EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]ActbP6071028
G1/S-specific cyclin-D2Ccnd2 Cyl-2P3028024
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]UbcP0CG5021
40S ribosomal protein S10Rps10P6332520
Apoptosis regulator Bcl-2Bcl2 Bcl-2P1041720
Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC (CRK1) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha)Mapk14 Crk1 Csbp1 Csbp2P4781120
Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (Testis-expressed gene 189 protein) (Transcription factor-like protein MRG15)Morf4l1 Mrg15 Tex189P6076220
Phosphoglycerate kinase 1 (EC Pgk-1P0941120
60S ribosomal protein L23Rpl23P6283019
Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)Anapc5 MNCb-2778Q8BTZ419
E3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (Double minute 2 protein) (Oncoprotein Mdm2) (p53-binding protein Mdm2)Mdm2P2380419
Epidermal growth factor receptor (EC
60S ribosomal protein L36a (60S ribosomal protein L44)Rpl36a Rpl44P8388218
Fructose-bisphosphate aldolase A (EC (Aldolase 1) (Muscle-type aldolase)Aldoa Aldo1P0506418
Glucose-6-phosphate isomerase (GPI) (EC (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)Gpi Gpi1P0674518
RING finger protein 11 (NEDD4 WW domain-binding protein 2) (Sid 1669)Rnf11 N4wbp2 Sid1669Q9QYK718
Transcription elongation factor B polypeptide 2 (Elongin 18 kDa subunit) (Elongin-B) (EloB) (RNA polymerase II transcription factor SIII subunit B) (SIII p18)Tceb2P6286918
40S ribosomal protein S24Rps24P6284917
Calmodulin (CaM)Calm1 Calm Cam Cam1; Calm2 Cam2 Camb; Calm3 Cam3 CamcP6220417
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein) (p21)Cdkn1a Cip1 Waf1P3968917
Peroxiredoxin-2 (EC (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1)Prdx2 Tdpx1 TpxQ6117117
60S ribosomal protein L41Rpl41P6294716
D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC (A10)PhgdhQ6175316
Protein CDV3 (Carnitine deficiency-associated protein 3) (Tyrosine-phosphorylated protein 36) (TPP36)Cdv3Q4VAA216
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)Atp2a2O5514316
Signal transducer and activator of transcriptionStat1 mCG_123683Q8C3V416
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)Fas Apt1 Tnfrsf6P2544616
Actin, aortic smooth muscle (Alpha-actin-2)Acta2 Actsa ActvsP6273715
H-2 class I histocompatibility antigen, K-B alpha chain (H-2K(B))H2-K1 H2-KP0190115
Major prion protein (PrP) (PrP27-30) (PrP33-35C) (CD antigen CD230)Prnp Prn-p PrpP0492515
Metallothionein-1 (MT-1) (Metallothionein-I) (MT-I)Mt1P0280215
Ornithine decarboxylase (ODC) (EC OdcP0086015
Protein unc-119 homolog BUnc119bQ8C4B415
S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC (Methionine adenosyltransferase 2) (MAT 2)Mat2aQ3THS615
Sideroflexin-1Sfxn1 FQ99JR115
40S ribosomal protein S9Rps9Q6ZWN514
60S ribosomal protein L27Rpl27P6135814
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 4)Alkbh4Q9D8F114
Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (EC (Activating transcription factor 2) (MXBP protein) (cAMP response element-binding protein CRE-BP1)Atf2P1695114
Cytochrome c, somaticCycsP6289714
DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16)Polr1d Rpo1-3P9730414
Engulfment and cell motility protein 1 (Protein ced-12 homolog)Elmo1Q8BPU714
Ferritin heavy chain (Ferritin H subunit) (EC [Cleaved into: Ferritin heavy chain, N-terminally processed]Fth1 FthP0952814
Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)Glrx3 Picot Txnl2Q9CQM914
Heterogeneous nuclear ribonucleoprotein K (hnRNP K)Hnrnpk HnrpkP6197914
Histone H3.3H3f3a H3.3a; H3f3b H3.3bP8424414
Lipoma HMGIC fusion partnerLhfpQ8BM8614
Low-density lipoprotein receptor (LDL receptor)LdlrP3595114
Macrophage colony-stimulating factor 1 (CSF-1) (MCSF) [Cleaved into: Processed macrophage colony-stimulating factor 1]Csf1 CsfmP0714114
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)Mapk1 Erk2 Mapk Prkm1P6308514
Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form)Naca Gm1878P7067014
Nitric oxide synthase, endothelial (EC (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII)Nos3 EcnosP7031314
Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)Nup50 Npap60Q9JIH214
Peroxiredoxin-1 (EC (Macrophage 23 kDa stress protein) (Osteoblast-specific factor 3) (OSF-3) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2)Prdx1 Msp23 Paga Tdpx2P3570014
Rab GDP dissociation inhibitor beta (Rab GDI beta) (GDI-3) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)Gdi2 Gdi3Q6159814
Signal transducer and activator of transcription 3 (Acute-phase response factor)Stat3 AprfP4222714
Transcription factor SOX-9Sox9 Sox-9Q0488714
40S ribosomal protein S27-likeRps27lQ6ZWY313
40S ribosomal protein S7Rps7P6208213
60S ribosomal protein L13a (Transplantation antigen P198) (Tum-P198 antigen)Rpl13a P198 Tstap198-7P1925313
60S ribosomal protein L14Rpl14Q9CR5713
ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]Slc25a5 Ant2P5188113
Calcium-regulated heat stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24)Carhsp1Q9CR8613
Catenin beta-1 (Beta-catenin)Ctnnb1 CatnbQ0224813
CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen 24) (Ly-24) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)Cd44 Ly-24P1537913
Cold shock domain-containing protein E1Csde1 D3Jfr1Q91W5013
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (EC (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)Rpn1Q91YQ513
Elongation factor 1-beta (EF-1-beta)Eef1b Eef1b2O7025113
Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta)Eif2s2Q99L4513
H-2 class I histocompatibility antigen, Q7 alpha chain (QA-2 antigen)H2-Q7P1442913
Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)Ipo8Q7TMY713
Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29)Itgb1P0905513
Leptin (Obesity factor)Lep ObP4116013
N-lysine methyltransferase SETD8 (EC 2.1.1.-) (H4-K20-HMTase SETD8) (Histone-lysine N-methyltransferase SETD8) (EC (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)Setd8Q2YDW713
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) (SP18) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]PpiaP1774213
Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA-binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1)Serbp1 Pairbp1Q9CY5813
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)PdgfraP2661813
Ras-related protein Rab-5ARab5a nnyRab5aQ9CQD113
Retinoblastoma-associated protein (pRb) (Rb) (pp105)Rb1 Rb-1P1340513
Serine/arginine-rich splicing factor 2 (Protein PR264) (Putative myelin regulatory factor 1) (MRF-1) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)Srsf2 Pr264 Sfrs10 Sfrs2Q6209313
T-complex protein 1 subunit delta (TCP-1-delta) (A45) (CCT-delta)Cct4 CctdP8031513
Thymosin beta-10Tmsb10 Ptmb10Q6ZWY813
Ubiquitin-conjugating enzyme E2 D2 (EC (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2)Ube2d2 Ubc4 Ubch4 Ubch5b Ube2d2aP6283813
Ubiquitin-conjugating enzyme E2 D3 (EC (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)Ube2d3P6107913
14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]YwhabQ9CQV812
3-ketoacyl-CoA thiolase, mitochondrial (EC (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase)Acaa2Q8BWT112
40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3)Rps2 Llrep3 Rps4P2544412
ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) (Binder of ARF2 protein 1)Arl2bp Bart Bart1Q9D38512
Beta-glucuronidase (EC Gus Gus-sP1226512
Bombesin receptor-activated protein C6orf89 homolog0Q99KU612
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)Cpt1a Cpt-1 Cpt1P9774212
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Interferon-gamma-inducible protein Mg11) (SAM domain and HD domain-containing protein 1)Samhd1 Mg11Q6071012
Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331)Fgfr1 FlgP1609212
High mobility group protein B1 (High mobility group protein 1) (HMG-1)Hmgb1 Hmg-1 Hmg1P6315812
Methyltransferase-like protein 9 (DORA reverse strand protein) (DREV)Mettl9 drev MNCb-5680Q9EPL412
Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20)Tomm20Q9DCC812
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