EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Alpha-1,2-mannosyltransferase ALG9 (EC (EC (Asparagine-linked glycosylation protein 9 homolog) (Disrupted in bipolar disorder protein 1 homolog) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase)Alg9 Dibd1Q8VDI96
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (EC (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb) (GlcNAc-T IVb) (GnT-IVb) (N-acetylglucosaminyltransferase IVb) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb)Mgat4bQ812F86
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)Napa SnapaQ9DB056
Amyloid-like protein 2 (APLP-2) (CDEI box-binding protein) (CDEBP)Aplp2Q063356
Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein)Anapc1 Mcpr Tsg24P539956
Ankyrin repeat domain 12, isoform CRA_a (Protein Ankrd12)Ankrd12 mCG_9056G5E8936
Ankyrin repeat domain-containing protein 10Ankrd10Q99LW06
Arf-GAP domain and FG repeat-containing protein 2 (HIV-1 Rev-binding protein-like protein) (Rev/Rex activation domain-binding protein related) (RAB-R)Agfg2 Hrbl RabrQ80WC76
Arginine/serine-rich protein PNISRSfrs18A2AJT56
Aspartate--tRNA ligase, cytoplasmic (EC (Aspartyl-tRNA synthetase) (AspRS)DarsQ922B26
Aspartyl/asparaginyl beta-hydroxylase (EC (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase)AsphQ8BSY06
ATP synthase subunit alpha, mitochondrialAtp5a1Q032656
ATP synthase subunit beta, mitochondrial (EC
ATP-binding cassette sub-family D member 3 (68 kDa peroxisomal membrane protein) (PMP68) (70 kDa peroxisomal membrane protein) (PMP70)Abcd3 Pmp70 Pxmp1P550966
ATP-binding cassette sub-family F member 1Abcf1Q6P5426
B-cell receptor-associated protein 29 (BCR-associated protein 29) (Bap29)Bcap29 Bap29Q613346
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (NIP3-like protein X) (NIP3L)Bnip3l NixQ9Z2F76
Beta-mannosidase (EC (Lysosomal beta A mannosidase) (Mannanase) (Mannase)Manba BmnQ8K2I46
Beta-secretase 1 (EC (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)Bace1 BaceP568186
Breast cancer metastasis-suppressor 1 homologBrms1Q99N206
Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22) (Sid 470) (p24)Chp1 Chp Sid470P610226
Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)Camkk2 Kiaa0787Q8C0786
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC Kiaa4163Q6PHZ26
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC PkacbP681816
cAMP-dependent protein kinase inhibitor gamma (PKI-gamma)PkigO701396
CAP-Gly domain-containing linker protein 1 (Restin)Clip1 Kiaa4046 RsnQ922J36
CDC42 small effector protein 1Cdc42se1Q8BHL76
CDGSH iron-sulfur domain-containing protein 2 (MitoNEET-related 1 protein) (Miner1) (Nervous system overexpressed protein 70)Cisd2 Cdgsh2 Noxp70 Zcd2Q9CQB56
CDK2-associated and cullin domain-containing protein 1Cacul1Q8R0X26
Cell division cycle protein 20 homolog (mmCdc20) (p55CDC)Cdc20Q9JJ666
Cell division cycle-associated protein 4 (Hematopoietic progenitor protein)Cdca4 HeppQ9CWM26
Centromere protein N (CENP-N)CenpnQ9CZW26
Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2)Cep97 Lrriq2Q9CZ626
Ceramide glucosyltransferase (EC (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase)UgcgO886936
Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Vacuolar protein sorting-associated protein 2) (mVps2)Chmp2aQ9DB346
Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b)Chmp4bQ9D8B36
Checkpoint protein HUS1 (mHUS1)Hus1Q8BQY86
Chordin-like protein 1 (Neuralin-1) (Neurogenesin-1) (Ventroptin)Chrdl1 Ng1 Nrln1Q920C16
Cleavage and polyadenylation specificity factor subunit 6Cpsf6Q6NVF96
Coatomer subunit zeta-2 (Zeta-2-coat protein) (Zeta-2 COP)Copz2Q9JHH96
Coiled-coil domain-containing protein 23Ccdc23Q99LQ46
Coiled-coil domain-containing protein 58Ccdc58Q8R3Q66
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrialChchd2Q9D1L06
Cold shock domain-containing protein C2 (RNA-binding protein PIPPin)Csdc2 PippinQ91YQ36
COMM domain-containing protein 9Commd9Q8K2Q06
Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated Src activator) (Protein FAM120A)FAM120A Kiaa0183 OssaQ6A0A96
Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog)Coro7Q9D2V76
Crossover junction endonuclease MUS81 (EC 3.1.22.-)Mus81Q91ZJ06
Cysteine and histidine-rich protein 1Cyhr1 Chrp Kiaa0496Q9QXA16
Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)Uqcrc2Q9DB776
Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform)Cyb5b Cyb5mQ9CQX26
Cytochrome c oxidase assembly protein COX15 homologCox15Q8BJ036
Cytochrome c oxidase copper chaperoneCox17 Cox17aP563946
