EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
Ephrin type-B receptor 3 (EC 2.7.10.1) (Developmental kinase 5) (mDK-5) (Tyrosine-protein kinase receptor SEK-4)Ephb3 Etk2 Mdk5 Sek4P5475412
Ephrin type-B receptor 4 (EC 2.7.10.1) (Developmental kinase 2) (mDK-2) (Hepatoma transmembrane kinase) (Tyrosine kinase MYK-1)Ephb4 Htk Mdk2 Myk1P5476112
Eukaryotic translation initiation factor 1 (eIF1) (Protein translation factor SUI1 homolog)Eif1 Sui1 Sui1-rs1P4802412
Eukaryotic translation initiation factor 2A (eIF-2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]Eif2a D3Ertd194eQ8BJW612
Exocyst complex component 2 (Exocyst complex component Sec5)Exoc2 Sec5 Sec5l1Q9D4H112
FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16)Supt16h Fact140 Factp140 Supt16Q920B912
Feline leukemia virus subgroup C receptor-related protein 1 (Feline leukemia virus subgroup C receptor) (Major facilitator superfamily domain containing 7B) (Mfsd7b)Flvcr1 Mfsd7bB2RXV412
Formin-like protein 3Fmnl3 Frl2 Kiaa2014Q6ZPF412
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16)Gabarapl2P6052112
Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma)Napg SnapgQ9CWZ712
Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST 5-5) (GST class-mu 2) (Glutathione S-transferase pmGT2)Gstm2P1562612
Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)Gna12 Gna-12P2760012
Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]Hnrnph2 Hnrph2P7033312
Histone H2A type 3Hist3h2aQ8BFU212
Histone H2B type 2-B (H2b 616)Hist2h2bbQ6452512
Ig mu chain C regionIghm Igh-6P0187212
Inactive tyrosine-protein kinase 7 (Protein chuzhoi) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)Ptk7Q8BKG312
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]InsrP1520812
Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)Itga1Q3V3R412
Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (Lymphocyte Peyer patch adhesion molecules subunit alpha) (LPAM subunit alpha) (VLA-4 subunit alpha) (CD antigen CD49d)Itga4Q0065112
Keratin, type I cytoskeletal 15 (Cytokeratin-15) (CK-15) (Keratin-15) (K15)Krt15 Krt1-15Q6141412
Keratin, type II cytoskeletal 79 (Cytokeratin-79) (CK-79) (Keratin-79) (K79) (Type-II keratin Kb38)Krt79 Kb38Q8VED512
Kinesin-like protein KIF23Kif23E9Q5G312
Kinetochore-associated protein 1Kntc1 Kiaa0166Q8C3Y412
Lactotransferrin (Lactoferrin) (EC 3.4.21.-)LtfP0807112
Laminin subunit gamma-1Lamc1F8VQJ312
Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC)LssQ8BLN512
Lethal(2) giant larvae protein homolog 2 (Lethal giant larvae-like protein 2)Llgl2 Llglh2Q3TJ9112
Lysozyme C-2 (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C) (Lysozyme C type M)Lyz2 Lyz LyzsP0890512
Matrin-3Matr3Q8K31012
Methylosome protein 50 (MEP-50) (WD repeat-containing protein 77)Wdr77 Mep50Q99J0912
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)Mink1 Map4k6 MinkQ9JM5212
N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylaspartylglutamate peptidase II) (NAAG-peptidase II) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II)Naalad2Q9CZR212
N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S)GnsQ8BFR412
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-75kD) (CI-75kD)Ndufs1Q91VD912
Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form) (skNAC)Naca Gm1878P7067012
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Murine herpes virus entry protein B) (mHveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor homolog) (Poliovirus receptor-related protein 2) (CD antigen CD112)Nectin2 Mph Pvr Pvrl2 PvsP3250712
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)Wwp2Q9DBH012
NEDD8-conjugating enzyme Ubc12 (EC 6.3.2.-) (NEDD8 carrier protein) (NEDD8 protein ligase) (Ubiquitin-conjugating enzyme E2 M)Ube2m Ubc-rs2 Ubc12P6108212
Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1)Syne1Q6ZWR612
Neurogenic locus notch homolog protein 2 (Notch 2) (Motch B) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain]Notch2O3551612
Neutral amino acid transporter B(0) (ATB(0)) (ASC-like Na(+)-dependent neutral amino acid transporter ASCT2) (Insulin-activated amino acid transporter) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)Slc1a5 Aaat Asct2 Slc1a7P5191212
Neutrophil gelatinase-associated lipocalin (NGAL) (Lipocalin-2) (SV-40-induced 24P3 protein) (Siderocalin LCN2) (p25)Lcn2P1167212
Nidogen-1 (NID-1) (Entactin)Nid1 EntP1049312
PaxillinPxnQ8VI3612
Perilipin-3 (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1)Plin3 M6prbp1 Tip47Q9DBG512
Phospholipase D3 (PLD 3) (EC 3.1.4.4) (Choline phosphatase 3) (Phosphatidylcholine-hydrolyzing phospholipase D3) (Schwannoma-associated protein 9) (SAM-9)Pld3 Sam9O3540512
Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase)Pla2g7 PafahQ6096312
Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.30)Parp4E9PYK312
Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1)Ptbp3 Rod1Q8BHD712
Pre-rRNA-processing protein TSR1 homologTsr1 Kiaa1401Q5SWD912
Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1)Colgalt1 Glt25d1Q8K29712
Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i)Psmb10 Lmp10 Mecl1O3595512
Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog)Prmt5 Jbp1 Skb1Q8CIG812
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (AKT1 kinase) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) (Thymoma viral proto-oncogene)Akt1 Akt RacP3175012
Ran GTPase-activating protein 1 (RanGAP1)Rangap1 Fug1P4606112
Ras GTPase-activating-like protein IQGAP2Iqgap2Q3UQ4412
Ras-related protein Rab-13Rab13Q9DD0312
RNA-binding protein FUS (Protein pigpen)FusP5695912
Septin-6Sept6 Kiaa0128Q9R1T412
Septin-8Sept8 Kiaa0202Q8CHH912
Serine protease 23 (EC 3.4.21.-)Prss23Q9D6X612
Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)Stk10 LokO5509812
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1)Mtor Frap Frap1Q9JLN912
Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)Oxsr1 Osr1Q6P9R212
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)Plk1 PlkQ0783212
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon)Ppp2r5e Kiaa4006Q6115112
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)Ppp2r1bQ7TNP212
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]Ppp6cQ9CQR612
Signal transducer and activator of transcription 1Stat1P4222512
Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-4)Atp1a4 Atp1al2Q9WV2712
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s)Oxct1 Oxct ScotQ9D0K212
SUMO-activating enzyme subunit 2 (EC 6.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)Uba2 Sae2 Uble1bQ9Z1F912
TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP)Tbc1d15Q9CXF412
Tensin-3 (Tensin-like SH2 domain-containing protein 1)Tns3 Tens1Q5SSZ512
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (Silica-induced gene 41 protein) (SIG-41) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)Tra2b Sfrs10 Silg41P6299612
Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Growth factor-regulated calcium channel) (GRC) (Osm-9-like TRP channel 2) (OTRPC2)Trpv2 GrcQ9WTR112
Transmembrane protein 206Tmem206Q9D77112
Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1)Tubg1 TubgP8388712
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (MK) (CD antigen CD262)Tnfrsf10b Dr5 KillerQ9QZM412
Tyrosine-protein kinase HCK (EC 2.7.10.2) (B-cell/myeloid kinase) (BMK) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p56-HCK/p59-HCK)HckP0810312
Unconventional myosin-IdMyo1dQ5SYD012
Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1)Vamp7 Sybl1P7028012
WD repeat-containing protein 26Wdr26Q8C6G812
ZyxinZyxQ6252312
60S ribosomal protein L17 (MCG123291, isoform CRA_d) (MCG50776) (Putative uncharacterized protein) (Ribosomal protein L17)Rpl17 mCG_123291 mCG_50776Q6ZWZ711
60S ribosomal protein L22-like 1Rpl22l1Q9D7S711
Acidic leucine-rich nuclear phosphoprotein 32 family member E (Cerebellar postnatal development protein 1) (LANP-like protein) (LANP-L)Anp32e Cpd1P9782211
Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase 2) (Lysophospholipase II) (LPL-II) (LysoPLA II) (mLyso II)Lypla2Q9WTL711
Adapter molecule crk (Proto-oncogene c-Crk) (p38)Crk CrkoQ6401011
Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]Ak2Q9WTP611
Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (IMP--aspartate ligase 1)Adssl1 Adss1P2865011
ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5)Nudt5Q9JKX611
Alpha-1-antitrypsin 1-2 (AAT) (Alpha-1 protease inhibitor 2) (Alpha-1-antiproteinase) (Serine protease inhibitor 1-2) (Serine protease inhibitor A1b) (Serpin A1b)Serpina1b Aat2 Dom2 Spi1-2P2259911
Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1)Man2c1Q91W8911
Alpha-N-acetylglucosaminidase (Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)) (Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB), isoform CRA_b) (N-acetyl-glucosaminidase) (Putative uncharacterized protein)Naglu mCG_20229O8832511
Anthrax toxin receptor 2Antxr2Q6DFX211
AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma-adaptin) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)Ap1g1 Adtg Clapg1P2289211
AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) (mBLVR1)Ap3d1 Ap3dO5477411
Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Delayed early response protein 2) (DER2) (Water channel protein for red blood cells and kidney proximal tubule)Aqp1Q0201311
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