EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC (IMPDH-II)IMPDH2 IMPD2P12268179
Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)KIF5B KNS KNS1P33176179
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)ATP2B4 ATP2B2 MXRA1P23634179
Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)PSME1 IFI5111Q06323179
Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta)PSME2Q9UL46179
Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)VDAC1 VDACP21796179
Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)COPB2P35606178
Copine-1 (Chromobindin 17) (Copine I)CPNE1 CPN1Q99829178
F-actin-capping protein subunit alpha-2 (CapZ alpha-2)CAPZA2P47755178
Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)SYNCRIP HNRPQ NSAP1O60506177
Nuclease-sensitive element-binding protein 1 (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Y-box transcription factor) (Y-box-binding protein 1) (YB-1)YBX1 NSEP1 YB1P67809177
Plasma membrane calcium-transporting ATPase 1 (PMCA1) (EC (Plasma membrane calcium ATPase isoform 1) (Plasma membrane calcium pump isoform 1)ATP2B1 PMCA1P20020177
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)PSMD6 KIAA0107 PFAAP4Q15008176
4-trimethylaminobutyraldehyde dehydrogenase (TMABADH) (EC (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC (Gamma-aminobutyraldehyde dehydrogenase) (EC (R-aminobutyraldehyde dehydrogenase) [Cleaved into: 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed]ALDH9A1 ALDH4 ALDH7 ALDH9P49189176
40S ribosomal protein S15a (Small ribosomal subunit protein uS8)RPS15A OK/SW-cl.82P62244176
Aldose reductase (AR) (EC (Aldehyde reductase) (Aldo-keto reductase family 1 member B1)AKR1B1 ALDR1P15121176
Inorganic pyrophosphatase (EC (Pyrophosphate phospho-hydrolase) (PPase)PPA1 IOPPP PPQ15181176
Protein S100-A6 (Calcyclin) (Growth factor-inducible protein 2A9) (MLN 4) (Prolactin receptor-associated protein) (PRA) (S100 calcium-binding protein A6)S100A6 CACYP06703176
Ubiquitin carboxyl-terminal hydrolase 5 (EC (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)USP5 ISOTP45974176
UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC
26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5)PSMD13Q9UNM6175
Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)ARPC1B ARC41O15143175
Alpha-2-HS-glycoprotein (Alpha-2-Z-globulin) (Ba-alpha-2-glycoprotein) (Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B]AHSG FETUA PRO2743P02765175
Arginine--tRNA ligase, cytoplasmic (EC (Arginyl-tRNA synthetase) (ArgRS)RARSP54136175
Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116)EIF3B EIF3S9P55884175
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]HNRNPA1 HNRPA1P09651175
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)RAC2P15153175
Ras-related protein Rab-21RAB21 KIAA0118Q9UL25175
Staphylococcal nuclease domain-containing protein 1 (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator)SND1 TDRD11Q7KZF4175
Sulfhydryl oxidase 1 (hQSOX) (EC (Quiescin Q6)QSOX1 QSCN6 UNQ2520/PRO6013O00391175
V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1)ATP6V1E1 ATP6E ATP6E2P36543175
Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B)VPS37BQ9H9H4175
Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)VAMP3 SYB3Q15836175
26S protease regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)PSMC1P62191174
60S ribosomal protein L27 (Large ribosomal subunit protein eL27)RPL27P61353174
Fatty acid-binding protein, epidermal (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein 5) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)FABP5Q01469174
Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)LGALS3 MAC2P17931174
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC HPRTP00492174
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]FKBP4 FKBP52Q02790174
Plastin-3 (T-plastin)PLS3P13797174
Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)TUBB3 TUBB4Q13509174
Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)ANXA3 ANX3P12429173
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)XPO1 CRM1O14980173
Phosphoglucomutase-1 (PGM 1) (EC (Glucose phosphomutase 1)PGM1P36871173
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]LMNA LMN1P02545173
Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)FSCN1 FAN1 HSN SNLQ16658172
Golgin subfamily A member 7 (Golgi complex-associated protein of 16 kDa)GOLGA7 GCP16 HDCKB03P HSPC041Q7Z5G4172
Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)IPO5 KPNB3 RANBP5O00410172
Protein FAM49B (L1)FAM49B BM-009Q9NUQ9172
Protein tweety homolog 3 (hTTY3)TTYH3 KIAA1691Q9C0H2172
