EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Cytosolic acyl coenzyme A thioester hydrolase (EC (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (CTE-IIa) (CTE-II) (Long chain acyl-CoA thioester hydrolase)ACOT7 BACHO00154153
S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)MAT2A AMS2 MATA2P31153153
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]GART PGFT PRGSP22102153
Vesicular integral-membrane protein VIP36 (Glycoprotein GP36b) (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36)LMAN2 C5orf8Q12907153
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)AP2M1 CLAPM1 KIAA0109Q96CW1152
CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)CD276 B7H3 PSEC0249 UNQ309/PRO352Q5ZPR3152
E3 ubiquitin-protein ligase UBR4 (EC (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (RING-type E3 ubiquitin transferase UBR4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1)UBR4 KIAA0462 KIAA1307 RBAF600 ZUBR1Q5T4S7152
GTPase KRas (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]KRAS KRAS2 RASK2P01116152
Methionine--tRNA ligase, cytoplasmic (EC (Methionyl-tRNA synthetase) (MetRS)MARSP56192152
Probable ATP-dependent RNA helicase DDX17 (EC (DEAD box protein 17) (DEAD box protein p72) (DEAD box protein p82) (RNA-dependent helicase p72)DDX17Q92841152
Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1)EEF1A2 EEF1AL STNQ05639151
Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)EIF3I EIF3S2 TRIP1Q13347151
Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]HNRNPH1 HNRPH HNRPH1P31943151
Platelet-activating factor acetylhydrolase IB subunit beta (EC (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta)PAFAH1B2 PAFAHBP68402151
60S ribosomal protein L21 (Large ribosomal subunit protein eL21)RPL21P46778150
60S ribosomal protein L23a (Large ribosomal subunit protein uL23)RPL23AP62750150
Catalase (EC
Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)M6PR MPR46 MPRDP20645150
Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31)ERP29 C12orf8 ERP28P30040150
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1)PARP1 ADPRT PPOLP09874150
Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD)STRAP MAWD UNRIPQ9Y3F4150
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC (Replication protein C) (RP-C)PPP2CAP67775150
Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa)MYO1BO43795150
Arrestin domain-containing protein 1ARRDC1Q8N5I2149
Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48)EIF3E EIF3S6 INT6P60228149
Heterogeneous nuclear ribonucleoprotein R (hnRNP R)HNRNPR HNRPRO43390149
Immunoglobulin kappa constant (Ig kappa chain C region) (Ig kappa chain C region AG) (Ig kappa chain C region CUM) (Ig kappa chain C region EU) (Ig kappa chain C region OU) (Ig kappa chain C region ROY) (Ig kappa chain C region TI)IGKCP01834149
POTE ankyrin domain family member E (ANKRD26-like family C member 1A) (Prostate, ovary, testis-expressed protein on chromosome 2) (POTE-2)POTEE A26C1A POTE2Q6S8J3149
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II)PACSIN2Q9UNF0149
Tyrosine-protein kinase Yes (EC (Proto-oncogene c-Yes) (p61-Yes)YES1 YESP07947149
Ubiquitin carboxyl-terminal hydrolase 14 (EC (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)USP14 TGTP54578149
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)SEC22B SEC22L1O75396149
ATP-binding cassette sub-family E member 1 (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40P61221148
CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109)CD109 CPAMD7Q6YHK3148
Collagen alpha-3(VI) chainCOL6A3P12111148
Dynamin-2 (EC DYN2P50570148
Histone H2AX (H2a/x) (Histone H2A.X)H2AFX H2AXP16104148
Integrin beta-5ITGB5P18084148
Leucine--tRNA ligase, cytoplasmic (EC (Leucyl-tRNA synthetase) (LeuRS)LARS KIAA1352Q9P2J5148
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)SFPQ PSFP23246148
Adipocyte plasma membrane-associated protein (Protein BSCv)APMAP C20orf3 UNQ1869/PRO4305Q9HDC9147
Lysozyme C (EC (1,4-beta-N-acetylmuramidase C)LYZ LZMP61626147
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)SNRPD3P62318147
10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF)HSPE1P61604146
40S ribosomal protein S17 (Small ribosomal subunit protein eS17)RPS17 RPS17LP08708146
Creatine kinase B-type (EC (B-CK) (Creatine kinase B chain)CKB CKBBP12277146
Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]HPP00738146
Lysine--tRNA ligase (EC (Lysyl-tRNA synthetase) (LysRS)KARS KIAA0070Q15046146
Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2)NAP1L4 NAP2Q99733146
Proliferating cell nuclear antigen (PCNA) (Cyclin)PCNAP12004146
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]LRP1 A2MR APRQ07954146
Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)TNPO1 KPNB2 MIP1 TRNQ92973146
Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3)APOC3P02656145
