EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Drebrin (Developmentally-regulated brain protein)DBN1 D0S117EQ16643105
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)EIF4E EIF4EL1 EIF4FP06730105
Exportin-T (Exportin(tRNA)) (tRNA exportin)XPOTO43592105
FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160)SSRP1 FACT80Q08945105
Ras-related protein Rab-3DRAB3D GOV RAB16O95716105
Regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1)UPF1 KIAA0221 RENT1Q92900105
Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)TXNL1 TRP32 TXL TXNLO43396105
Transmembrane protein 109 (Mitsugumin-23) (Mg23)TMEM109Q9BVC6105
Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1)TPBG 5T4Q13641105
Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein)TWF2 PTK9L MSTP011Q6IBS0105
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC (EC 6.-.-.-) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)UCHL1P09936105
Amyloid-like protein 2 (APLP-2) (APPH) (Amyloid protein homolog) (CDEI box-binding protein) (CDEBP)APLP2 APPL2Q06481104
Catechol O-methyltransferase (EC
Coxsackievirus and adenovirus receptor (CAR) (hCAR) (CVB3-binding protein) (Coxsackievirus B-adenovirus receptor) (HCVADR)CXADR CARP78310104
Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)KRT77 KRT1BQ7Z794104
LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48)LIMS1 PINCH PINCH1P48059104
MalectinMLEC KIAA0152Q14165104
Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)PGRMC2 DG6 PMBPO15173104
Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)TIMP1 CLGI TIMPP01033104
Mitogen-activated protein kinase kinase kinase kinase 4 (EC (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)MAP4K4 HGK KIAA0687 NIKO95819104
Proteasome-associated protein ECM29 homolog (Ecm29)ECM29 KIAA0368Q5VYK3104
Protein SEC13 homolog (SEC13-like protein 1) (SEC13-related protein)SEC13 D3S1231E SEC13L1 SEC13RP55735104
Protein tyrosine phosphatase type IVA 2 (EC (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)PTP4A2 PRL2 PTPCAAX2 BM-008Q12974104
Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2)SERINC1 KIAA1253 TDE1L TDE2 UNQ396/PRO732Q9NRX5104
Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein)SRP68Q9UHB9104
Src substrate cortactin (Amplaxin) (Oncogene EMS1)CTTN EMS1Q14247104
Surfeit locus protein 4SURF4 SURF-4O15260104
UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC (AGX-1); UDP-N-acetylglucosamine pyrophosphorylase (EC (AGX-2)]UAP1 SPAG2Q16222104
14 kDa phosphohistidine phosphatase (EC (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog)PHPT1 PHP14 CGI-202 HSPC141Q9NRX4103
Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less]SERPINA3 AACT GIG24 GIG25P01011103
Apolipoprotein M (Apo-M) (ApoM) (Protein G3a)APOM G3A NG20 HSPC336O95445103
ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)PFKM PFKXP08237103
Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2)CHMP2B CGI-84Q9UQN3103
DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]APEX1 APE APE1 APEX APX HAP1 REF1P27695103
GDP-L-fucose synthase (EC (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) (Protein FX) (Red cell NADP(H)-binding protein) (Short-chain dehydrogenase/reductase family 4E member 1)TSTA3 SDR4E1Q13630103
Glycogen [starch] synthase, muscle (EC GYSP13807103
Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1)HSPA1A HSP72 HSPA1 HSX70P08107103
Histone H2A type 1-C (Histone H2A/l)HIST1H2AC H2AFLQ93077103
Immunoglobulin heavy constant gamma 2 (Ig gamma-2 chain C region) (Ig gamma-2 chain C region DOT) (Ig gamma-2 chain C region TIL) (Ig gamma-2 chain C region ZIE)IGHG2P01859103
PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (JM5) (Prenylated Rab acceptor protein 2) (Protein JWa) (Putative MAPK-activating protein PM27)ARL6IP5 DERP11 JWA PRA2 PRAF3 HSPC127O75915103
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)RHOB ARH6 ARHBP62745103
Spermine synthase (SPMSY) (EC (Spermidine aminopropyltransferase)SMSP52788103
Tubulin--tyrosine ligase-like protein 12TTLL12 KIAA0153Q14166103
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)UBE2V2 MMS2 UEV2Q15819103
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)RAD23BP54727103
Aconitate hydratase, mitochondrial (Aconitase) (EC (Citrate hydro-lyase)ACO2Q99798102
Calmodulin-1CALM1 CALM CAM CAM1P62158102
Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]CASP14P31944102
Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Neuroendocrine differentiation factor) (Vacuolar protein sorting-associated protein 24) (hVps24)CHMP3 CGI149 NEDF VPS24 CGI-149Q9Y3E7102
Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain)F13A1 F13AP00488102
Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3)DRG1 NEDD3Q9Y295102
