EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)BAIAP2L1 IRTKSQ9UHR492
Carbonyl reductase [NADPH] 3 (EC (NADPH-dependent carbonyl reductase 3) (Short chain dehydrogenase/reductase family 21C member 2)CBR3O7582892
Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CFIm25) (CPSF 25 kDa subunit) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Pre-mRNA cleavage factor Im 25 kDa subunit)NUDT21 CFIM25 CPSF25 CPSF5O4380992
Collagen alpha-2(I) chain (Alpha-2 type I collagen)COL1A2P0812392
Complement factor H (H factor 1)CFH HF HF1 HF2P0860392
Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform)CYB5B CYB5M OMB5O4316992
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)EPS8L2 EPS8R2 PP13181Q9H6S392
Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (Putative oncogene protein hlc14-06-p)ITPA C20orf37 My049 OK/SW-cl.9Q9BY3292
Non-specific lipid-transfer protein (NSL-TP) (EC (Propanoyl-CoA C-acyltransferase) (SCP-chi) (SCPX) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X)SCP2P2230792
PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36)PDLIM1 CLIM1 CLP36O0015192
Periostin (PN) (Osteoblast-specific factor 2) (OSF-2)POSTN OSF2Q1506392
Prefoldin subunit 5 (C-Myc-binding protein Mm-1) (Myc modulator 1)PFDN5 MM1 PFD5Q9947192
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)S100A4 CAPL MTS1P2644792
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)SRSF7 SFRS7Q1662992
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)SLK KIAA0204 STK2Q9H2G292
Tetraspanin-9 (Tspan-9) (Tetraspan NET-5)TSPAN9 NET5O7595492
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)TPM1 C15orf13 TMSAP0949392
Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1)TUBG1 TUBGP2325892
Acetyl-CoA carboxylase 1 (ACC1) (EC (ACC-alpha) [Includes: Biotin carboxylase (EC]ACACA ACAC ACC1 ACCAQ1308591
Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K)ACTL6A BAF53 BAF53A INO80KO9601991
AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain)AP3B1 ADTB3AO0020391
BolA-like protein 2BOLA2 BOLA2A My016; BOLA2BQ9H3K691
Collagen alpha-2(VI) chainCOL6A2P1211091
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)DLST DLTSP3695791
DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)DNAJC7 TPR2 TTC2Q9961591
Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1)DYNLRB1 BITH DNCL2A DNLC2A ROBLD1 HSPC162Q9NP9791
Glucosamine 6-phosphate N-acetyltransferase (EC (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase)GNPNAT1 GNA1Q96EK691
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC (3-hydroxy-3-methylglutaryl coenzyme A synthase)HMGCS1 HMGCSQ0158191
Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)IPO4 IMP4B RANBP4Q8TEX991
Low-density lipoprotein receptor (LDL receptor)LDLRP0113091
Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC PIK4 PIK4CAP4235691
Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B')SNRPB COD SNRPB1P1467891
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)SMC3 BAM BMH CSPG6 SMC3L1Q9UQE791
26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))PSMD10O7583290
Adapter molecule crk (Proto-oncogene c-Crk) (p38)CRKP4610890
CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6)CMTM6 CKLFSF6Q9NX7690
Clathrin light chain B (Lcb)CLTBP0949790
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)COPS5 CSN5 JAB1Q9290590
Cytochrome cCYCS CYCP9999990
Epidermal growth factor receptor kinase substrate 8EPS8Q1292990
Glia maturation factor beta (GMF-beta)GMFBP6098390
Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]GPC4 UNQ474/PRO937O7548790
HLA class I histocompatibility antigen, Cw-12 alpha chain (MHC class I antigen Cw*12)HLA-C HLACP3050890
Importin subunit alpha-7 (Karyopherin subunit alpha-6)KPNA6 IPOA7O6068490
Kinectin (CG-1 antigen) (Kinesin receptor)KTN1 CG1 KIAA0004Q86UP290
Lysosomal alpha-mannosidase (Laman) (EC (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide]MAN2B1 LAMAN MANBO0075490
Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha)GMPPAQ96IJ690
Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase)MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995Q9NZL990
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)PABPC4 APP1 PABP4Q1331090
Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133)PROM1 PROML1 MSTP061O4349090
Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2)REEP5 C5orf18 DP1 TB2Q0076590
Secernin-1SCRN1 KIAA0193Q1276590
Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3)TMED4 ERS25Q7Z7H590
Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC; Orotidine 5'-phosphate decarboxylase (ODC) (EC (OMPdecase)]UMPS OK/SW-cl.21P1117290
von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]VWF F8VWFP0427590
3-mercaptopyruvate sulfurtransferase (MST) (EC TST2P2532589
Atlastin-3 (EC 3.6.5.-)ATL3Q6DD8889
Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (Tetherin) (CD antigen CD317)BST2Q1058989
Carboxypeptidase M (CPM) (EC
Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan)CSPG4 MCSPQ6UVK189
COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)GPS1 COPS1 CSN1Q1309889
Dual specificity protein phosphatase 3 (EC (EC (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR)DUSP3 VHRP5145289
Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75)KHSRP FUBP2Q9294589
Formin-like protein 2 (Formin homology 2 domain-containing protein 2)FMNL2 FHOD2 KIAA1902Q96PY589
Heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like) (hnRNP DL) (AU-rich element RNA-binding factor) (JKT41-binding protein) (Protein laAUF1)HNRNPDL HNRPDL JKTBPO1497989
Immunoglobulin heavy constant gamma 4 (Ig gamma-4 chain C region)IGHG4P0186189
Insulin-degrading enzyme (EC (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)IDEP1473589
Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)TPRP1227089
Palmitoyltransferase ZDHHC5 (EC (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)ZDHHC5 KIAA1748 ZNF375Q9C0B589
Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein Zsig9) (Transmembrane protein 4)CNPY2 MSAP TMEM4 ZSIG9 UNQ1943/PRO4426Q9Y2B089
Ras GTPase-activating-like protein IQGAP2IQGAP2Q1357689
Thymidylate kinase (EC (dTMP kinase)DTYMK CDC8 TMPK TYMKP2391989
Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)TNPO3 IPO12Q9Y5L089
Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)TMOD3Q9NYL989
Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP)ISG15 G1P2 UCRPP0516189
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)PSMD4 MCB1P5503688
60S ribosomal protein L37a (Large ribosomal subunit protein eL43)RPL37AP6151388
ADP-ribosylation factor 3ARF3P6120488
ATP synthase subunit g, mitochondrial (ATPase subunit g)ATP5LO7596488
Basic leucine zipper and W2 domain-containing protein 2BZW2 HSPC028 MSTP017Q9Y6E288
Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] [Includes: Lactose synthase A protein (EC; N-acetyllactosamine synthase (EC (Nal synthase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)]B4GALT1 GGTB2P1529188
Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL)SNTB2 D16S2531E SNT2B2 SNTLQ1342588
Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP)COPG2Q9UBF288
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (Defender against cell death 1) (DAD-1)DAD1P6180388
Endoglin (CD antigen CD105)ENG ENDP1781388
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (G1 to S phase transition protein 1 homolog)GSPT1 ERF3AP1517088
Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin)FLG2 IFPSQ5D86288
Histone H1.4 (Histone H1b) (Histone H1s-4)HIST1H1E H1F4P1041288
Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC (D-galactose 1-phosphate phosphatase) (EC (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1)IMPA1 IMPAP2921888
Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP)ITIH3Q0603388
Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)KRT7 SCLP0872988
Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1)LAMTOR3 MAP2K1IP1 MAPKSP1 PRO2783Q9UHA488
Rootletin (Ciliary rootlet coiled-coil protein)CROCC KIAA0445Q5TZA288
rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase)FBL FIB1 FLRNP2208788
Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]APCS PTX2P0274388
TAR DNA-binding protein 43 (TDP-43)TARDBP TDP43Q1314888
Target of Myb protein 1TOM1O6078488
Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M)VCAN CSPG2P1361188
Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]CACNA2D1 CACNL2A CCHL2A MHS3P5428988
Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4]AGT SERPINA8P0101987
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