EVpedia provide top 100+ EV markers, selected according to their identification number.
Based on EV proteomes, we defined the identification number of protein A as the number of datasets which contain protein A.
Therefore, proteins with higher identification numbers were more conserved.

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Protein name Gene symbol UniProt accession Identification number
High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha)Fcer1a Fce1aP204893
High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2)Ms4a2 Fce1b Fcer1b Ms4a1P204903
High mobility group protein B2 (High mobility group protein 2) (HMG-2)Hmgb2 Hmg2P306813
Histocompatibility 2, M region locus 10.1 (MHC class Ib antigen) (Protein H2-M10.1)H2-M10.1 M10O194433
Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (Lysine acetyltransferase 5)Kat5 Htatip Tip60Q8CHK43
Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A)Asf1aQ9CQE63
Histone H2A type 3Hist3h2aQ8BFU23
Histone-arginine methyltransferase CARM1 (EC 2.1.1.-) (EC 2.1.1.125) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4)Carm1 Prmt4Q9WVG63
Histone-lysine N-methyltransferase 2CKmt2c Mll3F8WI373
Histone-lysine N-methyltransferase SETDB1Setdb1D3YYC33
Homeobox even-skipped homolog protein 1 (EVX-1)Evx1P236833
Homeobox protein aristaless-like 3 (Proline-rich transcription factor ALX3)Alx3O701373
Homeobox protein HMX3 (Homeobox protein H6 family member 3) (Homeobox protein Nkx-5.1)Hmx3 Nkx-5.1 Nkx5-1P425813
Homeobox protein Hox-C12 (Homeobox protein Hox-3.8)Hoxc12 Hox-3.8 Hoxc-12Q8K5B83
Homeobox protein Hox-C4 (Homeobox protein Hox-3.5)Hoxc4 Hox-3.5 Hoxc-4Q086243
Homeobox protein Hox-D12 (Homeobox protein Hox-4.7) (Homeobox protein Hox-5.6)Hoxd12 Hox-4.7 Hoxd-12P238123
Homeobox protein Nkx-2.6 (Homeobox protein NK-2 homolog F)Nkx2-6 Nkx-2.6 Nkx2fP436883
Homeobox protein orthopediaOtpO091133
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)Six1Q622313
Homer protein homolog 1 (Homer-1) (VASP/Ena-related gene up-regulated during seizure and LTP 1) (Vesl-1)Homer1 Vesl1Q9Z2Y33
Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog)St13 Fam10a1 HipQ99L473
Hyaluronan and proteoglycan link protein 2 (Brain link protein 1)Hapln2 Bral1Q9ESM33
Hypoxia up-regulated protein 1 (GRP-170) (140 kDa Ca(2+)-binding protein) (CBP-140)Hyou1 Grp170Q9JKR63
Immunoglobulin superfamily member 5 (IgSF5) (Junctional adhesion molecule 4) (JAM-4)Igsf5 Jam4Q7TSN73
Importin subunit alpha-1 (Importin alpha P1) (Karyopherin subunit alpha-2) (Pendulin) (Pore targeting complex 58 kDa subunit) (PTAC58) (RAG cohort protein 1) (SRP1-alpha)Kpna2 Rch1P522933
Importin subunit alpha-7 (Importin alpha-S2) (Karyopherin subunit alpha-6)Kpna6 Kpna5O353453
Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD28 and CTLA-4-like protein) (CCLP) (CD28-related protein 1) (CRP-1) (CD antigen CD278)Icos AilimQ9WVS03
Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein)Ikbip IkipQ9DBZ13
Inner centromere proteinIncenpQ9WU623
Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase 2) (PPase 2)Ppa2Q91VM93
Inositol (Myo)-1(Or 4)-monophosphatase 1 (Inositol (Myo)-1(Or 4)-monophosphatase 1, isoform CRA_a) (Inositol monophosphatase 1) (Myo-inositol monophosphatase 1)Impa1 mCG_1639Q924B03
Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)Itpr2 Itpr5Q9Z3293
Inositol hexakisphosphate kinase 3 (InsP6 kinase 3) (EC 2.7.4.21) (Inositol hexaphosphate kinase 3)Ip6k3 Ihpk3Q8BWD23
