EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Histone deacetylase complex subunit SAP30L (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like)Sap30lQ5SQF86
Histone H1.2 (H1 VAR.1) (H1c)Hist1h1c H1f2P158646
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)Rbbp7 Rbap46Q609736
Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)Hmmr Ihabp RhammQ005476
Hydroxyacylglutathione hydrolase, mitochondrial (EC (Glyoxalase II) (Glx II)Hagh Glo2Q99KB86
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC (3-hydroxy-3-methylglutaryl coenzyme A synthase)Hmgcs1Q8JZK96
Immunity-related GTPase family M protein 1 (EC 3.6.5.-) (Interferon-inducible GTPase 3) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47) (LRG-47)Irgm1 Ifi1 Iigp3 IrgmQ607666
Immunoglobulin-binding protein 1 (Alpha4 phosphoprotein) (CD79a-binding protein 1) (Lymphocyte signal transduction molecule alpha 4) (Protein phosphatase 2/4/6 regulatory subunit) (p52)Igbp1 Pc52Q612496
Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5)Igfbp5 Igfbp-5Q070796
Integrin beta-6Itgb6Q9Z0T96
Interferon lambda receptor 1 (IFN-lambda R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA)Ifnlr1 Il28raQ8CGK56
Interleukin-11 receptor subunit alpha-1 (IL-11 receptor subunit alpha-1) (IL-11R subunit alpha-1) (IL-11R-alpha-1) (IL-11RA1) (Enhancer trap locus homolog 2) (Etl-2) (Novel cytokine receptor 1) (NR-1) (NR1)Il11ra1 Etl2 Il11raQ643856
Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1)Ift81 Cdv-1 Cdv1O355946
Kelch-like protein 6Klhl6Q6V5956
Kinesin-like protein KIF22Kif22Q3V3006
Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog)Krit1 Ccm1Q6S5J66
Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor)Klf4 Ezf Gklf ZieQ607936
La-related protein 1Larp1J3QNB16
Lactoylglutathione lyase (EC (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase)Glo1Q9CPU06
Lanosterol synthase (EC (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC)LssQ8BLN56
Long-chain-fatty-acid--CoA ligase 5 (EC (Long-chain acyl-CoA synthetase 5) (LACS 5)Acsl5 Facl5Q8JZR06
Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein)Luc7l3 CropQ5SUF26
Lupus La protein homolog (La autoantigen homolog) (La ribonucleoprotein)Ssb Ss-bP320676
Macoilin (Brain-specific adapter protein C61) (Transmembrane protein 57)Tmem57Q7TQE66
MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC Rps6kc1P491386
MCG11298 (MCG123328, isoform CRA_b) (MCG125709) (Mitochondrial import inner membrane translocase subunit Tim23) (Translocase of inner mitochondrial membrane 23 homolog (Yeast))Timm23 mCG_11298 mCG_123328 mCG_125709Q9CXU46
Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2Q925J96
Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11)Med11Q9D8C66
Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)Metap2 Mnpep P67eif2O086636
Methyltransferase-like protein 13 (EC 2.1.1.-)Mettl13 Kiaa0859Q91YR56
Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta)Map1lc3b Map1alc3 Map1lc3Q9CQV66
Mitochondrial carrier homolog 2Mtch2Q791V56
Mitochondrial import inner membrane translocase subunit TIM14 (DnaJ homolog subfamily C member 19)Dnajc19 Tim14 Timm14Q9CQV76
Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit)Tomm70a D16Wsu109eQ9CZW56
Mitochondrial inner membrane protein COX18Cox18 Oxa1l2Q8VC746
Mitofusin-1 (EC 3.6.5.-) (Transmembrane GTPase MFN1)Mfn1Q811U46
Multidrug and toxin extrusion protein 1 (MATE-1) (mMATE-1) (Solute carrier family 47 member 1)Slc47a1 Mate1Q8K0H16
Myeloid-associated differentiation marker (Myeloid up-regulated protein)Myadm MugO356826
Myotubularin (EC
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit) (Neuronal protein 15.6) (Np15.6) (p15.6)Ndufb11 Np15O091116
NADH dehydrogenase [ubiquinone] 1 subunit C2 (Complex I-B14.5b) (CI-B14.5b) (NADH-ubiquinone oxidoreductase subunit B14.5b)Ndufc2Q9CQ546
Neurochondrin (M-Sema F-associating protein of 75 kDa) (Norbin)Ncdn Kiaa0607 Sfap75Q9Z0E06
Neurogenic locus notch homolog protein 2 (Notch 2) (Motch B) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain]Notch2O355166
Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox)Ncf2 Noxa2 P67phoxO701456
NGFI-A-binding protein 1 (EGR-1-binding protein 1)Nab1Q611226
Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin)Nampt Pbef1Q99KQ46
Non-POU domain-containing octamer-binding protein (NonO protein)NonoQ99K486
Nuclear factor erythroid 2-related factor 1 (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1)Nfe2l1 Nrf1Q619856
Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62)Nup62Q638506
Nuclease-sensitive element-binding protein 1 (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Y-box transcription factor) (Y-box-binding protein 1) (YB-1)Ybx1 Msy-1 Msy1 Nsep1 Yb1P629606
Nucleolar protein 56 (Nucleolar protein 5A)Nop56 Nol5aQ9D6Z16
Nucleoporin SEH1 (Nup107-160 subcomplex subunit SEH1)Seh1lQ8R2U06
Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor)OgfrQ99PG26
PCNA-associated factor (HCV NS5A-transactivated protein 9 homolog) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF)Paf Ns5atp9Q9CQX46
Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC (Rotamase H)PpihQ9D8686
PHD finger protein 13Phf13Q8K2W66
Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]Pebp1 Pbp PebpP702966
Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC (Serine-exchange enzyme II)Ptdss2 Pss2Q9Z1X26
Potassium voltage-gated channel subfamily C member 3Kcnc3D3YZV26
POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1)Pou2f1 Oct-1 Otf-1 Otf1P254256
PQ-loop repeat-containing protein 1Pqlc1Q80XM96
pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein WDC146)Wdr33 Wdc146Q8K4P06
Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2 homolog) (DNA amplified in mammary carcinoma 1 protein)Bcas2 Dam1Q9D2876
Probable dimethyladenosine transferase (EC (DIM1 dimethyladenosine transferase 1 homolog) (DIM1 dimethyladenosine transferase 1-like) (Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (Probable 18S rRNA dimethylase) (Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase)Dimt1 Dimt1lQ9D0D46
Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc)Mycbp2 Pam Phr1Q7TPH66
Probable helicase with zinc finger domain (EC 3.6.4.-)Helz Kiaa0054Q6DFV56
Probable tRNA pseudouridine synthase 2 (EC 5.4.99.-)Trub2Q91WG36
Probable UDP-sugar transporter protein SLC35A5 (Solute carrier family 35 member A5)Slc35a5Q921R76
Proline-rich nuclear receptor coactivator 2Pnrc2Q9CR736
Proline-rich protein 13Prr13Q9CQJ56
Proteasome subunit alpha type-5 (EC (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)Psma5Q9Z2U16
Proteasome subunit alpha type-7 (EC (Proteasome subunit RC6-1)Psma7Q9Z2U06
Protein 1500012F01Rik1500012F01RikQ3V4946
Protein AF-9 (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog)Mllt3 Af9A2AM296
Protein AhnakAhnakE9Q6166
Protein EURL homologEurl D16Ertd472eQ9D7G46
Protein FAM115AFam115a Kiaa0738Q8BNE16
Protein FAM204AFam204a D19Ertd737eQ8C6C76
Protein Mis18-alphaMis18aQ9CZJ66
Protein phosphatase inhibitor 2 (IPP-2)Ppp1r2Q9DCL86
Protein SLX4IP (SLX4-interacting protein)Slx4ipQ9D7Y96
Protein Srsf6 (Splicing factor, arginine/serine-rich 6)Srsf6 Sfrs6 mCG_1675Q3TWW86
Protein Zfp946 (Uncharacterized protein)Zfp946 1300003B13RikQ8K3B46
Putative ataxin-7-like protein 3BAtxn7l3bQ3UD016
Putative monooxygenase p33MONOX (EC 1.-.-.-)P33monox Kiaa1191Q9DBN46
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (EC (DEAH box protein 15)Dhx15 Ddx15 Deah9O352866
Putative uncharacterized proteinNrasQ3TMF46
Ragulator complex protein LAMTOR5 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)Lamtor5 Hbxip XipQ9D1L96
Ran GTPase-activating protein 1 (RanGAP1)Rangap1 Fug1P460616
Rapamycin-insensitive companion of mTOR (AVO3 homolog) (mAVO3) (Protein pianissimo)Rictor Kiaa1999Q6QI066
Ras and Rab interactor 2 (Ras interaction/interference protein 2)Rin2Q9D6846
Ras-related protein Rab-3DRab3dP352766
Ras-related protein Rab-8BRab8bP610286
Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Renin/prorenin receptor)Atp6ap2 Atp6ip2Q9CYN96
Rho GTPase-activating protein 1 (Rho-type GTPase-activating protein 1)Arhgap1Q5FWK36
Ribosome biogenesis regulatory protein homologRrs1 Rrr MNCb-2643Q9CYH66
RNA polymerase II-associated factor 1 homologPaf1Q8K2T86
RNA-binding protein Musashi homolog 2 (Musashi-2)Msi2 Msi2hQ920Q66
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