EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
50S ribosomal protein L16 (Large ribosomal subunit protein uL16)rplP b3313 JW3275P0ADY73
50S ribosomal protein L17rplQ PP_0480Q88QL03
50S ribosomal protein L17rplQ Smlt0933B2FQK93
50S ribosomal protein L17 (Large ribosomal subunit protein bL17)rplQ b3294 JW3256P0AG443
50S ribosomal protein L18rplR Smlt0922B2FQK03
50S ribosomal protein L19rplS Smlt1377B2FUB63
50S ribosomal protein L2rplB spr0191Q8CWV53
50S ribosomal protein L2rplB PP_0457Q88QN23
50S ribosomal protein L2rplB Smlt0909B2FQ483
50S ribosomal protein L2 (Large ribosomal subunit protein uL2)rplB b3317 JW3279P604223
50S ribosomal protein L20rplT PP_2468Q88K243
50S ribosomal protein L20 (Large ribosomal subunit protein bL20)rplT pdzA b1716 JW1706P0A7L33
50S ribosomal protein L22rplV PP_0459Q88QN03
50S ribosomal protein L22 (Large ribosomal subunit protein uL22)rplV eryB b3315 JW3277P611753
50S ribosomal protein L23rplW Z4689 ECs4183P0ADZ23
50S ribosomal protein L23rplW LMRG_02174A0A0H3GFD13
50S ribosomal protein L24rplX E2348C_3572B7UK333
50S ribosomal protein L3rplC PP_0454Q88QN53
50S ribosomal protein L3 glutamine methyltransferase (L3 MTase) (EC 2.1.1.298) (N5-glutamine methyltransferase PrmB)prmB BE932_09270 SY51_13295 WM48_12435A0A067HDY13
50S ribosomal protein L30rpmD PA4245Q9HWF33
50S ribosomal protein L4rplD PP_0455Q88QN43
50S ribosomal protein L5rplE PP_0466Q88QM33
50S ribosomal protein L5rplE Smlt0918B2FQJ63
50S ribosomal protein L5 (Large ribosomal subunit protein uL5)rplE b3308 JW3270P623993
50S ribosomal protein L6 (Large ribosomal subunit protein uL6)rplF b3305 JW3267P0AG553
50S ribosomal protein L7/L12rplL PA4271Q9HWC83
50S ribosomal protein L7/L12rplL Smlt0897B2FQ373
50S ribosomal protein L9rplI PP_4874Q88DF13
50S ribosomal protein L9 (Large ribosomal subunit protein bL9)rplI b4203 JW4161P0A7R13
6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (LS) (Lumazine synthase) (EC 2.5.1.78)ribH PP_0517Q88QH63
6-phosphogluconolactonase (6-P-gluconolactonase) (EC 3.1.1.31)pgl BX23_03900A0A028DMI63
60 kDa chaperonin (GroEL protein) (Heat shock protein 60) (Protein Cpn60)groL groEL hsp60 hspB mopA HP_0010P423833
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL A1S_2664A3M8363
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL mopA Cj1221O692893
60 kDa chaperonin (GroEL protein) (Protein Cpn60)groL groEL mopA Z5748 ECs5124P0A6F73
7-cyano-7-deazaguanine synthase (EC 6.3.4.20) (7-cyano-7-carbaguanine synthase) (PreQ(0) synthase) (Queuosine biosynthesis protein QueC)queC Z0551 ECs0498Q8XE523
Aac6'-lb-cr (Aminoglycoside N(6')-acetyltransferase)aacA4 aac6'-lb-crC7S9C93
ABC transporter ATP-binding protein-iron transportABC-NBD spr0938Q8DPY33
ABC transporter maintaining OM lipid asymmetry, OM lipoprotein componentmlaA CE10_2732A0A0E0V8Q03
ABC transporter substrate-binding protein-amino acid transportABC-SBP spr0146Q8DRG23
ABC transporter substrate-binding protein-iron transportABC-SBP spr0934Q8DPY63
ABC transporter substrate-binding protein-oligopeptide transportaliA spr0327Q8DR613
