EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Putative hemolysinNMB2091Q9JXE14
Putative iron transport receptor proteinSmlt1148B2FRZ94
Putative lipoproteinMXAN_6574Q1CY274
Putative lipoproteinMXAN_0962Q1DDQ04
Putative lipoproteinMXAN_0283Q1DFL04
Putative lipoprotein NMB1126/NMB1164NMB1126; NMB1164Q7DDH44
Putative LppC family lipoproteinSmlt0742B2FNM54
Putative oar family adhesion proteinSmlt1619B2FJB14
Putative outer membrane antigen lipoproteinSmlt3215B2FLE94
Putative outer membrane esteraseSmlt3773B2FSC84
Putative outer membrane lipoproteinSmlt1018B2FR784
Putative outer membrane lipoproteinSmlt1826B2FLX94
Putative outer membrane Omp family proteinSmlt3805B2FSF74
Putative outer membrane Omp family proteinSmlt4123B2FI004
Putative outer membrane proteinSmlt0614B2FLU44
Putative outer membrane proteinSmlt0955B2FQM84
Putative outer membrane protein NMB0088NMB0088Q9K1M24
Putative outer membrane protein P1MXAN_7040Q1CWS04
Putative peptidaseSmlt0007B2FT854
Putative peptidoglycan-associated lipoproteinSmlt3703B2FRM84
Putative pili chaperone proteinSmlt0707B2FNJ14
Putative porin P (Outer membrane protein d1)oprP Smlt3943B2FTT74
Putative subfamily M23B unassigned peptidaseSmlt1724B2FK974
Putative subfamily S1C unassigned peptidaseSmlt3553B2FQC54
Putative TonB dependent receptorSmlt3340B2FN474
Putative TonB dependent receptorSmlt3444B2FP164
Putative TonB dependent receptor proteinSmlt0083B2FU424
Putative TonB dependent receptor proteinSmlt0359B2FJ304
Putative TonB dependent receptor proteinSmlt3254B2FM994
Putative vitamin B12 receptor proteinSmlt0585B2FLR84
Putrescine-binding periplasmic proteinNGO_1494Q5F6Q54
Putrescine-binding periplasmic proteinNGO_1253Q5F7C54
Pyridoxine/pyridoxal/pyridoxamine kinase (PN/PL/PM kinase) (EC 2.7.1.35) (B6-vitamer kinase)pdxK AKG99_14835 BHF46_01125 BV389_12650 ERS085386_00090 UN91_13845A0A066QR884
Pyruvate dehydrogenase E1 component (EC 1.2.4.1)aceE NGO_0565Q5F9394
Pyruvate oxidase (EC 1.2.3.3)spxB spr0642Q8DQJ44
Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (Guanine insertion enzyme) (tRNA-guanine transglycosylase)tgt AML07_05415 APZ14_19320 FORC28_4684A0A0F3USV44
Regulator of ribonuclease activity ByjgD rraB ECRM12581_27125A0A023Z7F94
Riboflavin biosynthesis protein (EC 2.7.1.26) (EC 2.7.7.2)NGO_0068Q5FAF64
Ribokinase (RK) (EC 2.7.1.15)rbsK_2 rbsK A4T40_24375 BE932_18020 BK248_08165 BK334_15990 ECONIH1_22090 MS6198_43200 SY51_21390 WM48_20730A0A061KEC04
Ribonuclease E (RNase E) (EC 3.1.26.12)rne NGO_1785Q5F5Y34
Ribonuclease R (RNase R) (EC 3.1.13.1)rnr PA4937Q9HUM74
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)prs NGO_0441Q5F9F54
Ribosomal protein L11 methyltransferase (L11 Mtase) (EC 2.1.1.-)prmA BX52_07560A0A0E2U9X44
Ribosomal RNA large subunit methyltransferase K/L [Includes: 23S rRNA m7G2069 methyltransferase (EC 2.1.1.264) (rRNA (guanine-N(7)-)-methyltransferase RlmK); 23S rRNA m2G2445 methyltransferase (EC 2.1.1.173) (rRNA (guanine-N(2)-)-methyltransferase RlmL)]rlmL ycbY AC789_1c09880 AKG99_06160 AML35_25590 APT94_18470 BE949_12200 BHF46_13525 BIQ85_05745 BK373_25370 BK375_14315 BK383_07125 BMT53_05340 BMT97_10125 BUE82_15200 BXT93_03330 ERS085386_02061 GJ11_05210 MJ49_01415 UC41_00625 WR15_11740A0A023LCR04
Ribosomal RNA small subunit methyltransferase B (EC 2.1.1.176) (16S rRNA m5C967 methyltransferase) (rRNA (cytosine-C(5)-)-methyltransferase RsmB)rsmB sun BE932_15385 SY51_18895A0A066SYQ74
Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Pentose-5-phosphate 3-epimerase) (PPE) (R5P3E)rpe Z4739 ECs4228P0AG094
RNA helicaseNGO_0650Q5F8W04
RNA polymerase sigma factor RpoD (Sigma-70)rpoD NGO_0999Q5F8054
RNA polymerase-binding transcription factor DksAdksA NGO_1904Q5F5L94