Matrix metalloproteinase-14 (MMP-14) (EC (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)MMP14P50281102
Membrane-associated progesterone receptor component 1 (mPR)PGRMC1 HPR6.6 PGRMCO00264102
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)PIP4K2A PIP5K2 PIP5K2AP48426102
Ras-related protein Rab-27B (C25KG)RAB27BO00194102
Serine/threonine-protein kinase OSR1 (EC (Oxidative stress-responsive 1 protein)OXSR1 KIAA1101 OSR1O95747102
Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]HADHB MSTP029P55084102
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)CBX3Q13185101
Heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) (Heterogeneous nuclear ribonucleoprotein 2H9) (hnRNP 2H9)HNRNPH3 HNRPH3P31942101
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)KPNA4 QIP1O00629101
Osteoclast-stimulating factor 1OSTF1Q92882101
Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC LTB4DHQ14914101
Receptor-type tyrosine-protein phosphatase F (EC (Leukocyte common antigen related) (LAR)PTPRF LARP10586101
Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1)SCAMP1 SCAMPO15126101
Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)PURA PUR1Q00577101
Transmembrane protein 2TMEM2 KIAA1412Q9UHN6101
Trypsin-3 (EC (Brain trypsinogen) (Mesotrypsinogen) (Serine protease 3) (Serine protease 4) (Trypsin III) (Trypsin IV)PRSS3 PRSS4 TRY3 TRY4P35030101
Tumor-associated calcium signal transducer 2 (Cell surface glycoprotein Trop-2) (Membrane component chromosome 1 surface marker 1) (Pancreatic carcinoma marker protein GA733-1)TACSTD2 GA733-1 M1S1 TROP2P09758101
Unconventional myosin-VI (Unconventional myosin-6)MYO6 KIAA0389Q9UM54101
Vitamin K-dependent protein SPROS1 PROSP07225101
Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)BAX BCL2L4Q07812100
Aspartyl aminopeptidase (EC ASPEP DAPQ9ULA0100
Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239)BCAM LU MSK19P50895100
Carbonic anhydrase 2 (EC (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II)CA2P00918100
E3 ubiquitin-protein ligase CHIP (EC (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)STUB1 CHIP PP1131Q9UNE7100
Exportin-7 (Exp7) (Ran-binding protein 16)XPO7 KIAA0745 RANBP16Q9UIA9100
Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC (Cellular glutathione peroxidase)GPX1P07203100
Hexokinase-1 (EC (Brain form hexokinase) (Hexokinase type I) (HK I)HK1P19367100
Nucleolar RNA helicase 2 (EC (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)DDX21Q9NR30100
Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)SERPINE1 PAI1 PLANH1P05121100
Prolactin-inducible protein (Gross cystic disease fluid protein 15) (GCDFP-15) (Prolactin-induced protein) (Secretory actin-binding protein) (SABP) (gp17)PIP GCDFP15 GPIP4P12273100
Putative heat shock protein HSP 90-beta 2 (Heat shock protein 90-beta b) (Heat shock protein 90Bb)HSP90AB2P HSP90BBQ58FF8100
Serine/threonine-protein kinase PAK 2 (EC (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]PAK2Q13177100
Tetraspanin-4 (Tspan-4) (Novel antigen 2) (NAG-2) (Transmembrane 4 superfamily member 7)TSPAN4 NAG2 TM4SF7O14817100
Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II)LYPLA2 APT2O9537299
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)MAP2K1 MEK1 PRKMK1Q0275099
E3 ubiquitin-protein ligase NEDD4-like (EC (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)NEDD4L KIAA0439 NEDL3Q96PU599
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)TRIM25 EFP RNF147 ZNF147Q1425899
Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2)ERBIN ERBB2IP KIAA1225 LAP2Q96RT199
Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40)KRT78 K5B KB40Q8N1N499
Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor]KNG1 BDK KNGP0104299
Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican)LUM LDC SLRR2DP5188499
Misshapen-like kinase 1 (EC (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)MINK1 B55 MAP4K6 MINK YSK2 ZC3Q8N4C899
Peripheral plasma membrane protein CASK (hCASK) (EC (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)CASK LIN2O1493699
Phospholipid transfer protein (Lipid transfer protein II)PLTPP5505899
Procollagen galactosyltransferase 1 (EC (Collagen beta(1-O)galactosyltransferase 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1)COLGALT1 GLT25D1 PSEC0241Q8NBJ599
Serine/threonine-protein kinase 26 (EC (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK)STK26 MASK MST4Q9P28999
Utrophin (Dystrophin-related protein 1) (DRP-1)UTRN DMDL DRP1P4693999
Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)DBIP0710898
Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein)ATXN10 SCA10Q9UBB498
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