EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
RNA-binding protein NOB1Nob1Q8BW106
rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (Nucleolar protein 1)FblP355506
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC (Calcium pump 3)Atp2a3Q645186
Serine-rich coiled-coil domain-containing protein 2 (Coiled-coil serine-rich protein 2) (Granule cell antiserum positive protein 14) (Protein GCAP14)Ccser2 Fam190b Gcap14 Kiaa1128Q3UHI06
Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101)Srrm1 Pop101Q52KI86
Serine/threonine-protein kinase A-Raf (EC (Proto-oncogene A-Raf)Araf A-raf Araf1P046276
Serine/threonine-protein kinase Nek9 (EC (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9)Nek9 NerccQ8K1R76
Serine/threonine-protein kinase SMG1 (SMG-1) (EC Kiaa0421Q8BKX66
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)Ppp2r5aQ6PD036
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-alpha-3) (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma)Ppp2r5cQ609966
SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes)Sh3kbp1 Ruk SetaQ8R5506
Short transient receptor potential channel 2 (TrpC2) (Transient receptor protein 2) (TRP-2) (mTrp2)Trpc2 Trp2 Trrp2Q9R2446
SID1 transmembrane family member 2Sidt2Q8CIF66
SLAM family member 5 (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)Cd84 Slamf5Q18PI66
Spermatid perinuclear RNA-binding proteinStrbp SpnrQ91WM16
Spermidine synthase (SPDSY) (EC (Putrescine aminopropyltransferase)SrmQ646746
SS18-like protein 2Ss18l2 Deb1Q9D1746
Stathmin (Leukemia-associated gene protein) (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)Stmn1 Lag Lap18 Pr22P542276
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (Peptide-binding protein 74) (PBP74) (p66 MOT)Hspa9 Grp75 Hsp74 Hspa9aP386476
Sulfiredoxin-1 (EC (Neoplastic progression protein 3)Srxn1 Npn3 SrxQ9D9756
SUMO-activating enzyme subunit 2 (EC 6.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)Uba2 Sae2 Uble1bQ9Z1F96
Superoxide dismutase [Cu-Zn] (EC
Synaptophysin-like protein 1 (Pantophysin)Sypl1 Pphn SyplO091176
Synaptosomal-associated protein 23 (SNAP-23) (Syndet) (Vesicle-membrane fusion protein SNAP-23)Snap23 SndtO090446
Tax1-binding protein 1 homologTax1bp1Q3UKC16
Tetraspanin-31 (Tspan-31) (Sarcoma-amplified sequence homolog)Tspan31 SasQ9CQ886
Thioredoxin domain-containing protein 9 (ATP-binding protein associated with cell differentiation)Txndc9 ApacdQ9CQ796
Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)Txnl1 Trp32 TxnlQ8CDN66
Thyrotroph embryonic factorTefQ9JLC66
TraB domain-containing proteinTrabdQ99JY46
Transcription factor SOX-5Sox5 Sox-5P357106
Transcriptional repressor protein YY1 (Delta transcription factor) (NF-E1) (UCR-motif DNA-binding protein) (Yin and yang 1) (YY-1)Yy1 UcrbpQ008996
Translation machinery-associated protein 7 (Coiled-coil domain-containing protein 72)Tma7 Ccdc72Q8K0036
Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (Transmembrane protein Tmp21) (p24 family protein delta-1) (p24delta1)Tmed10 Tmp21Q9D1D46
Transmembrane protein 161ATmem161aQ8VCA66
Transmembrane protein C5orf28 homologGm7120Q8VDR56
Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]HadhbQ99JY06
U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A)Snrpa Rnu1a-1Q621896
U2 small nuclear ribonucleoprotein A' (U2 snRNP A')Snrpa1P577846
Ubiquitin carboxyl-terminal hydrolase 14 (EC (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)Usp14Q9JMA16
Ubiquitin-conjugating enzyme E2 K (EC (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)Ube2k Hip2P610876
Ubiquitin-conjugating enzyme E2 N (EC (Bendless-like ubiquitin-conjugating enzyme) (Ubc13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)Ube2n BluP610896
Ubiquitin-related modifier 1Urm1Q9D2P46
Uncharacterized protein C10orf88 homolog0Q9D2Q36
Uncharacterized protein KIAA1551Kiaa1551Q5DTW76
Uncharacterized protein KIAA1958 homolog0Q8C4P06
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)Myo1cQ9WTI76
Uridine-cytidine kinase 2 (UCK 2) (EC (Cytidine monophosphokinase 2) (Uridine monophosphokinase 2)Uck2 UmpkQ99PM96
V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (P39) (Physophilin) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (Vacuolar proton pump subunit d 1)Atp6v0d1 Atp6dP518636
