EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)Arpc5Q9CPW422
Adenylosuccinate lyase (ASL) (EC (Adenylosuccinase) (ASase)Adsl AdlP5482222
Aspartate aminotransferase, cytoplasmic (cAspAT) (EC (EC (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)Got1P0520122
Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G)Epb41l2 Epb4.1l2O7031822
Barrier-to-autointegration factor (Breakpoint cluster region protein 1) (LAP2-binding protein 1) [Cleaved into: Barrier-to-autointegration factor, N-terminally processed]Banf1 Baf Bcrp1 L2bp1O5496222
Beta-hexosaminidase subunit alpha (EC (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha)HexaP2941622
Calpain-2 catalytic subunit (EC (80 kDa M-calpain subunit) (CALP80) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)Capn2O0852922
Casein kinase II subunit alpha (CK II alpha) (EC CkiiaQ6073722
CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (CD antigen CD151)Cd151 Peta3O3556622
Cyclin-dependent kinase 1 (CDK1) (EC (EC (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)Cdk1 Cdc2 Cdc2a Cdkn1P1144022
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)DlstQ9D2G222
E3 ubiquitin-protein ligase UBR4 (EC (N-recognin-4) (RING-type E3 ubiquitin transferase UBR4) (Zinc finger UBR1-type protein 1) (p600)Ubr4 Kiaa0462 Zubr1A2AN0822
Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)EtfaQ99LC522
Eukaryotic translation initiation factor 3 subunit M (eIF3m) (PCI domain-containing protein 1)Eif3m Pcid1Q99JX422
F-actin-capping protein subunit alpha-1 (CapZ alpha-1)Capza1 Cappa1P4775322
Fatty acid-binding protein, epidermal (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein 5) (Keratinocyte lipid-binding protein) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)Fabp5 Fabpe Klbp Mal1Q0581622
Fermitin family homolog 3 (Kindlin-3) (Unc-112-related protein 2)Fermt3 Kind3 Urp2Q8K1B822
GTPase KRas (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]Kras Kras2P3288322
Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)Hnrnpa3 Hnrpa3Q8BG0522
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)Hnrnpd Auf1 HnrpdQ6066822
Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) (pp68)Syncrip Hnrpq Nsap1 Nsap1lQ7TMK922
Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)Hnrnpc HnrpcQ9Z20422
High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor) (Ecotropic retrovirus receptor) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter)Slc7a1 Atrc1 Rec-1Q0914322
Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) (Adenosine 5'-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)Hint1 Hint Pkci Pkci1 Prkcnh1P7034922
Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Embryonic type II keratin-1) (Keratin-77) (K77) (Type-II keratin Kb39)Krt77 Krt1bQ6IFZ622
Lysine--tRNA ligase (EC (Lysyl-tRNA synthetase) (LysRS)KarsQ99MN122
Myb-binding protein 1A (Myb-binding protein of 160 kDa)Mybbp1a P160Q7TPV422
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)Slc9a3r1 Nherf Nherf1P7044122
Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2)Nrp2O3537522
Neuroplastin (Stromal cell-derived receptor 1) (SDR-1)Nptn Sdfr1 Sdr1P9730022
Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (SATT) (Solute carrier family 1 member 4)Slc1a4 Asct1O3587422
Nuclease-sensitive element-binding protein 1 (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Y-box transcription factor) (Y-box-binding protein 1) (YB-1)Ybx1 Msy-1 Msy1 Nsep1 Yb1P6296022
Nucleosome assembly protein 1-like 1 (Brain protein DN38) (NAP-1-related protein)Nap1l1 NrpP2865622
Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC (Cyclophilin C) (Rotamase C)Ppic CypcP3041222
Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Rotamase D)PpidQ9CR1622
Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)Pafah1b1 Lis-1 Lis1 PafahaP6300522
Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8)Prpf8 Prp8Q99PV022
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (EC (DEAH box protein 15)Dhx15 Ddx15 Deah9O3528622
Procollagen C-endopeptidase enhancer 1 (P14) (Procollagen COOH-terminal proteinase enhancer 1) (PCPE-1) (Procollagen C-proteinase enhancer 1) (Type 1 procollagen C-proteinase enhancer protein) (Type I procollagen COOH-terminal proteinase enhancer)Pcolce Pcpe1Q6139822
Prolyl endopeptidase (PE) (EC (Post-proline cleaving enzyme)Prep PepQ9QUR622
Puromycin-sensitive aminopeptidase (PSA) (EC (Cytosol alanyl aminopeptidase) (AAP-S)Npepps PsaQ1101122
Ras-related protein Rab-21 (Rab-12)Rab21P3528222
Rho-related GTP-binding protein RhoC (Silica-induced gene 61 protein) (SIG-61)Rhoc ArhcQ6215922
S-methyl-5'-thioadenosine phosphorylase (EC (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase)MtapQ9CQ6522
