EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Proteasome subunit alpha type-6 (EC (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain)PSMA6 PROS27P60900221
Protein disulfide-isomerase A6 (EC (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)PDIA6 ERP5 P5 TXNDC7Q15084221
Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)TSG101Q99816221
40S ribosomal protein S3a (Small ribosomal subunit protein eS1) (v-fos transformation effector protein) (Fte-1)RPS3A FTE1 MFTLP61247220
60S ribosomal protein L7a (Large ribosomal subunit protein eL8) (PLA-X polypeptide) (Surfeit locus protein 3)RPL7A SURF-3 SURF3P62424220
Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)ARPC2 ARC34 PRO2446O15144220
60S ribosomal protein L4 (60S ribosomal protein L1) (Large ribosomal subunit protein uL4)RPL4 RPL1P36578219
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC; Methenyltetrahydrofolate cyclohydrolase (EC; Formyltetrahydrofolate synthetase (EC]MTHFD1 MTHFC MTHFDP11586219
Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1)FLOT2 ESA1 M17S1Q14254218
Malate dehydrogenase, mitochondrial (EC
Proteasome subunit beta type-5 (EC (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X)PSMB5 LMPX MB1 XP28074218
Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)CSE1L CAS XPO2P55060217
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)HNRNPK HNRPKP61978217
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)SFN HME1P31947216
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)IDH1 PICDO75874216
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)NME1 NDPKA NM23P15531216
Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)PCBP1Q15365216
Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)ATP1B3P54709216
Prostaglandin F2 receptor negative regulator (CD9 partner 1) (CD9P-1) (Glu-Trp-Ile EWI motif-containing protein F) (EWI-F) (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD antigen CD315)PTGFRN CD9P1 EWIF FPRP KIAA1436Q9P2B2215
Chloride intracellular channel protein 4 (Intracellular chloride ion channel protein p64H1)CLIC4Q9Y696214
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2)HSPA4 APG2P34932214
Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC
Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC (nm23-H2)NME2 NM23BP22392213
Protein DJ-1 (DJ-1) (Oncogene DJ1) (Parkinson disease protein 7) (Parkinsonism-associated deglycase) (Protein deglycase DJ-1) (EC 3.1.2.-) (EC
Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]HBBP68871212
Ras-related protein Rab-11B (GTP-binding protein YPT3)RAB11B YPT3Q15907212
Proteasome subunit alpha type-4 (EC (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)PSMA4 HC9 PSC9P25789211
Ras-related protein Rap-1A (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)RAP1A KREV1P62834211
Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35)VPS35 MEM3 TCCCTA00141Q96QK1211
Macrophage migration inhibitory factor (MIF) (EC (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC (Phenylpyruvate tautomerase)MIF GLIF MMIFP14174210
Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)SEPT2 DIFF6 KIAA0158 NEDD5Q15019210
Actin, cytoplasmic 2 (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]ACTG1 ACTGP63261209
Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]APOBP04114209
Glycine--tRNA ligase (EC (EC (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS)GARSP41250209
IST1 homolog (hIST1) (Putative MAPK-activating protein PM28)IST1 KIAA0174P53990209
Neuroblast differentiation-associated protein AHNAK (Desmoyokin)AHNAK PM227Q09666209
Peroxiredoxin-5, mitochondrial (EC (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)PRDX5 ACR1 SBBI10P30044209
40S ribosomal protein S6 (Phosphoprotein NP33) (Small ribosomal subunit protein eS6)RPS6 OK/SW-cl.2P62753208
ATP synthase subunit alpha, mitochondrialATP5A1 ATP5A ATP5AL2 ATPMP25705208
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)DSPP15924208
Proteasome subunit beta type-2 (EC (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I)PSMB2P49721208
Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI)RNH1 PRI RNHP13489208
Tubulin alpha-1A chain (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]TUBA1A TUBA3Q71U36208
40S ribosomal protein S14 (Small ribosomal subunit protein uS11)RPS14 PRO2640P62263207
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]AGRN AGRINO00468207
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)PFKP PFKFQ01813207
Carbonyl reductase [NADPH] 1 (EC (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC (Short chain dehydrogenase/reductase family 21C member 1)CBR1 CBR CRN SDR21C1P16152207
