EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Citrate synthase, mitochondrial (EC (Citrate (Si)-synthase)CsQ9CZU638
Glutathione S-transferase P 1 (Gst P1) (EC (GST YF-YF) (GST class-pi) (GST-piB) (Preadipocyte growth factor)Gstp1 GstpibP1915738
Proteasome subunit alpha type-4 (EC (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)Psma4Q9R1P038
Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-)Vat1 Vat-1Q6246538
Transketolase (TK) (EC (P68)TktP4014238
Vinculin (Metavinculin)VclQ6472738
14-3-3 protein etaYwhahP6851037
40S ribosomal protein S16Rps16P1413137
60S ribosomal protein L7Rpl7P1414837
Annexin A11 (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50)Anxa11 Anx11P9738437
Basigin (Basic immunoglobulin superfamily) (HT7 antigen) (Membrane glycoprotein gp42) (CD antigen CD147)BsgP1857237
Fructose-bisphosphate aldolase A (EC (Aldolase 1) (Muscle-type aldolase)Aldoa Aldo1P0506437
Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1)Pcbp1P6033537
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)Pabpc1 Pabp1P2934137
Proteasome subunit beta type-1 (EC (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain)Psmb1O0906137
26S protease regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)Psmc6 Sug2P6233436
40S ribosomal protein S11Rps11P6228136
40S ribosomal protein S18 (Ke-3) (Ke3)Rps18P6227036
60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107)Rpl6P4791136
Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)Arpc4 Arc20P5999936
Actin-related protein 3 (Actin-like protein 3)Actr3 Arp3Q99JY936
Adenylyl cyclase-associated protein 1 (CAP 1)Cap1 CapP4012436
Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70)Anxa6 Anx6P1482436
Bifunctional purine biosynthesis protein PURH [Cleaved into: Bifunctional purine biosynthesis protein PURH, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); IMP cyclohydrolase (EC (ATIC) (IMP synthase) (Inosinicase)]Atic PurhQ9CWJ936
Glucose-6-phosphate isomerase (GPI) (EC (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)Gpi Gpi1P0674536
Major vault protein (MVP)MvpQ9EQK536
Malate dehydrogenase, cytoplasmic (EC (Cytosolic malate dehydrogenase)Mdh1 Mor2P1415236
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]Lrp1 A2mrQ91ZX736
Ras-related C3 botulinum toxin substrate 1 (p21-Rac1)Rac1P6300136
Ras-related protein Rab-10Rab10P6102736
Ras-related protein Rab-11BRab11bP4663836
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)Myo1cQ9WTI736
Valine--tRNA ligase (EC (Protein G7a) (Valyl-tRNA synthetase) (ValRS)Vars Bat6 G7a Vars2Q9Z1Q936
40S ribosomal protein S9Rps9Q6ZWN535
6-phosphogluconate dehydrogenase, decarboxylating (EC
Actin-related protein 2 (Actin-like protein 2)Actr2 Arp2P6116135
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)Actr1a Ctrn1P6116435
Aspartate--tRNA ligase, cytoplasmic (EC (Aspartyl-tRNA synthetase) (AspRS)DarsQ922B235
ATP synthase subunit alpha, mitochondrialAtp5a1Q0326535
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (CD antigen CD81)Cd81 Tapa1P3576235
Dihydropyrimidinase-related protein 2 (DRP-2) (Unc-33-like phosphoprotein 2) (ULIP-2)Dpysl2 Crmp2 Ulip2O0855335
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Centrosomin) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (p162)Eif3a Csma Eif3 Eif3s10P2311635
Ferritin heavy chain (Ferritin H subunit) (EC [Cleaved into: Ferritin heavy chain, N-terminally processed]Fth1 FthP0952835
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)Flna Fln Fln1Q8BTM835
Galectin-3-binding protein (Cyp-C-associated protein) (CyCAP) (Lectin galactoside-binding soluble 3-binding protein) (Protein MAMA)Lgals3bp Cycap MamaQ0779735
Guanine nucleotide-binding protein G(k) subunit alpha (G(i) alpha-3)Gnai3Q9DC5135
Nucleolin (Protein C23)Ncl NucP0940535
Poly(rC)-binding protein 2 (Alpha-CP2) (CTBP) (CBP) (Putative heterogeneous nuclear ribonucleoprotein X) (hnRNP X)Pcbp2 Cbp Hnrnpx HnrpxQ6199035
Radixin (ESP10)RdxP2604335
Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (CD antigen CD71)Tfrc TrfrQ6235135
