EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]Dag1 Dag-1Q6216519
E3 ubiquitin-protein ligase Itchy (EC (HECT-type E3 ubiquitin transferase Itchy homolog)ItchQ8C86319
Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (eIF-3 p25)Eif3k Eif3s12Q9DBZ519
Fructose-bisphosphate aldolase C (EC (Aldolase 3) (Brain-type aldolase) (Scrapie-responsive protein 2) (Zebrin II)Aldoc Aldo3 Scrg2P0506319
Fumarate hydratase, mitochondrial (Fumarase) (EC (EF-3)Fh Fh1P9780719
Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2)Glipr2 Gapr1Q9CYL519
Golgin subfamily A member 7Golga7 MNCb-1213Q91W5319
Histone H1.1 (H1 VAR.3) (Histone H1a) (H1a)Hist1h1a H1a H1f1P4327519
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)Rbbp4 Rbap48Q6097219
Importin subunit alpha-1 (Importin alpha P1) (Karyopherin subunit alpha-2) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (RAG cohort protein 1) (SRP1-alpha)Kpna2 Rch1P5229319
IST1 homologIst1 Kiaa0174Q9CX0019
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)Lasp1 Mln50Q6179219
Lupus La protein homolog (La autoantigen homolog) (La ribonucleoprotein)Ssb Ss-bP3206719
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)Mapre1Q6116619
Mitotic checkpoint protein BUB3 (WD repeat type I transmembrane protein A72.5)Bub3Q9WVA319
NADP-dependent malic enzyme (NADP-ME) (EC (Malic enzyme 1)Me1 Mod-1 Mod1P0680119
Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)Fkbp1a Fkbp1P2688319
Polymerase I and transcript release factor (Cav-p60) (Cavin-1)PtrfO5472419
Prohibitin (B-cell receptor-associated protein 32) (BAP 32)PhbP6777819
Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor of estrogen receptor activity)Phb2 Bap Bcap37 ReaO3512919
Protein DJ-1 (DJ-1) (Parkinson disease protein 7 homolog) (Protein deglycase DJ-1) (EC 3.1.2.-) (EC
Ras-related protein Rab-18Rab18P3529319
Ras-related protein Rap-2aRap2aQ80ZJ119
Ras-related protein Rap-2cRap2cQ8BU3119
Receptor-type tyrosine-protein phosphatase C (EC (Leukocyte common antigen) (L-CA) (Lymphocyte antigen 5) (Ly-5) (T200) (CD antigen CD45)Ptprc Ly-5P0680019
Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Renin/prorenin receptor)Atp6ap2 Atp6ip2Q9CYN919
rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (Histone-glutamine methyltransferase) (Nucleolar protein 1)FblP3555019
S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC (Methionine adenosyltransferase 2) (MAT 2)Mat2aQ3THS619
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)Atp2a2O5514319
Septin-9 (SL3-3 integration site 1 protein)Sept9 Kiaa0991 Sint1Q80UG519
Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2)Snrpd2P6231719
Sodium-coupled neutral amino acid transporter 1 (Amino acid transporter A1) (MNat2) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)Slc38a1 Nat2 Snat1Q8K2P719
Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4)Slc12a7 Kcc4Q9WVL319
Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)Txnl1 Trp32 TxnlQ8CDN619
Transcriptional activator protein Pur-beta (Purine-rich element-binding protein B) (Vascular actin single-stranded DNA-binding factor 2 p44 component)PurbO3529519
Tubulin beta-2A chainTubb2a Tubb2Q7TMM919
Tyrosine-protein kinase Yes (EC (Proto-oncogene c-Yes) (p61-Yes)Yes1 YesQ0473619
UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1)Uggt1 Gt Ugcgl1 Uggt Ugt1 UgtrQ6P5E419
Vacuolar protein sorting-associated protein 4A (EC
14-3-3 protein sigma (Stratifin)Sfn Mkrn3O7045618
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC (Tau-protein kinase PRKAA1) (EC
ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4) (mANC1)Slc25a4 Anc1 Ant1P4896218
Beta-enolase (EC (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase)Eno3 Eno-3P2155018
Bone marrow stromal antigen 2 (BST-2) (HM1.24 antigen) (CD antigen CD317)Bst2Q8R2Q818
Catenin beta-1 (Beta-catenin)Ctnnb1 CatnbQ0224818
Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP)Arcn1 CopdQ5XJY518
Collagen alpha-1(I) chain (Alpha-1 type I collagen)Col1a1 Cola1P1108718
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)Cops2 Csn2 Trip15P6120218
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) (Kip1 C-terminus-interacting protein 2)Cops5 Csn5 Jab1 Kic2O3586418
Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO)Coro1a Coro1O8905318
Disks large homolog 1 (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97) (Synapse-associated protein 97) (SAP-97) (SAP97)Dlg1 Dlgh1Q811D018
Fermitin family homolog 2 (Kindlin-2) (Pleckstrin homology domain-containing family C member 1)Fermt2 Plekhc1Q8CIB518
