EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb)MYL3P0859072
Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)MYH11 KIAA0866P3574972
Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (allergen Hom s 2)NACA HSD48Q1376572
Palmitoyl-protein thioesterase 1 (PPT-1) (EC (Palmitoyl-protein hydrolase 1)PPT1 CLN1 PPTP5089772
Proteasome assembly chaperone 1 (PAC-1) (Chromosome 21 leucine-rich protein) (C21-LRP) (Down syndrome critical region protein 2)PSMG1 C21LRP DSCR2 PAC1O9545672
Receptor-type tyrosine-protein phosphatase C (EC (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)PTPRC CD45P0857572
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)SRSF2 SFRS2Q0113072
Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)U2AF2 U2AF65P2636872
TLD domain-containing protein 1 (TBC/LysM-associated domain-containing protein 1)TLDC1 KIAA1609Q6P9B672
Transcriptional activator protein Pur-beta (Purine-rich element-binding protein B)PURBQ96QR872
C-type lectin domain family 11 member A (C-type lectin superfamily member 3) (Lymphocyte secreted C-type lectin) (Osteolectin) (Stem cell growth factor) (p47)CLEC11A CLECSF3 LSLCL SCGFQ9Y24071
Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)CDH2 CDHN NCADP1902271
DNA topoisomerase 2-alpha (EC (DNA topoisomerase II, alpha isozyme)TOP2A TOP2P1138871
Exocyst complex component 2 (Exocyst complex component Sec5)EXOC2 SEC5 SEC5L1Q96KP171
GDP-mannose 4,6 dehydratase (EC (GDP-D-mannose dehydratase) (GMD)GMDSO6054771
Histone deacetylase 2 (HD2) (EC
Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed]H1F0 H1FVP0730571
Insulin-like growth factor-binding protein 7 (IBP-7) (IGF-binding protein 7) (IGFBP-7) (IGFBP-rP1) (MAC25 protein) (PGI2-stimulating factor) (Prostacyclin-stimulating factor) (Tumor-derived adhesion factor) (TAF)IGFBP7 MAC25 PSFQ1627071
Insulin-like growth factor-binding protein complex acid labile subunit (ALS)IGFALS ALSP3585871
Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)KIRREL KIRREL1 NEPH1Q96J8471
Myeloperoxidase (MPO) (EC [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]MPOP0516471
N-acetylglucosamine-6-sulfatase (EC (Glucosamine-6-sulfatase) (G6S)GNSP1558671
N-acetylmuramoyl-L-alanine amidase (EC (Peptidoglycan recognition protein 2) (Peptidoglycan recognition protein long) (PGRP-L)PGLYRP2 PGLYRPL PGRPL UNQ3103/PRO10102Q96PD571
N-alpha-acetyltransferase 10 (EC (N-terminal acetyltransferase complex ARD1 subunit homolog A) (NatA catalytic subunit Naa10)NAA10 ARD1 ARD1A TE2P4122771
Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)NCS1 FLUP FREQP6216671
Pentraxin-related protein PTX3 (Pentaxin-related protein PTX3) (Tumor necrosis factor alpha-induced protein 5) (TNF alpha-induced protein 5) (Tumor necrosis factor-inducible gene 14 protein) (TSG-14)PTX3 TNFAIP5 TSG14P2602271
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)RAP1GDS1P5230671
Ras-related protein Rab-3ARAB3AP2033671
Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)RCC1 CHC1P1875471
Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)RSL1D1 CATX11 CSIG PBK1 L12O7602171
Serine/threonine-protein phosphatase 5 (PP5) (EC (Protein phosphatase T) (PP-T) (PPT)PPP5C PPP5P5304171
Serum paraoxonase/arylesterase 1 (PON 1) (EC (EC (EC (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)PON1 PONP2716971
Sideroflexin-1 (Tricarboxylate carrier protein) (TCC)SFXN1Q9H9B471
Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61)SF3A3 SAP61Q1287471
TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1)TOM1L1 SRCASMO7567471
Translin-associated protein X (Translin-associated factor X)TSNAX TRAXQ9959871
Tyrosine-protein kinase Fyn (EC (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)FYNP0624171
Tyrosine-protein kinase JAK1 (EC (Janus kinase 1) (JAK-1)JAK1 JAK1A JAK1BP2345871
Vasorin (Protein slit-like 2)VASN SLITL2 UNQ314/PRO357/PRO1282Q6EMK471
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)VAPB UNQ484/PRO983O9529271
WD repeat-containing protein 61 (Meiotic recombination REC14 protein homolog) (SKI8 homolog) (Ski8) [Cleaved into: WD repeat-containing protein 61, N-terminally processed]WDR61Q9GZS371
Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)SLC39A6 LIV1 ZIP6Q1343371
40S ribosomal protein S27-like (Small ribosomal subunit protein eS27-like)RPS27LQ71UM570
Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29)ANP32B APRIL PHAPI2Q9268870
ATP synthase subunit e, mitochondrial (ATPase subunit e) [Cleaved into: ATP synthase subunit e, mitochondrial, N-terminally processed]ATP5I ATP5KP5638570
Beta-hexosaminidase subunit alpha (EC (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha)HEXAP0686570
Claudin-1 (Senescence-associated epithelial membrane protein)CLDN1 CLD1 SEMP1 UNQ481/PRO944O9583270
Collagen alpha-1(IV) chain [Cleaved into: Arresten]COL4A1P0246270
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)COPS6 CSN6 HVIPQ7L5N170
COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b)COPS7B CSN7BQ9H9Q270
Creatine kinase U-type, mitochondrial (EC (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK)CKMT1A CKMT; CKMT1B CKMTP1253270
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC (dUTP pyrophosphatase)DUTP3331670
DNA replication licensing factor MCM2 (EC (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)MCM2 BM28 CCNL1 CDCL1 KIAA0030P4973670
High affinity copper uptake protein 1 (Copper transporter 1) (hCTR1) (Solute carrier family 31 member 1)SLC31A1 COPT1 CTR1O1543170
Immunoglobulin heavy variable 3-23 (Ig heavy chain V-III region LAY) (Ig heavy chain V-III region POM) (Ig heavy chain V-III region TEI) (Ig heavy chain V-III region TIL) (Ig heavy chain V-III region TUR) (Ig heavy chain V-III region VH26) (Ig heavy chain V-III region WAS) (Ig heavy chain V-III region ZAP)IGHV3-23P0176470
Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11)SLC25A11 SLC20A4Q0297870
Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]MUC1 PUMP1594170
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)NEDD8Q1584370
Ornithine aminotransferase, mitochondrial (EC (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]OATP0418170
Persulfide dioxygenase ETHE1, mitochondrial (EC (Ethylmalonic encephalopathy protein 1) (Hepatoma subtracted clone one protein) (Sulfur dioxygenase ETHE1)ETHE1 HSCOO9557170
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)PIP4K2C PIP5K2CQ8TBX870
SuprabasinSBSN UNQ698/PRO1343Q6UWP870
Transmembrane protein 33 (Protein DB83) (SHINC-3)TMEM33 DB83P5708870
Transthyretin (ATTR) (Prealbumin) (TBPA)TTR PALBP0276670
V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D)ATP6V1D ATP6M VATDQ9Y5K870
5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)NT5C DNT1 UMPH2Q8TCD569
Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1)ORM1 AGP1P0276369
Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Anion exchanger 1) (Solute carrier family 4 member 1) (CD antigen CD233)SLC4A1 AE1 DI EPB3P0273069
Collagen alpha-1(III) chainCOL3A1P0246169
Complement component C8 beta chain (Complement component 8 subunit beta)C8BP0735869
E3 ubiquitin-protein ligase NEDD4 (EC (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)NEDD4 KIAA0093 NEDD4-1 PIG53P4693469
Exocyst complex component 8 (Exocyst complex 84 kDa subunit)EXOC8Q8IYI669
Glutaredoxin-1 (Thioltransferase-1) (TTase-1)GLRX GRXP3575469
Histidine triad nucleotide-binding protein 3 (HINT-3) (EC 3.-.-.-)HINT3Q9NQE969
Histone H2B type 1-K (H2B K) (HIRA-interacting protein 1)HIST1H2BK H2BFT HIRIP1O6081469
Mannan-binding lectin serine protease 2 (EC (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2) [Cleaved into: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain]MASP2O0018769
MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89)IMMT HMP MIC60 MINOS2 PIG4 PIG52Q1689169
MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein)MMS19 MMS19LQ96T7669
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)MYL12B MRLC2 MYLC2BO1495069
NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47)NSFL1C UBXN2CQ9UNZ269
Ras-related protein Rab-31 (Ras-related protein Rab-22B)RAB31 RAB22BQ1363669
Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3)RPA3 REPA3 RPA14P3524469
Serpin B3 (Protein T4-A) (Squamous cell carcinoma antigen 1) (SCCA-1)SERPINB3 SCCA SCCA1P2950869
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)SUMO2 SMT3B SMT3H2P6195669
SRA stem-loop-interacting RNA-binding protein, mitochondrialSLIRP C14orf156 DC23 DC50 PD04872Q9GZT369
Ubiquitin-conjugating enzyme E2 variant 3 (UEV-3) (EV and lactate/malate dehydrogenase domain-containing protein)UEVLD UEV3Q8IX0469
40S ribosomal protein S29 (Small ribosomal subunit protein uS14)RPS29P6227368
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)AFDN AF6 MLLT4P5519668
Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II)CRABP2P2937368
Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein)DMBT1 GP340Q9UGM368
Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22)DCTN3 DCTN22O7593568
Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1)EDF1O6086968
Fructose-2,6-bisphosphatase TIGAR (EC (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase)TIGAR C12orf5Q9NQ8868
Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94)HSPA4L APG1 OSP94O9575768
Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3)KRT3P1203568
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)LIMA1 EPLIN SREBP3 PP624Q9UHB668
Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit)TOMM34 URCC3Q1578568
Multidrug resistance protein 1 (EC (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243)ABCB1 MDR1 PGY1P0818368
Phosphatidylinositol 4-kinase type 2-alpha (EC (Phosphatidylinositol 4-kinase type II-alpha)PI4K2AQ9BTU668
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