Inositol polyphosphate multikinase (EC 2.7.1.151) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)Ipmk ImpkQ7TT163
Insulin-like peptide INSL6 (Insulin-like peptide 6) [Cleaved into: Insulin-like peptide INSL6 B chain; Insulin-like peptide INSL6 A chain]Insl6Q9QY053
Integral membrane protein DGCR2/IDD (Seizure-related membrane-bound adhesion protein)Dgcr2 Dgsc Idd Sez-12 Sez12P981543
Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein)Gpr137b Tm7sf1Q8BNQ33
Integral membrane protein GPR180Gpr180 MNCb-3029Q8BPS43
Integrator complex subunit 5 (Int5)Ints5Q8CHT33
Integrator complex subunit 7 (Int7)Ints7Q7TQK13
Integrator complex subunit 9 (Int9)Ints9 D14Ertd231eQ8K1143
Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (Lymphocyte Peyer patch adhesion molecules subunit alpha) (LPAM subunit alpha) (VLA-4 subunit alpha) (CD antigen CD49d)Itga4Q006513
Integrin alpha-E (Integrin alpha M290) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]ItgaeQ606773
Integrin alpha-V (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]ItgavP434063
Interferon alpha-inducible protein 27-like protein 2AIfi27 Ifi27l1E9Q1C53
Interferon alpha-inducible protein 27-like protein 2A (Interferon-stimulated gene 12 protein) (ISG12)Ifi27l2a Ifi27 Isg12Q8R4123
Interferon alpha-inducible protein 27-like protein 2B (Interferon-stimulated gene 12 protein B2) (ISG12(b2))Ifi27l2b Isg12(b2)Q8VC493
Interferon regulatory factor 5 (IRF-5)Irf5P564773
Interferon-induced protein 44-like [Cleaved into: Minor histocompatibility antigen HA-28 (HLA-HA28) (IFL8)]Ifi44l H28Q9BDB73
Interferon-inducible protein AIM2 (Interferon-inducible protein 210) (Ifi-210) (Interferon-inducible protein p210)Aim2 Gm1313 Ifi210Q91VJ13
Interleukin enhancer-binding factor 3Ilf3Q9Z1X43
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP)Il1rapQ617303
Interleukin-1 receptor-like 1 (Lymphocyte antigen 84) (Protein ST2) (Protein T1)Il1rl1 Ly84 St2 Ste2P147193
Interleukin-15 (IL-15)Il15P483463
Interleukin-15 receptor subunit alpha (IL-15 receptor subunit alpha) (IL-15R-alpha) (IL-15RA) (CD antigen CD215) [Cleaved into: Soluble interleukin-15 receptor subunit alpha (sIL-15 receptor subunit alpha) (sIL-15R-alpha) (sIL-15RA)]Il15raQ608193
Interleukin-17 receptor E (IL-17 receptor E) (IL-17RE)Il17reQ8BH063
Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Lymphocyte receptor beta) (LR-beta) (Novel cytokine receptor 8) (NR8) (Novel interleukin receptor) (CD antigen CD360)Il21r NilrQ9JHX33
Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Type I T-cell cytokine receptor) (TCCR) (WSX-1)Il27ra Tccr Wsx1O703943
Interleukin-3 receptor subunit alpha (IL-3 receptor subunit alpha) (IL-3R subunit alpha) (IL-3R-alpha) (IL-3RA) (Interleukin-3 receptor class II alpha chain) (CD antigen CD123)Il3ra Sut-1P269523
Interleukin-34 (IL-34)Il34Q8R1R43
Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CD antigen CD127)Il7rP168723
Interphotoreceptor matrix proteoglycan 2 (Sialoprotein associated with cones and rods proteoglycan) (Spacrcan)Impg2Q80XH23
Interstitial collagenase A (EC 3.4.24.7) (Matrix metalloproteinase-1a) (MMP-1a) (Mcol-A)Mmp1a McolAQ9EPL53
Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA)Isca1 Hbld2Q9D9243
Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2) (Iroquois-class homeobox protein Irx6)Irx2 Irx6 Irxa2P810663
