EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC
Mitochondrial fission 1 protein (FIS1 homolog) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11)Fis1 Ttc11Q9CQ9210
Mixed lineage kinase domain-like proteinMlklQ9D2Y410
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC (Formyltetrahydrofolate synthetase)Mthfd1l Fthfsdc1Q3V3R110
mRNA export factor (Rae1 protein homolog) (mRNA-associated protein mrnp 41)Rae1 Mrnp41Q8C57010
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC (DDAHI) (Dimethylargininase-1)Ddah1Q9CWS010
N-acylneuraminate cytidylyltransferase (EC (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase)CmasQ99KK210
N-alpha-acetyltransferase 15, NatA auxiliary subunit (N-terminal acetyltransferase 1) (NMDA receptor-regulated protein 1) (Protein tubedown-1)Naa15 Narg1 Nat1 Tbdn-1 TubedownQ80UM310
Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Arylacetamide deacetylase-like 1) (Chlorpyrifos oxon-binding protein) (CPO-BP)Nceh1 Aadacl1 Kiaa1363Q8BLF110
Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox)Ncf4P9736910
P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor)P2rx7 P2x7Q9Z1M010
Peroxidasin homolog (EC Kiaa0230Q3UQ2810
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(5)P-4-kinase isoform 2-alpha)Pip4k2a Pip5k2aO7017210
Phosphatidylinositol transfer protein beta isoform (PI-TP-beta) (PtdIns transfer protein beta) (PtdInsTP beta)PitpnbP5381110
Phospholipase A-2-activating protein (PLA2P) (PLAP)Plaa PlapP2761210
Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)Atp2b2 Pmca2Q9R0K710
Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1)Plekho2 Plekhq1Q8K12410
Polyadenylate-binding protein (PABP)Pabpc4 mCG_5546Q6PHQ910
Prefoldin subunit 2Pfdn2 Pfd2O7059110
Prenylcysteine oxidase (EC Kiaa0908Q9CQF910
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]Psen1 Ad3h Psnl1P4976910
Presequence protease, mitochondrial (EC 3.4.24.-) (Pitrilysin metalloproteinase 1)Pitrm1 Kiaa1104 Ntup1Q8K41110
Probable ATP-dependent RNA helicase DDX20 (EC (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1)Ddx20 Dp103 Gemin3Q9JJY410
Protein BRICK1 (BRK1)Brk1Q91VR810
Protein DEKDekQ7TNV010
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC (EC (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)FntaQ6123910
Protein SGT1 homolog (Suppressor of G2 allele of SKP1 homolog)Sugt1Q9CX3410
Protein-arginine deiminase type-4 (EC (Peptidylarginine deiminase IV) (Protein-arginine deiminase type IV)Padi4 Pad4 Pdi4Q9Z18310
Proteolipid protein 2Plp2Q9R1Q710
Putative ATP-dependent RNA helicase DHX30 (EC (DEAH box protein 30)Dhx30 HelgQ99PU810
Putative phospholipase B-like 2 (EC 3.1.1.-) (66.3 kDa protein) (76 kDa protein) (p76) (LAMA-like protein 2) (Lamina ancestor homolog 2) (Phospholipase B domain-containing protein 2) [Cleaved into: Putative phospholipase B-like 2 28 kDa form; Putative phospholipase B-like 2 40 kDa form; Putative phospholipase B-like 2 15 kDa form]Plbd2Q3TCN210
Putative uncharacterized protein (RAB23, member RAS oncogene family, isoform CRA_a) (Ras-related protein Rab-23)Rab23 mCG_10410Q9D4I910
RAB1A, member RAS oncogene familyRab1a Rab1Q5SW8810
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (Susceptibility to colon cancer 1) (CD antigen CD148)Ptprj Byp Scc1Q6445510
Replication factor C subunit 4 (Activator 1 subunit 4)Rfc4Q99J6210
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]Rpa1Q8VEE410
Retrovirus-related Env polyprotein from Fv-4 locusFv4 EnvP1137010
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (LBC'S first cousin) (Lymphoid blast crisis-like 1) (Oncogene LFC) (Rhobin)Arhgef2 Kiaa0651 Lbcl1 LfcQ6087510
Rho-associated protein kinase 1 (EC (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)Rock1P7033510
Ribonucleoside-diphosphate reductase subunit M2 (EC (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)Rrm2P1115710
Ribosome-binding protein 1 (Ribosome receptor protein) (RRp) (mRRp)Rrbp1Q99PL510
RNA-binding protein 8A (RNA-binding motif protein 8A) (Ribonucleoprotein RBM8A)Rbm8a Rbm8Q9CWZ310
RNA-binding protein Raly (Maternally-expressed hnRNP C-related protein) (hnRNP associated with lethal yellow protein)Raly MercQ6401210
Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3)Scamp3O3560910
Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific) (mSelB)Eefsec SelbQ9JHW410
Serine protease inhibitor A3M (Serpin A3M)Serpina3mQ0373410
Serine/threonine-protein kinase 25 (EC (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1)Stk25 Sok1Q9Z2W110
Sodium bicarbonate cotransporter 3 (Solute carrier family 4 member 7)Slc4a7 Nbc3Q8BTY210
Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)Atp1a3Q6PIC610
Solute carrier family 12 member 9 (Cation-chloride cotransporter-interacting protein 1) (Potassium-chloride transporter 9)Slc12a9 Cip1 Slc12a8Q99MR310