Dachshund homolog 1 (Dach1)Dach1 DachQ9QYB26
dCTP pyrophosphatase 1 (EC (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21-C6) (XTP3-transactivated gene A protein homolog)Dctpp1 Tdrg-TL1Q9QY936
Derlin-1 (Degradation in endoplasmic reticulum protein 1) (Der1-like protein 1)Derl1 Der1Q99J566
Diacylglycerol kinase alpha (DAG kinase alpha) (EC (80 kDa diacylglycerol kinase) (Diglyceride kinase alpha) (DGK-alpha)Dgka Dagk1O886736
Diacylglycerol kinase zeta (DAG kinase zeta) (EC (Diglyceride kinase zeta) (DGK-zeta)DgkzQ80UP36
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)DlstQ9D2G26
Disheveled-associated activator of morphogenesis 1Daam1Q8BPM06
DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)Ddit3 Chop Chop10 Gadd153P356396
DNA polymerase zeta catalytic subunit (EC (Protein reversionless 3-like) (REV3-like) (Seizure-related protein 4)Rev3l Polz Sez4Q614936
DNA repair and recombination protein RAD54-like (EC 3.6.4.-) (RAD54 homolog) (mHR54) (mRAD54)Rad54l Rad54P702706
DNA replication licensing factor MCM7 (EC (CDC47 homolog)Mcm7 Cdc47 Mcmd7Q618816
DnaJ homolog subfamily A member 2 (mDj3)Dnaja2Q9QYJ06
DnaJ homolog subfamily B member 6 (Heat shock protein J2) (HSJ-2) (MRJ) (mDj4)Dnajb6 Hsj2 MrjO549466
DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1)Dnajc1 Dnajl1 Mtj1Q617126
E3 SUMO-protein ligase RanBP2 (EC 6.3.2.-) (Ran-binding protein 2) (RanBP2)Ranbp2Q9ERU96
E3 ubiquitin-protein ligase MSL2 (EC 6.3.2.-) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184)Msl2 Kiaa1585 Msl2l1 Rnf184Q69ZF86
E3 ubiquitin-protein ligase RNF182 (EC 6.3.2.-) (RING finger protein 182)Rnf182Q8C4326
E3 ubiquitin-protein ligase SMURF2 (EC 6.3.2.-) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)Smurf2A2A5Z66
Ectonucleoside triphosphate diphosphohydrolase 5 (NTPDase 5) (EC (CD39 antigen-like 4) (ER-UDPase) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (EC (Nucleoside diphosphatase) (Uridine-diphosphatase ENTPD5) (UDPase ENTPD5)Entpd5 Cd39l4Q9WUZ96
EF-hand calcium-binding domain-containing protein 14 (Uncharacterized protein)Efcab14 4732418C07RikQ6PCQ66
EH domain-containing protein 2Ehd2Q8BH646
Enhancer of filamentation 1 (mEF1) (CRK-associated substrate-related protein) (CAS-L) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (p105)Nedd9 CaslO351776
Enoyl-CoA hydratase domain-containing protein 2, mitochondrialEchdc2 D4Ertd765eQ3TLP56
ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Oxidoreductin-1-L-alpha)Ero1lQ8R1806
Etoposide-induced protein 2.4 (p53-induced gene 8 protein)Ei24 Pig8Q610706
ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1)Elk4 Sap1P411586
Eukaryotic translation initiation factor 1 (eIF1) (Protein translation factor SUI1 homolog)Eif1 Sui1 Sui1-rs1P480246
Eukaryotic translation initiation factor 4B (eIF-4B)Eif4bQ8BGD96
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D)Eif5aP632426
Exocyst complex component 6Exoc6Q3U9D66
F-actin-capping protein subunit beta (CapZ beta)Capzb Cappb1P477576
F-box/WD repeat-containing protein 2Fbxw2A2AUF96
Fatty acid desaturase 1 (EC 1.14.19.-) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase)Fads1Q920L16
Forkhead box protein N3 (Checkpoint suppressor 1)Foxn3 Ches1Q499D06
FXYD domain-containing ion transport regulator 5 (EF-8) (Ion channel homolog RIC) (Oncoprotein-induced protein 2)Fxyd5 Oit2P978086
Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta)Aph1bQ8C7N76
GATA zinc finger domain-containing protein 1 (Ocular development-associated gene protein)Gatad1 OdagQ920S36
Geranylgeranyl transferase type-2 subunit beta (EC (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta)RabggtbP536126
Glutamate receptor-interacting protein 1 (GRIP-1)Grip1Q925T66
Glycerophosphodiester phosphodiesterase 1 (EC (Membrane-interacting protein of RGS16)Gde1 Mir16Q9JL566
Glycerophosphodiester phosphodiesterase domain-containing protein 1 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 4)Gdpd1 Gde4Q9CRY76
GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein)Gripap1 DXImx47e Kiaa1167Q8VD046
Guanine nucleotide-binding protein-like 1 (GTP-binding protein MMR1)Gnl1 Gna-rs1 Mmr1P369166
Hephaestin (EC 1.-.-.-)Heph Kiaa0698Q9Z0Z46
Heterogeneous nuclear ribonucleoprotein F (hnRNP F) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]Hnrnpf HnrpfQ9Z2X16
Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) (pp68)Syncrip Hnrpq Nsap1 Nsap1lQ7TMK96
High mobility group nucleosome-binding domain-containing protein 3Hmgn3Q9DCB16
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