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)ADAM10 KUZ MADMO14672207
Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)MARCKS MACS PRKCSLP29966207
RuvB-like 2 (EC (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)RUVBL2 INO80J TIP48 TIP49B CGI-46Q9Y230207
Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)TPM4P67936207
60S ribosomal protein L5 (Large ribosomal subunit protein uL18)RPL5 MSTP030P46777206
Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]COPAP53621206
DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4P31689206
Ferritin heavy chain (Ferritin H subunit) (EC (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed]FTH1 FTH FTHL6 OK/SW-cl.84 PIG15P02794206
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)NAPA SNAPAP54920205
Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22)BASP1 NAP22P80723205
Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4)EEF1D EF1DP29692205
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)SLC7A5 CD98LC LAT1 MPE16Q01650205
60S ribosomal protein L6 (Large ribosomal subunit protein eL6) (Neoplasm-related protein C140) (Tax-responsive enhancer element-binding protein 107) (TaxREB107)RPL6 TXREB1Q02878204
Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)CTNNA1P35221204
Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2)CHMP4B C20orf178 SHAX1Q9H444204
Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)LGALS1P09382204
GTPase NRas (Transforming protein N-Ras)NRAS HRAS1P01111204
Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9)OLA1 GTPBP9 PRO2455 PTD004Q9NTK5204
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)PLEC PLEC1Q15149204
Proteasome subunit beta type-6 (EC (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y)PSMB6 LMPY YP28072204
Ras-related protein Rab-5BRAB5BP61020204
Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23)SNAP23O00161204
40S ribosomal protein S11 (Small ribosomal subunit protein uS17)RPS11P62280203
40S ribosomal protein S9 (Small ribosomal subunit protein uS4)RPS9P46781203
60S ribosomal protein L11 (CLL-associated antigen KW-12) (Large ribosomal subunit protein uL5)RPL11P62913203
Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)ARPC3 ARC21O15145203
Aspartate--tRNA ligase, cytoplasmic (EC (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)DARS PIG40P14868203
F-actin-capping protein subunit beta (CapZ beta)CAPZBP47756203
Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP)TGFBI BIGH3Q15582203
Fructose-bisphosphate aldolase C (EC (Brain-type aldolase)ALDOC ALDCP09972202
Rho-related GTP-binding protein RhoGRHOG ARHGP84095202
Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)ATP1B1 ATP1BP05026202
26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)PSMD11O00231201
40S ribosomal protein S25 (Small ribosomal subunit protein eS25)RPS25P62851201
60S ribosomal protein L14 (CAG-ISL 7) (Large ribosomal subunit protein eL14)RPL14P50914201
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)AP2B1 ADTB2 CLAPB1P63010201
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (Histone H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205)H2AFY MACROH2A1O75367201
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)PABPC1 PAB1 PABP1 PABPC2P11940201
Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A) [Cleaved into: Protein S100-A8, N-terminally processed]S100A8 CAGA CFAG MRP8P05109201
Ras-related protein Rab-8BRAB8BQ92930201
Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)LAMC1 LAMB2P11047200
Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)STIP1P31948200
Tryptophan--tRNA ligase, cytoplasmic (EC (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]WARS IFI53 WRSP23381200
5'-nucleotidase (5'-NT) (EC (Ecto-5'-nucleotidase) (CD antigen CD73)NT5E NT5 NTEP21589199
60S ribosomal protein L3 (HIV-1 TAR RNA-binding protein B) (TARBP-B) (Large ribosomal subunit protein uL3)RPL3 OK/SW-cl.32P39023199
Destrin (Actin-depolymerizing factor) (ADF)DSTN ACTDP DSNP60981199
Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)DPYSL2 CRMP2 ULIP2Q16555199
Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a (Small ribosomal subunit protein eS31)]RPS27A UBA80 UBCEP1P62979199
Actin, alpha cardiac muscle 1 (Alpha-cardiac actin)ACTC1 ACTCP68032198
Adenine phosphoribosyltransferase (APRT) (EC
Collagen alpha-1(VI) chainCOL6A1P12109198
Cytosolic non-specific dipeptidase (EC (CNDP dipeptidase 2) (Carnosine dipeptidase II) (Epididymis secretory protein Li 13) (Glutamate carboxypeptidase-like protein 1) (Peptidase A)CNDP2 CN2 CPGL HEL-S-13 PEPAQ96KP4198
Threonine--tRNA ligase, cytoplasmic (EC (Threonyl-tRNA synthetase) (ThrRS)TARSP26639198
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