EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Cytosol aminopeptidase (EC (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Proline aminopeptidase) (EC (Prolyl aminopeptidase)Lap3 LapepQ9CPY728
EH domain-containing protein 2Ehd2Q8BH6428
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha)Eif2s1 Eif2aQ6ZWX628
Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (eIF-3-eta) (eIF3 p116)Eif3b Eif3s9Q8JZQ928
Glycogen phosphorylase, brain form (EC
Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)GnaqP2127928
Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 3) (HSP70.3) (Hsp68)Hspa1a Hsp70-3 Hsp70A1Q6169628
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)Hba Hba-a1P0194228
Histone H2A.Z (H2A/z)H2afz H2azP0C0S628
Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]Itga5P1168828
Keratin, type I cytoskeletal 10 (56 kDa cytokeratin) (Cytokeratin-10) (CK-10) (Keratin, type I cytoskeletal 59 kDa) (Keratin-10) (K10)Krt10 Krt1-10P0253528
L-lactate dehydrogenase B chain (LDH-B) (EC (LDH heart subunit) (LDH-H)Ldhb Ldh-2 Ldh2P1612528
Macrophage migration inhibitory factor (MIF) (EC (Delayed early response protein 6) (DER6) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC (Phenylpyruvate tautomerase)MifP3488428
Neutral alpha-glucosidase AB (EC (Alpha-glucosidase 2) (Glucosidase II subunit alpha)Ganab G2an Kiaa0088Q8BHN328
Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Transplantability-associated protein 1) (NOR1) (TRA1)Plscr1 Tra1b Tras1Q9JJ0028
Phosphoserine aminotransferase (PSAT) (EC (Endometrial progesterone-induced protein) (EPIP) (Phosphohydroxythreonine aminotransferase)Psat1 Psa PsatQ99K8528
Plastin-2 (65 kDa macrophage protein) (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (pp65)Lcp1 Pls2Q6123328
Proteasome subunit beta type-5 (EC (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit X)Psmb5O5523428
Ras-related protein Rab-1A (YPT1-related protein)Rab1A Rab1P6282128
Ras-related protein Rab-35Rab35Q6PHN928
Ras-related protein Rap-1A (Ras-related protein Krev-1)Rap1a Krev-1P6283528
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Protein X16) (Splicing factor, arginine/serine-rich 3)Srsf3 Sfrs3 Srp20 X16P8410428
Sodium-coupled neutral amino acid transporter 2 (Amino acid transporter A2) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2)Slc38a2 Ata2 Kiaa1382 Sat2 Snat2Q8CFE628
Superoxide dismutase [Cu-Zn] (EC
Thrombospondin-1Thbs1 Tsp1P3544128
Translationally-controlled tumor protein (TCTP) (21 kDa polypeptide) (p21) (p23)Tpt1 TrtP6302828
Tubulin alpha-1C chain (Alpha-tubulin 6) (Alpha-tubulin isotype M-alpha-6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]Tuba1c Tuba6P6837328
26S protease regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (CIP21) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)Psmc4 Tbp7P5477527
40S ribosomal protein S20Rps20P6086727
60S ribosomal protein L15Rpl15Q9CZM227
60S ribosomal protein L3 (J1 protein)Rpl3P2765927
Aconitate hydratase, mitochondrial (Aconitase) (EC (Citrate hydro-lyase)Aco2Q99KI027
Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)Arpc1bQ9WV3227
ADP-ribosylation factor 3Arf3P6120527
Alanine--tRNA ligase, cytoplasmic (EC (Alanyl-tRNA synthetase) (AlaRS)AarsQ8BGQ727
Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)Anxa3 Anx3O3563927
Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)M6pr 46mprP2466827
CD63 antigen (CD antigen CD63)Cd63P4173127
Copine-1 (Copine I)Cpne1Q8C16627
Creatine kinase B-type (EC (B-CK) (Creatine kinase B chain)Ckb CkbbQ0444727
Disco-interacting protein 2 homolog B (DIP2 homolog B)Dip2b Kiaa1463Q3UH6027
Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66)Eif3d Eif3s7O7019427
Histone H2A type 2-A (H2a-614) (H2a-615) (Histone H2A.2)Hist2h2aa1; Hist2h2aa2Q6GSS727
Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7)Ipo7 Ranbp7Q9EPL827
Leucine--tRNA ligase, cytoplasmic (EC (Leucyl-tRNA synthetase) (LeuRS)LarsQ8BMJ227
Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC (Oxytocinase) (OTase)LnpepQ8C12927
Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC (AIR carboxylase) (AIRC)]PaicsQ9DCL927
Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)PpibP2436927
