EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
60S ribosomal protein L35aRpl35aO5514225
CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1 homolog) (CD antigen CD82)Cd82 Kai1P4023725
COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)Cops4 Csn4O8854425
Cytoplasmic dynein 1 light intermediate chain 1 (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic)Dync1li1 Dncli1 Dnclic1Q8R1Q825
Elongation factor 1-delta (EF-1-delta)Eef1dP5777625
Endophilin-A2 (Endophilin-2) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) (SH3p8)Sh3gl1 Sh3d2bQ6241925
Exportin-2 (Exp2) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)Cse1l Xpo2Q9ERK425
Ferritin light chain 1 (Ferritin L subunit 1)Ftl1 Ftl Ftl-1P2939125
Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC GludP2644325
Glypican-1 [Cleaved into: Secreted glypican-1]Gpc1Q9QZF225
Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11)Gna11 Gna-11P2127825
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (HDP-1) (Helix-destabilizing protein) (Single-strand-binding protein) (Topoisomerase-inhibitor suppressed) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]Hnrnpa1 Fli-2 Hnrpa1 TisP4931225
Histone H2B type 1-F/J/L (H2B 291A)Hist1h2bf H2b-f; Hist1h2bj H2b-j; Hist1h2bl H2b-l; Hist1h2bn H2b-nP1085325
Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocyte-associated transmembrane protein 4) (KCT-4) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)Igsf8 Ewi2 Kct4 PgrlQ8R36625
Isoleucine--tRNA ligase, cytoplasmic (EC (Isoleucyl-tRNA synthetase) (IRS) (IleRS)IarsQ8BU3025
Leukocyte surface antigen CD47 (Integrin-associated protein) (IAP) (CD antigen CD47)Cd47Q6173525
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)Mapk1 Erk2 Mapk Prkm1P6308525
Multivesicular body subunit 12A (ESCRT-I complex subunit MVB12A) (Protein FAM125A)Mvb12a Fam125aQ78HU325
NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC (Diaphorase-1) [Cleaved into: NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form]Cyb5r3 Dia1Q9DCN225
Proliferating cell nuclear antigen (PCNA) (Cyclin)PcnaP1791825
Proteasome subunit alpha type-2 (EC (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3)Psma2 Lmpc3P4972225
Protein arginine N-methyltransferase 1 (EC (Histone-arginine N-methyltransferase PRMT1)Prmt1 Hrmt1l2 Mrmt1Q9JIF025
Ras-related protein Rab-8BRab8bP6102825
Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1)Rnh1 RnhQ91VI725
Serine--tRNA ligase, cytoplasmic (EC (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)Sars Sars1 SersP2663825
Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6)Slc6a6 TautO3531625
Tetraspanin-14 (Tspan-14) (Transmembrane 4 superfamily member 14)Tspan14 D14Ertd226e Tm4sf14Q8QZY625
Threonine--tRNA ligase, cytoplasmic (EC (Threonyl-tRNA synthetase) (ThrRS)TarsQ9D0R225
Ubiquitin-conjugating enzyme E2 N (EC (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)Ube2n BluP6108925
60S acidic ribosomal protein P1Rplp1P4795524
60S ribosomal protein L10 (Protein QM homolog)Rpl10 QmQ6ZWV324
Antithrombin-III (ATIII) (Serpin C1)Serpinc1 At3P3226124
AP-2 complex subunit mu (AP-2 mu chain) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein)Ap2m1 Clapm1P8409124
Coronin-1C (Coronin-3)Coro1cQ9WUM424
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]Eif4a3 Ddx48Q91VC324
Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit)Eif3h Eif3s3Q91WK224
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)Xpo1 Crm1Q6P5F924
Filamin-B (FLN-B) (ABP-280-like protein) (Actin-binding-like protein) (Beta-filamin)FlnbQ80X9024
Galactokinase (EC (Galactose kinase)Galk1 Galk GlkQ9R0N024
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Gng12Q9DAS924
Heat shock-related 70 kDa protein 2 (Heat shock protein 70.2)Hspa2 Hcp70.2 Hsp70-2P1715624
Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]Hnrnph1 Hnrph Hnrph1O3573724
Heterogeneous nuclear ribonucleoprotein L (hnRNP L)Hnrnpl HnrplQ8R08124
Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)Kif5b Khcs Kns1Q6176824
Non-POU domain-containing octamer-binding protein (NonO protein)NonoQ99K4824
Nucleosome assembly protein 1-like 4Nap1l4Q78ZA724
Obg-like ATPase 1 (GTP-binding protein 9)Ola1 Gtpbp9Q9CZ3024
Plexin-A1 (Plex 1) (Plexin-1)Plxna1 Kiaa4053P7020624
