EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Synaptobrevin homolog YKT6 (EC 2.3.1.-)YKT6O15498122
Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta)SSR4 TRAPDP51571122
3-hydroxyacyl-CoA dehydrogenase type-2 (EC (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)HSD17B10 ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2Q99714121
40S ribosomal protein S28 (Small ribosomal subunit protein eS28)RPS28P62857121
Acyl-protein thioesterase 1 (APT-1) (hAPT1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I)LYPLA1 APT1 LPL1O75608121
Casein kinase II subunit alpha (CK II alpha) (EC CK2A1P68400121
DNA topoisomerase 1 (EC (DNA topoisomerase I)TOP1P11387121
Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7)DBNL CMAP SH3P7 PP5423Q9UJU6121
Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]DAG1Q14118121
High mobility group protein B1 (High mobility group protein 1) (HMG-1)HMGB1 HMG1P09429121
PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2)GIPC1 C19orf3 GIPC RGS19IP1O14908121
Phenylalanine--tRNA ligase alpha subunit (EC (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)FARSA FARS FARSL FARSLAQ9Y285121
Proteasome subunit beta type-8 (EC (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein)PSMB8 LMP7 PSMB5i RING10 Y2P28062121
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)SKP1 EMC19 OCP2 SKP1A TCEB1LP63208121
Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9)SNX2 TRG9O60749121
40S ribosomal protein S15 (RIG protein) (Small ribosomal subunit protein uS19)RPS15 RIGP62841120
60S ribosomal protein L38 (Large ribosomal subunit protein eL38)RPL38P63173120
Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2)ARPC5LQ9BPX5120
Argininosuccinate synthase (EC (Citrulline--aspartate ligase)ASS1 ASSP00966120
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)DYNC1I2 DNCI2 DNCIC2Q13409120
Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic)DYNC1LI1 DNCLI1Q9Y6G9120
Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)SH3GL1 CNSA1 SH3D2BQ99961120
Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC (Insulin-regulated membrane aminopeptidase) (Insulin-responsive aminopeptidase) (IRAP) (Oxytocinase) (OTase) (Placental leucine aminopeptidase) (P-LAP) [Cleaved into: Leucyl-cystinyl aminopeptidase, pregnancy serum form]LNPEP OTASEQ9UIQ6120
Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter)ABCC1 MRP MRP1P33527120
Neprilysin (EC (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10)MME EPNP08473120
Quinone oxidoreductase (EC (NADPH:quinone reductase) (Zeta-crystallin)CRYZQ08257120
Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)SF3B1 SAP155O75533120
Beta-hexosaminidase subunit beta (EC (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]HEXB HCC7P07686119
Dihydropteridine reductase (EC (HDHPR) (Quinoid dihydropteridine reductase) (Short chain dehydrogenase/reductase family 33C member 1)QDPR DHPR SDR33C1P09417119
Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)FERMT2 KIND2 MIG2 PLEKHC1Q96AC1119
Galactokinase (EC (Galactose kinase)GALK1 GALKP51570119
Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4]ITIH4 IHRP ITIHL1 PK120 PRO1851Q14624119
MIT domain-containing protein 1MITD1Q8WV92119
Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)NRP1 NRP VEGF165RO14786119
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)PACSIN3Q9UKS6119
Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein)SRP14P37108119
Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1)SLC12A2 NKCC1P55011119
Tumor protein D54 (hD54) (Tumor protein D52-like 2)TPD52L2O43399119
Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC (Aldehyde dehydrogenase family 7 member A1) (EC (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase)ALDH7A1 ATQ1P49419118
Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2)FERMT3 KIND3 MIG2B URP2Q86UX7118
Matrin-3MATR3 KIAA0723P43243118
Probable ATP-dependent RNA helicase DDX6 (EC (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK)DDX6 HLR2 RCKP26196118
Retinal dehydrogenase 1 (RALDH 1) (RalDH1) (EC 1.2.1.-) (EC (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic)ALDH1A1 ALDC ALDH1 PUMB1P00352118
Sepiapterin reductase (SPR) (EC
V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16)ATP6V1G1 ATP6G ATP6G1 ATP6JO75348118
Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)VAPA VAP33Q9P0L0118
Wiskott-Aldrich syndrome protein family member 2 (WASP family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2)WASF2 WAVE2Q9Y6W5118
BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)BAG2O95816117
COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)COPS8 CSN8Q99627117
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)DLG1Q12959117
Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain)HBDP02042117
Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)SETQ01105117
Ras-related protein Rab-22A (Rab-22)RAB22A RAB22Q9UL26117
Serine protease 23 (EC 3.4.21.-) (Putative secreted protein Zsig13)PRSS23 ZSIG13 UNQ270/PRO307O95084117
Sorting nexin-3 (Protein SDP3)SNX3O60493117
Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA)TBCAO75347117
Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP)COPZ1 COPZ CGI-120 HSPC181P61923116
Hippocalcin-like protein 1 (Calcium-binding protein BDR-1) (HLP2) (Visinin-like protein 3) (VILIP-3)HPCAL1 BDR1P37235116
Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)PICALM CALMQ13492116
Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)STMN1 C1orf215 LAP18 OP18P16949116
Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6)TSPAN6 TM4SF6 UNQ767/PRO1560O43657116
Unconventional myosin-IdMYO1D KIAA0727O94832116
Xaa-Pro aminopeptidase 1 (EC (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)XPNPEP1 XPNPEPL XPNPEPL1Q9NQW7116
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)CD2APQ9Y5K6115
Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)COPEO14579115
Enoyl-CoA hydratase, mitochondrial (EC (Enoyl-CoA hydratase 1) (Short-chain enoyl-CoA hydratase) (SCEH)ECHS1P30084115
Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)TRAP1 HSP75Q12931115
Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9)IPO9 IMP9 KIAA1192 RANBP9 HSPC273Q96P70115
Lysosomal protective protein (EC (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]CTSA PPGBP10619115
Lysyl oxidase homolog 2 (EC (Lysyl oxidase-like protein 2) (Lysyl oxidase-related protein 2) (Lysyl oxidase-related protein WS9-14)LOXL2Q9Y4K0115
Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor)PTTG1IP C21orf1 C21orf3P53801115
Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5)TXNDC17 TXNL5Q9BRA2115
Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1)TMED2 RNP24Q15363115
Tubulin beta-2B chainTUBB2BQ9BVA1115
Tubulin beta-8 chain (Tubulin beta 8 class VIII)TUBB8Q3ZCM7115
Vesicle-fusing ATPase (EC (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF)NSFP46459115
60S ribosomal protein L34 (Large ribosomal subunit protein eL34)RPL34P49207114
Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28)CIB1 CIB KIP PRKDCIPQ99828114
Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a)CSNK2B CK2N G5AP67870114
Cytoskeleton-associated protein 4 (63-kDa cytoskeleton-linking membrane protein) (Climp-63) (p63)CKAP4Q07065114
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5GNG5 GNGT5P63218114
Immunoglobulin heavy constant mu (Ig mu chain C region) (Ig mu chain C region GAL) (Ig mu chain C region OU)IGHMP01871114
Leucine-rich repeat-containing protein 57LRRC57Q8N9N7114
Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17)PLIN3 M6PRBP1 TIP47O60664114
Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)USP9X DFFRX FAM USP9Q93008114
Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)PSME3P61289114
Protein transport protein Sec23A (SEC23-related protein A)SEC23AQ15436114
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)ATP2A2 ATP2BP16615114
Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed]SNX6Q9UNH7114
Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3)VDAC3Q9Y277114
40S ribosomal protein S21 (Small ribosomal subunit protein eS21)RPS21P63220113
60S ribosomal protein L35 (Large ribosomal subunit protein uL29)RPL35P42766113
ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]SLC25A6 ANT3 CDABP0051P12236113
Asparagine synthetase [glutamine-hydrolyzing] (EC (Cell cycle control protein TS11) (Glutamine-dependent asparagine synthetase)ASNS TS11P08243113
Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC
Glutathione S-transferase Mu 3 (EC (GST class-mu 3) (GSTM3-3) (hGSTM3-3)GSTM3 GST5P21266113
Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160)GLG1 CFR1 ESL1 MG160Q92896113
L-xylulose reductase (XR) (EC (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H)DCXR SDR20C1Q7Z4W1113
Nucleobindin-1 (CALNUC)NUCB1 NUCQ02818113
Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)PVR PVSP15151113
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