EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Serine palmitoyltransferase 1 (EC (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)Sptlc1 Lcb1O357044
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Protein X16) (Splicing factor, arginine/serine-rich 3)Srsf3 Sfrs3 Srp20 X16P841044
Serine/threonine-protein kinase 3 (EC (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]Stk3 Mess1 Mst2Q9JI104
Serine/threonine-protein kinase 4 (EC (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]Stk4 Mst1Q9JI114
Serine/threonine-protein kinase ICK (EC (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK)IckQ9JKV24
Serine/threonine-protein kinase mTOR (EC (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1)Mtor Frap Frap1Q9JLN94
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC; Endoribonuclease (EC 3.1.26.-)]Ern1 Ire1Q9EQY04
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon)Ppp2r5e Kiaa4006Q611514
Serine/threonine-protein phosphatase 5 (PP5) (EC (Protein phosphatase T) (PPT)Ppp5cQ606764
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC (Protein phosphatase 1C catalytic subunit)Ppp1ccP630874
SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2)Sertad2 Kiaa0127 MNCb-1504Q9JJG54
Serum paraoxonase/arylesterase 2 (PON 2) (EC (EC (Aromatic esterase 2) (A-esterase 2) (Serum aryldialkylphosphatase 2)Pon2Q620864
Serum response factor (SRF)SrfQ9JM734
SET domain-containing protein 4 (EC 2.1.1.-)Setd4 ORF21P584674
Short coiled-coil proteinScoc ScocoQ78YZ64
Signal peptidase complex subunit 3 (Signal peptidase complex subunit 3 homolog (S. cerevisiae))Spcs3Q6ZWQ74
Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)Sppl2a Imp3 Psl2 MNCb-3763Q9JJF94
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)Stam2 HbpO888114
Single-strand selective monofunctional uracil DNA glycosylase (EC 3.2.2.-)Smug1Q6P5C54
Ski-like protein (Ski-related oncogene) (Ski-related protein)Skil Skir SnoQ606654
Small integral membrane protein 19Smim19Q80ZU44
Small integral membrane protein 7Smim7Q5RKS24
Small integral membrane protein 8Smim8Q9CQQ04
Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG)SnrpgP623094
Smoothened homolog (SMO)Smo SmohP567264
SNW domain-containing protein 1 (Nuclear protein SkiP) (Ski-interacting protein)Snw1 SkiipQ9CSN14
Sodium-coupled neutral amino acid transporter 2 (Amino acid transporter A2) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2)Slc38a2 Ata2 Kiaa1382 Sat2 Snat2Q8CFE64
Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, liver) (GLUT-2)Slc2a2 Glut-2 Glut2P142464
Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2)Slc22a5 Octn2Q9Z0E84
Solute carrier organic anion transporter family member 2A1 (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2)Slco2a1 Oatp2a1 Slc21a2Q9EPT54
Sortilin (Neurotensin receptor 3) (NTR3) (mNTR3)Sort1Q6PHU54
Sorting nexin-2Snx2Q9CWK84
Sorting nexin-5Snx5Q9D8U84
Sorting nexin-9Snx9Q91VH24
Spectrin alpha chain, non-erythrocytic 1Sptan1 Spna2A3KGU54
Sperm protamine P1 (Cysteine-rich protamine)Prm1 Prm-1P023194
Spermatogenesis-associated protein 5 (Spermatogenesis-associated factor protein)Spata5 SpafQ3UMC04
Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction)Vipas39 Spe39 ViparQ8BGQ14
Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12)Srek1 Sfrs12 Srrp86Q8BZX44
Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)Spred2Q924S74
Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (mSART-3) (Tumor-rejection antigen SART3)Sart3 Kiaa0156Q9JLI84
StAR-related lipid transfer protein 4 (START domain-containing protein 4) (StARD4)Stard4Q99JV54
STE20-like serine/threonine-protein kinase (STE20-like kinase) (mSLK) (EC (Etk4) (STE20-related kinase SMAK) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)Slk Kiaa0204 Stk2O549884
Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2]Srebf2 Srebp2Q3U1N24
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC
Storkhead-box protein 2Stox2 Kiaa1392Q499E54
Striatin-4 (Zinedin)Strn4 ZinP584044
Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like)Smap2 Smap1lQ7TN294
Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (FGF-inducible protein 16) (XCAP-E homolog)Smc2 Cape Fin16 Smc2l1Q8CG484
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (QPs-1) (QPs1)SdhcQ9CZB04