Proliferation-associated protein 2G4 (IRES-specific cellular trans-acting factor 45 kDa) (ITAF45) (Mpp1) (Proliferation-associated protein 1) (Protein p38-2G4)Pa2g4 Ebp1 PlfapP5058027
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II)Pacsin2Q9WVE827
Ras-related protein Rab-5ARab5a nnyRab5aQ9CQD127
Ras-related protein Rap-2bRap2bP6122627
Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein)Rtn4 Kiaa0886 NogoQ99P7227
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Embryonic liver fodrin) (Fodrin beta chain)Sptbn1 Elf Spnb-2 Spnb2 Sptb2Q6226127
Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (Transmembrane protein Tmp21) (p24 family protein delta-1) (p24delta1)Tmed10 Tmp21Q9D1D427
Ubiquitin carboxyl-terminal hydrolase 5 (EC (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)Usp5 IsotP5639927
V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (P39) (Physophilin) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (Vacuolar proton pump subunit d 1)Atp6v0d1 Atp6dP5186327
V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1)Atp6v1e1 Atp6e Atp6e2P5051827
26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (MAD1)Psmd14 Pad1O3559326
26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B)Psmd5 Kiaa0072Q8BJY126
40S ribosomal protein S19Rps19Q9CZX826
60S ribosomal protein L11Rpl11Q9CXW426
60S ribosomal protein L13a (Transplantation antigen P198) (Tum-P198 antigen)Rpl13a P198 Tstap198-7P1925326
60S ribosomal protein L24Rpl24Q8BP6726
Adenine phosphoribosyltransferase (APRT) (EC
ADP-ribosylation factor 4Arf4P6175026
ADP-ribosylation factor 5Arf5P8408426
Aminopeptidase N (AP-N) (mAPN) (EC (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Membrane protein p161) (Microsomal aminopeptidase) (CD antigen CD13)Anpep Lap-1 Lap1P9744926
Apolipoprotein E (Apo-E)ApoeP0822626
ATP-dependent RNA helicase A (RHA) (EC (DEAH box protein 9) (mHEL-5) (Nuclear DNA helicase II) (NDH II)Dhx9 Ddx9O7013326
Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)Igf2rQ0711326
Choline transporter-like protein 2 (Solute carrier family 44 member 2)Slc44a2 Ctl2Q8BY8926
Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)Copg1 CopgQ9QZE526
Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)Slc29a1 Ent1Q9JIM126
Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC ((2E,6E)-farnesyl diphosphate synthase) (Cholesterol-regulated 39 kDa protein) (CR 39) (Dimethylallyltranstransferase) (EC (Farnesyl diphosphate synthase) (Geranyltranstransferase)FdpsQ920E526
Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog)St13 Fam10a1 HipQ99L4726
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]Cdc37Q6108126
Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)Ipo5 Kpnb3 Ranbp5Q8BKC526
Integrin-linked protein kinase (EC
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)Idh1O8884426
Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Keratin-6-alpha) (mK6-alpha) (Keratin-6A) (K6A)Krt6a Ker2 Krt2-6 Krt2-6a Krt6P5044626
Niban-like protein 1 (Protein FAM129B)Fam129bQ8R1F126
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC (Metastasis inhibition factor NM23) (NDPK-A) (Tumor metastatic process-associated protein) (nm23-M1)Nme1 Nm23P1553226
Protein disulfide-isomerase A6 (EC (Thioredoxin domain-containing protein 7)Pdia6 Txndc7Q922R826
Protein Niban (Protein FAM129A)Fam129a NibanQ3UW5326
Ras-related protein Rab-8A (Oncogene c-mel)Rab8a Mel Rab8P5525826
Ras-related protein Ral-ARala Ral Ral-aP6332126
Ras-related protein Ral-BRalbQ9JIW926
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC (EC
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)Snrpd3P6232026
Splicing factor, proline- and glutamine-rich (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)Sfpq PsfQ8VIJ626
Transgelin-2 (SM22-beta)Tagln2 Kiaa0120Q9WVA426
tRNA-splicing ligase RtcB homolog (EC (Focal adhesion-associated protein) (FAAP)Rtcb D10Wsu52eQ99LF426
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3)Tpm3 Tpm-5 Tpm5P2110726
Tubulin alpha-1B chain (Alpha-tubulin 2) (Alpha-tubulin isotype M-alpha-2) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain]Tuba1b Tuba2P0521326
Tubulin beta-6 chainTubb6Q922F426
40S ribosomal protein S10Rps10P6332525
40S ribosomal protein S13Rps13P6230125
40S ribosomal protein S15aRps15aP6224525
60S ribosomal protein L23Rpl23P6283025
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