EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
40S ribosomal protein S3 (EC (Small ribosomal subunit protein uS3)RPS3 OK/SW-cl.26P23396262
Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)EEF1G EF1G PRO1608P26641262
Ras-related protein Rab-14RAB14P61106262
T-complex protein 1 subunit zeta (TCP-1-zeta) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (HTR3) (Tcp20)CCT6A CCT6 CCTZP40227262
Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II)ANXA4 ANX4P09525261
Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)PPIB CYPBP23284260
ADP-ribosylation factor 1ARF1P84077258
CD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9)CD9 MIC3 TSPAN29 GIG2P21926258
T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]CCT7 CCTH NIP7-1Q99832258
Annexin A7 (Annexin VII) (Annexin-7) (Synexin)ANXA7 ANX7 SNX OK/SW-cl.95P20073257
Major vault protein (MVP) (Lung resistance-related protein)MVP LRPQ14764257
Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP)TXN TRDX TRX TRX1P10599257
WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)WDR1O75083257
Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)KPNB1 NTF97Q14974256
Protein disulfide-isomerase A3 (EC (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)PDIA3 ERP57 ERP60 GRP58P30101256
Ras-related C3 botulinum toxin substrate 1 (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)RAC1 TC25 MIG5P63000254
T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding)CCT4 CCTD SRBP50991254
Tubulin alpha-4A chain (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain)TUBA4A TUBA1P68366254
ATP synthase subunit beta, mitochondrial (EC ATPMB ATPSBP06576253
Transforming protein RhoA (Rho cDNA clone 12) (h12)RHOA ARH12 ARHA RHO12P61586253
Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin]MFGE8Q08431251
Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)SLC1A5 ASCT2 M7V1 RDR RDRCQ15758250
Transketolase (TK) (EC
Proteasome subunit alpha type-5 (EC (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)PSMA5P28066249
6-phosphogluconate dehydrogenase, decarboxylating (EC PGDHP52209248
EH domain-containing protein 4 (Hepatocellular carcinoma-associated protein 10/11) (PAST homolog 4)EHD4 HCA10 HCA11 PAST4 FKSG7Q9H223248
Guanine nucleotide-binding protein G(k) subunit alpha (G(i) alpha-3)GNAI3P08754248
Actin-related protein 3 (Actin-like protein 3)ACTR3 ARP3P61158247
CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)CD44 LHR MDU2 MDU3 MIC4P16070247
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)CD81 TAPA1 TSPAN28P60033247
Malate dehydrogenase, cytoplasmic (EC (Cytosolic malate dehydrogenase) (Diiodophenylpyruvate reductase) (EC MDHAP40925247
40S ribosomal protein S8 (Small ribosomal subunit protein eS8)RPS8 OK/SW-cl.83P62241246
Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-)VAT1Q99536246
40S ribosomal protein SA (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4) (Small ribosomal subunit protein uS2)RPSA LAMBR LAMR1P08865245
Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)ARPC4 ARC20P59998245
F-actin-capping protein subunit alpha-1 (CapZ alpha-1)CAPZA1P52907245
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]HSPG2P98160244
Ras-related protein Rab-1BRAB1BQ9H0U4244
Ras-related protein Rab-8A (Oncogene c-mel)RAB8A MEL RAB8P61006244
Protein disulfide-isomerase (PDI) (EC (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)P4HB ERBA2L PDI PDIA1 PO4DBP07237243
Ras-related protein Rap-2bRAP2BP61225243
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]B2M CDABP0092 HDCMA22PP61769242
40S ribosomal protein S18 (Ke-3) (Ke3) (Small ribosomal subunit protein uS13)RPS18 D6S218EP62269241
60S ribosomal protein L7 (Large ribosomal subunit protein uL30)RPL7P18124241
Ras-related protein Rab-2ARAB2A RAB2P61019241
Cathepsin D (EC [Cleaved into: Cathepsin D light chain; Cathepsin D heavy chain]CTSD CPSDP07339240
CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)CD59 MIC11 MIN1 MIN2 MIN3 MSK21P13987240
Ras-related protein Rab-35 (GTP-binding protein RAY) (Ras-related protein Rab-1C)RAB35 RAB1C RAYQ15286240
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon)CCT5 CCTE KIAA0098P48643240
Tubulin alpha-1B chain (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]TUBA1BP68363240
