_3670A7ZS815
50S ribosomal protein L28rpmB PA5316Q9HTN85
50S ribosomal protein L6rplF EcE24377A_3788A7ZSJ45
6-phosphogluconate dehydrogenase, decarboxylating (EC BET08_08655 SY51_11785A0A061K5W15
ABC transporter ATP-binding protein (ABC-F family ATPase) (Putative ABC transporter ATP-binding protein) (Putative ABC transporter ATP-binding protein YheS)ybiT yheS_1 A4T40_07810 APT94_22290 BE949_12915 BE963_18355 BHS81_04995 BIQ85_05035 BK251_07830 BK292_21295 BK334_19930 BK383_19155 BMT97_07920 BXT93_09385 ECONIH1_04685 ERS085406_04002 MS6198_08960A0A023L1Y15
ABC transporter substrate-binding proteinECONIH1_22565A0A0A1AJL25
ABC transporter substrate-binding proteinBE932_26475 SY51_02925A0A066T6865
ABC transporter substrate-binding proteinAPU18_19820 BE932_20070 SY51_23515A0A061YGV85
Acetyl-coenzyme A synthetase 1 (AcCoA synthetase 1) (Acs 1) (EC (Acetate--CoA ligase 1) (Acyl-activating enzyme 1)acsA1 PA0887Q9I5585
Aconitate hydratase A (ACN) (Aconitase) (EC ((2R,3S)-2-methylisocitrate dehydratase) ((2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase) (Iron-responsive protein-like) (IRP-like) (Probable 2-methyl-cis-aconitate hydratase) (EC (RNA-binding protein)acnA PA1562Q9I3F55
Adenylosuccinate synthetase (AMPSase) (AdSS) (EC (IMP--aspartate ligase)purA spr0021P658885
Alcohol dehydrogenaseadhA PA5427Q9HTD95
Aldehyde dehydrogenaseBE932_02700 SY51_08325A0A066SZX65
Aldehyde oxidaseBE932_25125 SY51_01660A0A066T1495
Aldehyde-alcohol dehydrogenaseadhE spr1837Q8DNA55
Aldehyde-alcohol dehydrogenaseadhE CE10_1418A0A0E0V3X75
Alkaline phosphatase (EC ECRM12581_2290A0A023YSZ55
ALS ss C and LacI and Peripla BP 3 domain contain ing proteinTTRE_0000894001A0A077ZJI95
Amidophosphoribosyltransferase (ATase) (EC (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPATase)purF PA3108Q513425
Amino acid transporter (Glutamate/aspartate ABC transporter substrate-binding protein)BE932_26875 SY51_03305A0A061KSF05
Aminopeptidase NpepN CE10_0960A0A0E0V2K35
Arginine transporter ATP-binding subunit (Glutamate/aspartate transport ATP-binding protein GltL)artP BE932_26860 SY51_03290A0A066T6945
Arginine/ornithine binding protein AotJaotJ PA0888G3XD475
Argininosuccinate lyase (ASAL) (EC (Arginosuccinase)argH PA5263P509875
Argininosuccinate lyase (ASAL) (EC (Arginosuccinase)argH BE932_19225 SY51_22760A0A061KXW55
Asparagine--tRNA ligase (EC (Asparaginyl-tRNA synthetase) (AsnRS)asnS BE932_28905 SY51_05280A0A066SSJ35
Aspartate aminotransferase (AspAT) (EC (Transaminase A)aspC PA3139P721735
Aspartate ammonia-lyase (Aspartase) (EC PA5429Q9HTD75
Aspartokinase (EC A5958_08635 AA102_12470 ACN77_13115 ACN81_05635 ACU90_04680 AM270_18540 AMK83_25475 BE957_27515 BK251_06625 BK292_00910 BMT53_13435 BMT61_09215 ERS085374_01601 ERS085379_04006 ERS139235_02640 GJ12_24700 HW42_01680 PU06_05905 UN86_02920A0A066RJM75
Aspartokinase (EC (Aspartate kinase)lysC PA0904O690775
ATP synthase subunit alpha (EC (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha)atpA NGO2148Q5F4Z25
ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b)atpF NGO2146Q5F4Z45
