EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
60 kDa chaperonin 1 (GroEL protein 1) (Protein Cpn60 1)groL1 groEL1 Ecok1_41970 APECO1_2246A1AJ517
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (ACCase subunit alpha) (Acetyl-CoA carboxylase carboxyltransferase subunit alpha) (EC PA3639Q9HXZ27
Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC (Acetate--CoA ligase) (Acyl-activating enzyme)acs BE932_19975 SY51_23445A0A061YD177
Acidic protein MsyB (SecY/secA suppressor protein)msyB A4T50_20895 APU18_13050 BE932_29460 ERS085406_01138 SY51_05820 WM48_05395E2QJT57
Aconitate hydratase (Aconitase) (EC SY51_07865A0A061YJD57
Adenylosuccinate lyase (ASL) (EC (Adenylosuccinase)BE932_29875 SY51_06225A0A066SWS67
Adenylosuccinate synthetase (AMPSase) (AdSS) (EC (IMP--aspartate ligase)purA PA4938Q9HUM67
Alkyl hydroperoxide reductase subunit C (EC (Alkyl hydroperoxide reductase protein C22) (Peroxiredoxin) (SCRP-23) (Sulfate starvation-induced protein 8) (SSI8) (Thioredoxin peroxidase)ahpC Z0749 ECs0644P0AE107
Aspartate ammonia-lyase (Aspartase) (EC Z5744 ECs5120Q8XDS07
Aspartate--tRNA ligase (EC (Aspartyl-tRNA synthetase) (AspRS)aspS BE932_04870 SY51_10360A0A061K5F67
ATP-dependent Clp protease ATP-binding subunit ClpA (Clp protease ClpX)clpA ACN77_12510 ACN81_15210 PU06_08875 RG28_00080A0A099B0K97
ATP-dependent Clp protease ATP-binding subunit ClpXclpX BE932_25810 SY51_02295A0A066SXC77
Beta-lactamase (EC blaCTX-M-15C7S9T07
Bifunctional glucose-1-phosphatase/inositol phosphatase (Glucose-1-phosphatase)BE932_29215 SY51_05580A0A066SWF77
Bifunctional protein PutAputA PA0782Q9I5F67
Bifunctional purine biosynthesis protein PurH [Includes: IMP cyclohydrolase (EC (IMP synthase) (Inosinicase) (ATIC); Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC (AICAR transformylase)]purH BE932_19490 SY51_23005A0A061KF777
Cag pathogenicity island protein (Cag24)HP_0545O252777
Carbonic anhydraseHP_1186O257987
Carbonic anhydrase (EC (Carbonate dehydratase)A4T50_24490 WM48_00680A0A0D8VVB17
Catalase-related peroxidase (EC 1.11.1.-)HP_0485O252297
Chaperone protein Skpskp hlpA Z0190 ECs0180P0AEU97
Chaperone SurA (Peptidyl-prolyl cis-trans isomerase SurA) (PPIase SurA) (EC (Rotamase SurA)surA PA0594Q9I5U37
Conserved hypothetical secreted proteinHP_1285O258727
Conserved hypothetical secreted proteinHP_1286O258737
D-ala-D-ala-carboxypeptidasedacC PA3999G3XD747
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC (2-oxoglutarate dehydrogenase complex component E2)BE932_27275 SY51_03695A0A061YGN47
DNA gyrase subunit A (EC BE932_08765 SY51_12810A0A066T8U17
DNA polymerase I (EC BE932_18690 SY51_22035A0A066T9A87
DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC (RNA polymerase subunit alpha) (Transcriptase subunit alpha)rpoA CKO_04708A8AQJ07
DNA-directed RNA polymerase subunit omega (RNAP omega subunit) (EC (RNA polymerase omega subunit) (Transcriptase subunit omega)rpoZ CKO_05106A8ARN67
Elongation factor Ts (EF-Ts)tsf PA3655O828517
Exodeoxyribonuclease IIIBE932_04205 SY51_09720A0A066SZZ47
Ferric aerobactin receptor (Ferric aerobactin receptor IutA) (IutA) (Ligand-gated channel protein)iutA AC789_145pl00610 BUE82_28005 MJ49_27155B1P7H47
Ferrichrome porin FhuA (Ferrichrome transporter)BE932_23885 SY51_00880A0A061KWY37
Ferripyoverdine receptorfpvA PA2398P486327
Flagellar hook-associated protein 2 (HAP2) (Flagellar cap protein)fliD BE932_05810 BET08_24985 SY51_10940A0A066T1U87
Flagellar hook-associated protein type 3 FlgLflgL PA1087Q9I4P27
Fumarase D (EC ydhZ Z2703 ECs2382P0ACX77
Gamma-glutamyl phosphate reductase (GPR) (EC (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase)proA BE932_24585 SY51_01530A0A066T1257
Gamma-glutamyltranspeptidaseggt ECW_m3706E0IZS57
GIDA and GidB and GIDA assoc 3 domain containing proteinTTRE_0000342901A0A077Z3W07
Glucose-1-phosphate adenylyltransferase (EC (ADP-glucose pyrophosphorylase) (ADPGlc PPase) (ADP-glucose synthase)glgC ECS88_3828B7MDR57
Glutamine synthetase (EC ECED1_4571B7N2L27
Glycine dehydrogenase (decarboxylating) 1 (EC (Glycine cleavage system P-protein 1) (Glycine decarboxylase 1) (Glycine dehydrogenase (aminomethyl-transferring) 1)gcvP1 PA2445Q9I1377
GlyoxalaseyhbL APU18_16310 BE932_14960 ERS085406_02951 SY51_18480 WM48_17835A0A066SXW27
Histidine porin OpdCopdC PA0162Q9I6X07
Histidine--tRNA ligase (EC (Histidyl-tRNA synthetase) (HisRS)hisS E2348C_2797B7UGW07