Fibulin-2 (FIBL-2)Fbln2P3788918
Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (IgE-binding protein) (L-34 galactoside-binding lectin) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)Lgals3P1611018
Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)Gja1 Cxn-43P2324218
Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)Glrx3 Picot Txnl2Q9CQM918
Glycylpeptide N-tetradecanoyltransferase 1 (EC (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1)Nmt1O7031018
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)Grb2Q6063118
H-2 class I histocompatibility antigen, L-D alpha chainH2-LP0189718
Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)Trap1 Hsp75Q9CQN118
Histone H1.0 (Histone H1') (Histone H1(0)) (MyD196) [Cleaved into: Histone H1.0, N-terminally processed]H1f0 H1fvP1092218
Histone H2B type 1-KHist1h2bkQ8CGP118
Histone H2B type 1-PHist1h2bpQ8CGP218
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC (HPRT B)Hprt1 HprtP0049318
Interferon-induced transmembrane protein 2 (Dispanin subfamily A member 2c) (DSPA2c) (Fragilis protein 3)Ifitm2Q99J9318
Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)Krt16 Krt1-16Q9Z2K118
Keratin, type I cytoskeletal 17 (Cytokeratin-17) (CK-17) (Keratin-17) (K17)Krt17 Krt1-17Q9QWL718
Keratin, type I cytoskeletal 42 (Cytokeratin-42) (CK-42) (Keratin-17n) (Keratin-42) (K42) (Type I keratin Ka22)Krt42 Ka22Q6IFX218
Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36)Krt73 Kb36Q6NXH918
Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC
Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)Myh10Q6187918
NSFL1 cofactor p47 (p97 cofactor p47)Nsfl1cQ9CZ4418
Peroxiredoxin-6 (EC (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.-) (Antioxidant protein 2) (Non-selenium glutathione peroxidase) (NSGPx) (EC Aop2 Ltw4 Prdx5O0870918
Phospholipid transfer protein (Lipid transfer protein II)PltpP5506518
Pigment epithelium-derived factor (PEDF) (Caspin) (Serpin F1) (Stromal cell-derived factor 3) (SDF-3)Serpinf1 Pedf Sdf3P9729818
Plectin (PCN) (PLTN) (Plectin-1) (Plectin-6)Plec Plec1Q9QXS118
Probable ATP-dependent RNA helicase DDX17 (EC (DEAD box protein 17)Ddx17Q501J618
Protein disulfide-isomerase A4 (EC (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)Pdia4 Cai Erp72P0800318
Protein flightless-1 homologFlii Fli1 FliihQ9JJ2818
Protein S100-A6 (5B10) (Calcyclin) (Prolactin receptor-associated protein) (S100 calcium-binding protein A6)S100a6 CacyP1406918
Protein transport protein Sec31A (SEC31-like protein 1) (SEC31-related protein A)Sec31a Sec31l1Q3UPL018
Ran-specific GTPase-activating protein (HpaII tiny fragments locus 9a protein) (Ran-binding protein 1) (RANBP1)Ranbp1 Htf9-a Htf9aP3402218
Ras GTPase-activating protein 3 (GAP1(IP4BP)) (GapIII) (Ins P4-binding protein)Rasa3Q6079018
Rho-related GTP-binding protein RhoBRhob ArhbP6274618
Serine-threonine kinase receptor-associated protein (UNR-interacting protein)Strap UnripQ9Z1Z218
Serine/arginine-rich splicing factor 2 (Protein PR264) (Putative myelin regulatory factor 1) (MRF-1) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)Srsf2 Pr264 Sfrs10 Sfrs2Q6209318
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Formin-binding protein 27) (FBP-27)Srgap2 Fbp27 Fnbp2Q91Z6718
Sorting nexin-9Snx9Q91VH218
Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)Sf3b1 Sap155Q99NB918
Synaptosomal-associated protein 23 (SNAP-23) (Syndet) (Vesicle-membrane fusion protein SNAP-23)Snap23 SndtO0904418
Syntaxin-binding protein 2 (MUSEC1) (Protein unc-18 homolog 2) (Munc18-2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B)Stxbp2 Unc18bQ6432418
Tissue factor (TF) (Coagulation factor III) (CD antigen CD142)F3 Cf-3 Cf3P2035218
Trifunctional enzyme subunit alpha, mitochondrial (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC; Long chain 3-hydroxyacyl-CoA dehydrogenase (EC]HadhaQ8BMS118
Tropomyosin alpha-4 chain (Tropomyosin-4)Tpm4Q6IRU218
Tubulin--tyrosine ligase-like protein 12Ttll12Q3UDE218
Ubiquitin-60S ribosomal protein L40 (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; 60S ribosomal protein L40 (CEP52)]Uba52 Ubcep2P6298418
Unconventional myosin-Ie (Unconventional myosin 1E)Myo1e Myr3E9Q63418
Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRTase) (EC; Orotidine 5'-phosphate decarboxylase (EC (OMPdecase)]UmpsP1343918
Vacuolar protein sorting-associated protein VTA1 homolog (SKD1-binding protein 1) (SBP1)Vta1Q9CR2618
Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)Vamp3 Syb3P6302418
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