Vesicular integral-membrane protein VIP36 (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36)Lman2Q9DBH56
Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161) (Zfp-161) (Zinc finger protein 5) (ZF5)Zbtb14 Zfp-5 Zfp161 Zfp5Q083766
Zinc finger CCCH domain-containing protein 11AZc3h11a Kiaa0663Q6NZF16
Zinc finger protein 292 (Zinc finger protein 15) (Zfp-15)Zfp292 Zfp15Q9Z2U26
Zinc finger protein 36, C3H1 type-like 1 (Butyrate response factor 1) (Protein TIS11B)Zfp36l1 Brf1 Tis11bP239506
Zinc finger protein 825Zfp825 BC012278Q91VL66
Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2)Snai2 Slug SlughP974696
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (EC (1-acylglycerol-3-phosphate O-acyltransferase 2) (1-AGP acyltransferase 2) (1-AGPAT 2) (Lysophosphatidic acid acyltransferase beta) (LPAAT-beta)Agpat2Q8K3K75
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC (Ubiquinone biosynthesis methyltransferase COQ5)Coq5 D5Ertd33eQ9CXI05
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Multiubiquitin chain-binding protein)Psmd4 Mcb1O352265
28S ribosomal protein S6, mitochondrial (MRP-S6) (S6mt)Mrps6 Rpms6P580645
28S ribosomal protein S7, mitochondrial (MRP-S7) (S7mt)Mrps7Q80X855
28S ribosomal protein S9, mitochondrial (MRP-S9) (S9mt)Mrps9Q9D7N35
3-phosphoinositide-dependent protein kinase 1 (mPDK1) (EC Pdk1Q9Z2A05
39S ribosomal protein L10, mitochondrial (L10mt) (MRP-L10)Mrpl10Q3TBW25
39S ribosomal protein L12, mitochondrial (L12mt) (MRP-L12)Mrpl12 Rpml12Q9DB155
39S ribosomal protein L3, mitochondrial (L3mt) (MRP-L3)Mrpl3Q99N955
39S ribosomal protein L33, mitochondrial (L33mt) (MRP-L33)Mrpl33Q9CQP05
39S ribosomal protein L47, mitochondrial (L47mt) (MRP-L47)Mrpl47Q8K2Y75
39S ribosomal protein L49, mitochondrial (L49mt) (MRP-L49)Mrpl49Q9CQ405
39S ribosomal protein L51, mitochondrial (L51mt) (MRP-L51) (bMRP-64) (bMRP64)Mrpl51 Mrp64Q9CPY15
4-hydroxybenzoate polyprenyltransferase, mitochondrial (EC (Para-hydroxybenzoate--polyprenyltransferase) (PHB:polyprenyltransferase)Coq2Q66JT75
40S ribosomal protein S11Rps11P622815
40S ribosomal protein S12Rps12 mCG_132913 mCG_6749Q6ZWZ65
40S ribosomal protein S14Rps14P622645
40S ribosomal protein S15aRps15aP622455
40S ribosomal protein S27Rps27Q6ZWU95
40S ribosomal protein S3a (Protein TU-11)Rps3a Rps3a1P973515
40S ribosomal protein S6 (Phosphoprotein NP33)Rps6P627545
5-phosphohydroxy-L-lysine phospho-lyase (EC (Alanine--glyoxylate aminotransferase 2-like 2)Phykpl Agxt2l2Q8R1K45
60S ribosomal protein L13 (A52)Rpl13P479635
60S ribosomal protein L24Rpl24Q8BP675
60S ribosomal protein L3 (J1 protein)Rpl3P276595
60S ribosomal protein L4Rpl4Q9D8E65
60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107)Rpl6P479115
Abhydrolase domain-containing protein 16A (EC 3.-.-.-) (HLA-B-associated transcript 5)Abhd16a Bat5 Ng26Q9Z1Q25
Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1)Ablim1 Ablim Kiaa0059Q8K4G55
Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (BRG1-associated factor 53A) (BAF53A)Actl6a Actl6 Baf53aQ9Z2N85
Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)Arpc5Q9CPW45
Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100)Ascc2 Asc1p100Q91WR35
Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase 2) (Lysophospholipase II) (LPL-II) (LysoPLA II) (mLyso II)Lypla2Q9WTL75
Adapter molecule crk (Proto-oncogene c-Crk) (p38)Crk CrkoQ640105
Adenosylhomocysteinase (AdoHcyase) (EC (CUBP) (Liver copper-binding protein) (S-adenosyl-L-homocysteine hydrolase)AhcyP502475
ADP-ribosylation factor 3Arf3P612055
ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)Arfgap1 Arf1gapQ9EPJ95
ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL-6-interacting protein 6) (Aip-6)Arl6ip6Q8BH075
Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (Alkaline phytoceramidase) (aPHC)Acer3 Aphc PhcaQ9D0995
Alpha-actinin-4 (F-actin cross-linking protein) (Non-muscle alpha-actinin 4)Actn4P577805
AMMECR1-like proteinAmmecr1lQ8JZZ65
Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (mVG5Q)Aggf1 Vg5qQ7TN315
Ankyrin repeat and SOCS box protein 8 (ASB-8)Asb8Q91ZT95
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