EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Epidermal growth factor receptor substrate 15-like 1 (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs) (Eps15-related protein) (Eps15R)Eps15l1 Eps15-rs Eps15RQ609025
EPM2A-interacting protein 1 (Laforin-interacting protein)Epm2aip1 Kiaa0766Q8VEH55
ER lumen protein retaining receptor 2 (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2)Kdelr2Q9CQM25
ES1 protein homolog, mitochondrialD10Jhu81eQ9D1725
ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)Elf3 Ert Esx JenQ3UPW25
Eukaryotic translation initiation factor 1A (eIF-1A) (Eukaryotic translation initiation factor 4C) (eIF-4C)Eif1aQ608725
Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)Eif3f Eif3s5Q9DCH45
Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2)Eif5b If2Q05D445
F-box only protein 2Fbxo2 Fbs1 Fbx2Q80UW25
F-box only protein 6 (F-box only protein 6b) (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2)Fbxo6 Fbs2 Fbxo6bQ9QZN45
F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14)Fbxl14 Fbl14 PpaQ8BID85
Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2)FRRS1 Sdfr2 Sdr2Q8K3855
Ferrochelatase (EC
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (FRS2-alpha) (Suc1-associated neurotrophic factor target 1) (SNT-1)Frs2 Frs2aQ8C1805
Flavin reductase (NADPH) (FR) (EC (Biliverdin reductase B) (BVR-B) (EC (Biliverdin-IX beta-reductase) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR)BlvrbQ923D25
Focal adhesion kinase 1 (FADK 1) (EC (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)Ptk2 Fadk Fak Fak1 Kiaa4203P341525
Forkhead box protein P3 (Scurfin)Foxp3Q99JB65
Frizzled-10 (Fz-10) (CD antigen CD350)Fzd10 Fz10Q8BKG45
G patch domain-containing protein 4Gpatch4 Gpatc4Q3TFK55
GA-binding protein alpha chain (GABP subunit alpha)Gabpa E4tf1aQ004225
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (EC (Beta-1,3-glucuronyltransferase 3) (Glucuronosyltransferase I) (GlcAT-I) (UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (GlcUAT-I)B3gat3P581585
Galectin-1 (Gal-1) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (S-Lac lectin 1)Lgals1 GbpP160455
Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)Gja1 Cxn-43P232425
GATS-like protein 2Gatsl2 GatsQ8CAB85
Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1)Gemin2 Sip1Q9CQQ45
General transcription factor IIIC, polypeptide 3 (Protein Gtf3c3)Gtf3c3 AL022818Q3TMP15
Glutaminyl-tRNA synthetase (Protein Qars)QarsQ8BML95
Glutathione S-transferase Mu 2 (EC (GST 5-5) (GST class-mu 2) (Glutathione S-transferase pmGT2)Gstm2P156265
Glypican-3 [Cleaved into: Secreted glypican-3]Gpc3Q8CFZ45
Golgin subfamily A member 5 (Golgin-84) (Protein Ret-II) (Protein Sumiko)Golga5 RetiiQ9QYE65
Golgin subfamily A member 7Golga7 MNCb-1213Q91W535
GTP:AMP phosphotransferase AK3, mitochondrial (EC (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1)Ak3 Ak3l Ak3l1 Akl3lQ9WTP75
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)Gapvd1 Gapex5 Kiaa1521Q6PAR55
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)Gnai2 Gnai-2P087525
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)Gng2P632135
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5Gng5 Gngt5Q80SZ75
Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)Gna13 Gna-13P276015
H-2 class II histocompatibility antigen, A beta chainH2-Ab1 H2-iabetaP144835
Helicase-like transcription factor (EC 3.6.4.-) (EC 6.3.2.-) (P113) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein)Hltf Smarca3 Snf2l3 Zbu1Q6PCN75
Heme transporter HRG1 (Heme-responsive gene 1 protein homolog) (HRG-1) (Solute carrier family 48 member 1)Slc48a1 Hrg1Q9D8M35
Hepatoma-derived growth factor (HDGF)Hdgf Tdrm1P518595
Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (Scaffold attachment factor A) (SAF-A)Hnrnpu HnrpuQ8VEK35
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)Hnrnpa2b1 Hnrpa2b1O885695
Histone acetyltransferase type B catalytic subunit (EC (Histone acetyltransferase 1)Hat1Q8BY715
Histone H2A.J (H2a/j)H2afjQ8R1M25
Histone H3.2Hist1h3b H3-53 H3.2 H3b; Hist1h3c H3-143; Hist1h3d H3-B; Hist1h3e H3-F; Hist1h3f H3.2-221 H3f; Hist2h3b H3.2-616; Hist2h3c1 H3.2-615 Hist2h3ca1; Hist2h3c2 H3.2-614 Hist2h3ca2P842285
Histone-lysine N-methyltransferase 2E (Lysine N-methyltransferase 2E) (EC (Myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog)Kmt2e Mll5Q3UG205
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Protein G9a)Ehmt2 Bat8 G9a Ng36Q9Z1485