ABC transporter, periplasmic binding proteinPP_1726Q88M483
Acetate kinase (EC 2.7.2.1) (Acetokinase)ackA UMNK88_2847A0A0E0U1C23
Acetate kinase (EC 2.7.2.1) (Acetokinase)ackA E2348C_2436B7UFV43
Acetate kinase 1 (EC 2.7.2.1) (Acetokinase 1)ackA1 NMB1518Q9JYM13
Acetolactate synthase (EC 2.2.1.6)ilvI PA4696Q9HVA03
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (ACCase subunit alpha) (Acetyl-CoA carboxylase carboxyltransferase subunit alpha) (EC 6.4.1.2)accA FTN_1508A0Q8083
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (ACCase subunit alpha) (Acetyl-CoA carboxylase carboxyltransferase subunit alpha) (EC 6.4.1.2)accA E2348C_0190B7UJ863
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase subunit beta) (Acetyl-CoA carboxylase carboxyltransferase subunit beta) (EC 6.4.1.2)accD spr0386Q7CRB73
Acetyltransferase (N(6)-hydroxylysine O-acetyltransferase) (Siderophore biosynthesis protein) (EC 2.3.1.102)BMT94_22870 EL75_3960 SK85_05020 SM09_03161A0A0A0FY803
Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12)aceF FTN_1493A0Q7Z53
Acetyltransferase YpeA (EC 2.3.1.-)ypeA BE932_09770 SY51_14110A0A061YET83
Aconitate hydratase (Aconitase) (EC 4.2.1.3)acnA FTN_1623A0Q8B73
Aconitate hydratase B (ACN) (Aconitase) (EC 4.2.1.3) ((2R,3S)-2-methylisocitrate dehydratase) ((2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase) (2-methyl-cis-aconitate hydratase) (EC 4.2.1.99) (Iron-responsive protein-like) (IRP-like) (RNA-binding protein)acnB yacI yacJ b0118 JW0114P366833
Aconitate hydratase B (EC 4.2.1.3) (EC 4.2.1.99) (2-methylisocitrate dehydratase)acnB Cj0835cQ0PA553
Aconitate hydratase B (EC 4.2.1.3) (EC 4.2.1.99) (2-methylisocitrate dehydratase)acnB CE10_0118A0A0E0V0733
Aconitate hydratase B (EC 4.2.1.3) (EC 4.2.1.99) (2-methylisocitrate dehydratase)acnB A4T50_24450 APU18_02310 BE932_23695 ERS085406_00519 SY51_00695 WM48_00640E2QF483
Acyl-CoA dehydrogenasefadE FTN_1437A0Q7U03
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (UDP-N-acetylglucosamine acyltransferase) (EC 2.3.1.129)lpxA EcE24377A_0185A7ZHS13
Adenosine-3'(2'),5'-bisphosphate nucleotidaseBX52_14930A0A0E2TLP73
Adenylate kinase (AK) (EC 2.7.4.3) (ATP-AMP transphosphorylase) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase)adk PA3686Q9HXV43
ADP-heptose--LPS heptosyltransferase (Lipopolysaccharide heptosyltransferase 1) (EC 2.-.-.-) (Lipopolysaccharide heptosyltransferase I)rfaC A5958_10800 ACN77_14045 AMK83_19520 AML07_29580 APZ14_22685 AUS26_20605 BE957_04095 BMT61_06695 ERS085379_03553 ERS139235_04039 FORC28_0155 GJ12_22540 PU06_07130 RG28_23290 UN86_06285A0A037YGF33
Aerobic respiration control protein ArcAarcA Z6004 ECs5359P0A9Q33
Agglutination proteintolC PP_4519Q88EE63
Agmatinase (EC 3.5.3.11) (Agmatine ureohydrolase) (AUH)speB E2348C_3189B7UHY33
Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)alaS lovB b2697 JW2667P009573
Aldehyde-alcohol dehydrogenase [Includes: Alcohol dehydrogenase (ADH) (EC 1.1.1.1); Acetaldehyde dehydrogenase [acetylating] (ACDH) (EC 1.2.1.10); Pyruvate-formate-lyase deactivase (PFL deactivase)]adhE ana b1241 JW1228P0A9Q73