26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)Psmd11Q8BG3234
26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) (Transplantation antigen P91A) (Tum-P91A antigen)Psmd3 P91a Tstap91aP1468534
60S acidic ribosomal protein P2Rplp2P9902734
60S ribosomal protein L4Rpl4Q9D8E634
Aldehyde dehydrogenase, mitochondrial (EC (AHD-M1) (ALDH class 2) (ALDH-E2) (ALDHI)Aldh2 Ahd-1 Ahd1P4773834
DnaJ homolog subfamily A member 2 (mDj3)Dnaja2Q9QYJ034
Histone H1.5 (H1 VAR.5) (H1b)Hist1h1b H1f5P4327634
Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (Lysosomal membrane glycoprotein type B) (LGP-B) (CD antigen CD107b)Lamp2 Lamp-2P1704734
Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1)Slc16a1 Mct1P5398634
Programmed cell death protein 6 (ALG-257) (Apoptosis-linked gene 2 protein) (ALG-2) (PMP41)Pdcd6 Alg2P1281534
Proteasome subunit alpha type-6Psma6Q9QUM934
Proteasome subunit alpha type-6 (EC (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain)Psma6Q9QUM934
Proteasome subunit alpha type-7 (EC (Proteasome subunit RC6-1)Psma7Q9Z2U034
Vacuolar protein sorting-associated protein 35 (Maternal-embryonic 3) (Vesicle protein sorting 35)Vps35 Mem3Q9EQH334
26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5)Psmd13Q9WVJ233
40S ribosomal protein S14Rps14P6226433
40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3)Rps2 Llrep3 Rps4P2544433
40S ribosomal protein S26Rps26P6285533
40S ribosomal protein S6 (Phosphoprotein NP33)Rps6P6275433
60S ribosomal protein L13 (A52)Rpl13P4796333
60S ribosomal protein L30Rpl30P6288933
60S ribosomal protein L5Rpl5P4796233
Aldose reductase (AR) (EC (Aldehyde reductase)Akr1b1 Akr1b3 Aldor1 Aldr1P4537633
Beta-actin-like protein 2 (Kappa-actin)Actbl2Q8BFZ333
Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC (Prolyl-tRNA synthetase) (ProRS)]Eprs QprsQ8CGC733
Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP)CalrP1421133
Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b)Chmp4bQ9D8B333
Copine-3 (Copine III)Cpne3 Kiaa0636Q8BT6033
Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1)Cyfip1 Kiaa0068 Shyc Sra1Q7TMB833
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)Adam10 Kuz MadmO3559833
DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2)Dnaja1 Dnaj2 Hsj2 Hspf4P6303733
EH domain-containing protein 4 (PAST homolog 2) (mPAST2)Ehd4 Past2Q9EQP233
Glycine--tRNA ligase (EC (EC (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS)GarsQ9CZD333
Pregnancy zone protein (Alpha-2-macroglobulin) (Alpha-2-M) [Cleaved into: Alpha-2-macroglobulin 165 kDa subunit; Alpha-2-macroglobulin 35 kDa subunit]Pzp A2mQ6183833
Proteasome subunit alpha type-1 (EC (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)Psma1Q9R1P433
Proteasome subunit beta type-6 (EC (Low molecular mass protein 19) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y)Psmb6 Lmp19Q6069233
Protein disulfide-isomerase (PDI) (EC (Cellular thyroid hormone-binding protein) (Endoplasmic reticulum resident protein 59) (ER protein 59) (ERp59) (Prolyl 4-hydroxylase subunit beta) (p55)P4hb Pdia1P0910333
Ras-related protein Rab-5CRab5cP3527833
Rho-related GTP-binding protein RhoG (Sid 10750)Rhog Arhg Sid10750P8409633
Tubulin alpha-4A chain (Alpha-tubulin 4) (Alpha-tubulin isotype M-alpha-4) (Tubulin alpha-4 chain)Tuba4a Tuba4P6836833
26S protease regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1)Psmc5 Sug1P6219632
40S ribosomal protein S3a (Protein TU-11)Rps3a Rps3a1P9735132
60 kDa heat shock protein, mitochondrial (EC (60 kDa chaperonin) (Chaperonin 60) (CPN60) (HSP-65) (Heat shock protein 60) (HSP-60) (Hsp60) (Mitochondrial matrix protein P1)Hspd1 Hsp60P6303832
60S ribosomal protein L14Rpl14Q9CR5732
60S ribosomal protein L18Rpl18P3598032
Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)Arpc2Q9CVB632
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)Napa SnapaQ9DB0532
Cathepsin B (EC (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]CtsbP1060532
Erythrocyte band 7 integral membrane protein (Protein 7.2b) (Stomatin)Stom Epb7.2 Epb72P5411632
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