EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Multiubiquitin chain-binding protein)Psmd4 Mcb1O3522617
26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14)Psmd8Q9CX5617
40S ribosomal protein S12Rps12 Rps12-ps3 mCG_132913 mCG_6749Q6ZWZ617
6-phosphogluconolactonase (6PGL) (EC
60S ribosomal protein L21Rpl21O0916717
60S ribosomal protein L35Rpl35Q6ZWV717
60S ribosomal protein L38Rpl38Q9JJI817
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1)Abi1 Ssh3bp1Q8CBW317
Acetyl-CoA carboxylase 1 (ACC1) (EC (ACC-alpha) (Acetyl-CoA carboxylase 265) [Includes: Biotin carboxylase (EC]Acaca Acac Gm738Q5SWU917
ADP-ribosylation factor 1Arf1P8407817
AHNAK nucleoprotein (desmoyokin)AhnakE9Q61617
Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I]Apoa1Q0062317
Ataxin-10 (Brain protein E46) (Spinocerebellar ataxia type 10 protein homolog)Atxn10 Sca10P2865817
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)Pfkp PfkcQ9WUA317
Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL)Sntb2 Snt2b2Q6123517
Beta-hexosaminidase subunit beta (EC (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (N-acetyl-beta-glucosaminidase subunit beta)HexbP2006017
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase 53 kDa substrate)Baiap2Q8BKX117
Calcium-binding protein 39 (MO25alpha) (Protein Mo25)Cab39 Mo25Q0613817
Calmodulin-1Calm1 Calm Cam Cam1P0DP2617
Catalase (EC Cas-1 Cas1P2427017
Cathepsin L1 (EC (Cathepsin L) (Major excreted protein) (MEP) (p39 cysteine proteinase) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain]Ctsl Ctsl1P0679717
Ceruloplasmin (EC (Ferroxidase)CpQ6114717
Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)Cope Cope1O8907917
Collagen alpha-2(VI) chainCol6a2Q0278817
DNA replication licensing factor MCM7 (EC (CDC47 homolog)Mcm7 Cdc47 Mcmd7Q6188117
Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p150-glued)Dctn1O0878817
Dynamin-1-like protein (EC (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1)Dnm1l Drp1Q8K1M617
EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1)Edil3 Del1O3547417
EH domain-containing protein 3Ehd3 Ehd2Q9QXY617
Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4)Erp44 Kiaa0573 Txndc4Q9D1Q617
Ephrin type-A receptor 2 (EC (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2)Epha2 Eck Myk2 Sek2Q0314517
Epidermal growth factor receptor kinase substrate 8Eps8Q0850917
Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1)Etf1Q8BWY317
Eukaryotic translation initiation factor 5 (eIF-5)Eif5P5932517
Eukaryotic translation initiation factor 6 (eIF-6) (B4 integrin interactor) (CAB) (p27(BBP))Eif6 Itgb4bpO5513517
Fibrinogen gamma chainFggQ8VCM717
Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1 homolog)Flot2 Esa1 M17s1Q6063417
Glucosylceramidase (EC (Acid beta-glucosidase) (Beta-glucocerebrosidase) (D-glucosyl-N-acylsphingosine glucohydrolase)GbaP1743917
Glutathione reductase, mitochondrial (GR) (GRase) (EC Gr1P4779117
Glutathione S-transferase omega-1 (GSTO-1) (EC (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC (S-(Phenacyl)glutathione reductase) (SPG-R) (p28)Gsto1 Gstx GtsttlO0913117
Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]HpQ6164617
Hemoglobin subunit beta-1 (Beta-1-globin) (Hemoglobin beta-1 chain) (Hemoglobin beta-major chain)Hbb-b1P0208817
Hippocalcin-like protein 1 (Neural visinin-like protein 3) (NVL-3) (NVP-3) (Visinin-like protein 3) (VILIP-3)Hpcal1P6274817
Histidine--tRNA ligase, cytoplasmic (EC (Histidyl-tRNA synthetase) (HisRS)HarsQ6103517
Histone H2B type 1-M (H2B 291B)Hist1h2bmP1085417
Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]Itm2bO8905117
Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3)Itih3Q6170417
Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)Kirrel Kirrel1 Neph1Q80W6817
Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha)Lama4P9792717
Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC (Leukotriene A(4) hydrolase)Lta4hP2452717
Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14)Cd14P1081017
NADPH--cytochrome P450 reductase (CPR) (P450R) (EC
Neuropilin-1 (A5 protein) (CD antigen CD304)Nrp1 NrpP9733317
Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin)Nampt Pbef1Q99KQ417
Ornithine aminotransferase, mitochondrial (EC (Ornithine--oxo-acid aminotransferase)OatP2975817
PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)Pdlim5 EnhQ8CI5117
Phosphate carrier protein, mitochondrial (Phosphate transport protein) (PTP) (Solute carrier family 25 member 3)Slc25a3Q8VEM817
Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia) (CALM)Picalm Calm Fit1Q7M6Y317
Phosphoglucomutase-1 (PGM 1) (EC (Glucose phosphomutase 1) (Phosphoglucomutase-2)Pgm1 Pgm2Q9D0F917
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]UbcP0CG5017
Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC (Deubiquitinating enzyme FAF-X) (Fat facets homolog) (Fat facets protein-related, X-linked) (Ubiquitin carboxyl-terminal hydrolase FAM) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)Usp9x Fafl FamP7039817
Proteasome subunit beta type-8 (EC (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i)Psmb8 Lmp7 Mc13P2806317
Proteasome-associated protein ECM29 homolog (Ecm29)Ecm29 Kiaa0368Q6PDI517
Protein kinase C and casein kinase II substrate protein 3Pacsin3Q99JB817
Protein NDRG1 (N-myc downstream-regulated gene 1 protein) (Protein Ndr1)Ndrg1 Ndr1 Ndrl Tdd5Q6243317
Protein SEC13 homolog (SEC13-like protein 1) (SEC13-related protein)Sec13 Sec13l1Q9D1M017
Protein XRP2Rp2 Rp2hQ9EPK217
Ras-related protein R-Ras2Rras2P6207117
Retinoid-inducible serine carboxypeptidase (EC 3.4.16.-) (Serine carboxypeptidase 1)Scpep1 RiscQ920A517
Ribose-phosphate pyrophosphokinase 1 (EC (Phosphoribosyl pyrophosphate synthase I) (PRS-I)Prps1Q9D7G017
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)Sqstm1 A170 STAPQ6433717
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC
Serpin B6 (Placental thrombin inhibitor) (Proteinase inhibitor 6) (PI-6)Serpinb6 Serpinb6a Spi3Q6085417
Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein)Srp68Q8BMA617
Sorting nexin-6 [Cleaved into: Sorting nexin-6, N-terminally processed]Snx6Q6P8X117
STIP1 homology and U box-containing protein 1 (EC (Carboxy terminus of Hsp70-interacting protein) (E3 ubiquitin-protein ligase CHIP) (RING-type E3 ubiquitin transferase CHIP)Stub1 ChipQ9WUD117
Syntaxin-binding protein 3 (MUNC-18-3) (Mammalian homolog of Unc-18c) (Munc-18c) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C)Stxbp3 Stxbp3a Unc18cQ6077017
Thioredoxin reductase 1, cytoplasmic (TR) (EC (Thioredoxin reductase TR1)Txnrd1 Trxr1Q9JMH617
Transmembrane emp24 domain-containing protein 9 (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2)Tmed9 Gp25l2Q99KF117
Ubiquitin carboxyl-terminal hydrolase 14 (EC (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)Usp14Q9JMA117
UPF0568 protein C14orf166 homolog0Q9CQE817
V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1)Atp6v1c1 Atp6c Atp6c1 VatcQ9Z1G317
Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25)Vps25 D11Wsu68eQ9CQ8017
Vesicle-fusing ATPase (EC (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Suppressor of K(+) transport growth defect 2) (Protein SKD2) (Vesicular-fusion protein NSF)Nsf Skd2P4646017
Vesicular integral-membrane protein VIP36 (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36)Lman2Q9DBH517
55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1)Mpp1P7029016
60S ribosomal protein L17Rpl17Q9CPR416
Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31)Anp32b Pal31Q9EST516
ADP-ribosylation factor-like protein 3Arl3Q9WUL716
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]Agrn AgrinA2ASQ116
ATPase Asna1 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase)Asna1 ArsaO5498416
Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)Capns1 Capn4O8845616
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC PkacaP0513216
Capping protein (Actin filament), gelsolin-like (Capping protein (Actin filament), gelsolin-like, isoform CRA_a) (Macrophage-capping protein) (Putative uncharacterized protein)Capg mCG_129296Q99LB416
Cofilin-2 (Cofilin, muscle isoform)Cfl2P4559116
Complement C1r-A subcomponent (EC (Complement component 1 subcomponent r-A) [Cleaved into: Complement C1r-A subcomponent heavy chain; Complement C1r-A subcomponent light chain]C1ra C1rQ8CG1616
Complement component receptor 1-like protein (Complement regulatory protein Crry) (Protein p65)Cr1l Crry CryQ6473516
Cullin-1 (CUL-1)Cul1Q9WTX616
Cyclin-dependent kinase 2 (EC (Cell division protein kinase 2)Cdk2 Cdkn2P9737716
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