EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)Ndufb5Q9CQH37
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC (EC (NADH-ubiquinone oxidoreductase 24 kDa subunit)Ndufv2Q9D6J67
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit)Ndufv3Q8BK307
Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)NficP702557
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC (Metastasis inhibition factor NM23) (NDPK-A) (Tumor metastatic process-associated protein) (nm23-M1)Nme1 Nm23P155327
Nucleus accumbens-associated protein 2 (NAC-2) (BTB/POZ domain-containing protein 14A)Nacc2 Btbd14aQ9DCM77
Oxidative stress-responsive serine-rich protein 1 (Oxidative stress-responsive protein 1) (Peroxide-inducible transcript 1 protein)Oser1Q9D7227
PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF)Psip1 LedgfQ99JF87
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)Pik3r1P264507
Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor)Pttg1ipQ8R1437
Pleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1)Plekha3 Fapp1Q9ERS47
Pre-mRNA branch site protein p14 (SF3b 14 kDa subunit)Sf3b14P597087
Probable E3 ubiquitin-protein ligase HECTD2 (EC 6.3.2.-) (HECT domain-containing protein 2)Hectd2Q8CDU67
Probable G-protein coupled receptor 85 (Super conserved receptor expressed in brain 2)Gpr85 Sreb2P608947
Prostaglandin E synthase 3 (EC (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Sid 3177) (Telomerase-binding protein p23)Ptges3 Sid3177 TebpQ9R0Q77
Protein BEX3 (Brain-expressed X-linked protein 3 homolog) (Nerve growth factor receptor-associated protein 1) (p75NTR-associated cell death executor)Ngfrap1 Bex3 NadeQ9WTZ97
Protein FAM63A (NF-E2 inducible protein)Fam63a NiQ76LS97
Protein FAM76AFam76aQ922G27
Protein HnrnprHnrnprF7B5B57
Protein Morc3Morc3F7BJB97
Protein Mpv17 (Mpv-17)Mpv17P192587
Protein Ppp2r5d (Protein phosphatase 2, regulatory subunit B (B56), delta isoform) (Protein phosphatase 2, regulatory subunit B (B56), delta isoform, isoform CRA_b) (Protein phosphatase 2A B56delta regulatory subunit)Ppp2r5d mCG_2696Q91V897
Protein SON (Negative regulatory element-binding protein) (NRE-binding protein)Son NrebpQ9QX477
Protein-L-isoaspartate O-methyltransferase (EC
Putative RNA-binding protein Luc7-like 2 (CGI-74 homolog)Luc7l2Q7TNC47
Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha)Rabep1 Rab5ep Rabpt5 Rabpt5aO355517
Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18)Lamtor1Q9CQ227
RalA-binding protein 1 (RalBP1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (Ral-interacting protein 1)Ralbp1 Rip1Q621727
Ras-related protein Rab-22A (Rab-22) (Rab-14)Rab22a Rab22P352857
Ras-related protein Rab-9A (Sid 99)Rab9a Rab9 Sid99Q9R0M67
Ras-responsive element-binding protein 1 (RREB-1) (RAS-responsive zinc finger transcription factor RREB)Rreb1Q3UH067
Receptor expression-enhancing protein 3Reep3 D10Ucla1Q99KK17
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]Rpa1Q8VEE47
RNA-binding protein 10 (RNA-binding motif protein 10)Rbm10 Kiaa0122Q99KG37
RNA-binding protein 28 (RNA-binding motif protein 28)Rbm28Q8CGC67
RNA-binding protein 39 (Coactivator of activating protein 1 and estrogen receptors) (Coactivator of AP-1 and ERs) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Transcription coactivator CAPER)Rbm39 Caper Rnpc2Q8VH517
RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1)Dusp11 Pir1Q6NXK57
Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)Runx1 Aml1 Cbfa2 Pebp2abQ033477
Serine hydroxymethyltransferase, cytosolic (SHMT) (EC (Glycine hydroxymethyltransferase) (Serine methylase)Shmt1 ShmtP504317
Serine/arginine-rich splicing factor 10 (FUS-interacting serine-arginine-rich protein 1) (Neural-salient serine/arginine-rich protein) (Neural-specific SR protein) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)Srsf10 Fusip1 Nssr Sfrs13a Srsf13aQ9R0U07
Serine/threonine-protein kinase NLK (EC (Nemo-like kinase)NlkO549497
Serine/threonine-protein phosphatase 4 regulatory subunit 1Ppp4r1Q8K2V17
snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Small nuclear RNA-activating complex polypeptide 3)Snapc3Q9D2C97
Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)Atp1b3P973707
Sorting nexin-6 [Cleaved into: Sorting nexin-6, N-terminally processed]Snx6Q6P8X17
SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2)Nabp1 Obfc2a Ssb2Q8BGW57
SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)SparcP072147
