EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)Trap1 Hsp75Q9CQN14
Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84) (Tumor-specific transplantation 84 kDa antigen) (TSTA)Hsp90ab1 Hsp84 Hsp84-1 HspcbP114994
Hect domain and RLD 3 (Hect domain and RLD 3, isoform CRA_b) (Protein Herc3)Herc3 mCG_123509A6H6S04
Hepatocyte growth factor-regulated tyrosine kinase substrateHgs HrsQ99LI84
Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)Hnrnpa3 Hnrpa3Q8BG054
Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]Hnrnph2 Hnrph2P703334
Hexokinase-2 (EC (Hexokinase type II) (HK II)Hk2O085284
HIG1 domain family member 2AHigd2aQ9CQJ14
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC (P2A)Pde7aP704534
High affinity copper uptake protein 1 (Copper transporter 1) (CTR1) (Solute carrier family 31 member 1)Slc31a1Q8K2114
High mobility group protein HMGI-C (High mobility group AT-hook protein 2)Hmga2 HmgicP529274
Histidine--tRNA ligase, cytoplasmic (EC (Histidyl-tRNA synthetase) (HisRS)HarsQ610354
Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Lysine N-methyltransferase 1D)Ehmt1 Euhmtase1 Glp Kmt1dQ5DW344
HIV Tat-specific factor 1 homologHtatsf1Q8BGC04
HMG box domain containing 4 (Protein Hmgxb4)Hmgxb4Q80Y324
Homeobox protein PKNOX1 (PBX/knotted homeobox 1)Pknox1O704774
Homeobox protein SIX3 (Sine oculis homeobox homolog 3)Six3Q622334
Homeobox protein SIX4 (Sine oculis homeobox homolog 4) (Skeletal muscle-specific ARE-binding protein AREC3)Six4 Arec3Q613214
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 proteinHerpud1Q9JJK54
Homologous-pairing protein 2 homolog (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) (Tat-binding protein 1-interacting protein) (TBP-1-interacting protein)Psmc3ip Hop2 TbpipO350474
Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC (Aminoglycoside phosphotransferase domain-containing protein 1)Hykk Agphd1Q5U5V24
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC (3-hydroxy-3-methylglutarate-CoA lyase)HmgclP380604
Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7)Hif3a Mop7Q0VBL64
Influenza virus NS1A-binding protein homolog (NS1-BP) (NS1-binding protein homolog) (Kelch family protein Nd1-L) (ND1-L2) (Nd1-S)Ivns1abp Kiaa0850 Nd1 Nd1L Nd1S Ns1 Ns1bpQ920Q84
Inhibitor of growth protein 1Ing1Q9QXV34
Inhibitor of growth protein 2 (Inhibitor of growth 1-like protein) (p33ING2)Ing2 Ing1lQ9ESK44
INO80 complex subunit B (High mobility group AT-hook 1-like 4) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4)Ino80b Hmga1l4 Papa1 Znhit4Q99PT34
Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Protein PCD-6) (Purkinje cell protein 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)Itpr1 Insp3r Pcd6 Pcp1P118814
Insulin-induced gene 1 protein (INSIG-1)Insig1Q8BGI34
Insulin-like 3RlfE9Q5324
Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) (Transmembrane protein 219)Tmem219Q9D1234
Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha/beta receptor 2) (Type I interferon receptor 2)Ifnar2O356644
Interferon regulatory factor 1 (IRF-1)Irf1P153144
Interferon-induced 35 kDa protein homolog (IFP 35) (Ifi-35)Ifi35Q9D8C44
Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Fragilis protein 3)Ifitm2Q99J934
Interleukin-1 receptor-associated kinase 1 (IRAK) (IRAK-1) (EC (Pelle-like protein kinase) (mPLK)Irak1 Il1rakQ624064
Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1) (ActA-binding protein 70) (PLK-interacting protein) (Signaling molecule that associates with the mouse pelle-like kinase) (SIMPL)Irak1bp1 Aip70 SimplQ9ESJ74
Interleukin-17 receptor C (IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14)Il17rcQ8K4C24
Intraflagellar transport protein 172 homolog (Protein wimple)Ift172 Kiaa1179 WimQ6VH224
Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56)Ift80 Kiaa1374 Wdr56Q8K0574
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (NifU-like N-terminal domain-containing protein) (NifU-like protein)Iscu NifunQ9D7P64
Isoaspartyl peptidase/L-asparaginase (EC (EC (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]Asrgl1Q8C0M94
Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)Idh2P540714
IST1 homologIst1 Kiaa0174Q9CX004
Kelch-like protein 26Klhl26Q8BGY44
Keratin, type I cytoskeletal 42 (Cytokeratin-42) (CK-42) (Keratin-17n) (Keratin-42) (K42) (Type I keratin Ka22)Krt42 Ka22Q6IFX24
Keratinocyte-associated protein 3 (KCP-3)Krtcap3Q8K1774
Kinesin-like protein KIF1CKif1cO350714
KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2 homolog) (KRR-R motif-containing protein 1)Krr1 Hrb2Q8BGA54
Kynurenine--oxoglutarate transaminase 1 (EC (Cysteine-S-conjugate beta-lyase) (EC (Glutamine transaminase K) (GTK) (Glutamine--phenylpyruvate transaminase) (EC (Kynurenine aminotransferase I) (KATI) (Kynurenine--oxoglutarate transaminase I)Ccbl1 KatQ8BTY14
