EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Transmembrane glycoprotein NMB (DC-HIL) (Dendritic cell-associated transmembrane protein) (Osteoactivin)Gpnmb Dchil Hgfin NmbQ99P9111
Transmembrane protein 106BTmem106bQ80X7111
Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]HadhbQ99JY011
tRNA (cytosine(34)-C(5))-methyltransferase (EC (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2)Nsun2 D13Wsu123e MisuQ1HFZ011
Tubulin-specific chaperone D (Beta-tubulin cofactor D) (Tubulin-folding cofactor D)TbcdQ8BYA011
Twinfilin-1 (Protein A6)Twf1 Ptk9Q91YR111
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)Tmem55aQ9CZX711
U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A)Snrpa Rnu1a-1Q6218911
Ubiquitin domain-containing protein 1Ubtd1Q91WB711
Ubiquitin-conjugating enzyme E2 variant 3 (UEV-3) (EV and lactate/malate dehydrogenase domain-containing protein)Uevld Attp Uev3Q3U1V611
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)Uba6 Ube1l2Q8C7R411
UBX domain-containing protein 1 (Protein 2B28) (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein) (mY33K)Ubxn1 D19Ertd721e Saks1Q922Y111
UMP-CMP kinase (EC (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK)Cmpk1 Cmk Cmpk Uck Umk UmpkQ9DBP511
Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle)Myo5a DiluteQ9910411
Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (CD antigen CD87)PlaurP3545611
V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D)Atp6v1d Atp6m VatdP5774611
Vacuolar protein sorting-associated protein 29 (Vesicle protein sorting 29)Vps29Q9QZ8811
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)Vamp5Q9Z2P811
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (Edb)Vamp8O7040411
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) (mSec22b)Sec22b Sec22l1O0854711
Vitamin D-binding protein (DBP) (VDB) (Gc-globulin) (Group-specific component)GcP2161411
Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (Neuroimmune protein F5)Kcnab2 Ckbeta2 I2rf5 Kcnb3P6248211
WASH complex subunit 4 (WASH complex subunit SWIP)Washc4 Kiaa1033Q3UMB911
WASH complex subunit 5 (WASH complex subunit strumpellin)Washc5 Kiaa0196Q8C2E711
[F-actin]-methionine sulfoxide oxidase MICAL1 (EC (Molecule interacting with CasL protein 1) (MICAL-1) (mMical1) (NEDD9-interacting protein with calponin homology and LIM domains)Mical1 Mical NicalQ8VDP311
3'(2'),5'-bisphosphate nucleotidase 1 (EC (Bisphosphate 3'-nucleotidase 1) (PAP-inositol 1,4-phosphatase) (PIP)Bpnt1Q9Z0S110
5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)Nt5c Dnt1Q9JM1410
60S ribosomal protein L36Rpl36P4796410
A-kinase anchor protein 2 (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL) (Protein kinase A-anchoring protein 2) (PRKA2)Akap2O5493110
Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (BRG1-associated factor 53A) (BAF53A)Actl6a Actl6 Baf53aQ9Z2N810
Actin-related protein 10 (Actin-related protein 11)Actr10 Act11 Actr11 Arp11Q9QZB710
Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin-2)Adgrl2 Kiaa0786 Lphn2Q8JZZ710
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V)Mgat5Q8R4G610
Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)Actn3O8899010
Alpha-parvin (Actopaxin)Parva Actp MNCb-0301Q9EPC110
Apoptosis inhibitor 5 (API-5) (AAC-11)Api5O3584110
Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (MEB3) (Solute carrier family 4 member 1) (CD antigen CD233)Slc4a1 Ae1P0491910
Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5)B4galt5 Bgt-5Q9JMK010
Beta-2-glycoprotein 1 (APC inhibitor) (Activated protein C-binding protein) (Apolipoprotein H) (Apo-H) (Beta-2-glycoprotein I) (B2GPI) (Beta(2)GPI)Apoh B2gp1Q0133910
Beta-arrestin-2 (Arrestin beta-2)Arrb2Q91YI410
Cadherin-2 (Neural cadherin) (N-cadherin) (CD antigen CD325)Cdh2P1511610
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC
Calmodulin (Putative uncharacterized protein)Calm1Q3UKW210
Calumenin (Crocalbin)CaluO3588710
Capping protein (Actin filament) muscle Z-line, alpha 1 (F-actin-capping protein subunit alpha-1) (Putative uncharacterized protein)Capza1 mCG_9780Q5RKN910
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (EC (Golli-interacting protein) (GIP) (Nuclear LIM interactor-interacting factor 3) (NLI-interacting factor 3) (Small C-terminal domain phosphatase 1) (SCP1) (Small CTD phosphatase 1)Ctdsp1 Nif3 NliifP5846610