ATP synthase subunit beta (EC (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)atpD NGO2150Q5F4Z05
ATP synthase subunit delta (ATP synthase F(1) sector subunit delta) (F-type ATPase subunit delta) (F-ATPase subunit delta)atpH Ec53638_2106A0A0E1T1N55
ATP-dependent Clp protease ATP-binding subunit ClpXclpX spr1427P637925
ATP-dependent Clp protease ATP-binding subunit ClpXclpX PA1802Q9I2U05
ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)ftsH PA4751Q9HV485
Beta-barrel assembly-enhancing protease (EC 3.4.-.-)yggG_1 bepA AC067_02815 APT94_12520 BE932_09990 BE949_09980 BE963_28215 BIQ85_14040 BK375_00680 BMT94_06155 BMT97_17080 ERS085366_00328 SM09_02653 SY51_14320 UC41_17200A0A023KM275
Beta-lactamase (EC bla(ampc-EC6) BE932_21230 SY51_23940Q5MAJ85
Branched chain amino acid ABC transporter substrate-binding protein (Leucine ABC transporter substrate-binding protein)BE932_16240 SY51_19735A0A061KAJ25
Capsid proteinBX23_14150A0A028E3K75
Carboxy-terminal peptidaseprc NMB1332Q9JZ215
Catalase-peroxidase (CP) (EC (Peroxidase/catalase)katG Ecok1_39170 APECO1_2524A1AIC15
Cell division protein FtsAftsA SF0091 S0093P0ABH35
Cell division protein FtsH (HflK protein) (Protease modulator HflK)hflK A5958_07485 AMK83_03575 BE957_26555 ERS085379_04133 ERS085386_00992 ERS139235_04250 UN86_20825A0A066R9J05
Cell division protein FtsZftsZ PA4407P472045
Cell division protein ZipAzipA PA1528Q9I3I55
Chitin-binding protein CbpD (Protease LasD)cbpD lasD PA0852Q9I5895
CTP synthase (EC (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)pyrG PA3637Q9HXZ45
Cystathionine gamma-synthase (EC SY51_22645A0A061L1M85
Cytochrome b562UN86_21160 WR15_06660A0A0A6VHK75
Cytochrome c oxidase, cbb3-type, CcoO subunitccoO2 PA1556Q9I3G15
Cytochrome c5cycB PA5300Q9HTQ45
Cytochrome c551 peroxidaseHP_1461O259975
Cytochrome c551 peroxidase (CCP) (Cytochrome c peroxidase) (EC PA4587P145325
D-methionine-binding lipoprotein MetQmetQ yaeC b0197 JW0193P286355
D-serine dehydratase (EC (D-serine deaminase) (DSD)dsdA BE932_09425 SY51_13775A0A061L3755
Dihydropteroate synthase (DHPS) (EC (Dihydropteroate pyrophosphorylase)folP BE932_14800 SY51_18320A0A061KD915
DNA ligase (EC (Polydeoxyribonucleotide synthase [NAD(+)])ligA A4T40_17325 BK334_04040 ECONIH1_13890 MS6198_27350A0A023L5205
DNA polymerase III subunit beta (EC Z5192 ECs4636P0A9905
DNA-binding transcriptional repressoruidR ECED1_1817B7MV945
DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC (RNA polymerase subunit beta) (Transcriptase subunit beta)rpoB spr1777Q8DNF05
DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC (RNA polymerase subunit beta') (Transcriptase subunit beta')rpoC spr1776Q8DNF15
DUF2190 domain-containing protein (Membrane protein)A4T50_20360 APT94_24685 BE932_28620 BK334_20280 BMT94_17150 SM09_00047 SY51_04995A0A061YK475
Elongation factor Tu (EF-Tu)tuf tufA spr1343P640315
Elongation factor Tu 1 (EF-Tu 1) (Bacteriophage Q beta RNA-directed RNA polymerase subunit III) (P-43)tufA b3339 JW3301P0CE475
Enolase (EC (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)eno PA3635Q9HXZ55
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