EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Polyubiquitin-B [Cleaved into: Ubiquitin]UBBP0CG4761
Putative RNA-binding protein Luc7-like 2LUC7L2 CGI-59 CGI-74Q9Y38361
Ras GTPase-activating-like protein IQGAP3IQGAP3Q86VI361
Signal peptidase complex subunit 2 (EC 3.4.-.-) (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit)SPCS2 KIAA0102 SPC25Q1500561
Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog)SLC35F6 C2orf18 UNQ3047/PRO9863Q8N35761
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)SPTBN2 KIAA0302 SCA5O1502061
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)TJP1 ZO1Q0715761
Trafficking protein particle complex subunit 6BTRAPPC6BQ86SZ261
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (EC (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (hB-ind1) (Protein-tyrosine phosphatase-like A domain-containing protein 1)HACD3 BIND1 PTPLAD1Q9P03561
Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Protein TM7XN1) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]ADGRG1 GPR56 TM7LN4 TM7XN1 UNQ540/PRO1083Q9Y65360
Calmodulin-like protein 5 (Calmodulin-like skin protein)CALML5 CLSPQ9NZT160
Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10)TRIP10 CIP4 STOT STPQ1564260
Claudin domain-containing protein 1 (Membrane protein GENX-3745)CLDND1 C3orf4 HSPC174 PSEC0054 UNQ2511/PRO6000Q9NY3560
Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog)NCAPD2 CAPD2 CNAP1 KIAA0159Q1502160
E3 ubiquitin-protein ligase RBX1 (EC 6.3.2.-) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed]RBX1 RNF75 ROC1P6287760
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Membrane component chromosome 6 surface marker 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC; Nucleotide pyrophosphatase (NPPase) (EC (Nucleotide diphosphatase)]ENPP1 M6S1 NPPS PC1 PDNP1P2241360
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ER-Golgi intermediate compartment 32 kDa protein) (ERGIC-32)ERGIC1 ERGIC32 KIAA1181 HT034Q969X560
Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)GJA1 GJALP1730260
Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59)GORASP2 GOLPH6Q9H8Y860
HLA class I histocompatibility antigen, A-34 alpha chain (Aw-34) (HLA class I histocompatibility antigen, A-10 alpha chain) (MHC class I antigen A*34)HLA-A HLAAP3045360
Lysosomal Pro-X carboxypeptidase (EC (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP)PRCP PCPP4278560
Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated]NF1P2135960
Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)NCBP1 CBP80 NCBPQ0916160
Olfactomedin-4 (OLM4) (Antiapoptotic protein GW112) (G-CSF-stimulated clone 1 protein) (hGC-1) (hOLfD)OLFM4 GW112 UNQ362/PRO698Q6UX0660
PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b)PHF5AQ7RTV060
Pleckstrin (Platelet 47 kDa protein) (p47)PLEK P47P0856760
Ras-related protein Rab-9ARAB9A RAB9P5115160
Septin-6SEPT6 KIAA0128 SEP2Q1414160
Serine/threonine-protein kinase MRCK beta (EC (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)CDC42BPB KIAA1124Q9Y5S260
Sorting nexin-12SNX12Q9UMY460
Transmembrane 9 superfamily member 4 (Tumor cannibalism associated protein 1)TM9SF4 KIAA0255 TUCAP1Q9254460
Tubulin-specific chaperone E (Tubulin-folding cofactor E)TBCEQ1581360
Tyrosine-protein phosphatase non-receptor type 6 (EC (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)PTPN6 HCP PTP1CP2935060
Alpha-N-acetylglucosaminidase (EC (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form]NAGLU UFHSD1P5480259
Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2)SLC4A2 AE2 EPB3L1 HKB3 MPB3LP0492059
Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]EPB41L3 DAL1 KIAA0987Q9Y2J259
Chromosome-associated kinesin KIF4A (Chromokinesin-A)KIF4A KIF4O9523959
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)CUL5 VACM1Q9303459
EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1)EMILIN1 EMIQ9Y6C259
Exocyst complex component 1 (Exocyst complex component Sec3)EXOC1 SEC3 SEC3L1 BM-012Q9NV7059
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC (Serine/threonine-protein kinase GSK3B) (EC
Histone-arginine methyltransferase CARM1 (EC (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4)CARM1 PRMT4Q86X5559
Lamin-B2LMNB2 LMN2Q0325259
Lysophospholipase-like protein 1 (EC 3.1.2.-)LYPLAL1Q5VWZ259
Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3)TIMP3P3562559
Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex)MTA2 MTA1L1 PIDO9477659
Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein)MISP C19orf21Q8IVT259
NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC (Malic enzyme 2)ME2P2336859
Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56)NCAM1 NCAMP1359159
Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Arylacetamide deacetylase-like 1)NCEH1 AADACL1 KIAA1363Q6PIU259
Nicotinamide N-methyltransferase (EC
Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha)PITPNA PITPNQ0016959
Phospholipase A-2-activating protein (PLA2P) (PLAP)PLAA PLAPQ9Y26359
Pleckstrin homology-like domain family A member 3 (TDAG51/Ipl homolog 1)PHLDA3 TIH1Q9Y5J559
Protein PBDC1 (Polysaccharide biosynthesis domain-containing protein 1)PBDC1 CXorf26Q9BVG459
Ras-related C3 botulinum toxin substrate 3 (p21-Rac3)RAC3P6076359
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta)PPP2R5DQ1473859
Serine/threonine-protein phosphatase CPPED1 (EC (Calcineurin-like phosphoesterase domain-containing protein 1) (Complete S-transactivated protein 1)CPPED1 CSTP1Q9BRF859
Switch-associated protein 70 (SWAP-70)SWAP70 KIAA0640 HSPC321Q9UH6559
Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3)TENM3 KIAA1455 ODZ3 TNM3Q9P27359
Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C)TSPAN1O6063559
Tubulin alpha-8 chain (Alpha-tubulin 8) (Tubulin alpha chain-like 2)TUBA8 TUBAL2Q9NY6559
V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F)ATP6V1F ATP6S14 VATFQ1686459
WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP)WASHC4 KIAA1033Q2M38959
39S ribosomal protein L44, mitochondrial (L44mt) (MRP-L44) (EC 3.1.26.-) (Mitochondrial large ribosomal subunit protein mL44)MRPL44Q9H9J258
ATP-dependent DNA helicase Q1 (EC (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1)RECQL RECQ1 RECQL1P4606358
BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]BIDP5595758
C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280)MRC2 CLEC13E ENDO180 KIAA0709 UPARAPQ9UBG058
Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog)CORO7P5773758
Dynamin-like 120 kDa protein, mitochondrial (EC (Optic atrophy protein 1) [Cleaved into: Dynamin-like 120 kDa protein, form S1]OPA1 KIAA0567O6031358
Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210)EVPLQ9281758
Ephrin type-B receptor 4 (EC (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)EPHB4 HTK MYK1 TYRO11P5476058
GrpE protein homolog 1, mitochondrial (HMGE) (Mt-GrpE#1)GRPEL1 GREPEL1Q9HAV758
Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)ITGAM CD11B CR3AP1121558
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)MAPK3 ERK1 PRKM3P2736158
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)NAE1 APPBP1 HPP1Q1356458
Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2)SYNE2 KIAA1011 NUAQ8WXH058
Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (Nucleoporin Nup93)NUP93 KIAA0095Q8N1F758
PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)PDLIM7 ENIGMAQ9NR1258
Probable ATP-dependent RNA helicase DDX46 (EC (DEAD box protein 46) (PRP5 homolog)DDX46 KIAA0801Q7L01458
Protein NipSnap homolog 1 (NipSnap1)NIPSNAP1Q9BPW858
RNA-binding protein 39 (CAPER alpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1)RBM39 HCC1 RNPC2Q1449858
SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein)SNAPIN BLOC1S7 SNAP25BP SNAPAPO9529558
Sushi repeat-containing protein SRPXSRPX ETX1P7853958
Thrombospondin-4THBS4 TSP4P3544358
tRNA (cytosine(34)-C(5))-methyltransferase (EC (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (tRNA (cytosine-5-)-methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4)NSUN2 SAKI TRM4Q08J2358
Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1)TNFAIP8O9537958
Tyrosine-protein kinase receptor UFO (EC (AXL oncogene)AXL UFOP3053058
Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)]MYO1G HA2B0I1T258
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)PLCD1P5117857
Arfaptin-1 (ADP-ribosylation factor-interacting protein 1)ARFIP1P5336757
BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5)BAG5 KIAA0873Q9UL1557
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]PAPSS1 ATPSK1 PAPSSO4325257
Carboxypeptidase E (CPE) (EC (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase)CPEP1687057
Collagen alpha-1(XIV) chain (Undulin)COL14A1 UNDQ0570757
Complement component C8 gamma chainC8GP0736057
Cullin-2 (CUL-2)CUL2Q1361757
Dipeptidyl peptidase 2 (EC (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase)DPP7 DPP2 QPPQ9UHL457
Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2)EML2 EMAP2 EMAPL2O9583457
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