Aldose dehydrogenase (Soluble aldose sugar dehydrogenase YliI)yliI A4T40_07925 BK334_20045 ECONIH1_04800 MS6198_09190A0A0A1A5Y13
Aliphatic amidase (EC 3.5.1.4) (Acylamide amidohydrolase)amiE PA3366P114363
Alkene reductase (N-ethylmaleimide reductase)nemA A4T40_12910 BK334_14390 ECONIH1_09585 MS6198_18650A0A0A1A5Q33
Alpha, 1-6-glucosidase (EC 3.2.1.70)dexB spr0310Q8DR673
Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding proteinPA5153Q9HU313
Amino acid ABC transporter substrate-binding proteinBE932_15285 SY51_18795A0A061YH543
Amino acid ABC transporter, periplasmic amino acid-binding proteinPP_5024Q88D053
Aminoacyl-histidine dipeptidase (Cytosol nonspecific dipeptidase)BE932_24555 SY51_01500A0A066SWZ03
Aminopeptidase PpepP PA5224Q9HTW63
Aminotransferase (EC 2.6.1.-)BE932_19820 SY51_23315A0A061KYQ13
AMP nucleosidase (EC 3.2.2.4)amn A4T40_14770 ECONIH1_11420 MS6198_22360A0A0A1A6A93
AmpDh2ampDh2 PA5485Q9HT863
Anthranilate dioxygenase large subunitantA PA2512Q9I0X03
Anthranilate dioxygenase reductaseantC PA2514Q9I0W83
Anthranilate dioxygenase small subunitantB PA2513Q9I0W93
Anthranilate synthase component I (EC 4.1.3.27)trpE_2 Z2547Q8X3T13
Antigen 43 beta chain (Fluffing protein)EC958_5138 UG58_26200W9A1463
Antigen 43 precusor SapsapQ6KD183
Arabinose 5-phosphate isomerase (API) (EC 5.3.1.13)BE932_11480 SY51_15235A0A061YHP93
Arabinose 5-phosphate isomerase (API) (EC 5.3.1.13)gutQ srlQ ACN002_2715 ACN77_07450 AM270_01300 AML07_12055 APT94_01105 APZ14_09695 BE949_27305 BIQ85_15005 BK251_06850 BK292_15470 BK375_13040 BK383_11270 BK400_05450 BMT53_21605 BMT94_15870 BMT97_02750 BUE82_04810 ERS085366_01909 ERS139235_00341 ERS150876_01384 FORC28_1200 HMPREF3040_01078 SM09_02833 UC41_18060A0A023LDT03
Arabinose 5-phosphate isomerase KpsF (API) (EC 5.3.1.13) (K-antigen-specific arabinose 5-phosphate isomerase) (K-API) (Polysialic acid capsule expression protein kpsF)kpsFQ473343
Arginine/ornithine transport ATP-binding protein AotPaotP PA0892O305063
Aspartate ammonia-lyase (Aspartase) (EC 4.3.1.1)aspA Cj0087Q0PC503
Aspartate carbamoyltransferase (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase)pyrB EC55989_4805B7LCV33
Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase)asd A4T40_22825 AC067_11645 AWP75_04795 BK248_05760 BK334_23125 BXT93_08215 ECONIH1_20025 ERS085366_00100 MS6198_39380A0A069CKL03
ATP synthase subunit alpha (EC 3.6.3.14) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha)atpA FTN_1648A0Q8E13
ATP synthase subunit alpha (EC 3.6.3.14) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha)atpA Cj0105Q9PJ213
ATP synthase subunit alpha (EC 3.6.3.14) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha) (Vegetative protein 100) (VEG100)atpA BSU36830P378083
ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b)atpF FTN_1650A0Q8E33
ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b)atpF PP_5417Q88BX03
ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b)atpF Smlt4115B2FHZ23
ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b)atpF Z5234 ECs4678P0ABA23
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