EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox)Ncf2 Noxa2 P67phoxO701459
Non-specific lipid-transfer protein (NSL-TP) (EC (Propanoyl-CoA C-acyltransferase) (SCP-chi) (SCPX) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X)Scp2 Scp-2P320209
Nuclear protein localization protein 4 homolog (Protein NPL4)Nploc4 Kiaa1499 Npl4P606709
NudC domain-containing protein 2Nudcd2 D11Ertd603eQ9CQ489
Peptidoglycan recognition protein 1 (Cytokine tag7) (Peptidoglycan recognition protein short) (PGRP-S)Pglyrp1 Pglyrp Pgrp Pgrps Tag7O885939
Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase)Fkbp3 Fkbp25Q624469
Phosphatase and actin regulator 4 (Protein Humpty dumpty) (Humdy)Phactr4 Kiaa4120Q501J79
Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC Pik4 Pik4caE9Q3L29
Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha)Pitpna PitpnP538109
Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41)Prpsap2Q8R5749
Plakophilin-4 (Armadillo-related protein)Pkp4 ArmrpQ68FH09
Platelet-activating factor acetylhydrolase IB subunit beta (EC (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta)Pafah1b2 PafahbQ612069
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor)Puf60Q3UEB39
Progressive ankylosis protein (Fn54 protein)Ankh AnkQ9JHZ29
Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)Psme3P612909
Protein CYR61 (3CH61) (CCN family member 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10)Cyr61 Ccn1 Igfbp10P184069
Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Lectin mannose-binding 1) (p58)Lman1 Ergic53Q9D0F39
Protein mago nashi homologMagohP613279
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1)Ppp1r12a Mypt1Q9DBR79
Proto-oncogene vav (p95vav)Vav1 VavP278709
Pumilio homolog 3Pum3 D19Bwg1357e Kiaa0020Q8BKS99
Putative adenosylhomocysteinase 3 (AdoHcyase 3) (EC (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2)Ahcyl2Q68FL49
Putative RNA-binding protein Luc7-like 2 (CGI-74 homolog)Luc7l2Q7TNC49
Putative uncharacterized protein (Rab22B) (Ras-related protein Rab-31)Rab31 Rab22BQ3TXV49
Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (Roadblock domain-containing protein 3)Lamtor2 Mapbpip Robld3Q9JHS39
Ras-related protein Rab-31Rab31Q921E29
Ras-related protein Rab-3DRab3dP352769
Ras-related protein Rab-4BRab4b Rab4Q91ZR19
Regulator of chromosome condensation (Chromosome condensation protein 1)Rcc1 Chc1Q8VE379
RELT-like protein 1Rell1Q8K2J79
Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3)Rpa3Q9CQ719
Retinal dehydrogenase 1 (RALDH 1) (RalDH1) (EC 1.2.1.-) (EC (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic)Aldh1a1 Ahd-2 Ahd2 Aldh1P245499
Ribose-phosphate pyrophosphokinase 2 (EC (Phosphoribosyl pyrophosphate synthase II) (PRS-II)Prps2Q9CS429
Ribosomal L1 domain-containing protein 1Rsl1d1Q8BVY09
Rootletin (Ciliary rootlet coiled-coil protein)Crocc Kiaa0445Q8CJ409
SEC24 related gene family, member C (S. cerevisiae), isoform CRA_a (Sec24-related gene family, member C (S. cerevisiae))Sec24c mCG_121333G3X9729
Serine/threonine-protein kinase 26 (EC (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MST4)Stk26 Mst4Q99JT29
Serine/threonine-protein kinase 38 (EC (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)Stk38 Ndr1Q91VJ49
Serine/threonine-protein kinase 4 (EC (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]Stk4 Mst1Q9JI119
Serine/threonine-protein kinase MARK2 (EC (EC (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (mPar-1b)Mark2 EmkQ055129
Serine/threonine-protein kinase PAK 4 (EC (p21-activated kinase 4) (PAK-4)Pak4 Kiaa1142Q8BTW99
Serum amyloid A-3 proteinSaa3P049189
Serum deprivation-response protein (Cavin-2) (Phosphatidylserine-binding protein)Sdpr SdrQ639189
Signal recognition particle 9 kDa protein (SRP9)Srp9P499629
Signal transducing adapter molecule 1 (STAM-1)Stam Stam1P702979
Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Sodium- and chloride-dependent GABA transporter 4) (GAT-4) (Solute carrier family 6 member 11)Slc6a11 Gabt3 Gabt4 Gat-4 Gat3 Gat4P316509
Sorting nexinSnx18 Snag1Q8C7889
