EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Alpha-enolase (EC (2-phospho-D-glycerate hydro-lyase) (Enolase 1) (Non-neural enolase) (NNE)Eno1 Eno-1P1718263
Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8)Hspa8 Hsc70 Hsc73P6301762
Pyruvate kinase PKM (EC (Pyruvate kinase muscle isozyme)Pkm Pk3 Pkm2 PykmP5248062
Phosphoglycerate kinase 1 (EC Pgk-1P0941159
Tubulin beta-5 chainTubb5P9902459
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)Gapdh GapdP1685857
Transitional endoplasmic reticulum ATPase (TER ATPase) (EC (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)VcpQ0185357
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (SEZ-2)YwhazP6310156
Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84) (Tumor-specific transplantation 84 kDa antigen) (TSTA)Hsp90ab1 Hsp84 Hsp84-1 HspcbP1149956
Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CBP-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha)Anxa5 Anx5P4803655
Elongation factor 2 (EF-2)Eef2P5825255
Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Tumor-specific transplantation 86 kDa antigen) (TSTA)Hsp90aa1 Hsp86 Hsp86-1 HspcaP0790155
Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)Anxa2 Anx2 Cal1hP0735654
Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1)Eef1a1 Eef1aP1012654
Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)Myh9Q8VDD554
Moesin (Membrane-organizing extension spike protein)MsnP2604153
14-3-3 protein beta/alpha (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]YwhabQ9CQV851
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) (SP18) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]PpiaP1774251
Histone H4Hist1h4a; Hist1h4b H4-53; Hist1h4c H4-12; Hist1h4d; Hist1h4f; Hist1h4h; Hist1h4i; Hist1h4j; Hist1h4k; Hist1h4m; Hist2h4a Hist2h4; Hist4h4P6280650
Serum albuminAlb Alb-1 Alb1P0772450
Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC (Sodium pump subunit alpha-1)Atp1a1Q8VDN250
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta)Cct2 CctbP8031450
Talin-1Tln1 TlnP2603950
40S ribosomal protein S3 (EC
Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]ActbP6071049
Rab GDP dissociation inhibitor beta (Rab GDI beta) (GDI-3) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)Gdi2 Gdi3Q6159849
78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)Hspa5 Grp78P2002948
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)Gnai2 Gnai-2P0875248
Programmed cell death 6-interacting protein (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (E2F1-inducible protein) (Eig2)Pdcd6ip Aip1 AlixQ9WU7848
T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (Tailless complex polypeptide 1A) (TCP-1-A) (Tailless complex polypeptide 1B) (TCP-1-B)Tcp1 Cct1 CctaP1198348
T-complex protein 1 subunit delta (TCP-1-delta) (A45) (CCT-delta)Cct4 CctdP8031548
Triosephosphate isomerase (TIM) (EC (Triose-phosphate isomerase)Tpi1 TpiP1775148
Fatty acid synthase (EC [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC; [Acyl-carrier-protein] S-malonyltransferase (EC; 3-oxoacyl-[acyl-carrier-protein] synthase (EC; 3-oxoacyl-[acyl-carrier-protein] reductase (EC; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC; Enoyl-[acyl-carrier-protein] reductase (EC; Oleoyl-[acyl-carrier-protein] hydrolase (EC]FasnP1909647
Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29)Itgb1P0905547
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon)Cct5 Ccte Kiaa0098P8031647
T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta)Cct8 CctqP4293247
14-3-3 protein epsilon (14-3-3E)YwhaeP6225946
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]YwhagP6198246
Clathrin heavy chain 1CltcQ68FD546
Gelsolin (Actin-depolymerizing factor) (ADF) (Brevin)Gsn GsbP1302046
L-lactate dehydrogenase A chain (LDH-A) (EC (LDH muscle subunit) (LDH-M)Ldha Ldh-1 Ldh1P0615146
Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) (Sperm surface protein SP47) (MP47)Mfge8P2195646
Peroxiredoxin-1 (EC (Macrophage 23 kDa stress protein) (Osteoblast-specific factor 3) (OSF-3) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2)Prdx1 Msp23 Paga Tdpx2P3570046
Ras-related protein Rab-7aRab7a Rab7P5115046
Tubulin beta-4B chain (Tubulin beta-2C chain)Tubb4b Tubb2cP6837246
Ubiquitin-like modifier-activating enzyme 1 (EC (Ubiquitin-activating enzyme E1) (Ubiquitin-activating enzyme E1 X) (Ubiquitin-like modifier-activating enzyme 1 X)Uba1 Sbx Ube1 Ube1ax Ube1xQ0205346
40S ribosomal protein S8Rps8P6224245
Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35)Anxa1 Anx1 Lpc-1 Lpc1P1010745
Cell division control protein 42 homolog (G25K GTP-binding protein)Cdc42P6076645
Chloride intracellular channel protein 1 (Nuclear chloride ion channel 27) (NCC27)Clic1Q9Z1Q545
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC (ATP-dependent RNA helicase eIF4A-1)Eif4a1 Ddx2a Eif4aP6084345
Fibronectin (FN) [Cleaved into: Anastellin]Fn1P1127645
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)Gnb1P6287445
Phosphoglycerate mutase 1 (EC (EC (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B)Pgam1Q9DBJ145
Ras-related protein Rap-1b (GTP-binding protein smg p21B)Rap1bQ99JI645
Receptor of activated protein C kinase 1 (12-3) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein kinase C 1) (p205) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]Rack1 Gnb2-rs1 Gnb2l1P6804045
ATP synthase subunit beta, mitochondrial (EC
Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)Dync1h1 Dhc1 Dnch1 Dnchc1 DyhcQ9JHU444
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)Ppp2r1aQ76MZ344
T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Matricin) (mTRiC-P5)Cct3 CctgP8031844
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97)Psmd2Q8VDM443
4F2 cell-surface antigen heavy chain (4F2hc) (Solute carrier family 3 member 2) (CD antigen CD98)Slc3a2 Mdu1P1085243
Cofilin-1 (Cofilin, non-muscle isoform)Cfl1P1876043
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Endoplasmic reticulum resident protein 99) (ERp99) (Heat shock protein 90 kDa beta member 1) (Polymorphic tumor rejection antigen 1) (Tumor rejection antigen gp96)Hsp90b1 Grp94 Tra-1 Tra1P0811343
GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)Ran Rasl2-8P6282743
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2)Gnb2P6288043
Importin subunit beta-1 (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG)Kpnb1 ImpnbP7016843
Profilin-1 (Profilin I)Pfn1P6296243
Syntenin-1 (Scaffold protein Pbp1) (Syndecan-binding protein 1)SdcbpO0899243
40S ribosomal protein S4, X isoformRps4x Rps4P6270242
60S acidic ribosomal protein P0 (60S ribosomal protein L10E)Rplp0 ArbpP1486942
CD9 antigen (CD antigen CD9)Cd9P4024042
D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC (A10)PhgdhQ6175342
Histone H1.2 (H1 VAR.1) (H1c)Hist1h1c H1f2P1586442
Histone H1.4 (H1 VAR.2) (H1e)Hist1h1e H1f4P4327442
Peroxiredoxin-2 (EC (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1)Prdx2 Tdpx1 TpxQ6117142
Ras GTPase-activating-like protein IQGAP1Iqgap1Q9JKF142
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (GDI-1) (Rho-GDI alpha)Arhgdia C87222 Gdi1Q99PT142
14-3-3 protein theta (14-3-3 protein tau)YwhaqP6825441
Complement C3 (HSE-MSF) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]C3P0102741
Ezrin (Cytovillin) (Villin-2) (p81)Ezr Vil2P2604041
Malate dehydrogenase, mitochondrial (EC Mor1P0824941
T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]Cct7 CcthP8031341
Alpha-actinin-4 (Non-muscle alpha-actinin 4)Actn4P5778040
Protein disulfide-isomerase A3 (EC (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)Pdia3 Erp Erp60 Grp58P2777340
Transforming protein RhoARhoa Arha Arha2Q9QUI040
Adenosylhomocysteinase (AdoHcyase) (EC (CUBP) (Liver copper-binding protein) (S-adenosyl-L-homocysteine hydrolase)AhcyP5024739
Annexin A4 (Annexin IV) (Annexin-4)Anxa4 Anx4P9742939
Annexin A7 (Annexin VII) (Annexin-7) (Synexin)Anxa7 Anx7Q0707639
EH domain-containing protein 1 (PAST homolog 1) (mPAST1)Ehd1 Past1Q9WVK439
Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)Eef1gQ9D8N039
Galectin-1 (Gal-1) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (S-Lac lectin 1)Lgals1 GbpP1604539
Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)Myl6 MylnQ6060539
Ras-related protein Rab-14Rab14Q91V4139
T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta-1)Cct6a Cct6 Cctz Cctz1P8031739
Tubulin alpha-1A chain (Alpha-tubulin 1) (Alpha-tubulin isotype M-alpha-1) (Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]Tuba1a Tuba1P6836939
V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha)Atp6v1a Atp6a1 Atp6a2 Atp6v1a1P5051639
V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 2)Atp6v1b2 Atp6b2 Vat2P6281439
40S ribosomal protein SA (37 kDa laminin receptor precursor) (37LRP) (37 kDa oncofetal antigen) (37/67 kDa laminin receptor) (LRP/LR) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (OFA/iLRP)Rpsa Lamr1 P40-8P1420638
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