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC (Iron-sulfur subunit of complex II) (Ip)SdhbQ9CQA34
Succinate-semialdehyde dehydrogenase, mitochondrial (EC (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)Aldh5a1Q8BWF04
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (EC (GTP-specific succinyl-CoA synthetase subunit beta) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)Suclg2Q9Z2I84
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)Socs3 Cis3 Cish3O357184
Surfeit locus protein 4Surf4 Surf-4Q643104
Survival motor neuron proteinSmn1 SmnP978014
SUZ domain-containing protein 1Szrd1 D4Ertd22eQ6NXN14
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (mSNF5)Smarcb1 Baf47 Ini1 Snf5l1Q9Z0H34
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (60 kDa BRG-1/Brm-associated factor subunit B) (BRG1-associated factor 60B) (BAF60B)Smarcd2 Baf60bQ99JR84
Synapsin-2 (Synapsin II)Syn2Q643324
T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (Cctz-2)Cct6bQ613904
Target of rapamycin complex subunit LST8 (TORC subunit LST8) (G protein beta subunit-like) (Protein GbetaL) (Mammalian lethal with SEC13 protein 8) (mLST8)Mlst8 Gbl Lst8Q9DCJ14
TATA box-binding protein-associated factor RNA polymerase I subunit D (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D)Taf1d Josd3Q9D4V44
TBC1 domain family member 14Tbc1d14 D5Ertd110e Kiaa1322Q8CGA24
Testis-expressed sequence 30 proteinTex30Q3TUU54
Tetraspanin-13 (Tspan-13) (Transmembrane 4 superfamily member 13)Tspan13 Tm4sf13Q9D8C24
Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)Txn2P974934
Thyroid transcription factor 1-associated protein 26 (TTF-1-associated protein 26) (Coiled-coil domain-containing protein 59)Ccdc59 D10Ertd718e Tap26Q8R2N04
Tissue factor (TF) (Coagulation factor III) (CD antigen CD142)F3 Cf-3 Cf3P203524
TOX high mobility group box family member 4 (Epidermal Langerhans cell protein LCP1)Tox4Q8BU114
Transcription factor E2F5 (E2F-5)E2f5Q615024
Transcription factor IIIA (TFIIIA)Gtf3aQ8VHT74
Transcription factor Maf (Proto-oncogene c-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog)Maf Maf2P548434
Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)]Gtf2a1Q99PM34
Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma)Gtf2a2Q80ZM74
Transcriptional activator Myb (Proto-oncogene c-Myb)MybP068764
Transcriptional activator protein Pur-beta (Purine-rich element-binding protein B) (Vascular actin single-stranded DNA-binding factor 2 p44 component)PurbO352954
Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)Gatad2bQ8VHR54
Transducin beta-like protein 2Tbl2Q9R0994
Transforming acidic coiled-coil-containing protein 1Tacc1Q6Y6854
Translation machinery-associated protein 16Tma16Q9CR024
Translationally-controlled tumor protein (TCTP) (21 kDa polypeptide) (p21) (p23)Tpt1 TrtP630284
Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha)Ssr1Q9CY504
Transmembrane and coiled-coil domains protein 3Tmcc3Q8R3104
Transmembrane protein 131-likeKiaa0922Q3U3D74
Transmembrane protein 183Tmem183 Tmem183a MNCb-2755Q9JJB94
Transmembrane protein 214Tmem214Q8BM554
Transmembrane protein 223Tmem223Q9CQE24
Transmembrane protein 256Tmem256Q5F2854
Transmembrane protein C16orf54 homolog0Q8C7084
Triggering receptor expressed on myeloid cells 2 (TREM-2) (Triggering receptor expressed on monocytes 2)Trem2 Trem2a Trem2b Trem2cQ99NH84
Trk-fusedTfg mCG_130891Q8C2C64
tRNA-specific adenosine deaminase 1 (mADAT1) (EC (tRNA-specific adenosine-37 deaminase)Adat1Q9JHI24
Tubulin alpha-1A chain (Alpha-tubulin 1) (Alpha-tubulin isotype M-alpha-1) (Tubulin alpha-1 chain)Tuba1a Tuba1P683694
Tubulin alpha-1B chain (Alpha-tubulin 2) (Alpha-tubulin isotype M-alpha-2) (Tubulin alpha-2 chain)Tuba1b Tuba2P052134
Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (Thymus-expressed acidic protein) (TEAP) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1)Trp53inp1 SipQ9QXE44
U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C)Snrpc Snrp1cQ622414
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (U11/U12 snRNP 48 kDa protein)Snrnp48Q9D3614
U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10)Mphosph10Q810V04
U6 snRNA-associated Sm-like protein LSm5Lsm5P623224
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