Lambda-crystallin homolog (EC (L-gulonate 3-dehydrogenase) (Gul3DH)Cryl1 CryQ99KP34
LanC-like protein 1 (40 kDa erythrocyte membrane protein) (p40)Lancl1 Gpr69aO891124
Latent-transforming growth factor beta-binding protein 4 (LTBP-4)Ltbp4Q8K4G14
Leucine carboxyl methyltransferase 1 (Leucine carboxyl methyltransferase 1, isoform CRA_b) (Protein Lcmt1)Lcmt1 mCG_20988A2RTH54
Leucine-rich repeat-containing protein 49 (Tubulin polyglutamylase complex subunit 4) (PGs4) (p79)Lrrc49Q91YK04
Leucine-rich repeat-containing protein 58Lrrc58Q3UGP94
Leukocyte elastase inhibitor A (Serine protease inhibitor EIA) (Serpin B1a)Serpinb1a Serpinb1Q9D1544
Leydig cell tumor 10 kDa protein homologD8Ertd738eQ8R1F04
LIM and senescent cell antigen-like-containing domain protein 2 (Particularly interesting new Cys-His protein 2) (PINCH-2)Lims2 Pinch2Q91XD24
LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)Lmo4P619694
LIM domain-binding protein 3 (Protein cypher) (Protein oracle) (Z-band alternatively spliced PDZ-motif protein)Ldb3 Kiaa0613Q9JKS44
Lipid phosphate phosphohydrolase 1 (EC (35 kDa PAP) (mPAP) (Hydrogen peroxide-inducible protein 53) (Hic53) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)Ppap2a Hpic53 Lpp1Q614694
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)DbtP533954
Ly-6/neurotoxin-like protein 1 (GC26) (Secreted Ly-6/uPAR domain-containing protein 2) (Secreted Ly-6/uPAR-related protein 2) (SLURP-2)Lynx1 Slurp2Q9WVC24
Lysine-specific demethylase 5B (EC 1.14.11.-) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1)Kdm5b Jarid1b Kiaa4034 Plu1Q80Y844
Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5)Lpar6 P2ry5 P2y5Q8BMC04
Lysozyme C-1 (EC (1,4-beta-N-acetylmuramidase C) (Lysozyme C type P)Lyz1 Lzp-sP178974
Major facilitator superfamily domain-containing protein 10 (Tetracycline transporter-like protein)Mfsd10 TetranQ9D2V84
Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2)Mfsd6 Mmr2Q8CBH54
Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]Masp1 Crarf Masp3P980644
MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1)Mapk1ip1 MissQ9D7G94
Maternal embryonic leucine zipper kinase (EC (Protein kinase PK38) (mPK38) (Tyrosine-protein kinase MELK) (EC Kiaa0175 Pk38Q618464
Max dimerization protein 3 (Max dimerizer 3) (Max-associated protein 3)Mxd3 Mad3Q80US84
Max-binding protein MNT (Myc antagonist MNT) (Protein ROX)Mnt RoxO087894
MCG115964 (WD repeat-containing protein 70)Wdr70 mCG_115964G3X9344
MCG13402, isoform CRA_a (Polypyrimidine tract-binding protein 1)Ptbp1 mCG_13402Q8BGJ54
MCG142440 (Olfactory receptor 900) (Olfactory receptor MOR170-2)Olfr900 mCG_142440Q8VGD44
MCG48959 (Peroxiredoxin 6, related sequence 1) (Protein Prdx6b)Prdx6b Prdx6-ps1 Prdx6-rs1 Prdx6-rs1-ps mCG_48959Q8BG374
MCG60589 (Olfactory receptor MOR159-1) (Olfactory receptor Olfr360) (Protein Olfr360)Olfr360 mCG_60589Q8VFP34
Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)Med22 Surf5Q622764
Membrane-associated phosphatidylinositol transfer protein 2 (Drosophila retinal degeneration B homolog 2) (RdgB2) (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)Pitpnm2 Kiaa1457 Nir3Q6ZPQ64
Meteorin (Hypoxia/reoxygenation regulatory factor)Metrn HyracQ8C1Q44
Meteorin-like proteinMetrnlQ8VE434
Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC (Peptidase M 1)Metap1Q8BP484
Methyltransferase-like protein 25 (EC 2.1.1.-)Mettl25Q6NXH84
Methyltransferase-like protein 6 (EC 2.1.1.-)Mettl6Q8BVH94
Mevalonate kinase (MK) (EC
Microtubule-associated protein 4 (MAP-4)Map4 Mtap4P275464
MIP18 family protein FAM96AFam96aQ9DCL24
Mitochondrial import inner membrane translocase subunit TIM16 (Mitochondria-associated granulocyte macrophage CSF-signaling molecule) (Presequence translocated-associated motor subunit PAM16)Pam16 Magmas Tim16 Timm16Q9CQV14
Mitochondrial import receptor subunit TOM7 homolog (Translocase of outer membrane 7 kDa subunit homolog)Tomm7Q9D1734
Mitochondrial Rho GTPase 2 (MIRO-2) (EC 3.6.5.-) (Ras homolog gene family member T2)Rhot2 Arht2Q8JZN74
Mitogen-activated protein kinase kinase kinase 3 (EC (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)Map3k3 Mekk3Q610844
MOB kinase activator 1A (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B)Mob1a Mobk1b Mobkl1bQ921Y04
Monoglyceride lipase (MGL) (EC (Monoacylglycerol lipase) (MAGL)MgllO356784
MOSC domain-containing protein 2, mitochondrial (EC 1.-.-.-) (Mitochondrial amidoxime reducing component 2) (mARC1) (Moco sulfurase C-terminal domain-containing protein 2) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 2)Marc2 Mg87 Mosc2Q922Q14
Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein)Mbnl1 Exp MbnlQ9JKP54
Musculoskeletal embryonic nuclear protein 1Mustn1Q99JI14
Myb-binding protein 1A (Myb-binding protein of 160 kDa)Mybbp1a P160Q7TPV44
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