EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)Smad4 Dpc4 Madh4P974715
Myelin basic protein (MBP) (Myelin A1 protein)Mbp ShiP043705
Myelin-associated neurite-outgrowth inhibitor (Mani)Fam168b Kiaa4042Q80XQ85
Myocyte enhancer factor 2D (Myocyte-specific enhancer factor 2D)Mef2d mCG_142619Q921S65
Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)Myh6 MyhcaQ025665
Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)Myh9Q8VDD55
Myotrophin (Granule cell differentiation protein) (Protein V-1)Mtpn GcdpP627745
N-acylneuraminate cytidylyltransferase (EC (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase)CmasQ99KK25
N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (Histone methyltransferase SMYD2) (EC (SET and MYND domain-containing protein 2)Smyd2Q8R5A05
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)Ndufs6 Ip13P525035
Nardilysin (EC (N-arginine dibasic convertase) (NRD convertase) (NRD-C)Nrd1Q8BHG15
Negative elongation factor B (NELF-B) (Cofactor of BRCA1)Nelfb Cobra1 MNCb-5210Q8C4Y35
NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) [Includes: Putative peptidyl-prolyl cis-trans isomerase (PPIase) (EC (Rotamase)]NktrP304155
NT-3 growth factor receptor (EC (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)Ntrk3 TrkCQ6VNS15
Nuclear migration protein nudC (Nuclear distribution protein C homolog) (Silica-induced gene 92 protein) (SIG-92)NudcO356855
Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133)Nup133Q8R0G95
Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC)NfycP703535
Nuclear transport factor 2 (NTF-2)Nutf2 Ntf2P619715
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (JC7)Nucks1 NucksQ80XU35
Nucleolysin TIAR (TIA-1-related protein)Tial1P703185
NudC domain-containing protein 1Nudcd1Q6PIP55
Olfactory receptor 168 (Olfactory receptor MOR271-1) (Olfactory receptor Olfr168) (Protein Olfr168)Olfr168Q8VF055
ORM1-like protein 3Ormdl3Q9CPZ65
Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)Osbpl9 Orp9A2A8Z15
Paired box protein Pax-3Pax3 Pax-3P246105
Pantothenate kinase 1 (mPank) (mPank1) (EC (Pantothenic acid kinase 1)Pank1 PankQ8K4K65
Pecanex-like protein 4Pcnxl4Q3UVY55
Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC (Cyclophilin C) (Rotamase C)Ppic CypcP304125
Period circadian protein homolog 3 (mPER3) (Circadian clock protein PERIOD 3)Per3O703615
Peroxisomal membrane protein PMP34 (34 kDa peroxisomal membrane protein) (Solute carrier family 25 member 17)Slc25a17 Pmp34 Pmp35O705795
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC (Polyamine oxidase)Paox PaoQ8C0L65
Peroxisome assembly factor 2 (PAF-2) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1)Pex6Q99LC95
PHD finger protein 14Phf14Q9D4H95
Phosphatidate cytidylyltransferase 2 (EC (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2)Cds2Q99L435
Phosphatidylinositol 4-kinase type 2-beta (EC (Phosphatidylinositol 4-kinase type II-beta)Pi4k2bQ8CBQ55
Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha)Pitpna PitpnP538105
Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta)PhkbQ7TSH25
Platelet-derived growth factor receptor-like protein (PDGFR-like protein)PdgfrlQ6PE555
Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (PH domain-containing adaptor PHAD47) (Tandem PH domain-containing protein 2) (TAPP-2)Plekha2 Tapp2Q9ERS55
Polyadenylate-binding protein-interacting protein 2B (PABP-interacting protein 2B) (PAIP-2B) (Poly(A)-binding protein-interacting protein 2B)Paip2b Kiaa1155Q91W455
Potassium channel erg1a (Potassium voltage-gated channel subfamily H member 2)Kcnh2Q53Z095
Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)Kcnq2 Kqt2Q9Z3515
PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4)Prdm4Q80V635
Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3)Pbx3O353175
Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog)Cwc22 NcmQ8C5N35
Prefoldin subunit 5 (C-Myc-binding protein Mm-1) (EIG-1) (Myc modulator 1)Pfdn5 Eig1 Mm1 Pfd5Q9WU285
Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1)Npepl1Q6NSR85