HTH-type transcriptional repressor PurR (Pur regulon repressor) (Purine nucleotide synthesis repressor)purR EC1303_c17820A0A0E1LXL37
Integration host factor subunit beta (IHF-beta)ihfB himD EcE24377A_1009A7ZK017
Iron(III) ABC transporter, periplasmic iron-binding protein (CeuE)HP_1561O260827
Isocitrate lyase (ICL) (EC (Isocitrase) (Isocitratase)PA2634Q9I0K47
LipoproteinA4T50_06530 APU18_19580 BE932_10825 BE963_28830 BK383_10895 BUE82_05220 HMPREF3040_04038 SY51_14880A0A061YGI67
Lipoyl synthase (EC (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA)lipA EcE24377A_0652A7ZJ157
LPP20 lipoproteinlpp20 HP_1456P0A0V07
Malic enzymePA5046Q9HUD37
Maltose operon protein MalM (Maltose-binding protein)BE932_19710 SY51_23210A0A061KXS97
Membrane fusion protein (MtrC)HP_0606O253277
Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH) (EC PA3570P288107
Motility protein FimVfimV PA3115Q9HZA67
N-acetylneuraminic acid channel protein (N-acetylnuraminic acid outer membrane channel protein) (Putative N-acetylneuraminic acid outer membrane channel protein nanC) (Putative N-acetylneuraminic acid outer membrane channel protein nanC Porin nanC) (Putative uncharacterized protein yjhA)yjhA A4X18_13330 ACU90_17215 AM266_23005 AWG90_17470 EL75_4896 EL79_4114 EL80_5290 OK10_23245 SM09_03181 SY51_16940Q6KCY77
NADH-quinone oxidoreductase subunit C/D (EC (NADH dehydrogenase I subunit C/D) (NDH-1 subunit C/D)nuoC nuoCD nuoD PA2639Q9I0J97
Neuraminyllactose-binding hemagglutinin (Flagellar sheath adhesin) (N-acetylneuraminyllactose-binding fibrillar hemagglutinin receptor-binding subunit) (NLBH)hpaA HP_0797P559697
Nucleoid occlusion factor SlmAslmA EcE24377A_4142A7ZTJ27
Osmotically inducible lipoprotein OsmEosmE PA4876Q9HUT77
Outer membrane lipoproteinybaY CE10_0426A0A0E0V1A47
Outer membrane protein (Omp19)HP_0896O255567
Outer membrane protein (Omp20)HP_0912O255707
Outer membrane protein (Omp21)HP_0913O255717
Outer membrane protein (Omp27)HP_1177O257917
Outer membrane protein (Omp28)HP_1243O258407
Outer membrane protein (Omp29) (Outer membrane protein (Omp5))HP_0227 HP_1342O345237
Outer membrane protein (Omp32)HP_1501O260317
Outer membrane protein (Omp6)HP_0229O250157
Outer-membrane lipoprotein carrier proteinlolA APT94_21875 BE949_12490 BIQ85_05465 BK375_14860 BMT94_04235 BMT97_10370 SM09_01738 UC41_14315A0A0D8WAK37
Oxygen-insensitive NAD(P)H nitroreductasenfnB AC789_1c06140A0A0E1L4N67
Peptide methionine sulfoxide reductase MsrA/MsrB [Includes: Peptide methionine sulfoxide reductase MsrA (Protein-methionine-S-oxide reductase) (EC (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase); Peptide methionine sulfoxide reductase MsrB (EC (Peptide-methionine (R)-S-oxide reductase)]msrAB msrA HP_0224O250117
Periplasmic serine endoprotease DegP-like (EC SY51_00935A0A061KXL27
Periplasmic serine endoprotease DegP-like (EC APU18_16215 BE932_15055 ERS085406_02969 SY51_18565A0A061KHZ97
Phage shock protein A (Phage shock protein PspA)pspA A4T50_22895 APU18_11445 ERS085406_00709 WM48_06975A0A0D6IKJ07
Phosphatidylserine decarboxylase proenzyme (EC [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]psd PA4957Q9HUK87
Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC ECRM12581_25010A0A023Z5Q17
Phosphoenolpyruvate synthase (PEP synthase) (EC (Pyruvate, water dikinase)ppsA PA1770Q9I2W97
Phosphoenolpyruvate synthase (PEP synthase) (EC (Pyruvate, water dikinase)BE932_03955 SY51_09480A0A066SS877
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC (SAICAR synthetase)purC EcE24377A_2757A7ZPS17
Plasminogen-binding protein PgbApgbA HP_0508O252497
Predicted outer membrane porin proteinyfaZ E2348C_2394B7UFR27
Probable acyl-CoA dehydrogenasePA2815Q9I0287
Probable malate:quinone oxidoreductase 1 (EC (MQO 1) (Malate dehydrogenase [quinone] 1)mqo1 mqoA PA3452Q9HYF47
Probable phosphatase YcdX (EC 3.1.3.-)ycdX BE932_29360 SY51_05720A0A066SSD17
Probable phospholipid-binding lipoprotein MlaAmlaA vacJ b2346 JW2343P765067
Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion proteinmexH PA4206Q9HWH57
Probable TonB-dependent receptorPA2911Q9HZT67
Processing protease (YmxG)HP_0657O253717
Protease (PqqE)HP_1012O256567
Protein YceIyceI BE932_29485 SY51_05845A0A061KYU47
Protein YgiWygiW Z4376 ECs3906P0ADU67
PslEpslE PA2235Q9I1N47
Putative beta-lactamase HcpC (EC (Cysteine-rich protein C)hcpC HP_1098O257287
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