EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Cystatin-C (Cystatin-3)Cst3P2146016
Cytochrome c oxidase subunit 2 (Cytochrome c oxidase polypeptide II)Mtco2 COII mt-Co2P0040516
DNA topoisomerase 2-alpha (EC (DNA topoisomerase II, alpha isozyme)Top2a Top-2 Top2Q0132016
DnaJ homolog subfamily C member 7 (Cytoplasmic CAR retention protein) (CCRP) (MDj11) (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)Dnajc7 Ttc2Q9QYI316
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)Map2k1 Mek1 Prkmk1P3193816
Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2)Elob Tceb2P6286916
Embigin (Teratocarcinoma glycoprotein Gp-70)Emb Gp70P2199516
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit)Eif4eP6307316
FERM, RhoGEF and pleckstrin domain-containing protein 1Farp1F8VPU216
Filamin-C (FLN-C) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)Flnc Abpl Fln2Q8VHX616
Glycogen phosphorylase, liver form (EC
Glycogenin-1 (GN-1) (GN1) (EC GygQ9R06216
Heterochromatin protein 1-binding protein 3Hp1bp3Q3TEA816
Histone H2A type 1-HHist1h2ahQ8CGP616
Histone H2A type 2-C (H2a-613B)Hist2h2ac Hist2h2abQ6452316
Histone H2A.V (H2A.F/Z)H2afv H2avQ3THW516
Inter alpha-trypsin inhibitor, heavy chain 4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4)Itih4A6X93516
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-33 receptot beta chain)Il1rapQ6173016
Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14)Krt14 Krt1-14Q6178116
Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta)Lamb1 Lamb-1 Lamb1-1P0246916
Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)Lamc1 Lamb-2 Lamc-1P0246816
Long-chain-fatty-acid--CoA ligase 1 (EC (Long-chain acyl-CoA synthetase 1) (LACS 1)Acsl1 Acsl2 Facl2P4121616
Lysosomal protective protein (EC (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]Ctsa PpgbP1667516
MAGUK p55 subfamily member 6 (Dlgh4 protein) (P55T protein) (Protein associated with Lin-7 2)Mpp6 Dlgh4 Pals2Q9JLB016
Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56)Ncam1 NcamP1359516
Nucleolar protein 58 (MSSP) (Nucleolar protein 5) (SIK-similar protein)Nop58 Nol5Q6DFW416
Osteoclast-stimulating factor 1 (SH3 domain protein 3)Ostf1 Sh3d3 Sh3p2Q6242216
Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1)Pef1Q8BFY616
Probable ATP-dependent RNA helicase DDX6 (EC (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK homolog)Ddx6 Hlr2 RckP5482316
Prostaglandin E synthase 3 (EC (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Sid 3177) (Telomerase-binding protein p23)Ptges3 Sid3177 TebpQ9R0Q716
Protein 4.1 (P4.1) (4.1R) (Band 4.1)Epb41 Epb4.1 Kiaa4056P4819316
Protein MEMO1 (Mediator of ErbB2-driven cell motility 1) (Memo-1)Memo1Q91VH616
Protein SET (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)SetQ9EQU516
Protein transport protein Sec23B (SEC23-related protein B)Sec23bQ9D66216
Protein tweety homolog 2 (mTTY2)Ttyh2Q3TH7316
Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif)Ankfy1 Ankhzn Kiaa1255Q810B616
Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC (EC (ATP-dependent DNA helicase VIII) (GAP SH3 domain-binding protein 1) (HDH-VIII)G3bp1 G3bpP9785516
Ras-related protein Rab-11A (Rab-11)Rab11a Rab11P6249216
Ras-related protein Rab-22A (Rab-22) (Rab-14)Rab22a Rab22P3528516
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC (LCA-related phosphatase) (PTPTY-28)Ptpra Lrp PtpaP1805216
Rho GTPase-activating protein 1 (Rho-type GTPase-activating protein 1)Arhgap1Q5FWK316
Scavenger receptor class B member 1 (SRB1) (SR-BI)Scarb1 Srb1Q6100916
Sialic acid synthase (N-acetylneuraminate-9-phosphate synthase) (EC (N-acetylneuraminic acid phosphate synthase)Nans SasQ99J7716
Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)Atp1b1 Atp4bP1409416
STE20-like serine/threonine-protein kinase (STE20-like kinase) (mSLK) (EC (Etk4) (STE20-related kinase SMAK) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)Slk Kiaa0204 Stk2O5498816
Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (FGF-inducible protein 16) (XCAP-E homolog)Smc2 Cape Fin16 Smc2l1Q8CG4816
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Mad member-interacting protein 1)Smc3 Bam Bmh Cspg6 Mmip1 Smc3l1 SmcdQ9CW0316
Syndecan-4 (SYND4) (Ryudocan core protein)Sdc4O3598816
Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3)TgfbiP8219816
Transmembrane protein 2Tmem2 Kiaa1412Q5FWI316