Probable E3 ubiquitin-protein ligase HERC4 (EC 6.3.2.-) (HECT domain and RCC1-like domain-containing protein 4)Herc4Q6PAV25
Probable folate receptor delta (FR-delta) (Folate receptor 4) (Folate-binding protein 3)Folr4 Folbp3Q9EQF45
Profilin-1 (Profilin I)Pfn1P629625
Profilin-2 (Profilin II)Pfn2Q9JJV25
Progressive ankylosis protein (Fn54 protein)Ankh AnkQ9JHZ25
Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor of estrogen receptor activity)Phb2 Bap Bcap37 ReaO351295
Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Rpn13 homolog)Adrm1 Gp110Q9JKV15
Proteasome subunit alpha type-3 (EC (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit K)Psma3O704355
Proteasome subunit alpha type-6 (EC (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain)Psma6Q9QUM95
Proteasome subunit beta type-10 (EC (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i)Psmb10 Lmp10 Mecl1O359555
Proteasome subunit beta type-4 (EC (Low molecular mass protein 3) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3)Psmb4 Lmp3P990265
Protein bicaudal D homolog 2 (Bic-D 2)Bicd2 Kiaa0699Q921C55
Protein C-ets-1 (p54)Ets1 Ets-1P275775
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (p140mDIA) (mDIA1)Diaph1 Diap1O088085
Protein disulfide-isomerase TMX3 (EC (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3)Tmx3 Kiaa1830 Txndc10Q8BXZ15
Protein DJ-1 (EC 3.4.-.-) (Parkinson disease protein 7 homolog)Park7Q99LX05
Protein Enpp7Enpp7D3Z6V65
Protein FAM126BFam126b D1Ertd53eQ8C7295
Protein FAM192A (NEFA-interacting nuclear protein NIP30)Fam192a Nip30Q91WE25
Protein FAM203A (Brain protein 16)Fam203a Brp16 MNCb-5873Q8C3I85
Protein FAM49BFam49bQ921M75
Protein FAM69AFam69aQ9D6I75
Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha) (mt-Fem)Fem1b F1aa Kiaa0396Q9Z2G05
Protein Ftsj1Ftsj1Q8CBC75
Protein Gm13212Gm13212E9PWQ25
Protein Gm14325Gm14325A2AW675
Protein jagunal homolog 1Jagn1Q5XKN45
Protein LLP homolog (Protein LAPS18-like)LlphQ9D9455
Protein MGARP (Corneal endothelium-specific protein 1) (CESP-1) (Hypoxia up-regulated mitochondrial movement regulator protein) (Mitochondria-localized glutamic acid-rich protein) (Ovary-specific acidic protein)Mgarp Cesp1 Hummr OsapQ8VI645
Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (Methyltransferase-like protein 21A)Mettl21A Fam119aQ9CQL05
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-)Pomgnt1Q91X885
Protein Olfr1206Olfr1206A2ATJ95
Protein phosphatase 1D (EC (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)Ppm1d Wip1Q9QZ675
Protein phosphatase 1M (EC (Protein phosphatase 2C isoform eta) (PP2C-eta) (PP2CE)Ppm1m Ppm1eQ8BU275
Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B)Prrc2b Bat2l Bat2l1 Kiaa0515Q7TPM15
Protein PRRC2C (BAT2 domain-containing protein 1) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)Prrc2c Bat2d Bat2d1 Bat2l2 Kiaa1096Q3TLH45
Protein Rab42 (Rab43) (Uncharacterized protein)Rab42 9530096D07Rik Rab42-ps Rab43Q0PD085
Protein Red (Cytokine IK) (IK factor) (Protein RER)Ik Red RerQ9Z1M85
Protein Rnpepl1Rnpepl1G5E8725
Protein SFI1 homologSfi1 Kiaa0542Q3UZY05
Protein Tob2 (Transducer of erbB-2 2)Tob2Q9JM555
Protein transport protein Sec61 subunit betaSec61bQ9CQS85
Protein YIPF5 (YIP1 family member 5) (YPT-interacting protein 1 A)Yipf5 Yip1aQ9EQQ25
Protein Ythdc1Ythdc1E9PW445
Protein Zfp955bZfp955bL7N2325
Purine nucleoside phosphorylase (PNP) (EC (Inosine phosphorylase) (Inosine-guanosine phosphorylase)Pnp Np Pnp1P234925
Putative adenosylhomocysteinase 3 (AdoHcyase 3) (EC (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2)Ahcyl2Q68FL45
Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2 (EC (RNA polymerase II-associated protein 2)Rpap2Q8VC345
Putative sodium-coupled neutral amino acid transporter 10 (Solute carrier family 38 member 10)Slc38a10Q5I0125
Putative uncharacterized proteinSpeer3Q9D4A35
Putative uncharacterized proteinGrik1Q3UZT15
Rab5 GDP/GTP exchange factor (Rabex-5)Rabgef1 Rabex5Q9JM135
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