EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
HLA class I histocompatibility antigen, B-44 alpha chain (Bw-44) (MHC class I antigen B*44)HLA-B HLABP3048154
Isochorismatase domain-containing protein 2ISOC2Q96AB354
Leucine-rich alpha-2-glycoprotein (LRG)LRG1 LRGP0275054
Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171)L1CAM CAML1 MIC5P3200454
Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2)NRP2 VEGF165R2O6046254
Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC (Bcl-2 inhibitor of transcription 1)PTRH2 BIT1 PTH2 CGI-147Q9Y3E554
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)PPL KIAA0568O6043754
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)NOP2 NOL1 NSUN1P4608754
Prostate stem cell antigenPSCA UNQ206/PRO232O4365354
Putative elongation factor 1-alpha-like 3 (EF-1-alpha-like 3) (Eukaryotic elongation factor 1 A-like 3) (eEF1A-like 3) (Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5)EEF1A1P5 EEF1AL3Q5VTE054
Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5)SERPINB5 PI5P3695254
Suppressor of tumorigenicity 14 protein (EC (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein)ST14 PRSS14 SNC19 TADG15Q9Y5Y654
Talin-2TLN2 KIAA0320Q9Y4G654
Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)THRAP3 TRAP150Q9Y2W154
TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP)TIPRLO7566354
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)TRA2B SFRS10P6299554
Transmembrane protein 59 (Liver membrane-bound protein)TMEM59 C1orf8 HSPC001 UNQ169/PRO195Q9BXS454
Tyrosine-protein phosphatase non-receptor type 1 (EC (Protein-tyrosine phosphatase 1B) (PTP-1B)PTPN1 PTP1BP1803154
ADP-ribosylation factor-like protein 15 (ADP-ribosylation factor-related protein 2) (ARF-related protein 2)ARL15 ARFRP2Q9NXU553
Aldehyde dehydrogenase X, mitochondrial (EC (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1)ALDH1B1 ALDH5 ALDHXP3083753
Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2) (High-affinity hepatic bile acid-binding protein) (HBAB) (Indanol dehydrogenase) (EC (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC DDH DDH1Q0482853
ATP-binding cassette sub-family B member 6, mitochondrial (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter)ABCB6 MTABC3 PRP UMATQ9NP5853
Biglycan (Bone/cartilage proteoglycan I) (PG-S1)BGN SLRR1AP2181053
Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit)CPN2 ACBPP2279253
Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC
Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)CLINT1 ENTH EPN4 EPNR KIAA0171Q1467753
Complement C1q subcomponent subunit AC1QAP0274553
Delta-aminolevulinic acid dehydratase (ALADH) (EC (Porphobilinogen synthase)ALADP1371653
Developmentally-regulated GTP-binding protein 2 (DRG-2)DRG2P5503953
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)DLAT DLTAP1051553
Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)EDC4 HEDLSQ6P2E953
Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10)EXOSC3 RRP40 CGI-102Q9NQT553
Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed]ACBD3 GCP60 GOCAP1 GOLPH1Q9H3P753
Huntingtin (Huntington disease protein) (HD protein)HTT HD IT15P4285853
Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]HABP2 HGFAL PHBPQ1452053
Phosphomannomutase 2 (PMM 2) (EC
Polyubiquitin-C [Cleaved into: Ubiquitin]UBCP0CG4853
Protein FAM98AFAM98AQ8NCA553
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)RPS6KA1 MAPKAPK1A RSK1Q1541853
Semaphorin-3C (Semaphorin-E) (Sema E)SEMA3C SEMAEQ9998553
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon)PPP2R5EQ1653753
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC
Signal recognition particle 54 kDa protein (SRP54)SRP54P6101153
Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65)SYT1 SVP65 SYTP2157953
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRPP7832453
V-type proton ATPase 16 kDa proteolipid subunit (V-ATPase 16 kDa proteolipid subunit) (Vacuolar proton pump 16 kDa proteolipid subunit)ATP6V0C ATP6C ATP6L ATPLP2744953
Vacuolar protein sorting-associated protein 16 homolog (hVPS16)VPS16Q9H26953
5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein)XRN2Q9H0D652
Actin, gamma-enteric smooth muscle (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin)ACTG2 ACTA3 ACTL3 ACTSGP6326752
Alpha-1-acid glycoprotein 2 (AGP 2) (Orosomucoid-2) (OMD 2)ORM2 AGP2P1965252
Cathepsin G (CG) (EC
Cullin-4A (CUL-4A)CUL4AQ1361952
Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 11 (Complex III subunit IX) (Ubiquinol-cytochrome c reductase 8 kDa protein)]UQCRFS1P4798552
Cytochrome c1, heme protein, mitochondrial (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)CYC1P0857452
DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)DNAJC3 P58IPK PRKRIQ1321752
Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V)FUBP1Q96AE452
Glutaminase kidney isoform, mitochondrial (GLS) (EC (K-glutaminase) (L-glutamine amidohydrolase)GLS GLS1 KIAA0838O9492552
H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)GAR1 NOLA1Q9NY1252
Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]HCFC1 HCF1 HFC1P5161052
Immunoglobulin kappa variable 4-1 (Ig kappa chain V-IV region B17) (Ig kappa chain V-IV region JI) (Ig kappa chain V-IV region Len) (Ig kappa chain V-IV region STH)IGKV4-1P0631252
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)IGF2BP2 IMP2 VICKZ2Q9Y6M152
Kallistatin (Kallikrein inhibitor) (Peptidase inhibitor 4) (PI-4) (Serpin A4)SERPINA4 KST PI4P2962252
Keratin, type I cytoskeletal 15 (Cytokeratin-15) (CK-15) (Keratin-15) (K15)KRT15 KRTBP1901252
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC PEPCK2Q1682252
Prostaglandin E synthase 2 (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) (EC [Cleaved into: Prostaglandin E synthase 2 truncated form]PTGES2 C9orf15 PGES2Q9H7Z752
Prostatic acid phosphatase (PAP) (EC (5'-nucleotidase) (5'-NT) (EC (Ecto-5'-nucleotidase) (Thiamine monophosphatase) (TMPase) [Cleaved into: PAPf39]ACPPP1530952
Ras-related protein Rab-25 (CATX-8)RAB25 CATX8P5773552
Serine/threonine-protein kinase MARK2 (EC (EC (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)MARK2 EMK1Q7KZI752
Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit)SF3B5 SF3B10Q9BWJ552
Sulfide:quinone oxidoreductase, mitochondrial (SQOR) (EC 1.8.5.-)SQRDL CGI-44Q9Y6N552
THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF)ALYREF ALY BEF THOC4Q86V8152
U6 snRNA-associated Sm-like protein LSm5LSM5Q9Y4Y952
U6 snRNA-associated Sm-like protein LSm6LSM6P6231252
Ubiquitin domain-containing protein 1UBTD1Q9HAC852
Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]UMODP0791152
60S ribosomal protein L36a (60S ribosomal protein L44) (Cell growth-inhibiting gene 15 protein) (Cell migration-inducing gene 6 protein) (Large ribosomal subunit protein eL42)RPL36A RPL44 GIG15 MIG6P8388151
Aspartyl/asparaginyl beta-hydroxylase (EC (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase)ASPH BAHQ1279751
CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1)CNOT9 RCD1 RQCD1Q9260051
Collagen alpha-1(VII) chain (Long-chain collagen) (LC collagen)COL7A1Q0238851
Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac)DIABLO SMACQ9NR2851
Dynein assembly factor 5, axonemal (HEAT repeat-containing protein 2)DNAAF5 HEATR2Q86Y5651
Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR)KIAA0319L AAVR KIAA1837 PP791Q8IZA051
Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1)SH3GLB1 KIAA0491 CGI-61Q9Y37151
Exostosin-1 (EC (EC (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1) (Putative tumor suppressor protein EXT1)EXT1Q1639451
Ficolin-3 (Collagen/fibrinogen domain-containing lectin 3 p35) (Collagen/fibrinogen domain-containing protein 3) (Hakata antigen)FCN3 FCNH HAKA1O7563651
Glutamyl aminopeptidase (EAP) (EC (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249)ENPEPQ0707551
Glycerol-3-phosphate phosphatase (G3PP) (EC (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC (Phosphoglycolate phosphatase) (PGP)PGPA6NDG651
Golgi phosphoprotein 3 (Coat protein GPP34) (Mitochondrial DNA absence factor) (MIDAS)GOLPH3 GPP34Q9H4A651
Inositol monophosphatase 3 (IMP 3) (IMPase 3) (EC (EC (Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase) (Golgi-resident PAP phosphatase) (gPAPP) (Inositol monophosphatase domain-containing protein 1) (Inositol-1(or 4)-monophosphatase 3) (Myo-inositol monophosphatase A3)IMPAD1 IMPA3Q9NX6251
Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed]MX1P2059151
Keratin, type II cytoskeletal 80 (Cytokeratin-80) (CK-80) (Keratin-80) (K80) (Type-II keratin Kb20)KRT80 KB20Q6KB6651
Laminin subunit gamma-2 (Cell-scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma)LAMC2 LAMB2T LAMNB2Q1375351
Leukosialin (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43)SPN CD43P1615051
Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B)MYL6B MLC1SAP1464951
Olfactomedin-like protein 3 (HNOEL-iso) (hOLF44)OLFML3 PSEC0035 PSEC0173 PSEC0244 UNQ663/PRO1294Q9NRN551
Oxidoreductase HTATIP2 (EC 1.1.1.-) (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2)HTATIP2 CC3 TIP30Q9BUP351
Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC (Cyclophilin C) (Rotamase C)PPIC CYPCP4587751
Phosphatidylinositide phosphatase SAC1 (EC 3.1.3.-) (Suppressor of actin mutations 1-like protein)SACM1L KIAA0851Q9NTJ551
Proteasome activator complex subunit 4 (Proteasome activator PA200)PSME4 KIAA0077Q1499751
Protein dopey-2DOPEY2 C21orf5 KIAA0933Q9Y3R551
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