EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)TPM3P06753198
26S protease regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)PSMC3 TBP1P17980197
40S ribosomal protein S13 (Small ribosomal subunit protein uS15)RPS13P62277197
Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1]DCD AIDD DSEPP81605197
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)HNRNPA2B1 HNRPA2B1P22626197
Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]ITGA3 MSK18P26006197
Ras-related protein R-Ras (p23)RRASP10301197
26S protease regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) (Protein MSS1)PSMC2 MSS1P35998196
60S ribosomal protein L8 (Large ribosomal subunit protein uL2)RPL8P62917196
Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)GNA11 GA11P29992196
Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)LAMP2P13473196
40S ribosomal protein S7 (Small ribosomal subunit protein eS7)RPS7P62081195
Alanine--tRNA ligase, cytoplasmic (EC (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42)AARSP49588195
Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)SLC44A1 CD92 CDW92 CTL1Q8WWI5195
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)EIF5AP63241195
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)KRT5P13647195
Tubulin alpha-1C chain (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]TUBA1C TUBA6Q9BQE3195
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))XRCC5 G22P2P13010195
BRO1 domain-containing protein BROX (BRO1 domain- and CAAX motif-containing protein)BROX BROFTI C1orf58Q5VW32194
Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14)KRT14P02533194
Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1)SLC16A1 MCT1P53985194
26S protease regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)PSMC6 SUG2P62333193
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)ACTR1A CTRN1P61163193
ATP-dependent RNA helicase A (RHA) (EC (DEAH box protein 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II)DHX9 DDX9 LKP NDH2Q08211193
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)CANXP27824193
Ras-related protein Rab-5ARAB5A RAB5P20339193
60S ribosomal protein L13 (Breast basic conserved protein 1) (Large ribosomal subunit protein eL13)RPL13 BBC1 OK/SW-cl.46P26373192
Cytosol aminopeptidase (EC (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC (Prolyl aminopeptidase)LAP3 LAPEP PEPSP28838192
Glycogen phosphorylase, brain form (EC
Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein)ST13 AAG2 FAM10A1 HIP SNC6P50502192
Niban-like protein 1 (Meg-3) (Melanoma invasion by ERK) (MINERVA) (Protein FAM129B)FAM129B C9orf88Q96TA1192
Nucleolin (Protein C23)NCLP19338192
Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP)NAP1L1 NRPP55209192
Tubulin beta-6 chain (Tubulin beta class V)TUBB6Q9BUF5192
40S ribosomal protein S5 (Small ribosomal subunit protein uS7) [Cleaved into: 40S ribosomal protein S5, N-terminally processed]RPS5P46782191
Aminopeptidase N (AP-N) (hAPN) (EC (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13)ANPEP APN CD13 PEPNP15144191
Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)ITGA2 CD49BP17301191
Proteasome subunit beta type-4 (EC (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)PSMB4 PROS26P28070191
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC PPP1AP62136191
Coatomer subunit beta (Beta-coat protein) (Beta-COP)COPB1 COPB MSTP026P53618190
Protein S100-A9 (Calgranulin-B) (Calprotectin L1H subunit) (Leukocyte L1 complex heavy chain) (Migration inhibitory factor-related protein 14) (MRP-14) (p14) (S100 calcium-binding protein A9)S100A9 CAGB CFAG MRP14P06702190
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)SPTBN1 SPTB2Q01082190
UTP--glucose-1-phosphate uridylyltransferase (EC (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase)UGP2 UGP1Q16851190
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)XRCC6 G22P1P12956190
26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)PSMD12O00232189
60S ribosomal protein L15 (Large ribosomal subunit protein eL15)RPL15 EC45 TCBAP0781P61313189
ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)PFKLP17858189
Coronin-1C (Coronin-3) (hCRNN4)CORO1C CRN2 CRNN4Q9ULV4189
Glutathione S-transferase omega-1 (GSTO-1) (EC (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC (S-(Phenacyl)glutathione reductase) (SPG-R)GSTO1 GSTTLP28P78417189
Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)MYH10P35580189
Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)RTN4 KIAA0886 NOGO My043 SP1507Q9NQC3189
Transaldolase (EC TAL TALDO TALDORP37837189
Ubiquitin-conjugating enzyme E2 N (EC (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)UBE2N BLUP61088189
26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)PSMD3O43242188
Choline transporter-like protein 2 (Solute carrier family 44 member 2)SLC44A2 CTL2 PSEC0210Q8IWA5188
Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)GNAQ GAQP50148188
Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]APOA1P02647187
Myoferlin (Fer-1-like protein 3)MYOF FER1L3 KIAA1207Q9NZM1187
AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)AP2A1 ADTAA CLAPA1O95782186
Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC (Prolyl-tRNA synthetase)]EPRS GLNS PARS QARS QPRS PIG32P07814186
CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63)CD63 MLA1 TSPAN30P08962186
Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)COPG1 COPGQ9Y678186
40S ribosomal protein S20 (Small ribosomal subunit protein uS10)RPS20P60866185
60S ribosomal protein L17 (60S ribosomal protein L23) (Large ribosomal subunit protein uL22) (PD-1)RPL17P18621185
60S ribosomal protein L30 (Large ribosomal subunit protein eL30)RPL30P62888185
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12GNG12Q9UBI6185
Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (Scaffold attachment factor A) (SAF-A) (p120) (pp120)HNRNPU HNRPU SAFA U21.1Q00839185
Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2)PCBP2Q15366185
Sorcin (22 kDa protein) (CP-22) (CP22) (V19)SRIP30626185
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)HSPA9 GRP75 HSPA9B mt-HSP70P38646185
Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28)VPS28Q9UK41185
Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)CAPNS1 CAPN4 CAPNSP04632184
Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36)SCARB2 CD36L2 LIMP2 LIMPIIQ14108184
NicastrinNCSTN KIAA0253 UNQ1874/PRO4317Q92542184
Ras-related protein Ral-BRALBP11234184
6-phosphogluconolactonase (6PGL) (EC
Catenin beta-1 (Beta-catenin)CTNNB1 CTNNB OK/SW-cl.35 PRO2286P35222183
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)EIF3A EIF3S10 KIAA0139Q14152183
Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)HNRNPC HNRPCP07910183
Ras-related protein Rab-13 (Cell growth-inhibiting gene 4 protein)RAB13 GIG4P51153183
Superoxide dismutase [Cu-Zn] (EC (Superoxide dismutase 1) (hSod1)SOD1P00441183
Vasodilator-stimulated phosphoprotein (VASP)VASPP50552183
60S ribosomal protein L10a (CSA-19) (Large ribosomal subunit protein uL1) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6)RPL10A NEDD6P62906182
Ferritin light chain (Ferritin L subunit)FTLP02792182
Plexin-B2 (MM1)PLXNB2 KIAA0315O15031182
Ras-related protein Rab-6A (Rab-6)RAB6A RAB6P20340182
Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)TF PRO1400P02787182
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)PSMD1Q99460181
Calpain-1 catalytic subunit (EC (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)CAPN1 CANPL1 PIG30P07384181
DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14)DNAJA2 CPR3 HIRIP4O60884181
Lactoylglutathione lyase (EC (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase)GLO1Q04760181
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)SPTAN1 NEAS SPTA2Q13813181
26S protease regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)PSMC5 SUG1P62195180
Alcohol dehydrogenase [NADP(+)] (EC (Aldehyde reductase) (Aldo-keto reductase family 1 member A1)AKR1A1 ALDR1 ALRP14550180
Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2)GLIPR2 C9orf19 GAPR1Q9H4G4180
Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1)PA2G4 EBP1Q9UQ80180
Ras-related protein R-Ras2 (Ras-like protein TC21) (Teratocarcinoma oncogene)RRAS2 TC21P62070180
Disco-interacting protein 2 homolog B (DIP2 homolog B)DIP2B KIAA1463Q9P265179
Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein)HSPH1 HSP105 HSP110 KIAA0201Q92598179
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)HNRNPD AUF1 HNRPDQ14103179
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