Tubulin beta-1 chainTubb1A2AQ0716
Tyrosine-protein phosphatase non-receptor type 6 (EC (70Z-SHP) (Hematopoietic cell protein-tyrosine phosphatase) (PTPTY-42) (Protein-tyrosine phosphatase 1C) (PTP-1C) (SH-PTP1) (SHP-1)Ptpn6 Hcp Hcph Ptp1CP2935116
Ubiquitin thioesterase OTUB1 (EC (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (Ubiquitin-specific-processing protease OTUB1)Otub1Q7TQI316
Ubiquitin-conjugating enzyme E2 K (EC (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)Ube2k Hip2P6108716
Unconventional myosin-Ib (MIH-L) (Myosin I alpha) (MMI-alpha) (MMIa)Myo1bP4673516
Unconventional myosin-X (Unconventional myosin-10)Myo10F8VQB616
V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)Atp6v0a1 Atp6n1Q9Z1G416
V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1)Atp6v1g1 Atp6g1Q9CR5116
Vacuolar protein sorting-associated protein 26A (H58 protein) (H beta 58) (Vesicle protein sorting 26A) (mVPS26)Vps26a Vps26P4033616
10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10)Hspe1Q6443315
4-trimethylaminobutyraldehyde dehydrogenase (TMABADH) (EC (Aldehyde dehydrogenase family 9 member A1) (EC
40S ribosomal protein S28Rps28P6285815
60S ribosomal protein L29Rpl29 Rpl43P4791515
60S ribosomal protein L36a (60S ribosomal protein L44)Rpl36a Rpl44P8388215
Acetoacetyl-CoA synthetase (EC
Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-)Smpdl3b Asml3bP5824215
Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)DbiP3178615
Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein)Aebp1 AclpQ640N115
Alpha-mannosidase 2 (EC (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)Man2a1 Mana2P2704615
Aminopeptidase B (AP-B) (EC (Arginine aminopeptidase) (Arginyl aminopeptidase) (Cytosol aminopeptidase IV)RnpepQ8VCT315
Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]ApobE9Q41415
BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5)Bag5Q8CI3215
Basic leucine zipper and W2 domain-containing protein 2Bzw2Q91VK115
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC (G-protein-coupled receptor kinase 2)Grk2 Adrbk1Q99MK815
Bone morphogenetic protein 1 (BMP-1) (EC (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)Bmp1P9806315
Calmodulin-1Calm1 Calm Cam Cam1P6220415
cAMP-dependent protein kinase type II-beta regulatory subunitPrkar2bP3132415
Carboxypeptidase E (CPE) (EC (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase)CpeQ0049315
CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1)Cd2ap Mets1Q9JLQ015
Cell surface glycoprotein MUC18 (Gicerin) (Melanoma cell adhesion molecule) (Melanoma-associated antigen MUC18) (CD antigen CD146)Mcam Muc18Q8R2Y215
Coagulation factor X (EC (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]F10O8894715
Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated Src activator) (Protein FAM120A)FAM120A Kiaa0183 OssaQ6A0A915
COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (JAB1-containing signalosome subunit 7a)Cops7a Csn7aQ9CZ0415
COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (JAB1-containing signalosome subunit 8)Cops8 Csn8Q8VBV715
Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog)Coro7Q9D2V715
CTP synthase 1 (EC (CTP synthetase 1) (UTP--ammonia ligase 1)Ctps1 CtpsP7069815
Cullin-3 (CUL-3)Cul3Q9JLV515
Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1)Uqcrc1Q9CZ1315
Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3)Drg1 Drg Nedd-3 Nedd3P3223315
DNA-directed RNA polymerase II subunit RPB2 (EC (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2)Polr2bQ8CFI715
ELAV-like protein 1 (Elav-like generic protein) (Hu-antigen R) (HuR) (MelG)Elavl1 Elra HuaP7037215
Electron transfer flavoprotein subunit beta (Beta-ETF)EtfbQ9DCW415
Epoxide hydrolase 1 (EC (Epoxide hydratase) (Microsomal epoxide hydrolase)Ephx1Q9D37915
ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase alpha) (Endoplasmic reticulum oxidoreductin-1-like protein) (Oxidoreductin-1-L-alpha)Ero1a Ero1lQ8R18015
FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (T160)Ssrp1Q0894315
Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP)Khsrp Fubp2Q3U0V115
H-2 class I histocompatibility antigen, K-B alpha chain (H-2K(B))H2-K1 H2-KP0190115
Histone H2A type 1-BHist1h2abC0HKE115
Histone H2A type 2-B (H2a-613A)Hist2h2abQ6452215
Histone H2B type 1-C/E/GHist1h2bc; Hist1h2be; Hist1h2bgQ6ZWY915
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