Proto-oncogene tyrosine-protein kinase Src (EC (Proto-oncogene c-Src) (pp60c-src) (p60-Src)SRC SRC1P12931172
Puromycin-sensitive aminopeptidase (PSA) (EC (Cytosol alanyl aminopeptidase) (AAP-S)NPEPPS PSAP55786172
V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)ATP6V1B2 ATP6B2 VPP3P21281172
40S ribosomal protein S26 (Small ribosomal subunit protein eS26)RPS26P62854171
Aldehyde dehydrogenase family 16 member A1ALDH16A1Q8IZ83171
Coactosin-like proteinCOTL1 CLPQ14019171
Eukaryotic translation initiation factor 2 subunit 3 (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX)EIF2S3 EIF2GP41091171
Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha)LAMA5 KIAA0533 KIAA1907O15230171
MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)MARCKSL1 MLP MRPP49006171
Protein disulfide-isomerase A4 (EC (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)PDIA4 ERP70 ERP72P13667171
40S ribosomal protein S10 (Small ribosomal subunit protein eS10)RPS10P46783170
40S ribosomal protein S19 (Small ribosomal subunit protein eS19)RPS19P39019170
60S ribosomal protein L24 (60S ribosomal protein L30) (Large ribosomal subunit protein eL24)RPL24P83731170
Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))CTNND1 KIAA0384O60716170
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]FGBP02675170
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1)GFPT1 GFAT GFPTQ06210170
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)SLC9A3R1 NHERF NHERF1O14745170
Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin)NAMPT PBEF PBEF1P43490170
Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)LCP1 PLS2P13796170
Vacuolar protein sorting-associated protein 4B (EC (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1)VPS4B SKD1 VPS42 MIG1O75351170
26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Mov34 protein homolog) (Proteasome subunit p40)PSMD7 MOV34LP51665169
GTPase HRas (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]HRAS HRAS1P01112169
Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)GNAI1P63096169
Septin-7 (CDC10 protein homolog)SEPT7 CDC10Q16181169
40S ribosomal protein S24 (Small ribosomal subunit protein eS24)RPS24P62847168
60S ribosomal protein L18a (Large ribosomal subunit protein eL20)RPL18AQ02543168
60S ribosomal protein L9 (Large ribosomal subunit protein uL6)RPL9 OK/SW-cl.103; RPL9P7; RPL9P8; RPL9P9P32969168
Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B)CSTB CST6 STFBP04080168
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)ITGB3 GP3AP05106168
Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3)MYL12A MLCB MRLC3 RLCP19105168
Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1)SEPT9 KIAA0991 MSFQ9UHD8168
Valine--tRNA ligase (EC (Protein G7a) (Valyl-tRNA synthetase) (ValRS)VARS G7A VARS2P26640168
ATP-dependent RNA helicase DDX3X (EC (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (Helicase-like protein 2) (HLP2)DDX3X DBX DDX3O00571167
Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1)PEF1 ABP32 UNQ1845/PRO3573Q9UBV8167
Purine nucleoside phosphorylase (PNP) (EC (Inosine phosphorylase) (Inosine-guanosine phosphorylase)PNP NPP00491167
26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (26S proteasome-associated PAD1 homolog 1)PSMD14 POH1O00487166
60S ribosomal protein L10 (Laminin receptor homolog) (Large ribosomal subunit protein uL16) (Protein QM) (Tumor suppressor QM)RPL10 DXS648E QMP27635166
60S ribosomal protein L13a (23 kDa highly basic protein) (Large ribosomal subunit protein uL13)RPL13AP40429166
Barrier-to-autointegration factor (Breakpoint cluster region protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed]BANF1 BAF BCRG1O75531166
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170)HYOU1 GRP170 ORP150Q9Y4L1166
Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7)IPO7 RANBP7O95373166
Calcium-binding protein 39 (MO25alpha) (Protein Mo25)CAB39 MO25 CGI-66Q9Y376165
Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)EIF3F EIF3S5O00303165
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)GNAS GNAS1 GSPP63092165
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)GNB4Q9HAV0165
Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]HNRNPF HNRPFP52597165
Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C)STXBP3O00186165
40S ribosomal protein S12 (Small ribosomal subunit protein eS12)RPS12P25398164
CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151)CD151 TSPAN24P48509164
Elongation factor 1-beta (EF-1-beta)EEF1B2 EEF1B EF1BP24534164
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