RNA-binding proteinNGO_1906Q5F5L74
S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284) (Alcohol dehydrogenase class-3) (EC 1.1.1.1) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-)frmA Ecok1_03310 APECO1_1645A1A8354
S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase)metK NGO0106Q5FAC04
S-ribosylhomocysteine lyase (EC 4.4.1.21) (AI-2 synthesis protein) (Autoinducer-2 production protein LuxS)luxS NGO2102Q5F5344
S-transferase (Thiol:disulfide oxidoreductase)BE932_13760 SY51_17305A0A061YDG64
SAM-dependent methyltransferaseNGO_0668Q5F8U24
Secreted proteinLMRG_00784A0A0H3GG314
Septum formation inhibitor MafNGO_0225Q5FA094
Septum formation inhibitor MafNGO_1585Q5F6H34
Septum formation inhibitor MafNGO_1392Q5F6Z74
Septum formation inhibitor MafNGO_1971Q5F5F74
Septum formation inhibitor MafNGO_1068Q5F7U94
Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)glyA NGO0866Q5F8C04
Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)glyA spr0928Q8DPZ04
Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1)glyA BV389_12405 UN91_26435A0A0F3UV944
Serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)serS NGO1335Q5F7524
Serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)serS AC789_1c09310A0A0E1L9D54
Serine/threonine protein kinaseLMRG_00967A0A0H3GI694
Sialidase A (EC 3.2.1.18) (Neuraminidase A)nanA spr1536P625764
Signal peptidase I (EC 3.4.21.89)NGO_0343Q5F9Q04
Signal recognition particle protein (Fifty-four homolog)ffh NGO_1700Q5F6664
Simple sugar transport system ATP-binding proteinLMRG_00841A0A0H3GG784
Single-stranded DNA-binding protein (SSB)NGO_1031Q5F7Y04
Siroheme synthase [Includes: Sirohydrochlorin ferrochelatase (EC 4.99.1.4); Precorrin-2 dehydrogenase (EC 1.3.1.76); Uroporphyrinogen-III C-methyltransferase (Urogen III methylase) (EC 2.1.1.107) (Uroporphyrinogen III methylase) (UROM) (SUMT)]cysG BY96_07205A0A027U1114
Site-determining proteinminD PA3244Q9HYZ64
Sortase ALMRG_02028A0A0H3GJ054
Spore cortex proteinNGO_2054Q5F5764
Stomatin 2NGO_0788Q5F8I54
Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)sucD E2348C_0608B7ULK54
Succinyldiaminopimelate aminotransferaseNGO_0460Q5F9D94
Succinylglutamate desuccinylase (EC 3.5.1.96)astE BE932_04175 SY51_09695A0A066SW014
Succinylornithine transaminase/acetylornithine aminotransferase (ACOAT) (SOAT) (Succinylornithine aminotransferase) (EC 2.6.1.11) (EC 2.6.1.81)aruC argD astC PA0895O305084
Superoxide dismutase [Cu-Zn] (EC 1.15.1.1)sodC1 Smlt0160B2FHC64
Surface protein pspApspA spr0121Q8DRI04
Tetratricopeptide repeat family proteinNGO_0747Q5F8M34
Tetratricopeptide repeat proteinBE932_27305 SY51_03725A0A066T6P34
Thiamine ABC transporter substrate-binding protein (Thiamine transporter substrate binding subunit)tbpA BE932_23395 SY51_00405A0A061YL544
Thiol-activated cytolysinLMRG_02624A0A0H3GD844
Thiol:disulfide interchange proteinNGO_1438Q5F6V74
Thiol:disulfide interchange protein DsbAdsbA PA5489P0C2B24
Thiol:disulfide interchange protein DsbD (EC 1.8.1.8) (Protein-disulfide reductase) (Disulfide reductase)dsbD NGO_0978Q5F8234
TonB-dependent receptorMXAN_1450Q1DCB64
TonB-dependent receptorNGO_0952Q5F8454
Transaldolase (EC 2.2.1.2)tal NGO1610Q5F6E94
Transcription termination factor Rho (EC 3.6.4.-) (ATP-dependent helicase Rho)rho NGO_0199Q5FA354
Transcription termination/antitermination protein NusAnusA NGO_1285Q5F7984
Transcriptional regulatorNGO_0718Q5F8P94
Transcriptional regulator LytRLMRG_01730A0A0H3GKG24
Transferrin-binding protein 2NGO_1496Q5F6Q34
Transketolase (EC 2.2.1.1)NGO_1028Q5F7Y34
Translation initiation factor IF-2infB NGO1286Q5F7974
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