EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Argininosuccinate lyase (ASAL) (EC (Arginosuccinase)AslQ91YI011
Argininosuccinate synthase (EC (Citrulline--aspartate ligase)Ass1 AssP1646011
Atlastin-3 (EC 3.6.5.-)Atl3Q91YH511
ATP-citrate synthase (EC (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme)AclyQ3V11711
Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)AidaQ8C4Q611
Band 4.1-like protein 5Epb41l5 Epb4.1l5 Kiaa1548Q8BGS111
BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain)Kctd12 Pfet1Q6WVG311
C4b-binding protein (C4bp)C4bpa C4bpP0860711
Cadherin-13 (Heart cadherin) (H-cadherin) (Truncated cadherin) (T-cad) (T-cadherin)Cdh13Q9WTR511
Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2)Ccar2Q8VDP411
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC
Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2)Cc2d1b Kiaa1836Q8BRN911
Cold shock domain-containing protein E1Csde1 D3Jfr1Q91W5011
Collagen alpha-2(I) chain (Alpha-2 type I collagen)Col1a2 Cola2Q0114911
Complement component 1 Q subcomponent-binding protein, mitochondrial (Complement component 1, q subcomponent binding protein) (Complement component 1, q subcomponent binding protein, isoform CRA_b) (p32-RACK)C1qbp mCG_21176Q8R5L111
Complement factor B (EC (C3/C5 convertase) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment]Cfb Bf H2-BfP0418611
COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1)Gps1 Cops1 Csn1Q99LD411
Cyclin-dependent kinase 4 (EC (CRK3) (Cell division protein kinase 4) (PSK-J3)Cdk4 Crk3P3028511
Cyclin-dependent kinase 6 (EC (CR2 protein kinase) (CRK2) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)Cdk6 Cdkn6 Crk2Q6426111
Cyclin-dependent kinase 9 (EC (EC (Cell division protein kinase 9)Cdk9Q99J9511
Cyclin-dependent-like kinase 5 (EC (CR6 protein kinase) (CRK6) (Cell division protein kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)Cdk5 Cdkn5 Crk6P4961511
Cystatin-B (Stefin-B)Cstb Cst6 StfbQ6242611
Cytochrome b-245 heavy chain (EC 1.-.-.-) (CGD91-phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta) (Heme-binding membrane glycoprotein gp91phox) (Neutrophil cytochrome b 91 kDa polypeptide) (gp91-1) (gp91-phox) (p22 phagocyte B-cytochrome)Cybb CgdQ6109311
Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)Uqcrc2Q9DB7711
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)Dock1Q8BUR411
Dipeptidyl peptidase 1 (EC (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)]CtscP9782111
DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]Apex1 Ape Apex Ref1P2835211
DnaJ homolog subfamily B member 6 (Heat shock protein J2) (HSJ-2) (MRJ) (mDj4)Dnajb6 Hsj2 MrjO5494611
DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)Dnajc3 P58ipkQ91YW311
Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) (mPIN)Dynll1 Dlc1 Dncl1 Dnclc1P6316811
E3 ubiquitin-protein ligase NEDD4-like (EC (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)Nedd4l Kiaa0439 Nedd4bQ8CFI011
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC (ATP-dependent RNA helicase eIF4A-2)Eif4a2 Ddx2bP1063011
Eukaryotic translation initiation factor 5B (eIF-5B) (EC (Translation initiation factor IF-2)Eif5b If2Q05D4411
Exportin-5 (Exp5) (Ran-binding protein 21)Xpo5 Kiaa1291 Ranbp21Q924C111
Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)Esyt1 Fam62a Mbc2Q3U7R111
Glutamine synthetase (GS) (EC (Glutamate decarboxylase) (EC (Glutamate--ammonia ligase)Glul GlnsP1510511
Glycylpeptide N-tetradecanoyltransferase 2 (EC (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Type II N-myristoyltransferase)Nmt2O7031111
GTPase NRas (Neuroblastoma ras oncogene) (Putative uncharacterized protein)Nras mCG_6411Q9D09111
Heterogeneous nuclear ribonucleoprotein L-likeHnrnpll HnrpllQ921F411
Histone H2AHist1h2aa mCG_49751Q8CGP411
Histone H2A.J (H2a/j)H2afjQ8R1M211
Inositol monophosphatase 3 (IMP 3) (IMPase 3) (EC (EC (Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase) (Golgi-resident PAP phosphatase) (gPAPP) (Inositol monophosphatase domain-containing protein 1) (Inositol-1(or 4)-monophosphatase 3) (Myo-inositol monophosphatase A3)Impad1 Impa3Q80V2611
Insulin-degrading enzyme (EC (Insulin protease) (Insulinase) (Insulysin)IdeQ9JHR711
Insulin-like growth factor 1 receptor (EC (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]Igf1rQ6075111
Integrin beta-5Itgb5O7030911
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Glucocorticoid-attenuated response gene 16 protein) (GARG-16) (Interferon-induced 56 kDa protein) (IFI-56K) (P56)Ifit1 Garg16 Ifi56 Isg56Q6428211
Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD antigen CD321)F11r Jam1 Jcam Jcam1O8879211
Kininogen-1 [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kininogen-1 light chain]Kng1 KngO0867711
