EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
UPF0586 protein C9orf41 homolog0Q80UY18
V-type proton ATPase 21 kDa proteolipid subunit (V-ATPase 21 kDa proteolipid subunit) (23 kDa subunit of V-ATPase) (Vacuolar proton pump 21 kDa proteolipid subunit)Atp6v0b Atp6fQ91V378
Vasculin (GC-rich promoter-binding protein 1) (mGPBP)Gpbp1 GpbpQ6NXH38
Voltage-dependent anion-selective channel protein 1 (VDAC-1) (mVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Voltage-dependent anion-selective channel protein 5) (VDAC-5) (mVDAC5)Vdac1 Vdac5Q609328
Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Epo-immediate response gene protein FM22)Zc3h15 Dfrp1Q3TIV58
Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27)Trim27 RfpQ621588
14-3-3 protein epsilon (14-3-3E)YwhaeP622597
26S protease regulatory subunit 7Psmc2Q8BVQ97
26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)Psmd11Q8BG327
39S ribosomal protein L48, mitochondrial (L48mt) (MRP-L48)Mrpl48Q8JZS97
40S ribosomal protein S19Rps19Q9CZX87
40S ribosomal protein S21Rps21Q9CQR27
40S ribosomal protein S25Rps25P628527
40S ribosomal protein S4, X isoformRps4x Rps4P627027
6-phosphogluconate dehydrogenase, decarboxylating (EC
6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC
60 kDa heat shock protein, mitochondrial (60 kDa chaperonin) (Chaperonin 60) (CPN60) (HSP-65) (Heat shock protein 60) (HSP-60) (Hsp60) (Mitochondrial matrix protein P1)Hspd1 Hsp60P630387
60S acidic ribosomal protein P1Rplp1P479557
60S ribosomal protein L18Rpl18P359807
60S ribosomal protein L27a (L29)Rpl27aP141157
60S ribosomal protein L31Rpl31P629007
60S ribosomal protein L7a (Surfeit locus protein 3)Rpl7a Surf-3 Surf3P129707
A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10)Akap10O888457
Adenosine kinase (AK) (EC (Adenosine 5'-phosphotransferase)AdkP552647
ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4)Arl6ip4Q9JM937
Adrenergic receptor kinase, beta 1 (Beta-adrenergic receptor kinase 1)Adrbk1Q7TS647
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)Actr1a Ctrn1P611647
Arfaptin-2 (ADP-ribosylation factor-interacting protein 2)Arfip2Q8K2217
Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC (Arginine-tRNA--protein transferase 1)Ate1Q9Z2A57
Armadillo repeat-containing protein 8Armc8Q9DBR37
ATP synthase subunit delta, mitochondrial (F-ATPase delta subunit)Atp5dQ9D3D97
ATP synthase subunit f, mitochondrialAtp5j2P561357
ATP-binding cassette sub-family B member 8, mitochondrialAbcb8Q9CXJ47
ATP-citrate synthase (EC (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme)AclyQ91V927
Baculoviral IAP repeat-containing protein 6 (EC 6.3.2.-) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)Birc6 Kiaa1289O887387
Basic leucine zipper and W2 domain-containing protein 1Bzw1Q9CQC67
Bromodomain-containing protein 8Brd8Q8R3B77
Cardiolipin synthase (CLS) (EC 2.7.8.-)Crls1Q80ZM87
Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)Clcf1 Bsf3 Nnt1Q9QZM37
Casein kinase II subunit alpha (CK II alpha) (EC CkiiaQ607377
CCAAT/enhancer-binding protein gamma (C/EBP gamma) (Granulocyte colony-stimulating factor promoter element 1-binding protein) (GPE1-BP) (GPE1-binding protein) (Immunoglobulin enhancer-binding protein 1) (IG/EBP-1)CebpgP535687
CCR4-NOT transcription complex subunit 11Cnot11 D1Bwg0212eQ9CWN77
CD166 antigen (Activated leukocyte cell adhesion molecule) (Protein DM-GRASP) (CD antigen CD166)AlcamQ614907
Collagen alpha-1(XVI) chainCol16a1Q8BLX77
Copper transport protein ATOX1 (Metal transport protein ATX1)Atox1O089977
Coronin-1A (Coronin-like protein A) (Clipin-A) (Coronin-like protein p57) (Tryptophan aspartate-containing coat protein) (TACO)Coro1a Coro1O890537
CTP synthase 2 (EC (CTP synthetase 2) (CTPsH) (UTP--ammonia ligase 2)Ctps2P703037
Cyclin-dependent kinase 12 (EC (EC (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12)Cdk12 Crk7 Crkrs Kiaa0904Q14AX67
Cyclin-dependent kinases regulatory subunit 2 (CKS-2)Cks2P563907
Cyclin-G1 (Cyclin-G)Ccng1 CcngP519457
Cyclin-Y (Cyclin fold protein 1)Ccny Cfp1Q8BGU57
Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (mM-rdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta)Pitpnc1Q8K4R47
Cytoplasmic tRNA 2-thiolation protein 2Ctu2 Ncs2Q3U3087
Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (mDkk-3)Dkk3Q9QUN97
DNA polymerase beta (EC (EC 4.2.99.-)PolbQ8K4097
DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Endoplasmic reticulum DnaJ-PDI fusion protein 1) (J domain-containing protein disulfide isomerase-like protein) (J domain-containing PDI-like protein) (JPDI)Dnajc10 Erdj5 JpdiQ9DC237
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok))Dok1 DokP974657
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 6.3.2.-) (Triad1 protein) (UbcM4-interacting protein 48)Arih2 Ari2 Triad1 Uip48Q9Z1K67
Egl nine homolog 1 (EC (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)Egln1Q91YE37
Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)EtfaQ99LC57
Electron transfer flavoprotein subunit beta (Beta-ETF)EtfbQ9DCW47
Ephrin type-A receptor 7 (EC (Developmental kinase 1) (mDK-1) (EPH homology kinase 3) (EHK-3) (Embryonic brain kinase) (EBK)Epha7 Ebk Ehk3 Mdk1Q617727
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)Egfl7 Megf7Q9QXT57
Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II)Eif4ebp2P704457
Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein homolog)Eif4h Wbscr1Q9WUK27
Eukaryotic translation initiation factor 5 (eIF-5)Eif5P593257
Eyes absent homolog 3 (EC
F-box only protein 42Fbxo42Q6PDJ67
Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog)Fzr1 Fyr FzrQ9R1K57
Forkhead box protein K2 (Cellular transcription factor ILF-1) (Interleukin enhancer-binding factor 1)Foxk2 Ilf1Q3UCQ17
General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6)Gtf3c6Q9D8P77
Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I-branching beta-1,6-acetylglucosaminyltransferase family polypeptide 1) (N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase)Gcnt2 Ignt1Q6T5E47
Glycerol-3-phosphate acyltransferase 4 (GPAT4) (EC (1-acylglycerol-3-phosphate O-acyltransferase 6) (1-AGP acyltransferase 6) (1-AGPAT 6) (Acyl-CoA:glycerol-3-phosphate acyltransferase 4) (Lysophosphatidic acid acyltransferase zeta) (LPAAT-zeta)Agpat6 Gpat4Q8K2C87
Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin)Gosr2 Gs27O351667
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)Grb2Q606317
Hairy/enhancer-of-split related with YRPW motif protein 2 (HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (mHRT2) (Protein gridlock homolog)Hey2 Chf1 Herp Herp1 Hesr2 Hrt2Q9QUS47
Heterogeneous nuclear ribonucleoprotein M (hnRNP M)Hnrnpm HnrpmQ9D0E17
Histone H2A type 1Hist1h2ab; Hist1h2ac; Hist1h2ad; Hist1h2ae; Hist1h2ag; Hist1h2ai; Hist1h2an; Hist1h2aoP227527
Homeodomain-interacting protein kinase 2 (EC (Nuclear body-associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase)Hipk2 Nbak1 StankQ9QZR57
Ifngr2 protein (Interferon gamma receptor 2) (Protein Ifngr2)Ifngr2 ifngr2 mCG_11456Q639537
INO80 complex subunit CIno80cQ8BHA07
Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]Itm2bO890517
Integrin-linked protein kinase (EC
Interferon-inducible GTPase 1 (EC 3.6.5.-)Iigp1 Irga6Q9QZ857
KATNB1-like protein 1 (Katanin p80 subunit B-like 1)Katnbl1Q9CWJ37
Leptin receptor gene-related protein (Endospanin-1) (OB-R gene-related protein) (OB-RGRP)Leprot Lepr ObrO890137
Leptin receptor overlapping transcript-like 1 (Endospanin-2)Leprotl1Q9CQ747
Leucine-rich repeat-containing protein FAM211AFam211aQ7TSF47
Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein)Laptm5Q611687
Macrophage migration inhibitory factor (MIF) (EC (Delayed early response protein 6) (DER6) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC (Phenylpyruvate tautomerase)MifP348847
Male-specific lethal 1 homolog (MSL-1) (Hampin) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1)Msl1 Msl1l1Q6PDM17
MCG140255 (Protein Psg23)Psg23 mCG_140255Q9D2U07
MCG20149, isoform CRA_a (Methyltransferase like 7A1) (Protein Mettl7a1)Mettl7a1 Mettl7a mCG_20149Q8C6B07
Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta)Mat2bQ99LB67
Multiple coagulation factor deficiency protein 2 homolog (Neural stem cell-derived neuronal survival protein)Mcfd2 SdnsfQ8K5B27
Myristoylated alanine-rich C-kinase substrate (MARCKS)Marcks MacsP266457
N-alpha-acetyltransferase 50 (EC 2.3.1.-) (N-acetyltransferase NAT13) (NatE catalytic subunit)Naa50 Mak3 Nat13Q6PGB67
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (Complex I-B17.2) (CI-B17.2) (CIB17.2) (NADH-ubiquinone oxidoreductase subunit B17.2)Ndufa12Q7TMF37
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit)Ndufa2Q9CQ757
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