CD97 antigen (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: CD97 antigen subunit alpha; CD97 antigen subunit beta]CD97P48960145
Junctional adhesion molecule A (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet F11 receptor) (Platelet adhesion molecule 1) (PAM-1) (CD antigen CD321)F11R JAM1 JCAM UNQ264/PRO301Q9Y624145
Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)FKBP1A FKBP1 FKBP12P62942145
Protein NDRG1 (Differentiation-related gene 1 protein) (DRG-1) (N-myc downstream-regulated gene 1 protein) (Nickel-specific induction protein Cap43) (Reducing agents and tunicamycin-responsive protein) (RTP) (Rit42)NDRG1 CAP43 DRG1 RTPQ92597145
Acylamino-acid-releasing enzyme (AARE) (EC (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH)APEH D3F15S2 D3S48E DNF15S2P13798144
cAMP-dependent protein kinase type II-alpha regulatory subunitPRKAR2A PKR2 PRKAR2P13861144
Dynamin-1-like protein (EC (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)DNM1L DLP1 DRP1O00429144
Glutamine--tRNA ligase (EC (Glutaminyl-tRNA synthetase) (GlnRS)QARSP47897144
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)HIST1H3A H3FA; HIST1H3B H3FL; HIST1H3C H3FC; HIST1H3D H3FB; HIST1H3E H3FD; HIST1H3F H3FI; HIST1H3G H3FH; HIST1H3H H3FK; HIST1H3I H3FF; HIST1H3J H3FJP68431144
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]CDC37 CDC37AQ16543144
Myelin protein zero-like protein 1 (Protein zero-related)MPZL1 PZR UNQ849/PRO1787O95297144
Thioredoxin reductase 1, cytoplasmic (TR) (EC (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Thioredoxin reductase TR1)TXNRD1 GRIM12 KDRFQ16881144
tRNA-splicing ligase RtcB homolog (EC C22orf28 HSPC117Q9Y3I0144
26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B)PSMD5 KIAA0072Q16401143
Antithrombin-III (ATIII) (Serpin C1)SERPINC1 AT3 PRO0309P01008143
Calpain-2 catalytic subunit (EC (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)CAPN2 CANPL2P17655143
Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain]C5 CPAMD4P01031143
Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC (Red cell acid phosphatase 1)ACP1P24666143
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (DDAH-2) (Dimethylarginine dimethylaminohydrolase 2) (EC (DDAHII) (Dimethylargininase-2) (Protein G6a) (S-phase protein)DDAH2 DDAH G6A NG30O95865143
Plasminogen (EC [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]PLGP00747143
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase)PCMT1P22061143
Ras suppressor protein 1 (RSP-1) (Rsu-1)RSU1 RSP1Q15404143
Alcohol dehydrogenase class-3 (EC (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC ADHX FDHP11766142
Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1)EIF3M HFLB5 PCID1 GA17 PNAS-125Q7L2H7142
Gamma-enolase (EC (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE)ENO2P09104142
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)HIST1H2BC H2BFL; HIST1H2BE H2BFH; HIST1H2BF H2BFG; HIST1H2BG H2BFA; HIST1H2BI H2BFKP62807142
Probable ATP-dependent RNA helicase DDX5 (EC (DEAD box protein 5) (RNA helicase p68)DDX5 G17P1 HELR HLR1P17844142
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)PPP2R2AP63151142
Sialic acid synthase (N-acetylneuraminate synthase) (EC (N-acetylneuraminate-9-phosphate synthase) (EC (N-acetylneuraminic acid phosphate synthase) (N-acetylneuraminic acid synthase)NANS SASQ9NR45142
Spliceosome RNA helicase DDX39B (EC (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)DDX39B BAT1 UAP56Q13838142
Adenylate kinase isoenzyme 1 (AK 1) (EC (EC (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase)AK1P00568141
Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein)CACYBP S100A6BP SIP PNAS-107Q9HB71141
Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20)CHMP6 VPS20Q96FZ7141
Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP)ARCN1 COPDP48444141
Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)ETF1 ERF1 RF1 SUP45L1P62495141
Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)ESYT1 FAM62A KIAA0747 MBC2Q9BSJ8141
Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10)KRT6B K6B KRTL1P04259141
Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)MAPRE1Q15691141
Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3)SLC16A3 MCT4O15427141
Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6)PZP CPAMD6P20742141
Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC (Glycine hydroxymethyltransferase) (Serine methylase)SHMT2P34897141
Synaptophysin-like protein 1 (Pantophysin)SYPL1 SYPLQ16563141
Aspartate aminotransferase, cytoplasmic (cAspAT) (EC (EC (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)GOT1P17174140
Ephrin type-A receptor 2 (EC (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)EPHA2 ECKP29317140
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)GRB2 ASHP62993140
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