Lactoylglutathione lyase (EC (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase)Glo1Q9CPU011
m7GpppX diphosphatase (EC (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS)Dcps Dcs1 Hint5Q9DAR711
MalectinMlec Kiaa0152Q6ZQI311
Membrane-associated progesterone receptor component 1Pgrmc1 PgrmcO5502211
Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)Ncbp1 Cbp80Q3UYV911
Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (CBP-interacting protein 4) (Nucleoporin Nup93)Nup93 Cip4 Kiaa0095Q8BJ7111
Nucleoside diphosphate kinase (EC
Pachytene checkpoint protein 2 homolog (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13)Trip13 Pch2Q3UA0611
Paralemmin-1 (Paralemmin)PalmQ9Z0P411
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1)Pin1Q9QUR711
PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b)Phf5aP8387011
Phosphoribosyl pyrophosphate synthetase 1-like 3Prps1l3G3UXL211
Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1)Serping1 C1nhP9729011
Poly [ADP-ribose] polymerase 12 (PARP-12) (EC (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1)Parp12 Zc3hdc1Q8BZ2011
Potassium-transporting ATPase alpha chain 2 (EC (Non-gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)Atp12a Atp1al1Q9Z1W811
Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 11) (FBP-11) (Formin-binding protein 3)Prpf40a Fbp11 Fnbp3Q9R1C711
Programmed cell death protein 10 (TF-1 cell apoptosis-related protein 15)Pdcd10 Tfar15Q8VE7011
Protein eva-1 homolog B (Protein FAM176B)Eva1b Fam176bQ8K2Y311
Protein kinase C delta type (EC (Tyrosine-protein kinase PRKCD) (EC (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]Prkcd PkcdP2886711
Protein lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)Lin7c Mals3 Veli3O8895211
Protein S100-A4 (Metastasin) (Metastatic cell protein) (PEL98) (Placental calcium-binding protein) (Protein 18A2) (Protein Mts1) (S100 calcium-binding protein A4)S100a4 Capl Mts1P0709111
Protein tyrosine phosphatase type IVA 2 (EC (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)Ptp4a2 Prl2O7027411
Purine nucleoside phosphorylase (PNP) (EC (Inosine phosphorylase) (Inosine-guanosine phosphorylase)Pnp Np Pnp1P2349211
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC (PDHE1-A type I)Pdha1 Pdha-1P3548611
Ras GTPase-activating protein 2 (GAP1m)Rasa2P5806911
Ras-related protein Rab-32Rab32Q9CZE311
Ras-related protein Rab-34 (Ras-related homolog) (Ras-related protein Rab-39) (Ras-related protein Rah)Rab34 Rab39 Rah Rah1Q6400811
Ras-related protein Rab-3ARab3aP6301111
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (p85SPR)Arhgef7 Kiaa0142 Pak3bpQ9ES2811
Rho-related GTP-binding protein RhoDRhod Arhd RhomP9734811
S-adenosylhomocysteine hydrolase-like protein 1 (IP3R-binding protein released with inositol 1,4,5-trisphosphate) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2)Ahcyl1 IrbitQ80SW111
Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1)Scamp1Q8K02111
Serine incorporator 3 (Axotomy-induced glyco/Golgi protein 1) (AIGP-1) (Axotomy-induced glycoprotein 1) (Membrane protein TMS-1) (Tumor differentially expressed protein 1)Serinc3 Aigp1 Diff33 Tde1 Tms1Q9QZI911
Serine protease inhibitor A3N (Serpin A3N)Serpina3n Spi2Q91WP611
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)Srsf5 Hrs Sfrs5O3532611
Serine/threonine-protein kinase VRK1 (EC (Serine/threonine-protein kinase 51PK) (Vaccinia-related kinase 1)Vrk1Q80X4111
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform)Ppp3ca CalnaP6332811
Signal recognition particle 14 kDa protein (SRP14) [Cleaved into: Signal recognition particle 14 kDa protein, N-terminally processed]Srp14P1625411
Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)Stam2 HbpO8881111
Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE)SnrpeP6230511
Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8)Slc6a8 CrtQ8VBW111
Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9)Slc6a9 Glyt1P2857111
Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3)Slc5a3Q9JKZ211
Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC (Na(+)/K(+) ATPase alpha(+) subunit) (Sodium pump subunit alpha-2)Atp1a2Q6PIE511
Sorting nexin-17Snx17Q8BVL311
Sorting nexin-27Snx27 Kiaa0488Q3UHD611
Splicing factor 3B subunit 6 (Pre-mRNA branch site protein p14) (SF3b 14 kDa subunit)Sf3b6 Sf3b14P5970811
Superoxide dismutase [Mn], mitochondrial (EC Sod-2P0967111
Synaptophysin-like protein 1 (Pantophysin)Sypl1 Pphn SyplO0911711
Thimet oligopeptidase (EC
Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Plasma cell-specific thioredoxin-related protein) (PC-TRP) (Thioredoxin-like protein p46)Txndc5 Tlp46Q91W9011
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