Septin-7 (CDC10 protein homolog)Sept7 Cdc10O5513122
Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (Serine protease 11)Htra1 Htra Prss11Q9R11822
Syntaxin-4Stx4 Stx4aP7045222
Tetraspanin-4 (Tspan-4) (Transmembrane 4 superfamily member 7)Tspan4 Tm4sf7Q9DCK322
Toll-interacting proteinTollipQ9QZ0622
Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)PuraP4266922
Transportin-1 (Importin beta-2) (Karyopherin beta-2)Tnpo1 Kpnb2Q8BFY922
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]GartQ6473722
Tubulin beta-2B chainTubb2bQ9CWF222
Tubulin beta-3 chainTubb3Q9ERD722
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 (EC 2.7.7.-)Uap1l1Q3TW9622
60S ribosomal protein L26 (Silica-induced gene 20 protein) (SIG-20)Rpl26P6125521
Acid ceramidase (AC) (ACDase) (Acid CDase) (EC (Acylsphingosine deacylase) (N-acylsphingosine amidohydrolase) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta]Asah1 AsahQ9WV5421
Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (Single-stranded DNA-binding protein p9) (p14)Sub1 Pc4 Rpo2tc1P1103121
Alcohol dehydrogenase [NADP(+)] (EC (Aldehyde reductase) (Aldo-keto reductase family 1 member A1)Akr1a1 Akr1a4Q9JII621
Alpha-2-macroglobulin-P (Alpha-2-macroglobulin)A2m A2mpQ6GQT121
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)Ap1b1 Adtb1O3564321
Aspartate aminotransferase, mitochondrial (mAspAT) (EC (EC (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)Got2 Got-2P0520221
Aspartyl aminopeptidase (EC
ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)Abce1 RliP6122221
Biliverdin reductase A (BVR A) (EC (Biliverdin-IX alpha-reductase)BlvraQ9CY6421
BRO1 domain-containing protein BROX (BRO1 domain- and CAAX motif-containing protein)BroxQ8K2Q721
CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen 24) (Ly-24) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)Cd44 Ly-24P1537921
Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2)Chmp5 Snf7dc2Q9D7S921
Clusterin (Apolipoprotein J) (Apo-J) (Clustrin) (Sulfated glycoprotein 2) (SGP-2) [Cleaved into: Clusterin beta chain; Clusterin alpha chain]Clu Apoj Msgp-2Q0689021
Collagen alpha-1(VI) chainCol6a1Q0485721
Complement C4-B [Cleaved into: Complement C4 beta chain; Complement C4 alpha chain; C4a anaphylatoxin; Complement C4 gamma chain]C4b C4P0102921
Coronin-1B (Coronin-2)Coro1bQ9WUM321
DNA damage-binding protein 1 (DDB p127 subunit) (Damage-specific DNA-binding protein 1) (UV-damaged DNA-binding factor)Ddb1Q3U1J421
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)Rpn1Q91YQ521
EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1)Emilin1Q99K4121
Glycogen [starch] synthase, muscle (EC Gys Gys3Q9Z1E421
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas)Gnas Gnas1Q6R0H721
Heat shock protein 105 kDa (42 degrees C-HSP) (Heat shock 110 kDa protein) (Heat shock-related 100 kDa protein E7I) (HSP-E7I)Hsph1 Hsp105 Hsp110 Kiaa0201Q6169921
Hemoglobin subunit beta-2 (Beta-2-globin) (Hemoglobin beta-2 chain) (Hemoglobin beta-minor chain)Hbb-b2P0208921
Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A)Hnrnpab Cbf-a Cgbfa HnrpabQ9902021
Heterogeneous nuclear ribonucleoprotein M (hnRNP M)Hnrnpm HnrpmQ9D0E121
Histone H2B type 1-B (h2B-143)Hist1h2bbQ6447521
Histone H3.3H3f3a H3.3a; H3f3b H3.3bP8424421
Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC (IMPDH-II)Impdh2P2454721
Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa)Ilf2 Nf45Q9CXY621
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)Idh3aQ9D6R221
Junction plakoglobin (Desmoplakin III) (Desmoplakin-3)JupQ0225721
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)Krt2 K2e Krt2-17 Krt2aQ3TTY521
Keratin, type II cytoskeletal 2 oral (Keratin-76) (K76) (Type-II keratin Kb9)Krt76Q3UV1721
MARCKS-related protein (Brain protein F52) (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)Marcksl1 Mlp MrpP2866721
Methionine--tRNA ligase, cytoplasmic (EC (Methionyl-tRNA synthetase) (MetRS)MarsQ68FL621
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)Mapk3 Erk1 Prkm3Q6384421
Peroxiredoxin-4 (EC (Antioxidant enzyme AOE372) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372)Prdx4O0880721
Peroxiredoxin-5, mitochondrial (EC (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 2D-0014IV) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)Prdx5 Prdx6P9902921
Plastin-3 (T-plastin)Pls3Q99K5121
Polyubiquitin-B [Cleaved into: Ubiquitin]UbbP0CG4921
Pre-mRNA-processing factor 19 (EC (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)Prpf19 Prp19 SnevQ99KP621
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC (Lysyl hydroxylase 1) (LH1)Plod1 PlodQ9R0E221
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