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)Idh3aQ9D6R23
Isopentenyl-diphosphate Delta-isomerase 1 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1)Idi1P580443
Kalirin (EC 2.7.11.1) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)KalrnA2CG493
Kallikrein 1-related peptidase b9 (EC 3.4.21.35) (Epidermal growth factor-binding protein type C) (EGF-BP C) (Glandular kallikrein K9) (mGK-9) (Tissue kallikrein-9)Klk1b9 Egfbp3 Klk-9 Klk9P159493
Kallikrein 1-related peptidase b9 (Kallikrein 9) (Klk9 protein)Klk9 mCG_1051030Q32M273
Kallikrein 6, isoform CRA_a (Kallikrein-1) (Klk6 protein) (Neurosin)Klk6 Prss18 mCG_133315Q91Y823
KAT8 regulatory NSL complex subunit 1-like proteinKansl1l Kiaa4189Q5DTI63
Kelch domain-containing protein 10Klhdc10 Kiaa0265Q6PAR03
Kelch domain-containing protein 3 (Protein Peas) (Testis intracellular mediator protein)Klhdc3 PeasQ8VEM93
Kelch-like protein 11Klhl11Q8CE333
Kelch-like protein 22Klhl22 KelchlQ99JN23
Keratin associated protein 31-2 (MCG1025732) (Protein Krtap31-2)Krtap31-2 OTTMUSG00000002177 mCG_1025732Q8CAY53
Keratin, type I cuticular Ha2 (Hair keratin, type I Ha2) (Keratin-32) (K32)Krt32 Hka2 Krt1-2 Krtha2Q621683
Keratin, type I cuticular Ha5 (Hair keratin, type I Ha5) (Keratin-35) (K35)Krt35 Krt1-24Q497I43
Keratin, type II cuticular Hb3 (Keratin-83) (K83) (Type II hair keratin Hb3) (Type-II keratin Kb23)Krt83 Kb23 Krt2-25Q6IMF03
Keratin, type II cuticular Hb4 (65 kDa type II keratin) (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)Krt84 Krt2-16 Krthb4Q99M733
Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (mK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18)Krt75 Kb18Q8BGZ73
Keratin-associated protein 12-1Krtap12-1Q9Z2873
Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1)Kcp Crim2 Kcp1Q3U4923
Kinesin family member C2 (Kinesin-like protein KIFC2)Kifc2 mCG_23628G3X8Q63
Kinesin-like protein KIF24Kif24Q6NWW53
Kininogen-1 [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kininogen-1 light chain]Kng1 KngO086773
KiSS-1 receptor (KiSS-1R) (G-protein coupled receptor 54) (G-protein coupled receptor OT7T175) (mOT7T175) (Kisspeptins receptor) (Metastin receptor)Kiss1r Gpr54Q91V453
Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Dopamine receptor-regulating factor) (Transcription factor BTEB4)Klf16 Bteb4 DrrfP583343
Krueppel-like factor 2 (Lung krueppel-like factor)Klf2 LklfQ608433
Kv channel-interacting protein 2 (KChIP2) (A-type potassium channel modulatory protein 2) (Potassium channel-interacting protein 2)Kcnip2 Kchip2Q9JJ693
Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF)AfmidQ8K4H13
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.-) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT)AasdhpptQ9CQF63
L-gulonolactone oxidase (LGO) (EC 1.1.3.8) (L-gulono-gamma-lactone oxidase) (GLO)GuloP587103
L-serine dehydratase/L-threonine deaminase (SDH) (EC 4.3.1.17) (L-serine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19)SdsQ8VBT23
L1 cell adhesion molecule (Neural cell adhesion molecule L1)L1camQ6PGJ33
La-related protein 4 (La ribonucleoprotein domain family member 4)Larp4Q8BWW43
La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6)Larp6Q8BN593
Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) (Sperm surface protein SP47) (MP47)Mfge8P219563
Lactation elevated protein 1Lace1Q3V3843
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