Histone-lysine N-methyltransferase EZH1 (EC (ENX-2) (Enhancer of zeste homolog 1)Ezh1 Enx2P703515
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 proteinHerpud2 MNCb-2040Q9JJC95
Hsp90 co-chaperone Cdc37-like 1Cdc37l1Q9CZP75
Iduronate 2-sulfatase (EC (Alpha-L-iduronate sulfate sulfatase)IdsQ088905
Importin subunit beta-1 (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG)Kpnb1 ImpnbP701685
Inhibitor of growth protein 3 (p47ING3)Ing3Q8VEK65
Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC (IMPDH-II)Impdh2P245475
Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC (Inositol hexaphosphate kinase 1)Ip6k1 Ihpk1Q6PD105
Inositol monophosphatase 3 (IMP 3) (IMPase 3) (EC (EC (Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase) (Golgi-resident PAP phosphatase) (gPAPP) (Inositol monophosphatase domain-containing protein 1) (Inositol-1(or 4)-monophosphatase 3) (Myo-inositol monophosphatase A3)Impad1 Impa3Q80V265
Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A)Ints3Q7TPD05
Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26)Ints6 Dbi1 Ddx26Q6PCM25
Integrin beta-1-binding protein 1 (Bodenin)Itgb1bp1O356715
Interferon-induced protein 44 (Microtubule-associated protein 44)Ifi44 Mtap44Q8BV665
Interferon-induced, double-stranded RNA-activated protein kinase (EC (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC (p68 kinase)Eif2ak2 Pkr Prkr TikQ039635
Intraflagellar transport protein 20 homolog (mIFT20)Ift20Q610255
Intraflagellar transport protein 57 homolog (HIP1-interacting protein)Ift57 HippiQ8BXG35
JNK1/MAPK8-associated membrane protein (JKAMP) (JNK1-associated membrane protein) (JAMP) (Medulloblastoma antigen MU-MB-50.4 homolog)Jkamp JampQ8BI365
Josephin-2 (EC (Josephin domain-containing protein 2)Josd2Q9CR305
Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322)Jam2 VejamQ9JI595
KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog)Kansl3 Kiaa1310 Nsl3A2RSY15
Kelch domain-containing protein 2 (Endothelial differentiation inhibitory protein TNG)Klhdc2Q4G5Y15
Klra18 protein (Lectin-related NK cell receptor LY49R)Klra18Q9JHV45
La-related protein 7 (La ribonucleoprotein domain family member 7)Larp7 D3Wsu161eQ05CL85
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (L-type amino acid transporter 1) (Solute carrier family 7 member 5)Slc7a5 Lat1Q9Z1275
Late cornified envelope 1D (Protein Lce1d) (Small proline rich-like 7)Lce1d Sprrl7 mCG_119389Q9D7315
Late cornified envelope 3B (Protein Lce3b) (RIKEN cDNA 2310007F04)Lce3b 2310007F04Rik mCG_141034Q9CQM75
Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1)Ltbp1Q8CG195
Lebercilin (Leber congenital amaurosis 5 protein homolog)Lca5Q80ST95
Leucine-rich repeat-containing protein 39Lrrc39Q8BGI75
Leukemia-associated protein 7 homolog (Deleted in lymphocytic leukemia 7 homolog)Dleu7 Leu7Q8CHZ85
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN)Lima1 D15Ertd366e EplinQ9ERG05
Lipoyl synthase, mitochondrial (EC (Lipoate synthase) (LS) (Lip-syn) (mLIP1) (Lipoic acid synthase)Lias Lip1Q99M045
Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1)Ppfibp1 Kiaa1230Q8C8U05
Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-)Ppt2O354485
Lysozyme C-2 (EC (1,4-beta-N-acetylmuramidase C) (Lysozyme C type M)Lyz2 Lyz LyzsP089055
M-phase phosphoprotein 6Mphosph6Q9D1Q15
Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog)Nipa2 MNCb-2146Q9JJC85
MBT domain-containing protein 1Mbtd1Q6P5G35
Melanoregulin (Dilute suppressor protein) (Whn-dependent transcript 2)Mreg Dsu Gm974 Wdt2Q6NVG55
Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1)Mbd1Q9Z2E25
Methylosome protein 50 (MEP-50) (WD repeat-containing protein 77)Wdr77 Mep50Q99J095
Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC (APAF1-interacting protein) (Monocyte/macrophage protein 19)Apip Mmrp19Q9WVQ55
Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)McmbpQ8R3C05
Mitochondrial fission regulator 1-likeMtfr1l Fam54bQ9CWE05
Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog)Tomm22 Tom22Q9CPQ35
Mitochondrial nucleoid factor 1 (Mitochondrial protein M19)Mnf1Q9CQY65
Mitochondrial pyruvate carrier 2 (Brain protein 44)Mpc2 Brp44Q9D0235
Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)Mapk13 Serk4Q9Z1B75
Mitotic checkpoint protein BUB3 (WD repeat type I transmembrane protein A72.5)Bub3Q9WVA35
Monocyte to macrophage differentiation factor (Progestin and adipoQ receptor family member XI)Mmd Paqr11Q9CQY75
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