Protein S100-A11 (Calgizzarin) (Endothelial monocyte-activating polypeptide) (EMAP) (Protein S100-C) (S100 calcium-binding protein A11)S100a11 S100cP5054324
Vacuolar protein sorting-associated protein 37B (Vps37B) (ESCRT-I complex subunit VPS37B)Vps37bQ8R0J724
Vasodilator-stimulated phosphoprotein (VASP)VaspP7046024
Wiskott-Aldrich syndrome protein family member 2 (WASP family protein member 2) (Protein WAVE-2)Wasf2 Wave2Q8BH4324
116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)Eftud2 Snrp116O0881023
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC Cnp1P1633023
40S ribosomal protein S24Rps24P6284923
40S ribosomal protein S7Rps7P6208223
60S ribosomal protein L19Rpl19P8409923
60S ribosomal protein L32Rpl32P6291123
Actin, alpha skeletal muscle (Alpha-actin-1)Acta1 ActaP6813423
ADP-ribosylation factor-like protein 8B (ADP-ribosylation factor-like protein 10C) (Novel small G protein indispensable for equal chromosome segregation 1)Arl8b Arl10c Gie1Q9CQW223
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1)Aimp2 Jtv1Q8R01023
AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)Ap2a1 Adtaa Clapa1P1742623
Arrestin domain-containing protein 1Arrdc1Q99KN123
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) [Cleaved into: Endorepellin; LG3 peptide]Hspg2Q0579323
Catenin alpha-1 (102 kDa cadherin-associated protein) (Alpha E-catenin) (CAP102)Ctnna1 Catna1P2623123
Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Vacuolar protein sorting-associated protein 2) (mVps2)Chmp2aQ9DB3423
Coatomer subunit beta (Beta-coat protein) (Beta-COP)Copb1 CopbQ9JIF723
Cytosolic acyl coenzyme A thioester hydrolase (EC (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase)Acot7 BachQ91V1223
Deoxyribose-phosphate aldolase (DERA) (EC (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase)DeraQ91YP323
DNA topoisomerase 1 (EC (DNA topoisomerase I)Top1 Top-1Q0475023
E3 ubiquitin-protein ligase NEDD4 (EC (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)Nedd4 Kiaa0093 Nedd-4 Nedd4-1 Nedd4aP4693523
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D)Eif5aP6324223
Glutathione S-transferase Mu 1 (EC (GST 1-1) (GST class-mu 1) (Glutathione S-transferase GT8.7) (pmGT10)Gstm1P1064923
H-2 class I histocompatibility antigen, D-B alpha chain (H-2D(B))H2-D1P0189923
Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2)Hspa4 Apg2 Hsp110Q6131623
High mobility group protein B1 (High mobility group protein 1) (HMG-1)Hmgb1 Hmg-1 Hmg1P6315823
Histone H2AX (H2a/x) (Histone H2A.X)H2afx H2a.x H2ax Hist5-2axP2766123
Integrin alpha-V (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]ItgavP4340623
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)Itgb3O5489023
Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)Idh2P5407123
Myosin regulatory light chain 12B (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2)Myl12b Mrlc2 Mylc2bQ3THE223
Nucleolar protein 56 (Nucleolar protein 5A)Nop56 Nol5aQ9D6Z123
Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3)Plscr3Q9JIZ923
Probable ATP-dependent RNA helicase DDX5 (EC (DEAD box RNA helicase DEAD1) (mDEAD1) (DEAD box protein 5) (RNA helicase p68)Ddx5 Tnz2Q6165623
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC (Lysyl hydroxylase 3) (LH3)Plod3Q9R0E123
Protein tweety homolog 3 (mTTY3)Ttyh3 Kiaa1691Q6P5F723
S-formylglutathione hydrolase (FGH) (EC (Esterase 10) (Esterase D) (Sid 478)Esd Es10 Sid478Q9R0P323
Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (Sm-D autoantigen) (snRNP core protein D1)Snrpd1P6231523
Spliceosome RNA helicase Ddx39b (EC (56 kDa U2AF65-associated protein) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)Ddx39b Bat1 Bat1a Uap56Q9Z1N523
Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (Spliceosome-associated protein 130) (SAP 130)Sf3b3 Kiaa0017Q921M323
TAR DNA-binding protein 43 (TDP-43)Tardbp Tdp43Q921F223
Transaldolase (EC Tal TaldoQ9309223
Tryptophan--tRNA ligase, cytoplasmic (EC (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS]Wars WrsP3292123
Tyrosine-protein kinase Fyn (EC (Proto-oncogene c-Fyn) (p59-Fyn)FynP3968823
UTP--glucose-1-phosphate uridylyltransferase (EC (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase)Ugp2Q91ZJ523
Vacuolar protein sorting-associated protein 37C (ESCRT-I complex subunit VPS37C)Vps37cQ8R10523
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