EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Peptide/nickel transport system ATP-binding proteinLMRG_01639A0A0H3GMC54
Peptide/nickel transport system permeaseLMRG_01638A0A0H3GE464
Peptide/nickel transport system substrate-binding proteinLMRG_02699A0A0H3GFV14
Peptide/nickel transport system substrate-binding proteinLMRG_02384A0A0H3GCP24
Peptide/nickel transport system substrate-binding proteinLMRG_02397A0A0H3GH204
Peptide/nickel transport system substrate-binding proteinLMRG_01636A0A0H3GJB64
Peptidoglycan N-acetylglucosamine deacetylaseLMRG_00107A0A0H3GDH94
Peptidoglycan-associated lipoproteinpal excC b0741 JW0731P0A9124
Peptidoglycan-binding protein LysMNGO_1873Q5F5P44
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)NGO_1225Q5F7F34
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)Smlt1559B2FIF84
Peptidylprolyl isomeraseNGO_1655Q5F6A54
Peptidylprolyl isomeraseNGO_0766Q5F8K64
Peptidylprolyl isomerase (EC 5.2.1.8)NMB0345Q7DDR04
Peptidylprolyl isomerase (EC 5.2.1.8)NGO_1656Q5F6A44
Peptidylprolyl isomerase (EC 5.2.1.8)NGO_1714Q5F6524
Periplasmic proteinNGO_0416Q5F9H84
Periplasmic proteinNGO_0757Q5F8L54
Phage tail protein (Tail protein)BE932_30150 SY51_06485A0A061KGU54
Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)pheS NGO0299Q5F9U04
Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)pheT NGO0304Q5F9T64
Pheromone lipoproteinLMRG_02182A0A0H3GKQ34
Phosphate acetyltransferaseNGO_0214Q5FA204
Phosphate acyltransferase (EC 2.3.1.n2) (Acyl-ACP phosphotransacylase) (Acyl-[acyl-carrier-protein]--phosphate acyltransferase) (Phosphate-acyl-ACP acyltransferase)plsX NGO2171Q5F4X34
Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31)ppc NGO2020Q5F5A94
Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31)ppc spr0974Q8DPW54
Phosphoenolpyruvate synthase (PEP synthase) (EC 2.7.9.2) (Pyruvate, water dikinase)NGO_0200Q5FA344
PhosphofructokinaseBE932_04070 SY51_09590A0A061KZW94
PhosphoglucomutaseNGO_0375Q5F9L84
Phosphogluconate dehydrataseNGO_0714Q5F8Q34
Phosphogluconate dehydratase (EC 4.2.1.12) (6-phosphogluconate dehydratase)edd PA3194P319614
Phosphoglucosamine mutase (EC 5.4.2.10)glmM NGO1341Q5F7464
Phospholipase A(2) (EC 3.1.1.4)ECBD_4217A0A140NHI44
Phospholipase A1NGO_1492Q5F6Q74
Phosphomethylpyrimidine kinaseNGO_1160Q5F7L14
Phosphopentomutase (EC 5.4.2.7) (Phosphodeoxyribomutase)deoB Ecok1_44460 APECO1_1998A1AJV04
Phosphoribosylglycinamide formyltransferaseNGO_1049Q5F7W64
Pilin assembly proteinNGO_0095Q5FAD14
Pilus assembly proteinNGO_0055Q5FAG74
Pilus assembly protein PilFNGO_1673Q5F6894
Pilus assembly protein PilMNGO_0098Q5FAC84
Pilus assembly protein PilONGO_0096Q5FAD04
Pilus assembly protein PilWNGO_0595Q5F9124
Pilus assembly protein PilWNGO_0454Q5F9E44
Plasminogen-binding protein PgbBpgbB jhp_0797Q9ZKY54
Polar amino acid transport system ATP-binding proteinLMRG_02271A0A0H3GF444
Polar flagellin (FlaG)HP_0751O254474
Polyamine aminopropyltransferase (Putrescine aminopropyltransferase) (PAPT) (Spermidine synthase) (SPDS) (SPDSY) (EC 2.5.1.16)speE E2348C_0124B7UIG94
Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase) (PNPase)pnp NGO0335Q5F9Q74
Porphobilinogen deaminase (PBG) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)hemC NGO_0146Q5FA834
Probable ATP-binding component of ABC transporterPA4461Q9HVV64
