EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.


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Protein name Gene symbol UniProt accession Identification number
Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)Eif3f Eif3s5Q9DCH432
F-actin-capping protein subunit beta (CapZ beta)Capzb Cappb1P4775732
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)Hnrnpa2b1 Hnrpa2b1O8856932
Proteasome subunit alpha type-3 (EC (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit K)Psma3O7043532
Proteasome subunit alpha type-5 (EC (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)Psma5Q9Z2U132
Ras-related protein Rab-1BRab1bQ9D1G132
Ras-related protein Rab-2ARab2a Rab2P5399432
Ras-related protein Rab-6A (Rab-6)Rab6a Rab6 MNCb-1660P3527932
RuvB-like 1 (EC (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (DNA helicase p50) (Pontin 52) (TIP49a)Ruvbl1 Tip49 Tip49aP6012232
60S ribosomal protein L12Rpl12P3597931
60S ribosomal protein L18aRpl18aP6271731
60S ribosomal protein L27Rpl27P6135831
60S ribosomal protein L8Rpl8P6291831
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)Ap2a2 AdtabP1742731
Asparagine--tRNA ligase, cytoplasmic (EC (Asparaginyl-tRNA synthetase) (AsnRS)NarsQ8BP4731
ATP-citrate synthase (EC (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme)AclyQ91V9231
Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]CopaQ8CIE631
Destrin (Actin-depolymerizing factor) (ADF) (Sid 23)Dstn Dsn Sid23Q9R0P531
Elongation factor 1-beta (EF-1-beta)Eef1b Eef1b2O7025131
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)Eif3c Eif3s8Q8R1B431
Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (MMTV integration site 6) (Mammary tumor-associated protein INT-6) (Viral integration site protein INT-6) (eIF-3 p48)Eif3e Eif3s6 Int6P6022931
F-actin-capping protein subunit alpha-2 (CapZ alpha-2)Capza2 Cappa2P4775431
Glucose-6-phosphate 1-dehydrogenase X (G6PD) (EC G6pd G6pd-1Q0061231
Heterogeneous nuclear ribonucleoprotein K (hnRNP K)Hnrnpk HnrpkP6197931
Histone H3.2Hist1h3b H3-53 H3.2 H3b; Hist1h3c H3-143; Hist1h3d H3-B; Hist1h3e H3-F; Hist1h3f H3.2-221 H3f; Hist2h3b H3.2-616; Hist2h3c1 H3.2-615 Hist2h3ca1; Hist2h3c2 H3.2-614 Hist2h3ca2P8422831
Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2)Itih2Q6170331
Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Fragilis protein) (Interferon-inducible protein 15) (Mouse ifitm-like protein 1) (Mil-1)Ifitm3Q9CQW931
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (Type-II keratin Kb1)Krt1 Krt2-1P0410431
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (L-type amino acid transporter 1) (Solute carrier family 7 member 5)Slc7a5 Lat1Q9Z12731
Myeloid-associated differentiation marker (Myeloid up-regulated protein)Myadm MugO3568231
Proteasome subunit beta type-3 (EC (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)Psmb3Q9R1P131
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC Ppp1aP6213731
Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)Atp1b3P9737031
Staphylococcal nuclease domain-containing protein 1 (100 kDa coactivator) (p100 co-activator)Snd1Q78PY731
Thioredoxin (Trx) (ATL-derived factor) (ADF)Txn Txn1P1063931
Tripeptidyl-peptidase 2 (TPP-2) (EC (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II)Tpp2Q6451431
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1)Psmd1Q3TXS730
26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)Psmd12Q9D8W530
26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Mov34 protein) (Proteasome subunit p40)Psmd7 Mov-34 Mov34P2651630
40S ribosomal protein S25Rps25P6285230
60S ribosomal protein L27a (L29)Rpl27aP1411530
60S ribosomal protein L9Rpl9P5141030
Actin, alpha cardiac muscle 1 (Alpha-cardiac actin)Actc1 ActcP6803330
Actin, cytoplasmic 2 (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]Actg1 ActgP6326030
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)Actn1Q7TPR430
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)Ap2b1 Clapb1Q9DBG330
Arginine--tRNA ligase, cytoplasmic (EC (Arginyl-tRNA synthetase) (ArgRS)RarsQ9D0I930
ATP-dependent RNA helicase DDX3X (EC (D1Pas1-related sequence 2) (DEAD box RNA helicase DEAD3) (mDEAD3) (DEAD box protein 3, X-chromosomal) (Embryonic RNA helicase)Ddx3x D1Pas1-rs2 Ddx3 Dead3 ErhQ6216730
Eukaryotic translation initiation factor 3 subunit L (eIF3l) (66 kDa tyrosine-rich heat shock protein) (67 kDa polymerase-associated factor) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein) (HSP-66Y) (PAF67)Eif3l Eif3eip Eif3s6ip Paf67Q8QZY130
