EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC PKCA PRKACAP1725264
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC PHE1BP1117764
Pyruvate kinase PKLR (EC (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase)PKLR PK1 PKLP3061364
Ras-related protein Rab-43 (Ras-related protein Rab-41)RAB43 RAB41Q86YS664
Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)ARHGEF1Q9288864
Serine/threonine-protein kinase TAO3 (EC (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3)TAOK3 DPK JIK KDS MAP3K18Q9H2K864
Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1)SRPRB PSEC0230Q9Y5M864
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)SRGAP2 ARHGAP34 FNBP2 KIAA0456 SRGAP2AO7504464
Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4)SLC12A7 KCC4Q9Y66664
Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D)TBCD KIAA0988 SSD1 TFCD PP1096Q9BTW964
Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein)AGTRAP ATRAPQ6RW1364
Tyrosine-protein phosphatase non-receptor type 23 (EC (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)PTPN23 KIAA1471Q9H3S764
ATP synthase subunit delta, mitochondrial (F-ATPase delta subunit)ATP5DP3004963
Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43)SNTB1 SNT2B1Q1388463
BRCA2 and CDKN1A-interacting protein (P21- and CDK-associated protein 1) (Protein TOK-1)BCCIP TOK1Q9P28763
Cathepsin Z (EC (Cathepsin P) (Cathepsin X)CTSZQ9UBR263
Centromere/kinetochore protein zw10 homologZW10O4326463
Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N)CC2D1A AKI1Q6P1N063
DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)MSH2P4324663
DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40)POLR1C POLR1EO1516063
Dynactin subunit 4 (Dyn4) (Dynactin subunit p62)DCTN4Q9UJW063
Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35)EIF3J EIF3S1 PRO0391O7582263
Fructose-bisphosphate aldolase B (EC (Liver-type aldolase)ALDOB ALDBP0506263
Glycogen phosphorylase, muscle form (EC (Myophosphorylase)PYGMP1121763
Guanylate-binding protein 1 (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1)GBP1P3245563
Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL)HEBP2 C6orf34 SOULQ9Y5Z463
High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1) (High mobility group protein R)HMGA1 HMGIYP1709663
Immunoglobulin heavy variable 3-13 (Ig heavy chain V-III region BRO)IGHV3-13P0176663
Midkine (MK) (Amphiregulin-associated protein) (ARAP) (Midgestation and kidney protein) (Neurite outgrowth-promoting factor 2) (Neurite outgrowth-promoting protein)MDK MK1 NEGF2P2174163
NADPH--cytochrome P450 reductase (CPR) (P450R) (EC CYPORP1643563
Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase)QPRTQ1527463
Prefoldin subunit 6 (Protein Ke2)PFDN6 HKE2 PFD6O1521263
Protein phosphatase methylesterase 1 (PME-1) (EC PME1 PP2593 PRO0750Q9Y57063
Protein transport protein Sec61 subunit betaSEC61BP6046863
Ras-related protein Rab-39A (Rab-39)RAB39A RAB39Q1496463
Retinol dehydrogenase 11 (EC (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1)RDH11 ARSDR1 PSDR1 SDR7C1 CGI-82Q8TC1263
Sodium-coupled neutral amino acid transporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)SLC38A1 ATA1 NAT2 SAT1 SNAT1Q9H2H963
Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)SF3A1 SAP114Q1545963
Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (SF3b150) (Spliceosome-associated protein 145) (SAP 145)SF3B2 SAP145Q1343563
Thymidine phosphorylase (TP) (EC (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase)TYMP ECGF1P1997163
U6 snRNA-associated Sm-like protein LSm3LSM3 MDS017P6231063
UPF0160 protein MYG1, mitochondrialC12orf10Q9HB0763
Zinc transporter 1 (ZnT-1) (Solute carrier family 30 member 1)SLC30A1 ZNT1Q9Y6M563
3-ketoacyl-CoA thiolase, mitochondrial (EC (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1)ACAA2P4276562
Aminoacylase-1 (ACY-1) (EC (N-acyl-L-amino-acid amidohydrolase)ACY1Q0315462
Betaine--homocysteine S-methyltransferase 1 (EC
Casein kinase I isoform alpha (CKI-alpha) (EC (CK1)CSNK1A1P4872962
Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)CHORDC1 CHP1Q9UHD162
Dedicator of cytokinesis protein 7DOCK7 KIAA1771Q96N6762
Endonuclease domain-containing 1 protein (EC 3.1.30.-)ENDOD1 KIAA0830O9491962
Exportin-5 (Exp5) (Ran-binding protein 21)XPO5 KIAA1291 RANBP21Q9HAV462
Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)FBP1 FBPP0946762
Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98)TUBGCP3 GCP3Q96CW562
Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC (Dextrin 6-alpha-D-glucosidase)]AGL GDEP3557362