Probable binding protein component of ABC transporterPA1342Q9I4024
Probable binding protein component of ABC transporterPA4500Q9HVS14
Probable carbamoyl transferasePA5005Q9HUG04
Probable cold-shock proteinPA1159Q9I4H84
Probable cold-shock proteinPA0961Q9I4Z84
Probable DNA binding proteinPA3940Q9HX764
Probable endonuclease 4 (EC 3.1.21.2) (Endodeoxyribonuclease IV) (Endonuclease IV)nfo UMNK88_2704A0A0E0U0Z04
Probable FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (PPIase) (EC 5.2.1.8) (Rotamase)fkpA NMB1567Q9JYI84
Probable L,D-transpeptidase YbiS (EC 2.-.-.-)ybiS b0819 JW0803P0AAX84
Probable malate:quinone oxidoreductase (EC 1.1.5.4) (MQO) (Malate dehydrogenase [quinone])mqo NGO1980Q5F5E94
Probable malate:quinone oxidoreductase 2 (EC 1.1.5.4) (MQO 2) (Malate dehydrogenase [quinone] 2)mqo2 mqoB PA4640Q9HVF14
Probable outer membrane proteinPA1041Q9I4T34
Probable permease of ABC transporterPA4503Q9HVR84
Probable permease of ABC transporterPA4455Q9HVW24
Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion proteinPA2528Q9I0V54
Probable septum site-determining protein MinCminC NGO1816Q5F5V44
Probable siderophore receptorPA1365Q9I3X94
Probable transcriptional regulatory protein YebCyebC b1864 JW1853P0A8A04
Probable transcriptional regulatory protein YeeNyeeN BY96_23695A0A027TFL64
Probable zinc proteasePA0372Q9I6C24
Prokaryotic membrane lipolipid attachment site family proteinNGO_1251Q5F7C74
Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)proS NGO0566Q5F9384
Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)proS spr0243Q8DRB04
Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)proS PA0956Q9I5024
ProteaseNGO_1314Q5F7714
Protease 7 (EC 3.4.23.49) (Omptin) (Outer membrane protein 3B) (Protease A) (Protease VII)ompT b0565 JW0554P091694
Protease HtpX homolog (EC 3.4.24.-)htpX NGO0399Q5F9J44
Protease LasA (EC 3.4.24.-) (Staphylolytic protease)lasA PA1871P147894
Protease TldDtldD BX06_09880A0A028AIY84
Protein DcrBdcrB yhhR b3472 JW5682P0AEE14
Protein GrpE (HSP-70 cofactor)grpE NGO1422Q5F6X14
Protein GrpE (HSP-70 cofactor)grpE PA4762Q9HV424
Protein hcp1hcp1 PA0085Q9I7474
Protein RecA (Recombinase A)recA NGO0741Q5F8M94
Protein TolBtolB b0740 JW5100P0A8554
Protein TolBtolB Smlt3704B2FRM94
Protein translocase subunit SecAsecA NGO0996Q5F8074
Protein translocase subunit SecFsecF PA3820Q9HXI24
Protein-export protein SecBsecB NGO0116Q5FAB14
Pseudouridine synthase (EC 5.4.99.-)rluC A4T40_09205 BK334_17110 ECONIH1_06675 MS6198_12210A0A0A1A4694
PTS IIA-like nitrogen regulatory protein PtsN (PTS system nitrogen regulatory protein IIA(Ntr)) (PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN) (EC 2.7.1.-) (Transcriptional regulator)ptsN A4T50_10085 APU18_16335 BE932_14935 ERS085406_02946 SY51_18455 WM48_17810A0A066SXV74
PTS system N,N'-diacetylchitobiose-specific transporter subunit IIBUN91_27950A0A0F3UJH24
Purine nucleoside phosphorylase DeoD-type (PNP) (EC 2.4.2.1)deoD E2348C_4682B7UR124
Purine nucleoside phosphorylase DeoD-type (PNP) (EC 2.4.2.1)deoD UTI89_C5155Q1R2594
Putative adhesin complex proteinNMB2095Q9JXD84
Putative alkaline phosphataseSmlt3463B2FP334
Putative biopolymer transport exbB proteinexbB1 Smlt0010B2FT884
Putative exported endopeptidaseSmlt3450B2FP204
Putative fatty acid transport system, membrane proteinSmlt0423B2FJY44
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