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (SKAP55 homolog) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)Skap2 Prap Ra70 Saps Scap2 Skap55rQ3UND09
Src substrate cortactinCttn Ems1Q605989
Striatin-interacting protein 1 (Protein FAM40A)Strip1 Fam40a Kiaa1761Q8C0799
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC (Iron-sulfur subunit of complex II) (Ip)SdhbQ9CQA39
SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]Sae1 Aos1 Sua1 Ubl1a1 Uble1aQ9R1T29
Surfeit locus protein 4Surf4 Surf-4Q643109
SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) (SWI3-related protein) (BAF155)Smarcc1 Baf155 Srg3P974969
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (mSNF5)Smarcb1 Baf47 Ini1 Snf5l1Q9Z0H39
Switch-associated protein 70 (SWAP-70)Swap70 Kiaa0640Q6A0289
Syndecan-1 (SYND1) (CD antigen CD138)Sdc1 Synd-1 Synd1P188289
Syntaxin-3Stx3 Stx3aQ647049
Tax1-binding protein 1 homologTax1bp1Q3UKC19
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)Tjp1 Zo1P394479
TOM1-like protein 2 (Target of Myb-like protein 2)Tom1l2Q5SRX19
Translation initiation factor eIF-2B subunit beta (eIF-2B GDP-GTP exchange factor subunit beta)Eif2b2Q99LD99
Translation initiation factor eIF-2B subunit delta (eIF-2B GDP-GTP exchange factor subunit delta)Eif2b4 Eif2b Eif2bd Jgr1aQ617499
Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta)Ssr4Q621869
Transmembrane 9 superfamily member 4Tm9sf4 Kiaa0255Q8BH249
Transmembrane protein 176B (Protein LR8)Tmem176b Clast1 Lr8Q9R1Q69
Tsukushin (Tsukushi) (Leucine-rich repeat-containing protein 54)Tsku Lrrc54 TskQ8CBR69
Tumor protein D54 (Tumor protein D52-like 2)Tpd52l2Q9CYZ29
Tyrosine-protein kinase SYK (EC (Spleen tyrosine kinase)Syk ptk72 SykbP480259
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC (Ubiquitin thioesterase L3)Uchl3Q9JKB19
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)Uchl5 Uch37Q9WUP79
Ubiquitin-conjugating enzyme E2 L3 (EC (E2 ubiquitin-conjugating enzyme L3) (UbcM4) (Ubiquitin carrier protein L3) (Ubiquitin-protein ligase L3)Ube2l3 Ubce7P680379
Unconventional myosin-IXb (Unconventional myosin-9b)Myo9b Myr5Q9QY069
Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]PlauP068699
Vacuolar protein sorting-associated protein 45 (mVps45)Vps45 Vps45aP973909
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)Vamp2 Syb2P630449
WD repeat-containing protein 91Wdr91Q7TMQ79
WW domain-binding protein 2 (WBP-2)Wbp2P977659
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP/AP lyase Ku70) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Ku autoantigen protein p70 homolog) (Ku70)Xrcc6 G22p1 Ku70P234759
(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O (EC (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O)Ube2o Kiaa1734Q6ZPJ38
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-delta-1) (PLC-delta-1)Plcd1 PlcdQ8R3B18
2'-5'-oligoadenylate synthase-like protein 1 (2',5'-oligoadenylate synthetase-like 9)Oasl1 oasl9Q8VI948
5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (Brown locus protein) (Catalase B) (Tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1)Tyrp1 Tyrp-1P071478
Activin receptor type-1 (EC (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L)Acvr1 Acvrlk2 Tgfb1P371728
ADP-dependent glucokinase (ADP-GK) (ADPGK) (EC
Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA deacylase alaX) (AlaX) (AlaXp-II) (Alanyl-tRNA synthetase domain-containing protein 1)Aarsd1 AlaxQ3THG98
Alpha-N-acetylgalactosaminidase (EC (Alpha-galactosidase B)NagaQ9QWR88
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48)Apbb1ip Prel1Q8R5A38
Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)Anapc5 MNCb-2778Q8BTZ48
Anion exchange proteinSlc4a7F8VQC98
AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin)Ap3m1Q9JKC88
Apoptotic protease-activating factor 1 (APAF-1)Apaf1O888798
ATP synthase subunit d, mitochondrial (ATPase subunit d)Atp5hQ9DCX28
ATP synthase subunit e, mitochondrial (ATPase subunit e)Atp5i Atp5k Lfm-1 Lfm1Q061858
ATP synthase-coupling factor 6, mitochondrial (ATPase subunit F6)Atp5jP974508
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