Histone H2B type 3-B (H2B type 12)HIST3H2BBQ8N25762
Ig mu heavy chain disease protein (BOT)0P0422062
Immunoglobulin lambda constant 2 (Ig lambda chain C region Kern) (Ig lambda chain C region NIG-64) (Ig lambda chain C region SH) (Ig lambda chain C region X) (Ig lambda-2 chain C region)IGLC2P0CG0562
Isochorismatase domain-containing protein 1ISOC1 CGI-111Q96CN762
Lon protease homolog, mitochondrial (EC 3.4.21.-) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)LONP1 PRSS15P3677662
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC (Man(9)-alpha-mannosidase) (Man9-mannosidase) (Mannosidase alpha class 1A member 1) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA)MAN1A1P3390862
Matrilin-2MATN2 UNQ193/PRO219O0033962
NADP-dependent malic enzyme (NADP-ME) (EC (Malic enzyme 1)ME1P4816362
Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2)PLEKHB2 EVT2Q96CS762
Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)BCAS2 DAM1O7593462
Proline synthase co-transcribed bacterial homolog proteinPROSCO9490362
Proteasome subunit beta type-10 (EC (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i)PSMB10 LMP10 MECL1P4030662
Protein DEKDEKP3565962
Protein eva-1 homolog B (Protein FAM176B)EVA1B C1orf78 FAM176BQ9NVM162
Serine incorporator 5SERINC5 C5orf12Q86VE962
Tetranectin (TN) (C-type lectin domain family 3 member B) (Plasminogen kringle 4-binding protein)CLEC3B TNAP0545262
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)TNFRSF10B DR5 KILLER TRAILR2 TRICK2 ZTNFR9 UNQ160/PRO186O1476362
U2 small nuclear ribonucleoprotein A' (U2 snRNP A')SNRPA1P0966162
UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein)UBXN1 SAKS1Q0432362
26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27)PSMD9O0023361
60S ribosomal protein L36a-like (Large ribosomal subunit protein eL42-like)RPL36ALQ969Q061
A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)AKAP12 AKAP250Q0295261
Afamin (Alpha-albumin) (Alpha-Alb)AFM ALB2 ALBAP4365261
Aldo-keto reductase family 1 member C3 (EC 1.-.-.-) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Indanol dehydrogenase) (EC (Prostaglandin F synthase) (PGFS) (EC (Testosterone 17-beta-dehydrogenase 5) (EC (EC (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC DDH1 HSD17B5 KIAA0119 PGFSP4233061
Alpha-galactosidase A (EC (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Agalsidase)GLAP0628061
Amidophosphoribosyltransferase (ATase) (EC (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)PPAT GPATQ0620361
Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8)AIFM1 AIF PDCD8O9583161
C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1)SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6O6027161
Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC)CCAR2 DBC1 KIAA1967Q8N16361
Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22)CLTCL1 CLH22 CLTCL CLTDP5367561
Complement C1q subcomponent subunit BC1QBP0274661
Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8b) (Dynein light chain LC8-type 2)DYNLL2 DLC2Q96FJ261
E3 SUMO-protein ligase RanBP2 (EC 6.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)RANBP2 NUP358P4979261
Exocyst complex component 7 (Exocyst complex component Exo70)EXOC7 EXO70 KIAA1067Q9UPT561
Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin)FMNL1 C17orf1 C17orf1B FMNL FRL1O9546661
Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1)GID8 C20orf11Q9NWU261
Glutathione S-transferase Mu 2 (EC (GST class-mu 2) (GSTM2-2)GSTM2 GST4P2816161
Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2)HNRNPUL2 HNRPUL2Q1KMD361
Histidine triad nucleotide-binding protein 2, mitochondrial (HINT-2) (EC 3.-.-.-) (HINT-3) (HIT-17kDa) (PKCI-1-related HIT protein)HINT2Q9BX6861
Histone H2A type 1-J (Histone H2A/e)HIST1H2AJ H2AFEQ9987861
Keratin, type II cytoskeletal 79 (Cytokeratin-79) (CK-79) (Keratin-6-like) (Keratin-6L) (Keratin-79) (K79) (Type-II keratin Kb38)KRT79 K6L KB38 KRT6LQ5XKE561
MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3)CHCHD3 MIC19 MINOS3Q9NX6361
Mitochondrial import receptor subunit TOM22 homolog (hTom22) (1C9-2) (Translocase of outer membrane 22 kDa subunit homolog)TOMM22 TOM22Q9NS6961
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F)PPIF CYP3P3040561
Phosphoacetylglucosamine mutase (PAGM) (EC (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3)PGM3 AGM1O9539461
Phosphoserine phosphatase (PSP) (PSPase) (EC (L-3-phosphoserine phosphatase) (O-phosphoserine phosphohydrolase)PSPHP7833061
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