SPATS2-like proteinSpats2lQ91WJ77
Sulfated glycoprotein 1 (SGP-1) (Prosaposin)Psap Sgp1Q612077
Telomere length regulation protein TEL2 homologTelo2 Kiaa0683Q9DC407
THO complex subunit 1 (Tho1) (Nuclear matrix protein p84)Thoc1 Hpr1Q8R3N67
Transcription factor 25 (TCF-25) (Nuclear localized protein 1)Tcf25 D8Ertd325e Nulp1Q8R3L27
Transcription factor 4 (TCF-4) (Class A helix-loop-helix transcription factor ME2) (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2)Tcf4 Itf2 Sef2Q607227
Transcription factor E2F2 (E2F-2)E2f2P569317
Transcription factor SOX-7 (mSOX7)Sox7 Sox-7P406467
Transmembrane protein 248Tmem248Q3TBN17
Trinucleotide repeat-containing gene 6A proteinTnrc6a Kiaa1460Q3UHK87
U6 snRNA-associated Sm-like protein LSm6Lsm6P623137
Ubiquitin-conjugating enzyme E2 L3 (EC (UbcM4) (Ubiquitin carrier protein L3) (Ubiquitin-protein ligase L3)Ube2l3 Ubce7P680377
Uncharacterized proteinErmard 2210404J11RikE9Q0487
Uncharacterized protein C1orf198 homolog0Q8C3W17
Uncharacterized protein C6orf62 homolog0Q99LU87
UPF0378 protein KIAA0100Kiaa0100Q5SYL37
UPF0554 protein C2orf43 homolog0Q8BVA57
Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)Vapa Vap33Q9WV557
WD repeat and SOCS box-containing protein 2 (WSB-2) (SOCS box-containing WD protein SWiP-2)Wsb2 Swip2O549297
WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa)Wipi1 D11Ertd498eQ8R3E37
10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10)Hspe1Q644336
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (SEZ-2)YwhazP631016
26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)Psmd12Q9D8W56
28S ribosomal protein S5, mitochondrial (MRP-S5) (S5mt)Mrps5Q99N876
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC (Delta-5-3-ketosteroid isomerase)]Hsd3b2P261496
39S ribosomal protein L1, mitochondrial (L1mt) (MRP-L1)Mrpl1Q99N966
39S ribosomal protein L18, mitochondrial (L18mt) (MRP-L18)Mrpl18Q9CQL56
39S ribosomal protein L23, mitochondrial (L23mt) (MRP-L23) (L23 mitochondrial-related protein)Mrpl23 L23mrpO359726
40S ribosomal protein S18 (Ke-3) (Ke3)Rps18P622706
5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS-H) (EC (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1)Alas1Q8VC196
5-methylcytosine rRNA methyltransferase NSUN4 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 4) (Sperm head and tail associated protein)Nsun4 ShtapQ9CZ576
60S acidic ribosomal protein P0 (60S ribosomal protein L10E)Rplp0 ArbpP148696
60S ribosomal protein L10 (Protein QM homolog)Rpl10 QmQ6ZWV36
60S ribosomal protein L21 (MCG120646) (MCG121646, isoform CRA_a) (MCG121688) (MCG18971) (Ribosomal protein L21) (Rpl21 protein)Rpl21 mCG_120646 mCG_121646 mCG_121688 mCG_18971Q9CQM86
60S ribosomal protein L23aRpl23aP627516
60S ribosomal protein L35aRpl35aO551426
60S ribosomal protein L37Rpl37Q9D8236
60S ribosomal protein L38Rpl38Q9JJI86
78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)Hspa5 Grp78P200296
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (ADMP-2) (Aggrecanase-2) (Implantin)Adamts5Q9R0016
A-kinase anchor protein 1, mitochondrial (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein) (S-AKAP)Akap1 AkapO087156
Abhydrolase domain-containing protein 2 (EC 3.1.1.-) (Lung alpha/beta hydrolase 2) (MmLABH2)Abhd2 Labh-2 Labh2Q9QXM06
Acetyl-coenzyme A synthetase, cytoplasmic (EC (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme)Acss2 Acas2 Acecs1Q9QXG46
Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)Arpc1bQ9WV326
Activating transcription factor 7-interacting protein 1 (ATFa-associated modulator) (mAM) (MBD1-containing chromatin-associated factor 1)Atf7ip Mcaf1Q7TT186
Acyl-CoA desaturase 2 (EC (Delta(9)-desaturase 2) (Delta-9 desaturase 2) (Fatty acid desaturase 2) (Stearoyl-CoA desaturase 2)Scd2P130116
Acyl-CoA-binding domain-containing protein 5Acbd5Q5XG736
ADP-ribosylation factor 2Arf2Q8BSL76
ADP-ribosylation factor-like protein 4AArl4a Arl4P612136
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Protein TBX2)Arl6ip1 Arl6ipQ9JKW06
Alcohol dehydrogenase [NADP(+)] (EC (Aldehyde reductase) (Aldo-keto reductase family 1 member A1)Akr1a1 Akr1a4Q9JII66
All-trans retinoic acid-induced differentiation factor (Apoptosis-related protein 3) (APR-3)Atraid Apr3Q6PGD06
Allograft inflammatory factor 1-like (Ionized calcium-binding adapter molecule 2)Aif1l Iba2Q9EQX46
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