40S ribosomal protein S16 (Small ribosomal subunit protein uS9)RPS16P62249239
40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3) (Small ribosomal subunit protein uS5)RPS2 RPS4P15880239
Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)SLC2A1 GLUT1P11166239
Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]PEBP1 PBP PEBPP30086238
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)ARHGDIA GDIA1P52565238
T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5)CCT3 CCTG TRIC5P49368238
Actin-related protein 2 (Actin-like protein 2)ACTR2 ARP2P61160237
Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)GNA13Q14344237
Bifunctional purine biosynthesis protein PURH [Cleaved into: Bifunctional purine biosynthesis protein PURH, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); IMP cyclohydrolase (EC (ATIC) (IMP synthase) (Inosinicase)]ATIC PURH OK/SW-cl.86P31939235
Proteasome subunit alpha type-3 (EC (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)PSMA3 HC8 PSC8P25788232
40S ribosomal protein S4, X isoform (SCR10) (Single copy abundant mRNA protein) (Small ribosomal subunit protein eS4)RPS4X CCG2 RPS4 SCARP62701230
Beta-actin-like protein 2 (Kappa-actin)ACTBL2Q562R1230
Proteasome subunit alpha type-2 (EC (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3)PSMA2 HC3 PSC3P25787230
Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]RACK1 GNB2L1 HLC7 PIG21P63244230
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)MYO1CO00159230
Proteasome subunit alpha type-1 (EC (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)PSMA1 HC2 NU PROS30 PSC2P25786229
Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)LAMP1P11279228
Proteasome subunit beta type-3 (EC (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)PSMB3P49720228
Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]S100A11 MLN70 S100CP31949228
60S ribosomal protein L12 (Large ribosomal subunit protein uL11)RPL12P30050227
Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)FLNB FLN1L FLN3 TABP TAPO75369227
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)JUP CTNNG DP3P14923227
V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)ATP6V1A ATP6A1 ATP6V1A1 VPP2P38606227
60 kDa heat shock protein, mitochondrial (EC (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein)HSPD1 HSP60P10809226
ADP-ribosylation factor 4ARF4 ARF2P18085226
ADP-ribosylation factor 6ARF6P62330226
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)CAND1 KIAA0829 TIP120 TIP120AQ86VP6226
D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC (2-oxoglutarate reductase) (EC (Malate dehydrogenase) (EC PGDH3O43175226
Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)IGSF8 CD81P3 EWI2 KCT4Q969P0226
Proteasome subunit beta type-1 (EC (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain)PSMB1 PSC5P20618226
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)PSMD2 TRAP2Q13200225
Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)CALR CRTCP27797225
60S acidic ribosomal protein P0 (60S ribosomal protein L10E) (Large ribosomal subunit protein uL10)RPLP0P05388224
Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325Q14204224
Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)CYFIP1 KIAA0068Q7L576224
Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC (AIR carboxylase) (AIRC)]PAICS ADE2 AIRC PAISP22234224
Copine-3 (Copine III)CPNE3 CPN3 KIAA0636O75131223
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)NPM1 NPMP06748223
RuvB-like 1 (EC (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)RUVBL1 INO80H NMP238 TIP49 TIP49AQ9Y265223
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)PPP2R1AP30153223
Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B]VTNP04004223
60S acidic ribosomal protein P2 (Large ribosomal subunit protein P2) (Renal carcinoma antigen NY-REN-44)RPLP2 D11S2243E RPP2P05387222
60S ribosomal protein L18 (Large ribosomal subunit protein eL18)RPL18Q07020222
Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]ITGA6P23229222
Integrin alpha-V (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]ITGAV MSK8 VNRAP06756221
Neutral alpha-glucosidase AB (EC (Alpha-glucosidase 2) (Glucosidase II subunit alpha)GANAB G2AN KIAA0088Q14697221
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