CD5 antigen-like (Apoptosis inhibitor expressed by macrophages) (mAIM) (Apoptosis inhibitory 6) (SP-alpha)Cd5l Aim Api6Q9QWK410
Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1)Ccar1 Carp1Q8CH1810
Charged multivesicular body protein 2b (Chromatin-modifying protein 2b) (CHMP2b)Chmp2bQ8BJF910
Chloride intracellular channel protein 5Clic5Q8BXK910
Clathrin heavy chainCltcQ5SXR610
Clathrin light chain A (Lca)CltaO0858510
Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP)Copz1 CopzP6192410
Collagen alpha-1(XII) chainCol12a1Q6084710
Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform)Cyb5b Cyb5mQ9CQX210
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)Adam17 TaceQ9Z0F810
DNA replication licensing factor MCM5 (EC (CDC46 homolog) (P1-CDC46)Mcm5 Cdc46 Mcmd5P4971810
DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPC40)Polr1c Rpo1-1P5243210
DnaJ homolog subfamily C member 5 (Cysteine string protein) (CSP)Dnajc5P6090410
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (Defender against cell death 1) (DAD-1)Dad1P6180410
Dynactin subunit 4 (Dynactin subunit p62)Dctn4Q8CBY810
Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8) (DLC8b) (Dynein light chain LC8-type 2)Dynll2 Dlc2Q9D0M510
Endoplasmic reticulum resident protein 29 (ERp29)Erp29P5775910
Engulfment and cell motility protein 2 (Protein ced-12 homolog A)Elmo2 Kiaa1834Q8BHL510
Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)Erlin2 Spfh2Q8BFZ910
Eukaryotic translation initiation factor 4B (eIF-4B)Eif4bQ8BGD910
Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein homolog)Eif4h Wbscr1Q9WUK210
Filamin, alpha (Filamin-A)Flna RP23-436K3.1-002B7FAU910
Fragile X mental retardation syndrome-related protein 1 (mFxr1p)Fxr1 Fxr1hQ6158410
Frizzled-7 (Fz-7) (mFz7)Fzd7Q6109010
Gamma-glutamyl hydrolase (EC (Conjugase) (FGPH) (Folylpolyglutamate hydrolase) (GH) (Gamma-Glu-x carboxypeptidase)GghQ9Z0L810
Glia maturation factor beta (GMF-beta)GmfbQ9CQI310
Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)Gclm GlclrO0917210
Glutamyl aminopeptidase (EAP) (EC (Aminopeptidase A) (AP-A) (BP-1/6C3 antigen) (CD antigen CD249)EnpepP1640610
Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC (Cellular glutathione peroxidase) (Selenium-dependent glutathione peroxidase 1)Gpx1P1135210
Glyoxalase domain-containing protein 4Glod4Q9CPV410
Granulins (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Progranulin); Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7]GrnP2879810
GTP-binding protein 1 (G-protein 1) (GP-1) (GP1)Gtpbp1 GtpbpO0858210
GTP-binding protein SAR1bSar1b Sara1b Sara2Q9CQC910
Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 1) (HSP70.1)Hspa1b Hcp70.1 Hsp70-1 Hsp70a1 Hspa1P1787910
Heparan-alpha-glucosaminide N-acetyltransferase (EC (Transmembrane protein 76)Hgsnat D8Ertd354e Tmem76Q3UDW810
Hepatocyte growth factor receptorMetF8VQL010
Heterogeneous nuclear ribonucleoprotein U-like protein 1Hnrnpul1 Hnrpul1Q8VDM610
Hexokinase-2 (EC (Hexokinase type II) (HK II)Hk2O0852810
Hexokinase-3 (EC (Hexokinase type III) (HK III)Hk3Q3TRM810
Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)Hip1 Kiaa4113Q8VD7510
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC (3-hydroxy-3-methylglutaryl coenzyme A synthase)Hmgcs1Q8JZK910
Inositol-3-phosphate synthase 1 (IPS 1) (EC (Myo-inositol 1-phosphate synthase) (MI-1-P synthase) (MIP synthase)Isyna1 Ino1Q9JHU910
Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4)Igfbp4 Igfbp-4P4787910
Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)Krt19 Krt1-19P1900110
Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (mK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18)Krt75 Kb18Q8BGZ710
Kinesin light chain 1 (KLC 1)Klc1 Kns2O8844710
Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein Scythe)Bag6 Bat3Q9Z1R210
Leucine rich repeat containing 57 (Leucine rich repeat containing 57, isoform CRA_a) (Leucine-rich repeat-containing protein 57) (Putative uncharacterized protein)Lrrc57 mCG_11983Q8JZX510
Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (mLRP130)Lrpprc Lrp130Q6PB6610
Lymphocyte antigen 75 (Ly-75) (DEC-205) (CD antigen CD205)Ly75 Cd205Q6076710
Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]Masp1 Crarf Masp3P9806410
Mannose-1-phosphate guanyltransferase beta (EC (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta)GmppbQ8BTZ710
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