Sortilin (Neurotensin receptor 3) (NTR3) (mNTR3)Sort1Q6PHU510
Sorting nexin-33 (SH3 and PX domain-containing protein 3)Snx33 Sh3px3Q4VAA710
Sorting nexin-4Snx4Q91YJ210
Spermatogenesis-associated protein 5 (Spermatogenesis-associated factor protein)Spata5 SpafQ3UMC010
Splicing factor 3A subunit 1 (SF3a120)Sf3a1Q8K4Z510
Splicing factor 3B subunit 1 (Splicing factor 3b, subunit 1)Sf3b1 mCG_117542G5E86610
Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 snRNP auxiliary factor small subunit)U2af1Q9D88310
SRSF protein kinase 1 (EC (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)Srpk1O7055110
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)Suclg2Q9Z2I810
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)Smarcc2 Baf170Q6PDG510
Tetraspanin-3 (Tspan-3) (OSP-associated protein 1) (OAP-1) (Tetraspanin TM4-A) (Transmembrane 4 superfamily member 8)Tspan3 Tm4sf8Q9QY3310
Tetraspanin-6 (Tspan-6) (Transmembrane 4 superfamily member 6)Tspan6 Tm4sf6O7040110
Thioredoxin-dependent peroxide reductase, mitochondrial (EC (Antioxidant protein 1) (AOP-1) (PRX III) (Perioredoxin-3) (Protein MER5)Prdx3 Aop1 Mer5P2010810
Thrombospondin 1 (Thrombospondin-1)Thbs1Q80YQ110
Tissue alpha-L-fucosidase (EC (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1)Fuca1 FucaQ99LJ110
TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1)Tom1l1 SrcasmQ923U010
Trafficking protein particle complex subunit 3 (BET3 homolog)Trappc3 Bet3O5501310
Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (p24 family protein alpha-3) (p24alpha3) (p26)Tmed4 Ers25Q8R1V410
Tubulin alpha-3 chain (Alpha-tubulin 3/7) (Alpha-tubulin isotype M-alpha-3/7) (Tubulin alpha-3/alpha-7 chain) [Cleaved into: Detyrosinated tubulin alpha-3 chain]Tuba3a Tuba3; Tuba3b Tuba7P0521410
Tyrosine-protein kinase receptor UFO (EC (Adhesion-related kinase)Axl Ark UfoQ0099310
Tyrosine-protein phosphatase non-receptor type 11 (EC (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)Ptpn11P3523510
U2 small nuclear ribonucleoprotein A' (U2 snRNP A')Snrpa1P5778410
Ubiquitin carboxyl-terminal hydrolase 4 (EC (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein)Usp4 UnpP3512310
Ubiquitin-conjugating enzyme E2 D3 (EC ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)Ube2d3P6107910
Ubiquitin-conjugating enzyme E2 variant 2 (Ubc-like protein MMS2)Ube2v2 Mms2 Uev2Q9D2M810
Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (MUB) (MmMUB) (Protein HCG-1)Ubl3Q9Z2M610
Ubiquitin-like-conjugating enzyme ATG3 (EC 6.3.2.-) (Autophagy-related protein 3) (APG3-like)Atg3 Apg3lQ9CPX610
V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein C7-1) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)Atp6ap1 Atp6ip1 Atp6s1Q9R1Q910
Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)Vapa Vap33Q9WV5510
Zinc transporter ZIP4 (Activated in W/Wv mouse stomach 2) (mAWMS2) (Solute carrier family 39 member 4) (Zrt- and Irt-like protein 4) (ZIP-4)Slc39a4 Zip4Q78IQ710
[Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC (ADP-ribose-L-arginine cleaving enzyme)Adprh Arh1P5492310
2,4-dienoyl-CoA reductase, mitochondrial (EC (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH])Decr1Q9CQ629
2-oxoglutarate dehydrogenase, mitochondrial (EC (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)Ogdh Kiaa4192Q605979
26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27)Psmd9Q9CR009
40S ribosomal protein S29Rps29P622749
5'-3' exoribonuclease 2 (EC 3.1.13.-) (Protein Dhm1)Xrn2 Dhm1Q9DBR19
5'-nucleotidase (5'-NT) (EC (Ecto-5'-nucleotidase) (CD antigen CD73)Nt5e Nt5 NteQ615039
60S ribosomal protein L36Rpl36 mCG_20352Q6ZWZ49
Activating signal cointegrator 1 complex subunit 3 (EC
Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1)Ahsa1Q8BK649
Acyl-protein thioesterase 1 (APT-1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I)Lypla1 Apt1 Pla1aP978239
Adenylate kinase isoenzyme 1 (AK 1) (EC (EC (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase)Ak1Q9R0Y59
Aldo-keto reductase family 1 member C13 (EC 1.1.1.-)Akr1c13Q8VC289
Alpha-1-antitrypsin 1-3 (Alpha-1 protease inhibitor 3) (Alpha-1 protease inhibitor 6) (Alpha-1-antitrypsin 1-6) (Serine protease inhibitor 1-3) (Serine protease inhibitor 1-6) (Serine protease inhibitor A1c) (Serpin A1c)Serpina1c Dom3 Dom6 Spi1-3 Spi1-6Q008969
Alpha-1-antitrypsin 1-4 (Alpha-1 protease inhibitor 4) (Serine protease inhibitor 1-4) (Serine protease inhibitor A1d) (Serpin A1d)Serpina1d Dom4 Spi1-4Q008979
ATP synthase subunit delta, mitochondrial (F-ATPase delta subunit)Atp5dQ9D3D99
ATP synthase subunit gamma, mitochondrial (F-ATPase gamma subunit)Atp5c1Q91VR29
ATP-binding cassette sub-family F member 1Abcf1Q6P5429
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