Heterogeneous nuclear ribonucleoprotein F (hnRNP F) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]Hnrnpf HnrpfQ9Z2X130
Histone H1.3 (H1 VAR.4) (H1d)Hist1h1d H1f3P4327730
Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain]Itga6Q6173930
Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]Pebp1 Pbp PebpP7029630
Proteasome subunit beta type-2 (EC (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I)Psmb2Q9R1P330
Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)Sept2 Nedd-5 Nedd5P4220830
Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (GT1)Slc2a1 Glut-1 Glut1P1780930
Stress-induced-phosphoprotein 1 (STI1) (mSTI1) (Hsc70/Hsp90-organizing protein) (Hop)Stip1Q6086430
Voltage-dependent anion-selective channel protein 1 (VDAC-1) (mVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Voltage-dependent anion-selective channel protein 5) (VDAC-5) (mVDAC5)Vdac1 Vdac5Q6093230
WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1)Wdr1O8834230
26S protease regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)Psmc1P6219229
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (p42A)Psmd6Q99JI429
40S ribosomal protein S23Rps23P6226729
Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)Arpc3Q9JM7629
ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]Slc25a5 Ant2P5188129
Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22)Basp1 Nap22Q91XV329
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC; Methenyltetrahydrofolate cyclohydrolase (EC; Formyltetrahydrofolate synthetase (EC]Mthfd1Q922D829
Cathepsin D (EC
Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)Copb2O5502929
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1)Cand1 D10Ertd516e Kiaa0829Q6ZQ3829
Eukaryotic translation initiation factor 2 subunit 3, X-linked (Eukaryotic translation initiation factor 2 subunit gamma, X-linked) (eIF-2-gamma X)Eif2s3xQ9Z0N129
Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)Eif3i Eif3s2 Trip1Q9QZD929
Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)Gna13 Gna-13P2760129
Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (Scaffold attachment factor A) (SAF-A)Hnrnpu HnrpuQ8VEK329
Histone H3.1Hist1h3a H3a; Hist1h3g H3.1-221 H3g; Hist1h3h H3.1-291 H3h; Hist1h3i H3.1-I H3iP6843329
Hypoxia up-regulated protein 1 (GRP-170) (140 kDa Ca(2+)-binding protein) (CBP-140)Hyou1 Grp170Q9JKR629
Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)Krt5 Krt2-5Q922U229
Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (120 kDa lysosomal membrane glycoprotein) (CD107 antigen-like family member A) (LGP-120) (Lysosomal membrane glycoprotein A) (LGP-A) (P2B) (CD antigen CD107a)Lamp1 Lamp-1P1143829
Myristoylated alanine-rich C-kinase substrate (MARCKS)Marcks MacsP2664529
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)Npm1Q6193729
Proteasome subunit beta type-4 (EC (Low molecular mass protein 3) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3)Psmb4 Lmp3P9902629
RuvB-like 2 (EC (p47 protein)Ruvbl2Q9WTM529
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC
Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)Tf TrfQ921I129
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (Peptide-binding protein 74) (PBP74) (p66 MOT)Hspa9 Grp75 Hsp74 Hspa9aP3864729
Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)Tsg101Q6118729
Tyrosine-protein kinase Lyn (EC (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)LynP2591129
Vacuolar protein sorting-associated protein 4B (EC (Suppressor of K(+) transport growth defect 1) (Protein SKD1)Vps4b Skd1P4646729
26S protease regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Tat-binding protein 1) (TBP-1)Psmc3 Tbp1O8868528
40S ribosomal protein S17Rps17P6327628
40S ribosomal protein S5 [Cleaved into: 40S ribosomal protein S5, N-terminally processed]Rps5P9746128
60S ribosomal protein L22 (Heparin-binding protein HBp15)Rpl22P6798428
60S ribosomal protein L7a (Surfeit locus protein 3)Rpl7a Surf-3 Surf3P1297028
ADP-ribosylation factor 6Arf6P6233128
Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)Ano6 Tmem16fQ6P9J928
Asparagine synthetase [glutamine-hydrolyzing] (EC (Glutamine-dependent asparagine synthetase)AsnsQ6102428
ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)Pfkl Pfk-l PfkbP1238228
Chloride intracellular channel protein 4 (mc3s5/mtCLIC)Clic4Q9QYB128
Coagulation factor V (Activated protein C cofactor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]F5O8878328
Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y)H2afyQ9QZQ828
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